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| 1 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 2 | Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits显示文摘Displaced fractures of patella often require open reduction surgery and internal fixation to restore the extensor continuity and articular congruity.Fracture fixation with biodegradable magnesium(Mg)pins enhanced fracture healing.We hypothesized that fixation with Mg pins and their degradation over time would enhance healing of patellar fracture radiologically,mechanically,and histologically.Transverse patellar fracture surgery was performed on thirty-two 18-weeks old female New Zealand White Rabbits.The fracture was fixed with a pin made of stainless steel or pure Mg,and a figure-of-eight stainless steel band wire.Samples were harvested at week 8 or 12,and assessed with microCT,tensile testing,microindentation,and histology.Microarchitectural analysis showed that Mg group showed 12%higher in the ratio of bone volume to tissue volume at week 8,and 38.4%higher of bone volume at week 12.Tensile testing showed that the failure load and stiffness of Mg group were 66.9%and 104%higher than the control group at week 8,respectively.At week 12,Mg group was 60.8%higher in ultimate strength than the control group.Microindentation showed that,compared to the Control group,Mg group showed 49.9%higher Vickers hardness and 31%higher elastic modulus at week 8 and 12,respectively.At week 12,the new bone of Mg group remodelled to laminar bone,but those of the control group remained woven bone-like.Fixation of transverse patellar fracture with Mg pins and its degradation enhanced new bone formation and mechanical properties of the repaired patella compared to the Control group. | Dick Ho Kiu Chow Jiali Wang Peng Wan Lizhen Zheng Michael Tim Yun Ong Le Huang Wenxue Tong Lili Tan Ke Yang Ling Qin | 2021 | Bioactive Materials2021，6，11： | 3 |
| 3 | Microstructure, mechanical and tribological behaviors of MoS 2 -Ti composite coatings deposited by a hybrid HIPIMS method显示文摘 | Xiaopeng Qin Peiling Ke Aiying Wang Kwang Ho Kim | 2013 | Surface & Coatings Technology2013，，： | 2 |
| 4 | Effect of substrate bias on microstructure and tribological performance of GLC films using hybrid HIPIMS technique显示文摘The Cr-doped hydrogen-GLC films were prepared by a hybrid magnetron sputtering system composed of a direct current magnetron sputtering (DC-MS) source of carbon and a high power impulse magnetron sputtering (HIPIMS) source of Cr with reactive gas of C2H2.The hydrogen-free GLC and Cr-doped GLC films were also prepared for comparison.The influence of substrate bias on the Cr-doped hydrogen-GLC films was investigated.With the increase of substrate bias from 100 V to 250 V,the re-sputtering of weak bonding sp2 firstly occurred and induced an increased sp3 bonding.However,the following sp3 to sp2 transformation resulted in a decreased sp3 bonding.The change trends of surface roughness and friction coefficient with the increased bias voltages were the same as those of sp3 bond.The lowest surface roughness and lowest friction coefficient corresponded to the highest sp3 with the Cr-GLC-H films at the bias voltage of-100 V. | ZHANG Xue-qian KE Pei-ling WANG Ai-ying HUANG Mei-dong Kwang Ho KIM | 2012 | 中国有色金属学会会刊:英文版2012，22，S3： | 2 |
| 5 | The cellular and molecular biology of the inter- vertebral disc: A clinician~ primer显示文摘 | Erwin WM Hoed KE | 2014 | J Can Chiropr Assoc2014，58，3： | 1 |
| 6 | Role of soluble ceruloplasmin in iron up- take by midbrain and hippocampus neurons 显示文摘 | Ke Y Ho K Du J | 2006 | J Cell Biochem2006，98，： | 1 |
| 7 | Physical characterizations of microemulsion systems using tocopheryl polyethylene glycol 1000 succinate(TPGS)as a surfactant for the oral delivery of protein drugs显示文摘 | KE W T LIN S Y HO H O | 2005 | Journal of Controlled Release2005，102，2： | 1 |
| 8 | Exercise decreases cytosolic aconitase activity in the liver, spleen, and bone marrow in rats 显示文摘 | Ho KP Xiao DS Ke Y | 2001 | Biochem Biophys Res Commun2001，282，1： | 1 |
| 9 | Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritime 显示文摘 | Nelson KE Clayton RA Gill SR Gwinn ML Dodson RJ Haft DH Hickey EK Peterson JD Nelson WC Ketchum KA McDonald L Utterback TR Malek JA Linher KD Garrett MM Stewart AM Cotton MD Pratt MS Phillips CA Richardson D Heidelberg J Sutton GG Fleischmann RD Eisen JA White O Salzberg SL Smith HO Craig Venter J Fraser CM | 1999 | Nature1999，399，： | 1 |
| 10 | High transdominantRevM10 protein levels are required toinhibit HIV-1 replication in cell lines andprimary Tcells:Implication for gene therapy of AIDS显示文摘 | Agarwal M Ho KE | 1997 | GeneTher1997，4，： | 1 |
| 11 | Physical character- izations of microemulsion systems using tocopheryl polyethylene glycol 1000 succinate ( TPGS ) as a sur- factant for the oral delivery of protein drugs显示文摘 | KE W T LIN S Y HO H O | 2005 | J Control Release2005，102，2： | 1 |
| 12 | Exercise decreases cytosolic aconitase activity in the liver,spleen,and bone marrow in rats显示文摘 | Ho K P Xiao D S Ke Y | | 0，，01： | 1 |
| 13 | IL-17-producing NKT cells depend exclusively on IL-7for homeostasis and survival显示文摘 | KE W HO K KK | 2014 | Mucosal Immunol2014，7，10： | 1 |
| 14 | Effects of Siraitia grosvenorii extracts on high fat diet-induced obese mice:a comparison with artificial sweetener aspartame显示文摘Long-term artificial sweetener intake is linked to increased risk of obesity. In the present study, supplement of natural sweetener from Siraitia grosvenorii(SG)(or Momordica grosvenorii) fruit, compared with the artificial sweetener aspartame(ASM), was evaluated for anti-obesity effects on mice fed with high fat diet(HFD). We found that, in contrary to ASM, SG extracts prevented body weight gain, the insulin resistance and fat mass accumulation in HFD mice. SG extracts treatment inhibited the infiltration of inflammatory macrophages and lowered the levels of the fat inflammatory cytokines(leptin, macrophage chemoattractant protein 1(MCP-1) and tumor necrosis factor-α(TNF-α)) in adipose tissues. In addition, SG extracts supplement counteracted the remodeling of gut microbiota resulted from HFD. However, ASM supplement aggravated the HFD-induced obese performances, fat inflammation and dysregulation of gut microbiota. Taken together, our results indicate that supplement of SG extracts may represent a promising alternation of artificial sweeteners in preventing metabolic diseases. | Ke Lü Xiaowan Song Peng Zhang Wei Zhao Ning Zhang Fan Yang Wenqiang Guan Jianfu Liu He Huang Chi-Tang Ho Rong Di Hui Zhao | 2022 | Food Science and Human Wellness2022，11，4： | 1 |
| 15 | A role for calcium-calmodulin-dependent protein kinase II in the consolidation of visual object recognition memory显示文摘 | TINSLEY CJ NARDUZZO KE HO JW | 2009 | Eur J Neurosci2009，30，6： | 1 |
| 16 | Crystal structure and banded spherulite of poly ( trimethylene terephthalate ) 显示文摘 | HO R M KE K Z CHEN M | 2000 | Macromolecules2000，33，20： | 1 |
| 17 | Physical characterizations of microemulsion systems using tocopheryl polyethylene glycol 1000 succinate(TPGS) as a surfactant for the oral delivery of protein drugs显示文摘 | KE W T LIN S Y HO H O | | 0，，02： | 1 |
| 18 | Role of soluble ceruloplasmin in iron uptake by midbrain and hippocampus neurons 显示文摘 | Ke Y Ho K Du J | 2006 | J Cell Bioehem2006，98，4： | 1 |
| 19 | AZVZCS PWM FB DC/DC converter using a modified energy-recovery snubber 显示文摘 | SOO KE HO KY | 2002 | IEEE Trans on Industrial Electronics2002，49，5： | 1 |
| 20 | Exercise decreases cytosolic aconitase activity in the liver, spleen, and bone marrow in rats显示文摘 | Ho K P Xiao D S Ke Y | 2001 | Biochem Biophys Res Commun2001，282，1： | 1 |
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