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| 1 | PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling显示文摘Oral squamous cell carcinoma(OSCC)has a high incidence of metastasis.Tumour immunotherapy targeting PD-L1 or PD-1 has been revolutionary;however,only a few patients with OSCC respond to this treatment.Therefore,it is essential to gain insights into the molecular mechanisms underlying the growth and metastasis of OSCC.In this study,we analysed the expression levels of protein kinase D3(PKD3)and PD-L1 and their correlation with the expression of mesenchymal and epithelial markers.We found that the expression of PKD3 and PD-L1 in OSCC cells and tissues was significantly increased,which correlated positively with that of mesenchymal markers but negatively with that of epithelial markers.Silencing PKD3 significantly inhibited the growth,metastasis and invasion of OSCC cells,while its overexpression promoted these processes.Our further analyses revealed that there was positive feedback regulation between PKD3 and PD-L1,which could drive EMT of OSCC cells via the ERK/STAT1/3 pathway,thereby promoting tumour growth and metastasis.Furthermore,silencing PKD3 significantly inhibited the expression of PD-L1,and lymph node metastasis of OSCC was investigated with a mouse footpad xenograft model.Thus,our findings provide a theoretical basis for targeting PKD3 as an alternative method to block EMT for regulating PD-L1 expression and inhibiting OSCC growth and metastasis. | Bomiao Cui Jiao Chen Min Luo Yiying Liu Hongli Chen Die Lü Liwei Wang Yingzhu Kang Yun Feng Libin Huang Ping Zhang | 2021 | International Journal of Oral Science2021，13，1： | 1 |
| 2 | Optical and mechanical properties of far infrared transmitting glass ceramics显示文摘 | Zhu Shizhen Ma Hongli Calvez L | 2007 | J NowCryst Solids2007，353，19： | 1 |
| 3 | Transgenic tobacco expressed HPV16-L1 and LT-B combined immunization induces strong mucesal and systemic immune responses in mice显示文摘 | Hongli L Xukui L Ting L | 2013 | Hum Vaccine Immunother2013，9，1： | 1 |
| 4 | Research on novel grating eddy- current absolute-position sensor 显示文摘 | Weiwen L Hui Z Hongli Q | 2009 | Instrumentation and Meas- urement IEEE Transactions on2009，58，10： | 1 |
| 5 | J Non-Cryst Solids显示文摘 | Zhu Shizhen Ma Hongli Calvez L | 2007 | 353:12982007，353，： | 1 |
| 6 | Optical and mechanical properties of far infrared transmitting glass-ceramics 显示文摘 | ZHU Shizhen MA Hongli CALVEZ L | 2007 | Non-Cryst Solids2007，353，： | 1 |
| 7 | Effect of complexing agent concentration on properties of CdZnS thin films in ammonia-thiourea system显示文摘In this paper,the effects of different concentrations of complexing agent(ammonia)on the surface morphology,composition,structure and photoelectric properties of Cd Zn S films were studied.The results of X-ray diffraction(XRD),scanning electron microscopy(SEM)and UV-visible spectrum showed that the surface morphology of the films became worse and the content of zinc decreased significantly with the increase of ammonia concentration.The crystalline phase of Cd Zn S films was not influenced by the ammonia concentration.Because the film has good absorbance,transmittance greater than 70%and band gap width between 3.5 eV and 3.07 eV,it is suitable to be used as a buffer layer for solar cells.Cd S,Zn O and Zn(OH)_(2) were found in the precipitates at the bottom of the solution,and the formation of these precipitates affected the properties of the Cd Zn S films. | Lü Chaoqun XUE Yuming DAI Hongli WANG Luoxin WANG Yifan XIE Xin | 2023 | Optoelectronics Letters2023，19，4： | 0 |
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