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| 1 | Targeted therapy in advanced metastatic colorectal cancer: Current concepts and perspectives显示文摘The introduction of new cytotoxic substances as well as agents that target vascular endothelial growth factor(VEGF)and epidermal growth factor receptor(EGFR)signaling has improved clinical outcome of patients withmetastatic colorectal cancer(mCRC).In this review we summarize the most relevant clinical data on VEGF and EGFR targeting regimens in mCRC.The effects of available treatment strategies for mCRC are often temporary,with resistance and disease progression developing in most patients.Thus,new treatment strategies are urgently needed.Some GI peptides including gastrin and gastrin releasing peptide,certain growth factors such as insulin-like growth factor-ⅠandⅡand neuropeptides such as growth hormone releasing hormone(GHRH)are implicated in the growth of CRC.Experimental investigations in CRC with antagonistic analogs of bombesin/gastrin-releasing peptide,GHRH,and with cytotoxic peptides that can be targeted to peptide receptors on tumors,are summarized in the second part of the review. | Florian Hohla Thomas Winder Richard Greil Ferenc G Rick Norman L Block rew V Schally | 2014 | World Journal of Gastroenterology2014，20，20： | 3 |
| 2 | Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linkedwith suppression of K-Ras,COX-2,and pAkt显示文摘 | Hohla F Schally AV Kanashiro CA | 2007 | Proc Natl AcadSci U S A2007，104，18： | 1 |
| 3 | Targeting gastrin releasing peptide receptors :New options for the therapy and diagnosis of cancer 显示文摘 | Hohla F Schally AV | 2010 | Cell Cycle2010，9，9： | 1 |
| 4 | Targeted cytotoxic somatost- atin analog AN-162 inhibits growth of human colon carcinomas and increases sensitivity of doxorubicin resistant murine leukemia cells 显示文摘 | Hohla F Buchholz S Schally AV | 2010 | Cancer Lett2010，294，1： | 1 |
| 5 | Targeted cytotoxic somatostatin analog AN-162 inhibits growth of human colon carcinomas and increases sensitivity of doxorubicin resistant murine leukemia cells显示文摘 | Florian Hohla Stefan Buchholz Andrew V. Schally Awtar Krishan Ferenc G. Rick Luca Szalontay Andrea Papadia Gabor Halmos Frank Koster Elmar Aigner Christian Datz Stephan Seitz | 2010 | Cancer Letters2010，，1： | 1 |
| 6 | Differential expression of GHRH receptor and its splice variant 1 inhuman normal and malignant mucosa of the oesophagus and colon显示文摘 | Florian Hohla Angelika Moder Ursula Mayrhauser Cornelia Hauser-Kronberger Andrew Schally Jozsef Varga Marta Zarandi Stefan Buchholz Rudolf Huber Elmar Aigner Markus Ritter Christian Datz | 2008 | International Journal of Oncology2008，，1： | 1 |
| 7 | Targeted cytotoxic somatostatin analog AN-162 inhibits growth of human colon carcinomas and increases sensitivity of doxorubicin resistant murine leukemia cells显示文摘 | Hohla F Buchholz S Schally AV | 2010 | Cancer Lett2010，294，1： | 1 |
| 8 | Targeted cytotoxic somatostatin analog AN-162 inhibits growth of human colon carcinomas and increases sensitivity of doxorubicin resistant murine leukemia cells显示文摘 | Hohla F Buchholz S Schally A V | 2010 | Cancer Lett2010，294，1： | 1 |
| 9 | Systemic effect of catumaxomab in a patient with metastasized colorectal can- cer : a case report显示文摘 | Bezan A Hohla F Meissnitzer T | 2013 | BMC Cancer2013，13，1： | 1 |
| 10 | Female gender may predict response to FOLFIRINOX in patients with unresectablepancreatic cancer: A single institution retrospective review显示文摘 | Florian Hohla Georg Hopfinger Franz Romeder Gabriel Rinnerthaler Angelika Bezan Stefan St?ttner Cornelia Hauser-Kronberger Hanno Ulmer Richard Greil | 2014 | International Journal of Oncology2014，，1： | 1 |
| 11 | Systemic effect of catumaxomab in a patient with metastasized colorectal cancer:a case report显示文摘 | Bezan Angelika Hohla Florian Meissnitzer Thomas | 2013 | BMC Cancer2013，13，1： | 1 |
| 12 | Synergistic Inhibition of Growth of Lung Carcinomas by Antagonists of Growth Hormone-releasing Hormone in Combination with Docetaxel 显示文摘 | Hohla F Schally A V Szepeshazi K | 2006 | PNAS2006，103，14： | 1 |
| 13 | Growth inhibi- tion of non-small-cell lung carcinoma by BN/GRP antago- nist is linked with suppression of K-Ras, COX-2, and pAkt 显示文摘 | Hohla F Schally AV Kanashiro CA | 2007 | Proc Natl Acad Sci U S A2007，104，18： | 1 |
| 14 | GHRH antagonist causes DNA damage leading to P21 mediated cell cycle arrest and apoptosis in human colon cancer cells 显示文摘 | Hohla F Buchholz S Schally A V | 2009 | Cell Cycle2009，8，19： | 1 |
| 15 | Inhibition of estrogen receptor positive and negative breast cancer cell lines with a growth hormone releasing hormone antagonist 显示文摘 | Seitz S Hohla F Schally AV | 2008 | Oncol Rep2008，20，5： | 1 |
| 16 | Synergistic inhibition of growth of lung carcinomas by antagonists of growth hormone-releasing hormone in combination with docetaxel显示文摘 | Hohla F Schally A V Szepeshazi K | 2006 | Proc Natl Acad Sci USA2006，103，14： | 1 |
| 17 | Differential expression of GHRH receptor and its splice variant 1 in human normal and malignant mucosa of the oesophagus and colon显示文摘 | Hohla F Moder A Mayrhauser U | 2008 | Int J Oncol2008，33，1： | 1 |
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