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| 1 | Natural Variation in CCD4 Promoter Underpins Species-Specific Evolution of Red Coloration in Citrus Peel显示文摘Carotenoids and apocarotenoids act as phytohormones and volatile precursors that influence plant development and confer aesthetic and nutritional value critical to consumer preference.Citrus fruits display considerable natural variation in carotenoid and apocarotenoid pigments.In this study,using an integrated genetic approach we revealed that a 5;c/s-regulatory change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C3 0 apocarotenoids responsible for red coloration of citrus peel.Functional analyses demonstrated that in addition the known role in synthesizing 3-citraurin,CCD4b is also responsible for the production of another important C3 0 apocarotenoid pigment,p-citraurinene.Furthermore,analyses of the CCD4b promoter and transcripts from various citrus germplasm accessions established a tight correlation between the presence of a putative 5'c/s-regulatory enhancer within an MITE transposon and the enhanced allelic expression of CCD4b in C3 0 apocarotenoid-rich red-peeled accessions.Phylogenetic analysis provided further evidence that functional diversification of CCD4b and naturally occurring variation of the CCD4b promoter resulted in the stepwise evolution of red peels in mandarins and their hybrids.Taken together,our findings provide new insights into the genetic and evolutionary basis of apocarotenoid diversity in plants,and would facilitate breeding efforts that aim to improve the nutritional and aesthetic value of citrus and perhaps other fruit crops. | Xiongjie Zheng Kaijie Zhu Quan Sun Weiyi Zhang Xia Wang Hongbo Cao Meilian Tan Zongzhou Xie Yunliu Zeng Junli Ye Lijun Chai Qiang Xu Zhiyong Pan Shunyuan Xiao Paul D.Fraser Xiuxin Deng | 2019 | Molecular Plant2019，12，9： | 18 |
| 2 | Recent advances in gecko adhesion and friction mechanisms and development of gecko-inspired dry adhesive surfaces显示文摘The remarkable ability of geckos to climb and run rapidly on walls and ceilings has recently received considerable interest from many researchers.Significant progress has been made in understanding the attachment and detachment mechanisms and the fabrication of articulated gecko-inspired adhesives and structured surfaces.This article reviews the direct experiments that have investigated the properties of gecko hierarchical structures,i.e.,the feet,toes,setae,and spatulae,and the corresponding models to ascertain the mechanical principles involved.Included in this review are reports on gecko-inspired surfaces and structures with strong adhesion forces,high ratios of adhesion and friction forces,anisotropic hierarchical structures that give rise to directional adhesion and friction,and“intelligent”attachment and detachment motions. | Ming ZHOU Noshir PESIKA Hongbo ZENG Yu TIAN Jacob ISRAELACHVILI | 2013 | Friction2013，1，2： | 12 |
| 3 | Characteristics of the lunar samples returned by the Chang'E-5 mission显示文摘Forty-five years after the Apollo and Luna missions returned lunar samples,China's Chang’E-5(CE-5)mission collected new samples from the mid-latitude region in the northeastern Oceanus Procellarum of the Moon.Our study shows that 95%of CE-5 lunar soil sizes are found to be within the range of 1.40-9.35μm,while 95%of the soils by mass are within the size range of 4.84-432.27μm.The bulk density,true density and specific surface area of CE-5 soils are 1.2387 g/cm^(3),3.1952 g/cm^(3) and 0.56 m^(2)/g,respectively.Fragments from the CE-5 regolith are classified into igneous clasts(mostly basalt),agglutinate and glass.A few breccias were also found.The minerals and compositions of CE-5 soils are consistent with mare basalts and can be classified as low-Ti/low-Al/low-K type with lower rare-earth-element contents than materials rich in potassium,rare earth element and phosphorus.CE-5 soils have high FeO and low Mg index,which could represent a new class of basalt. | Chunlai Li Hao Hu Meng-Fei Yang Zhao-Yu Pei Qin Zhou Xin Ren Bin Liu Dawei Liu Xingguo Zeng Guangliang Zhang Hongbo Zhang Jianjun Liu Qiong Wang Xiangjin Deng Caijin Xiao Yonggang Yao Dingshuai Xue Wei Zuo Yan Su Weibin Wen Ziyuan Ouyang | 2022 | National Science Review2022，9，2： | 12 |
| 4 | Identification of the surgical indication line for the Denonvilliers’fascia and its anatomy in patients with rectal cancer显示文摘Background:The high rate of urogenital dysfunction after traditional total mesorectal excision(TME)has caused doubts among scholars on the standard fashion of dissection.We have proposed the necessity to preserve the Denonvilliers’fascia in patients with rectal cancer.However,how to accurately locate the Denonvilliers’fascia is unclear.This study aimed to explore anatomical features of the Denonvilliers’fascia by comparing autopsy findings and observations of surgical videos so as to propose a dissection method for the preservation of pelvic autonomic nerves during rectal cancer surgery.Methods:Five adult male cadaver specimens were dissected,and surgical videos of 135 patients who underwent TME for mid-low rectal cancer between January 2009 and February 2019 were reviewed to identify and compare the structure of the Denonvilliers’fascia.Results:The monolayer structure of the Denonvilliers’fascia was observed in 5 male cadaver specimens,and it was located between the rectum,the bottom of the bladder,the seminal vesicles,the vas deferens,and the prostate.The Denonvilliers’fascia was originated from the rectovesical pouch(or rectum-uterus pouch),down to fuse caudally with the rectourethral muscle at the apex of the prostate,and fused to the lateral ligaments on both sides.The fascia was thinner on the midline with a thickness of 1.06±0.10 mm.The crown shape of the Denonvilliers’fascia was slightly triangular,with a height of approximately 5.42±0.16 cm at midline.Nerves were more densely distributed in front of the Denonvilliers’fascia than behind,especially on both sides of it.Under laparoscopic view,the Denonvilliers’fascia was originated at the lowest point of the rectovesical pouch(or rectum-uterus pouch),with a thickened white line which was a good mark for identifying the Denonvilliers’fascia.Conclusion:Identification of the surgical indication line for the Denonvilliers’fascia could help us identify the Denonvilliers’fascia,and it would improve our ability to protect the pelvic autonomic function of patients undergoing TME for rectal cancer. | Jianglong Huang Jing Liu Jiafeng Fang Zongheng Zeng Bo Wei Tufeng Chen Hongbo Wei | 2020 | Cancer Communications2020，40，1： | 10 |
| 5 | Recent advances in designing conductive hydrogels for flexible electronics显示文摘Flexible electronics have emerged as an exciting research area in recent years,serving as ideal interfaces bridging biological systems and conventional electronic devices.Flexible electronics can not only collect physiological signals for human health monitoring but also enrich our daily life with multifunctional smart materials and devices.Conductive hydrogels(CHs)have become promising candidates for the fabrication of flexible electronics owing to their biocompatibility,adjustable mechanical flexibility,good conductivity,and multiple stimuli-responsive properties.To achieve on-demand mechanical properties such as stretchability,compressibility,and elasticity,the rational design of polymer networks via modulating chemical and physical intermolecular interactions is required.Moreover,the type of conductive components(eg,electron-conductive materials,ions)and the incorporation method also play an important role in the conductivity of CHs.Electron-CHs usually possess excellent conductivity,while ion-CHs are generally transparent and can generate ion gradients within the hydrogel matrices.This mini review focuses on the recent advances in the design of CHs,introducing various design strategies for electron-CHs and ion-CHs employed in flexible electronics and highlighting their versatile applications such as biosensors,batteries,supercapacitors,nanogenerators,actuators,touch panels,and displays. | Qiongyao Peng Jingsi Chen Tao Wang Xuwen Peng Jifang Liu Xiaogang Wang Jianmei Wang Hongbo Zeng | 2020 | InfoMat2020，2，5： | 8 |
| 6 | FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis显示文摘Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis(RA).Fatty acid-binding protein 4(FABP4),a novel adipokine that regulates inflammation and angiogenesis,has been extensively studied in a variety of organs and diseases.However,the effect of FABP4 on RA remains unclear.Here,we found that FABP4 expression was upregulated in synovial M1-polarized macrophages in RA.The increase in FABP4 promoted synovitis,angiogenesis,and cartilage degradation to exacerbate RA progression in vivo and in vitro,whereas BMS309403(a FABP4 inhibitor)and anagliptin(dipeptidyl peptidase 4 inhibitor)inhibited FABP4 expression in serum and synovial M1-polarized macrophages in mice to alleviate RA progression.Further studies showed that constitutive activation of mammalian target of rapamycin complex 1(mTORC1)by TSC1 deletion specifically in the myeloid lineage regulated FABP4 expression in macrophages to exacerbate RA progression in mice.In contrast,inhibition of mTORC1 by ras homolog enriched in brain(Rheb1)disruption specifically in the myeloid lineage reduced FABP4 expression in macrophages to attenuate RA development in mice.Our findings established an essential role of FABP4 that is secreted by M1-polarized macrophages in synovitis,angiogenesis,and cartilage degradation in RA.BMS309403 and anagliptin inhibited FABP4 expression in synovial M1-polarized macrophages to alleviate RA development.Hence,FABP4 may represent a potential target for RA therapy. | Dong Guo Chuangxin Lin Yuheng Lu Hong Guan Weizhong Qi Hongbo Zhang Yan Shao Chun Zeng Rongkai Zhang Haiyan Zhang Xiaochun Bai Daozhang Cai | 2022 | Bone Research2022，10，4： | 5 |
| 7 | Mechanically Strong Proteinaceous Fibers:Engineered Fabrication by Microfluidics显示文摘Lightweight and mechanically strong natural silk fibers have been extensively investigated over the past decades.Inspired by this research,many artificial spinning techniques(wet spinning,dry spinning,electrospinning,etc.)have been developed to fabricate robust protein fibers.As the traditional spinning methods provide poor control over the as-spun fibers,microfluidics has been integrated with these techniques to allow the fabrication of biological fibers in a well-designed manner,with simplicity and cost efficiency.The mechanical behavior of the developed fibers can be precisely modulated by controlling the type iop and size of microfluidic channel,flow rate,and shear force.This technique has been successfully used to manufacture a broad range of protein fibers,and can accelerate the production and application of protein fibers in various fields.This review outlines recent progress in the design and fabrication of protein-based fibers based on microfluidics.We first briefly discuss the natural spider silk-spinning process and the microfluidics spinning process.Next,the fabrication and mechanical properties of regenerated protein fibers via microfluidics are discussed,followed by a discussion of recombinant protein fibers.Other sourced protein fibers are also reviewed in detail.Finally,a brief outlook on the development of microfluidic technology for producing protein fibers is presented. | Jing Sun Jingsi Chen Kai Liu Hongbo Zeng | 2021 | Engineering2021，7，5： | 5 |
| 8 | Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease显示文摘Metabolic-associated fatty liver disease(MAFLD),which is previously known as non-alcoholic fatty liver disease(NAFLD),represents a major health concern worldwide with limited therapy.Here,we provide evidence that ferroptosis,a novel form of regulated cell death characterized by iron-driven lipid peroxidation,was comprehensively activated in liver tissues from MAFLD patients.The canonical-GPX4(cGPX4),which is the most important negative controller of ferroptosis,is downregulated at protein but not mRNA level.Interestingly,a non-canonical GPX4 transcript-variant is induced(inducible-GPX4,iGPX4)in MAFLD condition.The high fat-fructose/sucrose diet(HFFD)and methionine/choline-deficient diet(MCD)-induced MAFLD pathologies,including hepatocellular ballooning,steatohepatitis andfibrosis,were attenuated and aggravated,respectively,in cGPX4-and iGPX4-knockin mice.cGPX4 and iGPX4 isoforms also displayed opposing effects on oxidative stress and ferroptosis in hepatocytes.Knockdown of iGPX4 by siRNA alleviated lipid stress,ferroptosis and cell injury.Mechanistically,the triggered iGPX4 interacts with cGPX4 to facilitate the transformation of cGPX4 from enzymatic-active monomer to enzymatic-inactive oligomers upon lipid stress,and thus promotes ferroptosis.Co-immunoprecipitation and nano LC–MS/MS analyses confirmed the interaction between iGPX4 and cGPX4.Our results reveal a detrimental role of non-canonical GPX4 isoform in ferroptosis,and indicate selectively targeting iGPX4 may be a promising therapeutic strategy for MAFLD. | Jie Tong Dongjie Li Hongbo Meng Diyang Sun Xiuting Lan Min Ni Jiawei Ma Feiyan Zeng Sijia Sun Jiangtao Fu Guoqiang Li Qingxin Ji Guoyan Zhang Qirui Shen Yuanyuan Wang Jiahui Zhu Yi Zhao Xujie Wang Yi Liu Shenxi Ouyang Chunquan Sheng Fuming Shen Pei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 3 |
| 9 | Intermolecular and Surface Interactions in Engineering Processes显示文摘Interactions involving chemical reagents,solid particles,gas bubbles,liquid droplets,and solid surfaces in complex fluids play a vital role in many engineering processes,such as froth flotation,emulsion and foam formation,adsorption,and fouling and anti-fouling phenomena.These interactions at the molecular,nano-,and micro scale significantly influence and determine the macroscopic performance and efficiency of related engineering processes.Understanding the intermolecular and surface interactions in engineering processes is of both fundamental and practical importance,which not only improves production technologies,but also provides valuable insights into the development of new materials.In this review,the typical intermolecular and surface interactions involved in various engineering processes,including Derjaguin–Landau–Verwey–Overbeek(DLVO)interactions(i.e.,van der Waals and electrical doublelayer interactions)and non-DLVO interactions,such as steric and hydrophobic interactions,are first introduced.Nanomechanical techniques such as atomic force microscopy and surface forces apparatus for quantifying the interaction forces of molecules and surfaces in complex fluids are briefly introduced.Our recent progress on characterizing the intermolecular and surface interactions in several engineering systems are reviewed,including mineral flotation,petroleum engineering,wastewater treatment,and energy storage materials.The correlation of these fundamental interaction mechanisms with practical applications in resolving engineering challenges and the perspectives of the research field have also been discussed. | Jiawen Zhang Hongbo Zeng | 2021 | Engineering2021，7，1： | 3 |
| 10 | Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells显示文摘Whereas the critical roles of innate lymphoid cells(ILCs)in adult are increasingly appreciated,their developmental hierarchy in early human fetus remains largely elusive.In this study,we sorted human hematopoietic stem/progenitor cells,lymphoid progenitors,putative ILC progenitor/precursors and mature ILCs in the fetal hematopoietic,lymphoid and non-lymphoid tissues,from 8 to 12 post-conception weeks,for single-cell RNA-sequencing,followed by computational analysis and functional validation at bulk and single-cell levels.We delineated the early phase of ILC lineage commitment from hematopoietic stem/progenitor cells,which mainly occurred in fetal liver and intestine.We further unveiled interleukin-3 receptor as a surface marker for the lymphoid progenitors in fetal liver with T,B,ILC and myeloid potentials,while IL-3RA–lymphoid progenitors were predominantly B-lineage committed.Notably,we determined the heterogeneity and tissue distribution of each ILC subpopulation,revealing the proliferating characteristics shared by the precursors of each ILC subtype.Additionally,a novel unconventional ILC2 subpopulation(CRTH2–CCR9+ILC2)was identified in fetal thymus.Taken together,our study illuminates the precise cellular and molecular features underlying the stepwise formation of human fetal ILC hierarchy with remarkable spatiotemporal heterogeneity. | Chen Liu Yandong Gong Han Zhang Hua Yang Yang Zeng Zhilei Bian Qian Xin Zhijie Bai Man Zhang Jian He Jing Yan Jie Zhou Zongcheng Li Yanli Ni Aiqing Wen Yu Lan Hongbo Hu Bing Liu | 2021 | Cell Research2021，31，10： | 2 |
| 11 | 氧化石墨烯(GO)及复合物制备及其对汞吸附特性的研究显示文摘以石墨粉(G)为原料,通过化学方法制备了氧化石墨烯(GO)、纳米Fe_3O_4负载石墨烯复合材料(MGO)、纳米Ag颗粒修饰磁性氧化石墨烯(GO-Ag/MGO-Ag)四种吸附材料,对材料进行了表征并考察了氧化石墨烯及其复合物对烟气中汞的吸附作用。研究表明四种石墨烯基吸附剂可被成功合成和表征;GO在100-150℃时对Hg^0表现出优异的吸附性能,Ag-NPs修饰GO能有效提升吸附剂对汞的吸附能力,MGO-Ag复合吸附剂对汞的吸附能力最佳;MGOAg在150~200℃时表现出优异的汞吸附能力,在反复循环之后吸附性能几乎不变;以MGO-Ag为代表的可再生磁性石墨烯基复合吸附剂在中低温条件下对Hg^0具有优异的吸附性能,且能有效与飞灰进行分离,具有良好的工业应用前景。 | 田冲 Yuxi Liu 余学海 Hongbo Zeng 赵永椿 张军营 | 2017 | 工程热物理学报2017，38，9： | 2 |
| 12 | The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation显示文摘Dear Editor,Immunodeficiency,centromeric instability,and facial anomalies(ICF)syndrome is a rare autosomal recessive disorder characterized by antibody deficiency,facial dysmorphism,failure to thrive,and mental retardation.Patients with ICF syndrome suffer from recurrent and often fatal infections in early childhood.A hallmark of ICF syndrome is loss of DNA methylation in special genomic regions,most notably satellite repeats at centromeric regions,which leads to heterochromatin decondensation and chromosomal abnormalities in lymphocytes(Ehrlich et al.,2008). | Swanand Hardikar Zhengzhou Ying Yang Zeng Hongbo Zhao Bigang Liu Nicolas Veland Kevin McBride Xiaodong Cheng Taiping Chen | 2020 | Protein & Cell2020，11，3： | 2 |
| 13 | Trends of Mortality in End-Stage Liver Disease—China,2008–2020显示文摘Introduction:Liver cancer and cirrhosis represent the most prevalent forms of end-stage liver diseases(ESLDs).Notably,in China,deaths attributed to ESLDs contribute significantly to the global mortality rate of these disorders.Enhanced comprehension of the mortality profile associated with ESLDs in China could provide crucial insights into intervention prioritization,which could in turn help reduce the overall global burden of these diseases.Methods:Data were obtained from China’s Disease Surveillance Points system.The presentation includes both crude and age-standardized mortality rates,stratified by sex,residential location,and region.Using Joinpoint Regression,trends in annual mortality rates were estimated from the period of 2008 to 2020 and expressed as the average annual percentage change(AAPC).Results:In 2020,the gross mortality rate of ESLD stood at 30.08 cases per 100,000 individuals.A higher age-standardized ESLD mortality rate was observed in males and rural populations in comparison to their female and urban counterparts,respectively.Noticeably,the highest mortality rates associated with liver cancer and cirrhosis were reported in South and Southwest China,respectively.A positive correlation was noticed between age-specific ESLD mortality rates and advancing age.Interestingly,an annual decrease in the ESLD mortality rate was observed from 2008 to 2020.In urban contexts,the AAPC of cirrhosis was noted to be higher than that of liver cancer.Conclusions:The mortality rate associated with ESLDs in China decreased between 2008 and 2020.Nevertheless,the death burden attributable to ESLD continues to be alarmingly high.Future initiatives should prioritize the reduction of ESLD mortality in particular populations:males,elderly individuals,and those residing in rural regions of South and Southwest China.The emphasis of future interventions should beplaced on antiviral therapy for adults diagnosed with viral hepatitis,and on the prevention of hepatitis B virus(HBV)infection across all demographics. | Xiaoxiao Wang Huixin Liu Jinlei Qi Fangfang Zeng Lijun Wang Peng Yin Feng Liu Hongbo Li Yunning Liu Jiangmei Liu Lai Wei Xiaofeng Liang Yu Wang Huiying Rao Maigeng Zhou | 2023 | China CDC weekly2023，5，30： | 1 |
| 14 | A CO_(2)/N_(2)-Responsive Pickering Emulsion Stabilized by Novel Switchable Surface-Active Alumina Nanoparticles显示文摘This article reports the development of a novel switchable Pickering emulsion with rapid CO_(2)/N_(2) respon-siveness,which is stabilized using alumina nanoparticles hydrophobized in situ with a trace amount of a switchable superamphiphile via electrostatic interactions.With the introduction of CO_(2) for 30 s,the Pickering emulsion can be spontaneously demulsified with complete phase separation;the emulsion can then be reconstructed in response to N_(2) purging for 10 min followed by homogenization.Moreover,the stable Pickering emulsion can be stored for more than 60 days at room temperature with-out any visible change.The CO_(2)/N_(2)-responsive behavior of the switchable Pickering emulsion is attribu-ted to the reversible desorption/adsorption of the switchable surfactants on the surfaces of the alumina nanoparticles upon the alternative bubbling of CO_(2)or N_(2).Thanks to the simple fabrication of the surfac-tant and the hydrophobization of the alumina nanoparticles,this research has developed an extremely facile and cost-efficient method for preparing a rapidly CO_(2)/N_(2)-responsive switchable Pickering emul-sion.The dosage of the switchable surfactants has been significantly reduced by nearly 1500 times(from 150 to 0.1 mmol·L^(-1))as compared with the dosage used in previous studies.Moreover,the as-prepared CO_(2)/N_(2)-responsive switchable Pickering emulsion is environmentally friendly,mild,and nontoxic;thus,it holds great potential for practical applications with considerable economic and environmental benefits,such as oil transport,fossil fuel production,environmental gases detection,and the encapsulation and release of active ingredients. | An Chen Duo Wang Jingsi Chen Jianhong Xu Hongbo Zeng | 2022 | Engineering2022，8，5： | 1 |
| 15 | Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance 显示文摘 | Huijun Zhu Hongbo Chen Xiaowei Zeng | 2014 | Biomaterials2014，35，7： | 1 |
| 16 | Sliding Wear Behaviour of Nanocrystalline Fe 88 Si 12 Alloy Under Low Load and Speed显示文摘 | Licai Fu Jun Yang Qinling Bi Hongbo Zeng Weimin Liu | 2012 | Tribology Letters2012，，3： | 1 |
| 17 | Evidence for solar forcing of climate variation from δ18O of peat cellulose显示文摘 | Liu Tongsheng Jiang Hongbo Zhou Liping Hong Bing Zhu Yongxuan Li Handing Leng Xuetian Qin Xiaoquang Wang Yu Lin Qinghua Zeng Yiqiang | 2000 | Science in China (Series D)2000，43，2： | 1 |
| 18 | Effect of polycarboxylate ether comb-type polymer on viscosity and interfacial properties of kaolinite clay suspensions显示文摘 | Ling Zhang Qingye Lu Zhenghe Xu Qingxia Liu Hongbo Zeng | 2012 | Journal of Colloid And Interface Science2012，，1： | 1 |
| 19 | Structural transitions of 4:1 methanol–ethanol mixture and silicone oil under high pressure显示文摘A 4:1(volume ratio)methanol–ethanol(ME)mixture and silicone oil are two of the most widely used liquid pressure-transmitting media(PTM)in high-pressure studies.Their hydrostatic limits have been extensively studied using various methods;however,the evolution of the atomic structures associated with their emerging nonhydrostaticity remains unclear.Here,we monitor their structures as functions of pressure up to∼30 GPa at room temperature using in situ high-pressure synchrotron x-ray diffraction(XRD),optical micro-Raman spectroscopy,and ruby fluorescence spectroscopy in a diamond anvil cell.No crystallization is observed for either PTM.The pressure dependence of the principal diffraction peak position and width indicates the existence of a glass transition in the 4:1MEmixture at∼12 GPa and in the silicone oil at∼3 GPa,beyond which a pressure gradient emerges and grows quickly with pressure.There may be another liquid-to-liquid transition in the 4:1 ME mixture at∼5 GPa and two more glass-to-glass transitions in the silicone oil at∼10 GPa and∼16 GPa.By contrast,Raman signals only show peak weakening and broadening for typical structural disordering,and Raman spectroscopy seems to be less sensitive than XRD in catching these structural transitions related to hydrostaticity variations in both PTM.These results uncover rich pressure-induced transitions in the two PTM and clarify their effects on hydrostaticity with direct structural evidence.The high-pressure XRD and Raman data on the two PTM obtained in this work could also be helpful in distinguishing between signals from samples and those from PTM in future high-pressure experiments. | Xiehang Chen Hongbo Lou Zhidan Zeng Benyuan Cheng Xin Zhang Ye Liu Dazhe Xu Ke Yang Qiaoshi Zeng | 2021 | Matter and Radiation at Extremes2021，6，3： | 1 |
| 20 | Risk Factors and Pregnancy Outcome in Women with a History of Cesarean Section Complicated by Placenta Accreta显示文摘Objective:To explore the risk factors and pregnancy outcomes in women with a history of cesarean section complicated by placenta accreta(PA).Methods:This case-control study included clinical data from singleton mothers with a history of cesarean section in 11 public tertiary hospitals in seven provinces of China between January 2017 and December 2017.According to the intraoperative findings after delivery,the study population was divided into PA and non-PA groups.We compared the pregnancy outcomes between the two groups,used multivariate logistic regression to analyze the risk factors for placental accreta.Results:For this study we included 11,074 pregnant women with a history of cesarean section;and of these,869 cases were in the PA group and 10,205 cases were in the non-PA group.Compared with the non-PA group,the probability of postpartum hemorrhage(236/10,205,2.31%vs.283/869,32.57%),severe postpartum hemorrhage(89/10,205,0.87%vs.186/869,21.75%),diffuse intravascular coagulation(3/10,205,0.03%vs.4/869,0.46%),puerperal infection(33/10,205,0.32%vs.12/869,1.38%),intraoperative bladder injury(1/10,205,0.01%vs.16/869,1.84%),hysterectomy(130/10,205,1.27%vs.59/869,6.79%),and blood transfusion(328/10,205,3.21%vs.231/869,26.58%)was significantly increased in the PA group(P<0.05).At the same time,the neonatal birth weight 3250.00(2950.00–3520.00)g vs.2920.00(2530.00–3250.00)g),the probability of neonatal comorbidities(245/10,205,2.40%vs.61/869,7.02%),and the rate of neonatal intensive care unit admission(817/10,205,8.01%vs.210/869,24.17%)also increased significantly(P<0.05).Weight(odds ratio)(OR)=1.03,95%confidence interval(CI):1.01–1.05)),parity(OR=1.18,95%CI:1.03–1.34),number of miscarriages(OR=1.31,95%CI:1.17–1.47),number of previous cesarean sections(OR=2.57,95%CI:2.02–3.26),history of premature rupture of membrane(OR=1.61,95%CI:1.32–1.96),previous cesarean-section transverse incisions(OR=1.38,95%CI:1.12–1.69),history of placenta previa(OR=2.44,95%CI:1.50–3.96),and the combination of prenatal hemorrhage(OR=9.95,95%CI:8.42–11.75)and placenta previa(OR=91.74,95%CI:74.11–113.56)were all independent risk factors for PA.Conclusion:There was an increased risk of adverse outcomes in pregnancies complicated by PA in women with a history of cesarean section,and this required close clinical attention.Weight before pregnancy,parity,number of miscarriages,number of previous cesarean sections,history of premature rupture of membranes,past transverse incisions in cesarean sections,a history of placenta previa,prenatal hemorrhage,and placenta previa were independent risk factors for pregnancies complicated with PA in women with a history of cesarean section.These independent risk factors showed a high value in predicting the risk for placentab accreta in pregnancies of women with a history of cesarean section. | Yingyu Liang Lizi Zhang Shilei Bi Jingsi Chen Shanshan Zeng Lijun Huang Yulian Li Minshan Huang Hu Tan Jinping Jia Suiwen Wen Zhijian Wang Yinli Cao Shaoshuai Wang Xiaoyan Xu Ling Feng Xianlan Zhao Yangyu Zhao Qiying Zhu Hongbo Qi Lanzhen Zhang Hongtian Li Lili Du Dunjin Chen | 2022 | Maternal-Fetal Medicine2022，4，3： | 1 |
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