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| 1 | 瑞芬太尼或舒芬太尼复合丙泊酚在患儿纤维支气管镜检查中的应用显示文摘目的比较瑞芬太尼或舒芬太尼复合丙泊酚用于患儿纤维支气管镜(FOB)检查时的临床效果。方法选择2016年7~8月在本院行FOB检查患儿60例,男37例,女23例,年龄2个月~14岁,体重3.5~45.5kg,ASAⅠ或Ⅱ级,按随机数字表法分为两组:瑞芬太尼组(R组)和舒芬太尼组(S组),每组30例。R组静脉注射瑞芬太尼0.5μg/kg、丙泊酚2.5~3.0mg/kg、咪达唑仑0.5mg;S组静脉注射舒芬太尼0.2μg/kg、丙泊酚2.5~3mg/kg、咪达唑仑0.5mg。记录患儿术中追加麻醉药物情况、纤维支气管镜检查时间及苏醒时间、内镜医师对麻醉效果满意度评分、患儿苏醒期躁动评分等。结果两组患儿丙泊酚消耗量、检查操作时间及苏醒时间差异均无统计学意义。检查过程中,S组躁动发生率(3.3%)明显低于R组(26.7%)(P〈0.05)。S组苏醒期躁动评分明显低于R组(P〈0.05);S组内镜医师对麻醉效果满意程度评分明显高于R组(P〈0.05)。结论瑞芬太尼或舒芬太尼复合丙泊酚可安全用于小儿FOB检查,舒芬太尼复合丙泊酚不良反应发生率更低,并可在一定程度上减轻苏醒期躁动,提高内镜医师对麻醉效果的满意程度。 | 孙茫 刘阳 于晴 涂真真 李上莹莹 涂生芬 ZHANG Ping MA Zongfen WANG Hongjuan LIU Lu | 2016 | 临床麻醉学杂志2016，32，10： | 36 |
| 2 | Experimental Study of the Pressure Fluctuations in a Pump Turbine at Large Partial Flow Conditions显示文摘Frequent shifts of output and operating mode require a pump turbine with excellent stability. Current researches show that large partial flow conditions in pump mode experience positive-slope phenomena with a large head drop. The pressure fluctuation at the positive slope is crucial to the pump turbine unit safety. The operating instabilities at large partial flow conditions for a pump turbine are analyzed. The hydraulic performance of a model pump turbine is tested with the pressure fluctuations measured at unstable operating points near a positive slope in the performance curve. The hydraulic performance tests show that there are two separated positive-slope regions for the pump turbine, with the flow discharge for the first positive slope from 0.85 to 0.91 times that at the maximum efficiency point. The amplitudes of the pressure fluctuations at these unstable large partial flow conditions near the first positive slope are much larger than those at stable operating condtions. A dominant frequency is measured at 0.2 times the impeller rotational frequency in the flow passage near the impeller exit, which is believed to be induced by the rotating stall in the flow passage of the wicket gates. The test results also show hysteresis with pressure fluctuations when the pump turbine is operated near the first positive slope. The hysteresis creates different pressure fluctuations for those operation points even though their flow rates and heads are similar respectively. The pressure fluctuation characteristics at large partial flow conditions obtained by the present study will be helpful for the safe operation of pumped storage units. | RAN Hongjuan LUO Xianwu ZHU Lei ZHANG Yao WANG Xin XU Hongyuan | 2012 | Chinese Journal of Mechanical Engineering2012，25，6： | 33 |
| 3 | Research on solar aided coal-fired power generation system and performance analysis显示文摘Integrating solar power utilization systems with coal-fired power units, the solar aided coal-fired power generation (SACPG) shows a significant prospect for the large-scale utilization of solar energy and energy saving of thermal power units. The methods and mechanism of system integration were studied. The parabolic trough solar collectors were used to collect solar energy and the integration scheme of SACPG system was determined considering the matching of working fluid flows and energy flows. The thermodynamic characteristics of solar thermal power generation and their effects on the performance of thermal power units were studied, and based on this the integration and optimization model of system structure and parameters were built up. The integration rules and coupling mecha- nism of SACPG systems were summarized in accordance with simulation results. The economic analysis of this SACPG system showed that the solar LEC of a typical SACPG system, considering CO2 avoidance, is 0.098 $/kW·h, lower than that of SEGS, 0.14 $/kW·h. | YANG YongPing CUI YingHong HOU HongJuan GUO XiYan YANG ZhiPing WANG NinLing | 2008 | Science China(Technological Sciences)2008，51，8： | 30 |
| 4 | Clinical features and treatment status of hemifacial spasm in China显示文摘 | Wang Lin Hu Xingyue Dong Hongjuan Wang Wenzhao Huang Yue Jin Lingjing Luo Yumin Zhang Weixi Lian Yajun Liang Zhanhua Shang Huifang Feng Yabo wu Yiwen Chen Jun Luo Weifeng Wan Xinhua | 2014 | Chinese Medical Journal2014，，5： | 20 |
| 5 | Analysis of ionospheric anomaly preceding the Mw7.3 Yutian earthquake显示文摘On February 12,2014,a large Mw7. 3 earthquake occurred in Yutian of Xijiang Province,China.We processed the global ionosphere maps provided by CODE( the Center for Orbit Determination in Europe)and the foF2( the critical frequency of F2-layer) data of Chongqing ionosonde station to analyze the preearthquake ionospheric anomalies. Solar activities and magnetic storm were checked by the sliding inter quartile range method to remove their effects on the ionosphere. A positive ionospheric anomaly with the large amplitude of 20 TECU was observed near the epicenter on February 3( 10th day before the earthquake). In addition,the foF2 at Chongqing station had an unusual increase of more than 40% on the day,which was consistent with the TEC( Total Electron Content) anomaly. The global disturbance represents that the peak of TEC anomaly didn't coincide with the vertical projection of epicenter. The TEC anomalous area was closer to the equator,and it mainly occurred from local time 16 ∶ 00 to 20 ∶ 00. An enhancement of TEC with the small amplitude also appeared in the magnetically conjugated region. | Li Wang Guo Jinyun Yu Xuemin Yu Hongjuan | 2014 | Geodesy and Geodynamics2014，5，2： | 15 |
| 6 | Evaluation of solar aided biomass power generation systems with parabolic trough field显示文摘Solar and biomass are both renewable energy resources.Using biomass as fuel is becoming more and more attractive after governments increase the tariff for the electricity from the renewable sources.However the costs of power from a biomass power generation plant depend greatly on the availability and quality of the biomass resource.The commercialization of solar alone thermal power generation is hindered by its high initial investment and low thermal efficiency.In this paper,a concept of integrating solar into a biomass power generation system is put forward.In the system the oil heated by a parabolic trough solar field is used to replace the extraction steam to preheat the feed water(entering a biomass boiler) and the previous extraction steam thus saved can continue to do work in the lower stages of turbine.The performance of the hybrid system with different replacements is analyzed and compared through two typical solar aided biomass generating units.The results show that the integration not only reduces the consumption of biomass fuel(at the same generation capacity) but is also proved to be an efficient way to convert solar thermal energy into power.The results also show that with the same solar aperture area,the higher the grade of the replaced extraction steam,the better the thermal performance and economy. | HOU HongJuan YANG YongPing HU Eric SONG JiFeng DONG ChangQing MAO Jian | 2011 | Science China(Technological Sciences)2011，54，6： | 15 |
| 7 | Liquefaction macrophenomena in the great Wenchuan earthquake显示文摘On May 12,2008 at 14:28,a catastrophic magnitude Ms 8.0 earthquake struck the Sichuan Province of China.The epicenter was located at Wenchuan(31.00oN,103.40oE).Liquefaction macrophenomena and corresponding destruction was observed throughout a vast area of 500 km long and 200 km wide following the earthquake.This paper illustrates the geographic distribution of the liquefaction and the relationship between liquefaction behavior and seismic intensity,and summarizes the liquefaction macrophenomena,including sandboils and waterspouts,ground subsidence,ground fi ssures etc.,and relevant liquefaction features.A brief summary of the structural damage caused by liquefaction is presented and discussed.Based on comparisons with liquefaction phenomena observed in the 1976 Tangshan and 1975 Haicheng earthquakes,preliminary analyses were performed,which revealed some new features of liquefaction behavior and associated issues arising from this event.The site investigation indicated that the spatial non-uniformity of liquefaction distribution was obvious and most of the liquefi ed sites were located in regions of seismic intensity VIII.However,liquefaction phenomena at ten different sites in regions of seismic intensity VI were also observed for the fi rst time in China mainland.Sandboils and waterspouts ranged from centimeters to tens of meters,with most between 1 m to 3 m.Dramatically high water/sand ejections,e.g.,more than 10 m,were observed at four different sites.The sand ejections included silty sand,fi ne sand,medium sand,course sand and gravel,but the ejected sand amount was less than that in the 1976 Tangshan earthquake.Possible liquefaction of natural gravel soils was observed for the fi rst time in China mainland. | Chen Longwei Yuan Xiaoming Cao Zhenzhong Hou Longqing Sun Rui Dong Lin Wang Weiming Meng Fanchao Chen Hongjuan | 2009 | Earthquake Engineering and Engineering Vibration2009，8，2： | 14 |
| 8 | MCP-1-induced ERK/GSK-3β/Snail signaling facilitates the epithelial-mesenchymal transition and promotes the migration of MCF-7 human breast carcinoma cells显示文摘Monocyte chemoattractant protein-1(MCP-1)is a chemotactic cytokine that can bind to its receptor cysteine-cysteine chemokine receptor 2(CCR2)and plays an important role in breast cancer cell metastasis.However,the molecular mechanisms underlying MCP-1-induced alterations in cellular functions during tumor progression are poorly understood.Here,we showed that MCP-1 stimulated the epithelial-mesenchymal transition(EMT)and induced the tumorigenesis of breast cancer cells by downregulating E-cadherin,upregulating vimentin and fibronectin,activating matrix metallopeptidase-2(MMP-2),and promoting migration and invasion.Moreover,MCP-1 treatment reduced glycogen synthase kinase-3β(GSK-3β)activity via the MEK/ERK-mediated phosphorylation of serine-9 in MCF-7 cells.The inhibition of MEK/ERK by U0126 attenuated the MCP-1-induced phosphorylation of GSK-3βand decreased the expression of Snail,an EMT-related transcription factor,leading to the inhibition of MCF-7 cell migration and invasion.Inactivation of GSK-3βby LiCl(lithium chloride)treatment notably increased MMP-2 activity,vascular endothelial growth factor expression and EMT of MCF-7 cells.These findings revealed that MCP-1-induced EMT and migration are mediated by the ERK/GSK-3β/Snail pathway,and identified a potential novel target for therapeutic intervention in breast cancer. | Shun Li Juan Lu Yu Chen Niya Xiong Li Li Jing Zhang Hong Yang Chunhui Wu Hongjuan Zeng Yiyao Liu | 2017 | Cellular & Molecular Immunology2017，14，7： | 14 |
| 9 | Growth and characterization of 2-inch high quality β-Ga2O3 single crystals grown by EFG method显示文摘β-Ga_2O_3 is an ultra-wide band-gap semiconductor with promising applications in UV optical detectors,Schottky barrier diodes, field-effect transistors and substrates for light-emitting diodes. However, the preparation of large β-Ga_2O_3 crystals is undeveloped and many properties of this material have not been discovered yet. In this work, 2-inch β-Ga_2O_3 single crystals were grown by using an edge-defined film-fed growth method. The high quality of the crystal has been proved by high-resolution X-ray diffraction with 19.06 arcsec of the full width at half maximum. The electrical properties and optical properties of both the unintentionally doped and Si-doped β-Ga_2O_3 crystals were investigated systematically. | Shengnan Zhang Xiaozheng Lian Yanchao Ma Weidan Liu Yingwu Zhang Yongkuan Xu Hongjuan Cheng | 2018 | Journal of Semiconductors2018，39，8： | 12 |
| 10 | Targeting cancer stem cell pathways for cancer therapy显示文摘Since cancer stem cells(CSCs)were first identified in leukemia in 1994,they have been considered promising therapeutic targets for cancer therapy.These cells have self-renewal capacity and differentiation potential and contribute to multiple tumor malignancies,such as recurrence,metastasis,heterogeneity,multidrug resistance,and radiation resistance.The biological activities of CSCs are regulated by several pluripotent transcription factors,such as OCT4,Sox2,Nanog,KLF4,and MYC.In addition,many intracellular signaling pathways,such as Wnt,NF-κB(nuclear factor-κB),Notch,Hedgehog,JAK-STAT(Janus kinase/signal transducers and activators of transcription),PI3K/AKT/mTOR(phosphoinositide 3-kinase/AKT/mammalian target of rapamycin),TGF(transforming growth factor)/SMAD,and PPAR(peroxisome proliferator-activated receptor),as well as extracellular factors,such as vascular niches,hypoxia,tumor-associated macrophages,cancer-associated fibroblasts,cancer-associated mesenchymal stem cells,extracellular matrix,and exosomes,have been shown to be very important regulators of CSCs.Molecules,vaccines,antibodies,and CAR-T(chimeric antigen receptor T cell)cells have been developed to specifically target CSCs,and some of these factors are already undergoing clinical trials.This review summarizes the characterization and identification of CSCs,depicts major factors and pathways that regulate CSC development,and discusses potential targeted therapy for CSCs. | Liqun Yang Pengfei Shi Gaichao Zhao Jie Xu Wen Peng Jiayi Zhang Guanghui Zhang Xiaowen Wang Zhen Dong Fei Chen Hongjuan Cui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 12 |
| 11 | Measuring the Internal Velocity of Debris Flows Using Impact Pressure Detecting in the Flume Experiment显示文摘Measuring the internal velocity of debris flows is very important for debris flow dynamics research and designing debris flow control works. However, there is no appropriate method for measuring the internal velocity because of the destructive power of debris flow process. In this paper, we address this problem by using the relationship between velocity and kinetic pressure, as described by surface velocity and surface kinetic pressure data. Kinetic pressure is the difference of impact pressure and static pressure. The former is detected by force sensors installed in the flow direction at the sampling section. Observations show that static pressure can be computed using the formula for static water pressure by simply substituting water density for debris flow density. We describe the relationship between surface velocity and surface kinetic pressure using data from seven laboratory flume experiments. It is consistent with the relationship for single phase flow, which is the measurement principle of the Pitot tube. | YANG Hongjuan WEI Fangqiang HU Kaiheng Sergey CHERNOMORETS HONG Yong LI Xiaoyu XIE Tao | 2011 | Journal of Mountain Science2011，8，2： | 12 |
| 12 | Nidus vespae protein inhibiting proliferation of HepG2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing G1 cell cycle arrest显示文摘蛋白质说出 NVP (1 ) 从巢 vespae 被孤立。T 他现在的学习的目的是阐明 NVP (1 ) 是否并且怎么调制 HepG2 房间的增长。在 6.6 μg/ml 的集中的 NVP (1 ) 能在阶段 G 1 逮捕房间周期并且禁止 cyclinB, cyclinD1 和 cyclinE 的 mRNA 表示。NVP (1 ) 压制了 cdk2 蛋白质表示,但是增加了 p27 和 p21 蛋白质表示。然而, NVP (1 ) 没改变 p16 蛋白质表示层次。NVP (1 ) 在由原子染色质冷凝作用显示了的 HepG2 房间支持了 apoptosis,并且另外,表明小径的细胞外的调整信号的 kinase (英皇家空军之阶级最低之兵) 被激活。而且,当 HepG2 房间是有英皇家空军之阶级最低之兵禁止者 PD98059 的 pretreated 时,津贴蛋白质表示水平被稀释。这些结果证明 NVP (1 ) 通过表明小径的英皇家空军之阶级最低之兵禁止 HepG2 的增长。NVP (1 ) 能是为肝癌症的潜在的药。 | Changdong Wang Peng Chen Hongjuan Jin Xu Yan Lu Gan Yi Li Shiyi Zhou Junli Chang Yuesheng Wang Guangxiao Yang Guangyuan He | 2008 | Acta Biochimica et Biophysica Sinica2008，40，11： | 11 |
| 13 | Effect of Lichong Decoction on expression of IGF-I and proliferating cell nuclear antigen mRNA in rat model of uterine leiomyoma显示文摘OBJECTIVE:To study the effect of Lichong Decoction(Lichong Decoction for strengthening anti-pathogenic Qi and eliminating blood stasis) on the expression of insulin-like growth factor-I(IGF-I) and proliferating cell nuclear antigen(PCNA) mRNA in a rat model of uterine leiomyoma.METHODS:Fifty female Wistar rats were randomized into a normal control group,model group,Lichong Decoction group,Guizhifuling Capsule(Capsule containing Cassia Twig and Poria) group,and Mifepristone group.The uterine leiomyoma model was established by peritoneal injections of exogenous estrogen and progesterone hormone.The ultrastructural changes in cells of rat uterine tissues were observed with transmission electron microscopy,and the expression of IGF-I and PCNA mRNA was detected by real-time fluorescent quantitative PCR.RESULTS:Following treatment,cells in the Lichong Decoction group appeared to be arranged normally,the cellular morphology were almost in a normal state,hyperplasia and hypertrophy of the chondriosome was reduced,collagen fibers were arranged in a regular manner,without obvious hyperplasia,and the expression of IGF-I and PCNA mRNA was significantly decreased compared with the model group(P<0.01).CONCLUSIONS:The effect of Lichong Decoction on uterine leiomyoma is related to its function in reducing the expression of IGF-I and PCNA mRNA. | Donghua Li Yalan Zhang Hongjuan Han Jianguo Geng Xiaolei Xie Jiubo Zheng Yasong Wang Xiaoli Zou | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 11 |
| 14 | Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer's disease显示文摘One of the early pathological hallmarks of Alzheimer's disease(AD) is the deposition of amyloid-β(Aβ) plaques in the brain. There has been a tremendous interest in the development of Aβ plaques imaging probes for early diagnosis of AD in the past decades. Optical imaging, particularly near-infrared fluorescence(NIRF) imaging, has emerged as a safe, low cost, real-time, and widely available technique, providing an attractive approach for in vivo detection of Aβ plaques among many different imaging techniques. In this review,we provide a brief overview of the state-of-the-art development of NIRF Aβ probes and their in vitro and in vivo applications with special focus on design strategies and optical, binding, and brain-kinetic properties. | Hongjuan Tong Kaiyan Lou Wei Wang | 2015 | Acta Pharmaceutica Sinica B2015，5，1： | 9 |
| 15 | Precision Balance Method for Cupped Wave Gyro Based on Cup-bottom Trimming显示文摘The mechanical balance process is the key process to eliminate the quadrature error and improve the performance of the cupped wave gyro.The conventional mechanical balance method for cupped wave gyro based on cup-wall trimming requires high control accuracy of trimming quantity,which increases the production cost and decreases the fabrication efficiency in large extent.However,it is hard to reach the high balance accuracy with the natural frequency split of mHz grade by using the conventional method.In this paper,the lumped mass dynamic model of the cupped wave gyro is built by discretization method,and the effects of different position trimming on the natural frequency are analyzed.It is pointed out that trimming off a tiny quantity of material from cup-wall causes large variation of the natural frequency is the main reason for the low accuracy of the conventional mechanical balance method.Then,a precision balance method for cupped wave gyro based on cup-bottom trimming is presented and the entire procedures of this method are given.The static balance process and dynamic balance process of the precision balance method are simulated by the finite element software.The simulation result shows that the precision balance method based on cup-bottom trimming brings less additional natural frequency split in the static balance process,minimizes the natural frequency split to mHz grade and rectify the angle of mode offset to 0.1° grade in the dynamic balance process,furthermore,the method decreases the requirement for control accuracy of trimming quantity evidently.The research work provides references for structure optimization design and balance process plan of the cupped wave gyro. | TAO Yi XI Xiang XIAO Dingbang TAN Yingqi CUI Hongjuan WU Xuezhong | 2012 | Chinese Journal of Mechanical Engineering2012，25，1： | 9 |
| 16 | Effect of Electrical Current on the Tribological Behavior of the Cu-WS_2-G Composites in Air and Vacuum显示文摘As the traditional graphite-based composites cannot meet the requirement of rapid developing modern industry, novel sliding electrical contact materials with high self-lubricating performance in multiple environments are eagerly required. Herein a copper-based composite with WS2 and graphite as solid lubricant are fabricated by powder metallurgy hot-pressed method. The friction and wear behaviors of the composites with and without current are investigated under the condition with sliding velocity of 10 m/s and normal load of 2.5N/cm 2 in both air and vacuum. Morphologies of the worn surfaces are observed by optical microscope and compositions of the lubricating films are analyzed by XPS. Surface profile curves and roughness of the worn surfaces are obtained by 2205 surface profiler. The results of wear tests show that the friction coefficient and wear volume loss of the composites with current are greater than that without current in both air and vacuum due to the adverse effects of electrical current which damaged the lubricating film partially and roughed the worn surfaces. XPS results demonstrate that the lubricating film formed in air is composed of oxides of Cu, WS2 , elemental S and graphite, while the lubricating film formed in vacuum is composed of Cu, WS2 and graphite. Because of the synergetic lubricating action of oxides of Cu, WS2 and graphite, the composites show low friction coefficient and wear volume loss in air condition. Owing to the fact that graphite loses its lubricity which makes WS2 become the only lubricant, severe adhesive and abrasive wear occur and result in a high value of wear rate in vacuum condition. The formation of the lubricating film on the contact interface between the brush and ring is one of the factors which can greatly affect the wear performance of the brushes. The low contact voltage drop of the composites in vacuum condition is attributed to the high content of Cu in the surface film. This study fabricated a kind of new sliding electrical contact self-lubricating composite with dual-lubricant which can work well in both air and vacuum environments and provides a comprehensive analysis on the lubrication mechanisms of the composite. | QIAN Gang FENG Yi LI Bin HUANG Shiyin LIU Hongjuan DING Kewang | 2013 | Chinese Journal of Mechanical Engineering2013，26，2： | 8 |
| 17 | K-Ar age of the Cenozoic volcanic rocks in the Nangqen Basin, Qinghai Province and its geological significance显示文摘The Nangqen Basin is one of the typical shearing-extensional basins situated in the north part of the Hengduan Mts. Nine ages of the Cenozoic volcanic rocks from the basin by K-Ar isotope-dilution technique have been reported in the note. The apparent ages of whole rock and separated biotite range from 32.04 to 36.50 Ma. The 40Ar-K (%) correlation isochronal line shows that there existed neither argon excessing , nor radiogenetic argon loosing, i.e. the age represents the true diagenetic time. Volcanic activity in this area occurred in the post-collision environment and is controlled by lithosphere substantial thickening and violent intercontinental shearing-strike slip faults. There is age difference of the magmatic activity in the east, the west and the north Tibet. The multi-periodic eruption-intrusion of the magmatic melt since Cenozoic is a tracer showing the pulsating uplift of the Tibetan Plateau. | DENG Wanming SUN Hongjuan ZHANG Yuquan | 2000 | Chinese Science Bulletin2000，45，11： | 7 |
| 18 | Low-degree root-MUSIC algorithm for fast DOA estimation based on variable substitution technique显示文摘Dear editor,U-root-MUSIC[1]is one of the most popular unitary direction of arrival(DOA)estimation methods[2],and its eigenvalue decomposition(EVD)stage involves only real-valued(RV)arithmetic.Recently,a version of RV-root-MUSIC,which allows RV computations for both EVD and polynomial rooting,was reported in[3].Nevertheless,the RV-root-MUSIC polynomial is of a high degree 2(M-1),which meansit has unacceptably high complexity with large arrays[4]. | Fenggang YAN Ming JIN Hongjuan ZHOU Jun WANG Shuai LIU | 2020 | Science China(Information Sciences)2020，63，5： | 7 |
| 19 | Preparation of phosphorus-modified PITQ-13 catalysts and their performance in 1-butene catalytic cracking显示文摘A series of phosphorus-modified PITQ-13 catalysts was prepared by wet impregnation of NH4H2PO4solution into an HITQ-13 parent. The catalysts were characterized using XRD, N2adsorption, MAS NMR and NH3-TPD. Their catalytic performance in 1-butene catalytic cracking was evaluated in a fixed fluidized bed reactor. The results showed that the crystallinity, surface area and pore volume of P-modified PITQ-13catalysts decreased with the increasing amounts of P. The number of weak acid sites increased, whereas that of strong acidity decreased. The selectivity to propylene in 1-butene cracking reactions increased because of the decrease in strong acidity. The yield of propylene achieved41.6% over PITQ-13-2 catalyst with a P content of 1.0 wt%, which was 5.1% greater than that achieved over HITQ-13 catalyst. | Penghui Zeng Yun Liang Shengfu Ji Baojian Shen Honghai Liu Baojie Wang Hongjuan Zhao Mingfu Li | 2014 | Journal of Energy Chemistry2014，23，2： | 6 |
| 20 | Isolation of Growth Hormone-Releasing Hormone and Its Receptor Genes from Scatophagus argus and Their Expression Analyses显示文摘The teleost Scatophagus argus is a species whose females grows faster than males.Growth hormone(gh)mRNA abundance in females pituitary is higher than that in males;however the mechanism underlining such differential is still unknown.Growth hormone(GH)is tightly associated with GH-releasing hormone(Ghrh)in vertebrates.In this study,Ghrh gene(ghrh)and its receptor gene,ghrhr,were isolated from S.argus.Tissue expression analysis showed that ghrh and ghrhr were mainly expressed in hypothalamus while ghrhr was expressed in pituitary and gh was predominantly expressed in pituitary.Twenty cultured S.argus individuals were used to compare ghrh,ghrhr and gh mRNA abundances,120 g and 181 g average weight for male(n=11)and female(n=9),respectively.Real-time PCR indicated that the ghrh and ghrhr mRNA abundances in male hypothalamus were significantly higher than those in female hypothalamus while that of gh mRNA abundance was significantly higher in female pituitary than in male pituitary.The ghrh and ghrhr mRNA abundances were significantly up-regulated in female hypothalamus 3 h after injection of 0.1 mg kg^-1 body weight Ghrh while pituitary ghrhr and gh mRNA abundances were not affected.In female hypothalamus,ghrh and ghrhr m RNA abundances were not affected at 6 h post-injection of 4 mg kg^-1 body weight 17α-methyltes-tosterone(17α-MT)or 17β-Estradiol(E2).In female pituitary,ghrhr m RNA abundance was down-regulated by 17α-MT while that of gh m RNA abundance was up-regulated by E2.Our findings indicated that E2,rather than Ghrh,plays an important role in up-regulating the expression of gh in female S.argus,which should aid to understand the sexual dimorphism of teleost growth. | JIANG Dongneng SHI Hongjuan LIU Qianqing WANG Tuo HUANG Yuanqing HUANG Yang DENG Siping CHEN Huapu TIAN Changxu ZHU Chunhua LI Guangli | 2019 | Journal of Ocean University of China2019，18，6： | 6 |
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