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| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | High-Resolution Genome-wide Association Study Identifies Genomic Regions and Candidate Genes for Important Agronomic Traits in Wheat显示文摘Wheat(Triticum aestivum)is a major staple food crop worldwide.Genetic dissection of important agronomic traits is essential for continuous improvement of wheat yield to meet the demand of the world's growing population.We conducted a large-scale genome-wide association study(GWAS)using a panel of 768 wheat cultivars that were genotyped with 327609 single-nucleotide polymorphisms generated by genotyping-by-sequencing and detected 395 quantitative trait loci(QTLs)for 12 traits under 7 environments.Among them,273 QTLs were delimited to≤1.0-Mb intervals and 7 of them are either known genes(Rht-D,Vrn-B1,and Vrn-D1)that have been cloned or known QTLs(TaGA2ox8,APO1,TaSus1-7B,and Rht12)that were previously mapped.Eight putative candidate genes were identified for three QTLs that enhance spike seed setting and grain size using gene expression data and were validated in three bi-parental populations.Protein sequence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTLs affecting similar traits.Large r^2 values for additive effects observed among the QTLs for most traits indicated that the phenotypes of these identified QTLs were highly predictable.Results from this study demonstrated that significantly increasing GWAS population size and marker density greatly improves detection and identification of candidate genes underlying a QTL,solidifying the foundation for large-scale QTL fine mapping,candidate gene validation,and developing functional markers for genomics-based breeding in wheat. | Yunlong Pang Chunxia Liu Danfeng Wang Paul St.Amand Amy Bernardo Wenhui Li Fang He Linzhi Li Liming Wang Xiufang Yuan Lei Dong Yu Su Huirui Zhang Meng Zhao Yunlong Liangi Hongze Jia Xitong Shen Yue Lu Hongming Jiang Yuye Wu Anfei Li Honggang Wang Lingrang Kong Guihua Bai Shubing Liu | 2020 | Molecular Plant2020，13，9： | 8 |
| 3 | Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study)显示文摘 | Lin Shen Jin Li Jianming Xu Hongming Pan Guanghai Dai Shukui Qin Liwei Wang Jinwan Wang Zhenzhou Yang Yongqian Shu Ruihua Xu Lei Chen Yunpeng Liu Shiying Yu Lilian Bu Yongzhe Piao | 2015 | Gastric Cancer2015，，1： | 7 |
| 4 | Coordinated Demand Response of Rail Transit Load and Energy Storage System Considering Driving Comfort显示文摘Electric trains typically travel across the railway networks in an inter-provincial,inter-city and intra-city manner.The electric train generally serves as a load/source in tractive/brake mode,through which power networks and railway networks are closely coupled and mutually influenced.Based on the operational mode of rail trains and the characteristics of their load power,this paper proposes a coordinated optimal decisionmaking method of demand response for controllable load of rail trains and energy storage systems.First,a coordinated approach of dynamically adjusting the load of the controllable rail train in considering the driving comfort and energy storage battery is designed.Secondly,under the time conditions that satisfy the train’s operational diagram,the functional relationship between the train speed and the load power is presented.Based on this,in considering the constraints of the train’s arrival time,driving speed,motor power,and driving comfort,the capacity of energy storage batteries and other constraints,an optimization model for demand response in managing the traction power supply system under a two-part price and time-of-use(TOU)price is proposed.The objective is to minimize the energy consumption costs of rail transit trains,and optimize the speed trajectory of rail trains,the load power of traction system,and the output of energy storage batteries. | Hongming Yang Wangda Shen Qian Yu Junpeng Liu Yizhe Jiang Emmanuel Ackom Zhao Yang Dong | 2020 | CSEE Journal of Power and Energy Systems2020，6，4： | 4 |
| 5 | A distributed approach for lidar-based relative state estimation of multi-UAV in GPS-denied environments显示文摘In this paper,we present a distributed framework for the lidar-based relative state estimator which achieves highly accurate,real-time trajectory estimation of multiple Unmanned Aerial Vehicles(UAVs)in GPS-denied environments.The system builds atop a factor graph,and only on-board sensors and computing power are utilized.Benefiting from the keyframe strategy,each UAV performs relative state estimation individually and broadcasts very partial information without exchanging raw data.The complete system runs in real-time and is evaluated with three experiments in different environments.Experimental results show that the proposed distributed approach offers comparable performance with a centralized method in terms of accuracy and real-time performance.The flight test demonstrates that the proposed relative state estimation framework is able to be used for aggressive flights over 5 m/s. | Hongming SHEN Qun ZONG Hanchen LU Xuewei ZHANG Bailing TIAN Lei HE | 2022 | Chinese Journal of Aeronautics2022，35，1： | 3 |
| 6 | Plasmonic-enhanced two-photon fluorescence with single gold nanoshell显示文摘Single gold nanoshell with mutilpolar plasmon resonances is proposed to enhance two-photon fluorescence efficiently.The single emitter single nanoshell configuration is studied systematically by employing the finite-difference time-domain method.The emitter located inside or outside the nanoshell at various positions leads to a significantly different enhancement effect.The fluorescent emitter placed outside the nanoshell can achieve large fluorescence intensity given that both the position and orientation of the emission dipole are optimally controlled.In contrast,for the case of the emitter placed inside the nanoshell,it can experience substantial two-photon fluorescence enhancement without strict requirements upon the position and dipole orientations.Metallic nanoshell encapsulating many fluorescent emitters should be a promising nanocomposite configuration for bright two-photon fluorescence label.The results provide a comprehensive understanding about the plasmonic-enhanced two-photon fluorescence behaviors,and the nanocomposite configuration has great potential for optical detecting,imaging and sensing in biological applications. | ZHANG TianYue LU GuoWei SHEN HongMing Perriat P Martini M Tillement O GONG QiHuang | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，6： | 2 |
| 7 | Analysis of strand breakage caused by conductor vibration in transmission lines显示文摘I. Introduction A 31.2 km 110 kV transmission line is designed to operateunder 35 kV with conductor model AC-185 (aluminium strand-- 28 x 2.87 mm^2, steel core -- 7 x 2.50 mm^2) at average oper-ating stress of 24. 2%, and overhead ground wire model C-50(steel strand -- 7 x 2.97 mm^2) at average operating stress of20.6%. The whole line has 130 pole-towers, most of which are ofprestressed concrete double-pole structure, as shown in Fig.1. | Zhu Zhongming Suzhou Thermal Power Research Institute Shen Hongming | 1992 | Electricity1992，，2： | 2 |
| 8 | Speech Intelligibility Enhancement Algorithm Based on Multi-Resolution Power-Normalized Cepstral Coefficients(MRPNCC)for Digital Hearing Aids显示文摘Speech intelligibility enhancement in noisy environments is still one of the major challenges for hearing impaired in everyday life.Recently,Machine-learning based approaches to speech enhancement have shown great promise for improving speech intelligibility.Two key issues of these approaches are acoustic features extracted from noisy signals and classifiers used for supervised learning.In this paper,features are focused.Multi-resolution power-normalized cepstral coefficients(MRPNCC)are proposed as a new feature to enhance the speech intelligibility for hearing impaired.The new feature is constructed by combining four cepstrum at different time–frequency(T–F)resolutions in order to capture both the local and contextual information.MRPNCC vectors and binary masking labels calculated by signals passed through gammatone filterbank are used to train support vector machine(SVM)classifier,which aim to identify the binary masking values of the T–F units in the enhancement stage.The enhanced speech is synthesized by using the estimated masking values and wiener filtered T–F unit.Objective experimental results demonstrate that the proposed feature is superior to other comparing features in terms of HIT-FA,STOI,HASPI and PESQ,and that the proposed algorithm not only improves speech intelligibility but also improves speech quality slightly.Subjective tests validate the effectiveness of the proposed algorithm for hearing impaired. | Xia Wang Xing Deng Hongming Shen Guodong Zhang Shibing Zhang | 2021 | Computer Modeling in Engineering & Sciences2021，，2： | 0 |
| 9 | Three Dimensional Metal-Surface Processing Parameter Generation Through Machine Learning-Based Nonlinear Mapping显示文摘The accuracy and efficiency of three-dimensional(3D)surface forming,which directly affects the cycle and quality of production,is important in manufacturing.In practice,given the uncertainty of metal plate springback,an error exists between the actual plate and the target surface,which creates a nonlinear mapping from computer aided design models to bending surfaces.Technicians need to reconfigure parameters and process a surface multiple times to delicately control springback,which greatly wastes human and material resources.This study aims to address the springback control problem to improve the efficiency and accuracy of sheet metal forming.A basic computation approach is proposed based on the DeepFit model to calculate the springback value in 3D surface bending.To address the sample data shortage problem,we put forward an advanced approach by combining a deep learning model with case-based reasoning(CBR).Next,a multi-model fused bending parameter generation framework is devised to implement the advanced springback computation approach through surface data preprocessing,CBR-based model matching,convolution neural network-based machining surface generation,and bending parameter generation with a series of model transformations.Moreover,the proposed approaches and the framework are verified by considering saddle surface processing as an example.Overall,this study provides a new idea to improve the accuracy and efficiency of surface processing. | Min Zhu Yanjun Dong Bingqing Shen Haiyan Yu Lihong Jiang Hongming Cai | 2023 | Tsinghua Science and Technology2023，28，4： | 0 |
| 10 | Anisotropic magnetoelastic response in the magnetic Weyl semimetal Co_(3)Sn_(2)S_(2)显示文摘Co_(3)Sn_(2)S_(2) is a recently identified magnetic Weyl semimetal in Shandite compounds. Upon cooling, Co_(3)Sn_(2)S_(2) undergoes a ferromagnetic transition with c-axis polarized moments(0.3 μ_(B)/Co) around T_(C)= 175 K, followed by another magnetic anomaly around T_(A)≈ 140 K. A large intrinsic anomalous Hall effect is observed in the magnetic state below TC with a maximum of anomalous Hall angle near T_(A). Here, we report an elastic neutron scattering on the crystalline lattice of Co_(3)Sn_(2)S_(2) in a magnetic field up to 10 T. A strongly anisotropic magnetoelastic response is observed, while only a slight enhancement of the Bragg peaks is observed when B//c. The in-plane magnetic field(B//ab) dramatically suppresses the Bragg peak intensity probably by tilting the moments and lattice toward the external field direction. The in-plane magnetoelastic response commences from T_(C), and as it is further strengthened below T_(A), it becomes nonmonotonic against the field between T_(A) and T_(C) because of the competition from another in-plane magnetic order. These results suggest that a magnetic field can be employed to tune the Co_(3)Sn_(2)S_(2) lattice and its related topological states. | Chang Liu ChangJiang Yi XingYu Wang JianLei Shen Tao Xie Lin Yang Tom Fenne Uwe Stuhr ShiLiang Li HongMing Weng YouGuo Shi EnKe Liu HuiQian Luo | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，5： | 0 |
| 11 | China Natural Gas Industry Prosperity Index in the Third Quarter of 2019显示文摘The statistics of the China natural gas industry prosperity index show that it reached 154.18 in the third quarter of 2019,indicating a relatively prosperous state.The prosperity index of natural gas production enterprises reached 166.75,indicating a prosperous state.Natural gas sales companies'prosperity index reached 146.65,indicating a relatively prosperous state,and the prosperity trend index of the natural gas industry in the coming year is 223.28,indicating a very prosperous state.The details are shown in Fig.1 and Table 1. | Shen Xilin Fu Hongming Wu Junxian | 2019 | China Oil & Gas2019，26，5： | 0 |
| 12 | A Parallel Mapping and Planning Strategy for Micro Aerial Vehicle显示文摘Autonomous fight is a fundamental problem for various saplications of miaro aerial vehicles(MAVs).Thanks to the dewvelopment of Gudance.Navigation and Control(GNC)techndogle,the rsearch on this problem i abo becoming mature.However,safe fight in unknown,dut tered enviouments remains an open question,epeaially with real-time reguirement on onboard computer.This paper propoes a framnework including prlelly mapping and planning and implements it on Graphics Pmocessing Unit(GPU).First,a spherical coomlinate proijection is used in the ocupency grid map to avold menory cnflicts.After that,in the planning phase,a method baed on latice state space sampling is applied to obtain mutiple rajectorfe parlelly.Then,we design a series of aoft constraints to ensure that the MAV is in a safe known space with optimal dynamics.By solving the cost for each trajectory and comparison,the optimal trajectory can be generated.The efectivenes of the propeed strategy is demonstrated through simulation testa. | Zhuo Wang Qun Zong Hongming Shen Bailing Tian Hanchen Lu | 2022 | Guidance, Navigation and Control2022，2，2： | 0 |
| 13 | Constructing nanoporous Ni foam current collectors for stable lithium metal anodes显示文摘Lithium metal,as the most ideal anode material for high energy density batteries,has been researched for several decades.However,the dendrite formation and large volume change during repetitive lithium plating/stripping lead to a serious safety issue and impede the practical application of lithium metal anode.Herein,a nanoporous Ni foam current collector with high surface area and surface flaws is constructed via a facile oxidation-reduction method.The inherent macropore structure of Ni foam can partly accommodate the volume variation during Li plating/stripping.The well-distributed nanopores on the skeleton of Ni foam can effectively reduce the local current density,regulate the uniform lithium nucleation and deposition with homogenous distribution of Li^(+) flux.Moreover,the surface flaws induce the formation of ring Li structures at initial nucleation/deposition processes and concave Li metal spontaneously formed based on the ring Li structures during cycling,which can direct the even Li plating/stripping.Therefore,highly stable Coulombic efficiency is achieved at 1 mA cm^(-2) for 200 cycles.The symmetrical cell,based on the nanoporous Ni foam current collector,presents long lifespans of 1200 and 700 h respectively at different current densities of 0.5 and 1 mA cm^(-2) without short circuit.In addition,the LiFePO4 full cell,with the Li metal anode based on the nanoporous Ni foam current collector,shows excellent cycling performance at 1 C for 300 cycles and rate performance. | Shikun Liu Hongming Zhang Xiaoxu Liu Yu Yang Caixia Chi Shen Wang Junying Xue Tingting Hao Jiupeng Zhao Yao Li | 2021 | Journal of Energy Chemistry2021，30，7： | 0 |
| 14 | Spin excitations and spin wave gap in the ferromagnetic Weyl semimetal Co3Sn2S2显示文摘We report a comprehensive neutron scattering study on the spin excitations in the magnetic Weyl semimetal Co3Sn2S2 with a quasi-two-dimensional structure.Both in-plane and out-of-plane dispersions of the spin waves were revealed in the ferromagnetic state.Similarly,dispersive but damped spin excitations were found in the paramagnetic state.The effective exchange interactions were estimated using a semi-classical Heisenberg model to consistently reproduce the experimental TCand spin stiffness.However,a full spin wave gap below Eg=2.3 meV was observed at T=4 K.This value was considerably larger than the estimated magnetic anisotropy energy(~0.6 meV),and its temperature dependence indicated a significant contribution from the Weyl fermions.These results suggest that Co3Sn2S2 is a three-dimensional correlated system with a large spin stiffness,and the low-energy spin dynamics can interplay with the topological electron states. | Chang Liu JianLei Shen JiaCheng Gao ChangJiang Yi Di Liu Tao Xie Lin Yang Sergey Danilkin GuoChu Deng WenHong Wang ShiLiang Li YouGuo Shi HongMing Weng EnKe Liu HuiQian Luo | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，1： | 0 |
| 15 | Analysis of the Operation of China’s Natural Gas Industry in the Second Quarter of 2020显示文摘The statistics of the China natural gas industry prosperity index show that it reached 164.14 in the second quarter of 2020,indicating a prosperous state,and the prosperity index of natural gas production enterprises reached 187.56,also indicating a prosperous state.Natural gas sales companies’prosperity index reached 148.15,indicating a relatively prosperous state,and the prosperity trend index of the natural gas industry in the coming year is 256.29,indicating a very prosperous state.The details are shown in Fig.1 and Table 1. | Shen Xilin Fu Hongming | 2020 | China Oil & Gas2020，27，3： | 0 |
| 16 | Research on Nonlinear Frequency Compression Method of Hearing Aid with Adaptive Compression Ratio显示文摘To make full use of the residual audible frequency band of hearing-loss patients and improve the intelligibility of speech,an adaptive nonlinear frequency compression(NFC)algorithm is proposed,which amplifies signals below the cutoff frequency while compresses signals above the cutoff frequency.Firstly,high-frequency signals are decomposed to critical band signals according to the BARK scale.Secondly,the global compression ratio is determined according to the patient's cutoff frequency and maximum audible frequency.Thirdly,the sub-band compression ratio is adaptively determined based on the global compression ratio and normalized average energy of subband signals.Finally,the high frequency signals are transposed to low frequency bands by compression mapping,and the phases are adjusted to the same as the original low frequency signals.Experimental results of speech intelligibility with nine subjects demonstrate that compared to conventional amplitude amplification and nonlinear frequency compression algorithms the proposed algorithm significantly improves the intelligibility of initials and sentences,while not affects the intelligibility of finals and tones significantly. | Xia Wang Hongming Shen Huawei Tao Ruiyu Liang Xing Deng Haijian Shao Li Zhao Cairong Zou | 2019 | Computer Modeling in Engineering & Sciences2019，，11： | 0 |
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