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| 1 | TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells显示文摘免疫疗法和化疗的联合为癌症的某些类型的治疗被认为是一条有希望的途径。然而,内在的机制需要充分被调查为癌症 chemoimmunotherapy 指导更有效的协议的设计。联系危险的分子的模式(阻尼) 能激活有免疫力的房间,是众所周知的,包括树枝状的房间(DC ) ,经由像使用费的受体(TLR ) ;然而,在有免疫力的反应的激活免除化学对待药的肿瘤房间的阻尼的角色需要进一步被阐明。这里,我们发现那 colorectal 与 oxaliplatin (OXA ) 对待的癌症(CRC ) 房间或 5 氟尿嘧啶(5-Fu ) 释放了高活动性的组盒子 1 的高水平(HMGB1 ) 和热吃惊蛋白质 70 (HSP70 ) 。在 OXA/5-Fu 治疗以后,也展出的 CRC 病人的 sera 增加了 HMGB1 和 HSP70 的层次,哪个是著名阻尼。与 OXA/5-Fu 对待的垂死的 CRC 房间的上层清液支持了老鼠和人的 DC 成熟,与 HLA 医生, CD80 和 CD86 表示和 IL-1β 的改进的 upregulation;, TNF-α, MIP-1α, MIP-1β, RANTES 和 IP-10 生产。由 DC 组成的疫苗与导致的化学上强调的 CRC 房间的上层清液搏动了更重要的 IFN-γ在 vitro 并且在 vivo 生产 Th1 反应。然而,化学上强调的 CRC 房间的上层清液没能在 TLR4 缺乏的 DC 导致 phenotypic 成熟和 cytokine 生产,显示在导致阻尼的 DC 成熟和激活的 TLR4 的一个必要角色。而且,有化学上强调的 CRC 房间的上层清液的 pulsing 高效地没导致 IFN-γ在 TLR4 缺乏的 DC 生产 Th1 反应。一起,这些结果证明免除化学上强调的癌症房间的阻尼能经由 TLR4 激活 DC 并且提高反肿瘤 T 房间有免疫力的回答的正式就职,描出一条临床上相关的免疫助手小径由阻尼被触发。 | Hongliang Fang Bing Ang Xinyun Xu Xiaohui Huang Yanfeng Wu Yanping Sun Wenying Wang Nan Li Xuetao Cao Tao Wan | 2014 | Cellular & Molecular Immunology2014，11，2： | 11 |
| 2 | Adipocyte-derived microvesicles from obese mice induce M1 macrophage phenotype through secreted miR-155显示文摘The pro-inflammatory profile of M1 macrophage accumulation in adipose tissue is a central event leading to the metabolic complications of obesity.However,the mechanisms by which M1 macrophages are enriched in adipose tissue during weight gain remain incompletely understood.Here,we investigated the effects of adipocyte-derived microvesicles(ADM)on modulating macrophage phenotype in mice and explored the involved molecular signalling pathways.We found that,compared with ADM from lean mice(SD ADM),ADM from obese mice(HFD ADM)significantly enhanced M1 marker expression.The quantitative RTPCR assay demonstrated that miR-155 was upregulated in both HFD ADM and HFD ADM-treated macrophages.By depleting miR-155 expression in HFD ADM and increasing miR-155 level in SD ADM,we further illustrated that miR-155 in ADM-induced M1 macrophage polarization.Functionally,in contrast to SD ADM,HFD ADM significantly decreased the protein level of SOCS1,a proven miR-155 target,leading to activation of STAT1,and suppression of STAT6 signalling;these effects were reversed by silencing miR-155 in HFD ADM.Furthermore,the supernatant of bone marrow-derived macrophages pre-stimulated with miR-155-bearing ADM interfered with insulin signalling and insulin-induced glucose uptake in adipocytes.Collectively,these results provide the first evidence that M1 macrophage polarization can be mediated by miR-155-bearing ADM,which reciprocally regulates insulin signalling and glucose uptake in adipocytes.Our study reveals a novel mechanism through which obesity induces an imbalance in the M1-to-M2 macrophage ratio in adipose tissue,thus causing chronic inflammation and local insulin resistance. | Yaqin Zhang Hongliang Mei Xiaoai Chang Fang Chen Yunxia Zhu Xiao Han | 2016 | Journal of Molecular Cell Biology2016，8，6： | 11 |
| 3 | Sunway supercomputer architecture towards exascale computing:analysis and practice显示文摘In recent years,the improvements of system performance and energy efficiency for supercomputers have faced increasing challenges,which create more intensive demands on the architecture design for realizing exascale computing.This paper first analyzes the main requirements of exascale computing on the aspects of the parallel computing application and supercomputing center operation.Afterwards,a mapping scheme of'demands-challenges-architecture'is proposed.Then,the major challenges of exascale supercomputer,such as scalability,power consumption,data movement,programming and availability,are thoroughly analyzed,and the corresponding appropriate solutions are proposed.Moreover,this paper proposes the Sunway computer architecture towards exascale computing in which the many-core processor,network chipset and software system are all domestically-designed.The technology roadmap of Sunway supercomputer will hold the comprehensive design methods for the architecture,including the processor,interconnect network,assembly structure,power supply,cooling system,system software,parallel algorithm and application support,promising great advances for exascale supercomputing. | Jiangang GAO Fang ZHENG Fengbin QI Yajun DING Hongliang LI Hongsheng LU Wangquan HE Hongmei WEI Lifeng JIN Xin LIU Daoyong GONG Fei WANG Yan ZHENG Honghui SUN Zhou ZHOU Yong LIU Hongtao YOU | 2021 | Science China(Information Sciences)2021，64，4： | 3 |
| 4 | A method of elevated temperatures coupled with magnetic stirring to predict real time release from long acting progesterone PLGA microspheres显示文摘The object of the study was to develop a quick and reproducible accelerated in vitro release method to predict and deduce the function of the real time(37 °C) release for long acting PLGA microspheres. The method could be described in several steps. First, the release of the microspheres were studied using the sample and separate method at 37 °C with normal orbital shaking and elevated temperatures with magnetic stirring to further accelerate the release. Second, the most similar profile at elevated temperatures with the real time release was chosen with the help of the n value in the fitted Korsmeyer-Peppas Function. Third,the Weibull function and conversion ratio were used to deduce the function of real time release according to the chosen profile at elevated temperatures. The key point in this study was to provide a quick and precise method to predict the real time release for long acting progesterone PLGA microspheres. So the elevated temperatures coupled with magnetic stirring were used to accelerate the release further, and when there have many similar release profiles with the real time release at elevated temperatures, releasing time at elevated temperatures and the R2 of the final deduced function will be used to help choosing the most similar release profile with the real time release. Four different types of progesterone PLGA microspheres were used to verify the method, and all the deduced function correlated well with the real time releases, for R2 = 0.9912, 0.9781, 0.9918 and 0.9972, respectively. | Mingzhu Ye Hongliang Duan Lixia Yao Yicheng Fang Xiaoyu Zhang Ling Dong Feifei Yang Xinggang Yang Weisan Pan | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 3 |
| 5 | Overview of the Mars climate station for Tianwen-1 mission显示文摘The background and scientific objectives of the Mars Climate Station(MCS)for Tianwen-1 are introduced,accompanied by a comparative review of the status of related meteorological observation missions and of advanced sensing technologies.As one of the China Tianwen-1 Mission’s principal scientific payloads,the MCS contains four measurement sensors and one electronic processing unit that are specially designed to measure local temperature,pressure,wind,and sound on the Martian surface.The MCS’s measurement principles,technical schemes,ground calibration techniques,and adaptability evaluation to the Mars surface environment of MCS are introduced in details.The conclusion presents measurement performance specifications of the MCS,based on ground test results,that will provide guidance to future research based on data from the Tianwen-1 and later Mars missions. | YongQing Peng LeiBo Zhang ZhiGuo Cai ZhaoGang Wang HaiLong Jiao DongLi Wang XianTao Yang LianGuo Wang Xu Tan Feng Wang Jing Fang ZhouLu Sun HongLiang Feng XiaoRui Huang Yan Zhu Ming Chen LiangHai Li YanHua Li | 2020 | Earth and Planetary Physics2020，4，4： | 2 |
| 6 | Seasonal dynamic pattern analysis on global FPAR derived from AVHRR GIMMS NDVI显示文摘The purpose of this paper is to develop Advanced Very High Resolution Radiometer(AVHRR)Global Inventory Modelling and Mapping Studies(GIMMS)Normalised Difference Vegetation Index(NDVI;AVHRR GIMMS NDVI for short)based fraction of absorbed photosynthetically active radiation(FPAR)from 1982 to 2006 and focus on their seasonal and spatial patterns analysis.The available relationship between FPAR and NDVI was used to calculate FPAR values from 1982 to 2006 and validated by Moderate-resolution Imaging Spectroradiometer(MODIS)FPAR product.Then,the seasonal dynamic patterns were analysed,as well as the driving force of climatic factors.Results showed that there was an agreement between FPAR values from this study and those of the MODIS product in seasonal dynamic,and the spatial patterns of FPARvary with vegetation type distribution and seasonal cycles.The time series of average FPAR revealed a strong seasonal variation,regular periodic variations from January 1982 to December 2006,and opposite patterns between the Northern and Southern Hemispheres.Evergreen vegetation FPARvalues were close to 0.7.A clear single-peak curve was observed between 308N and 808N?an area covered by deciduous vegetation.In the Southern Hemisphere,the time series fluctuations of FPAR averaged by 0.78 latitude zones were not clear compared to those in the Northern Hemisphere.A significant positive correlation(PB0.01)was observed between the seasonal variation of temperature and precipitation and FPAR over most other global meteorological sites. | Dailiang Peng Bing Zhang Liangyun Liu Dongmei Chen Hongliang Fang Yong Hu | 2012 | International Journal of Digital Earth2012，5，5： | 2 |
| 7 | Georelational Analysis of Soil Type, Soil Salt Content, Landform, and Land Use in the Yellow River Delta, China显示文摘 | Hongliang Fang Gaohuan Liu Michael Kearney | 2005 | Environmental Management2005，，1： | 2 |
| 8 | Engineering HOF‑Based Mixed‑Matrix Membranes for Efficient CO_(2) Separation显示文摘Hydrogen-bonded organic frameworks(HOFs)have emerged as a new class of crystalline porous materials,and their application in membrane technology needs to be explored.Herein,for the first time,we demonstrated the utilization of HOF-based mixed-matrix membrane for CO_(2) separation.HOF-21,a unique metallo-hydrogen-bonded organic framework material,was designed and processed into nanofillers via amine modulator,uniformly dispersing with Pebax polymer.Featured with the mix-bonded framework,HOF-21 possessed moderate pore size of 0.35 nm and displayed excellent stability under humid feed gas.The chemical functions of multiple binding sites and continuous hydrogen-bonded network jointly facilitated the mass transport of CO_(2).The resulting HOF-21 mixed-matrix membrane exhibited a permeability above 750 Barrer,a selectivity of~40 for CO_(2)/CH_(4) and~60 for CO_(2)/N_(2),surpassing the 2008 Robeson upper bound.This work enlarges the family of mixed-matrix membranes and lays the foundation for HOF membrane development. | Yuhan Wang Yanxiong Ren Yu Cao Xu Liang Guangwei He Hanze Ma Hongliang Dong Xiao Fang Fusheng Pan Zhongyi Jiang | 2023 | Nano-Micro Letters2023，15，4： | 2 |
| 9 | Validation of MODIS and CYCLOPES LAI products using global field measurement data显示文摘 | Hongliang Fang Shanshan Wei Shunlin Liang | 2011 | Remote Sensing of Environment2011，，： | 2 |
| 10 | Atmospheric correction of landsat etm+landsurface imagery-part i:methods显示文摘 | Shunlin Liang Hongliang Fang Mingzhen Chen | 2001 | IEEE Transactions on Geoscience and Remote Sensing2001，39，11： | 1 |
| 11 | Atmospheric correction of landsat ETM+land surface imagery:II validation and applications显示文摘 | Shunlin Liang Hongliang Fang Jeffrey T Morisette | 2002 | IEEE Transactions on Geoscience and Remote Sensing2002，4，： | 1 |
| 12 | Atmospheric correction of Landsat ETMA- land surface imagery-part I : validation and appiications 显示文摘 | Liang Shunlin Fang Hongliang Morisette J T | 2002 | IEEE Transaction on Geoscience and Remote Sensing2002，40，12： | 1 |
| 13 | A new π-conjugated star-shaped polymer comprising of full fluorene units: An efficient blue emitter without reduction of color purity undergoing an annealing显示文摘 | Shijie Ren Jiangong Cheng Danli Zeng Wenqing Zhu Jing Sun Junping Du Erjian Xu Hongliang Zhong Yingchun Liu Qiang Fang | 2008 | Synthetic Metals2008，，1： | 1 |
| 14 | Association Between Lipid Profiles and Left Ventricular Hypertrophy:New Evidence from a Retrospective Study显示文摘Objective To explore the association between lipid profiles and left ventricular hypertrophy in a Chinese general population.Methods We conducted a retrospective observational study to investigate the relationship between lipid markers[including triglycerides,total cholesterol,low-density lipoprotein cholesterol,high-density lipoprotein(HDL)cholesterol,non-HDL-cholesterol,apolipoprotein A-I,apolipoprotein B,lipoprotein[a],and composite lipid profiles]and left ventricular hypertrophy.A total of 309,400 participants of two populations(one from Beijing and another from nationwide)who underwent physical examinations at different health management centers between 2009 and 2018 in China were included in the cross-sectional study.7,475 participants who had multiple physical examinations and initially did not have left ventricular hypertrophy constituted a longitudinal cohort to analyze the association between lipid markers and the new-onset of left ventricular hypertrophy.Left ventricular hypertrophy was measured by echocardiography and defined as an end-diastolic thickness of the mterventricular septum or left ventricle posterior wall>11 mm.The Logistic regression model was used in the cross-sectional study.Cox model and Cox model with restricted cubic splines were used in the longitudinal cohort.Results In the cross-sectional study for participants in the highest tertile of each lipid marker compared to the respective lowest,triglycerides[odds ratio(OR):1.2S0,95%CI:1.060 to 1.474],HDL-cholesterol(OR:0.780,95%CI:0.662 to 0.918),and lipoprotein(a)(OR:1.311,95%C7:1.115 to 1.541)had an association with left ventricular hypertrophy.In the longitudinal cohort,for participants in the highest tertile of each lipid marker at the baseline compared to the respective lowest,triglycerides[hazard ratio(HR):3.277,95%C/:1.720 to 6.244],HDL-cholesterol(HR:0.516,95%C7:0.283 to 0.940),non-HDL-cholesterol(HR:2.309,95%C/:1.296 to 4.112),apolipoprotein B(HR:2.244,95%CI:1.251 to 4.032)showed an association with new-onset left ventricular hypertrophy.In the Cox model with forward stepwise selection,triglycerides were the only lipid markers entered into the final model.Conclusion Lipids levels,especially triglycerides,are associated with left ventricular hypertrophy.Controlling triglycerides level potentiate to be a strategy in harnessing cardiac remodeling but deserve to be furdier investigated. | Xuewei Huang Keqiong Deng Juanjuan Qin Fang Lei Xingyuan Zhang Wenxin Wang Lijin Lin Yuming Zheng Dongai Yao Huiming Lu Feng Liu Lidong Chen Guilan Zhang Yueping Liu Qiongyu Yang Jingjing Cai Zhigang She Hongliang Li | 2022 | Chinese Medical Sciences Journal2022，37，2： | 1 |
| 15 | Improved estimation of aerosol optical depth from MODIS imagery over land surfaces显示文摘 | Shunlin Liang Bo Zhong Hongliang Fang | 2006 | Remote Sensing of Environment2006，，4： | 1 |
| 16 | Preparation and characterization of ibuprofen-loaded poly(lactide-co-glycolide)/poly(ethylene glycol)-g-chitosan electrospun membranes显示文摘 | Hongliang Jiang Dufei Fang Benjamin Hsiao Benjamin Chu Weilam Chen | 2004 | Journal of Biomaterials Science Polymer Edition2004，，3： | 1 |
| 17 | Improved estimation of aerosol optical depth from MODIS imagery over land surfaces显示文摘 | Liang Shunlin Zhong Bo Fang Hongliang | 2006 | Remote Sensing of Environment2006，104，： | 1 |
| 18 | Using NOAA/ AVHRR and Landsat TM to estimate rice area yem'-by-year显示文摘 | Fang Hongliang Wu Bingfang Liu Haiyan el al | 1998 | International Journal of Remote Sensing1998，19，3： | 1 |
| 19 | Integration of MODIS LAI and vegetation index products with the CSM–CERES–Maize model for corn yield estimation显示文摘 | Hongliang Fang Shunlin Liang Gerrit Hoogenboom | 2011 | International Journal of Remote Sensing2011，，4： | 1 |
| 20 | Atmospheric correction of Landsat ETM + land surface imagery--Part I: Methods 显示文摘 | Liang Shunlin Fang Hongliang Chen Mingzhen | 2001 | IEEE Transactions on Geoscience and Remote Sensing2001，39，11： | 1 |
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