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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Geographies of Money and Finance 显示文摘 | Leys hon A | 1998 | Progress in Human Geography1998，，3： | 1 |
| 3 | Proactive personality, employee creativity, and newcomer outcomes : a longitudinal study显示文摘 | KIM T-Y HON A H CRANT J M | 2009 | Journal of Business and Psychology2009，24，1： | 1 |
| 4 | 999 abuse:do mothers know what they are using? 显示文摘 | Hon KL Burd A | 2008 | J Dermatolog Treat2008，19，4： | 1 |
| 5 | Antifreeze proteins in winter rye are similar to pathogenesis-relatedproteins显示文摘 | W C Hon M Griffith A Mlynarz | 1995 | Plant Physiol1995，109，3： | 1 |
| 6 | Tillage-induced seasonal changes in soil physical properties affecting soil CO2 evolution under intensive cropping 显示文摘 | Franzluebbers A J Hons F M Zuberer D A | 1995 | Soil and Tillage Research1995，34，1： | 1 |
| 7 | Carbon and nitrogen sequestration and soil aggregation under sorghum cropping sequences显示文摘 | Wright A L Hons F M | 2005 | Biology and fertility of soils2005，41，2： | 1 |
| 8 | Tillage impacts on microbial biomass and soil carbon and nitrogen dynamics of corn and cotton rotations显示文摘 | Wright A L Hons F M Matocha J E Jr | 2005 | Appl Soil Ecol2005，29，1： | 1 |
| 9 | Soil C extracted with water or K2 SO4 : pH effect on determination of microbial biomass 显示文摘 | HANEY R L FRANZLUEBBERS A J HONS F M | 1999 | Canadian Journal of Soil Science1999，79，4： | 1 |
| 10 | Soil organic carbon,microbial biomass,and mineralizable carbon and nitrogen in sorghum显示文摘 | FRANZLUEBBERS A J HONS F M ZUBERER D A | 1995 | Soil Science of America Journal1995，，59： | 1 |
| 11 | Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy:a pooled analysis of two randomized ,controlled clinical trials显示文摘 | Major P Lortholary A Hon J | 2001 | J Clin Oncol2001，19，： | 1 |
| 12 | Hepatic arterial infu- sion of chemotherapy : the role of diagnostic and intervention- al radiology 显示文摘 | Ganeshan A Upponi S Hon LQ | 2008 | Ann Oncol2008，19，5： | 1 |
| 13 | Soil aggregation and carbon and nitro- gen storage under soybean cropping sequence 显示文摘 | Wright A L Hons F M | 2004 | Soil Science Society of America Journal2004，68，： | 1 |
| 14 | Shaping environments conductive to creativity the role of intrinsic motivation 显示文摘 | HON A H Y | 2012 | Cornell Hospitality Quarterly2012，53，1： | 1 |
| 15 | Antifreeze proteins in winter rye are similar to pathogenesis-related proteins显示文摘 | Hon W C Gfiffith M Mlynarz A | 1995 | Plant Physiol1995，109，： | 1 |
| 16 | Carbon and nitrogen sequestration and soil aggregation under sorghum cropping sequences显示文摘 | Wright A L Hons F M | 2004 | Biology and Fertility Soils2004，43，： | 1 |
| 17 | Soil Carbon and Nitrogen Storage in Aggregates from Different Tillage and Crop Regimes显示文摘 | WRIGHT A L HONS F M | 2005 | Soil Sci Soc Am J2005，69，1： | 1 |
| 18 | Developing the Helsinki Smart City: The Role ofCompetitions for Open Data Applications显示文摘 | He nd r i k H ie l kem a Pa t r i z i a Hon g i s t o | 2013 | Journalof the K nowledge Economy2013，，6： | 1 |
| 19 | Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy:a pooled analysis of two randomized,controlled clinical trials显示文摘 | Major P Lortholary A Hon J | | 0，，02： | 1 |
| 20 | Are we paid to be creative? the effect of compensation gap on creativity in an expatriate context 显示文摘 | HON A H Y LU L | 2015 | Journal of World Business2015，50，1： | 1 |
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