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| 1 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 2 | The Construction of Active Source Repeated Monitoring in the Qilian Mountain, Gansu Province显示文摘The exciting source of the active source repeated monitoring is located in the Xiliushui Reservoir in Zhangye,Gansu Province. The system began operating normally on July 9,2015,and we had completed a period of 40 days of continuous excitation experiment before November 10,2015. Our results reveal that the airgun source has good consistency and repeatability,and the detective system of active source can record signal clearly. The construction of active source repeated exploration projects has achieved some results,which can provide valuable experience for the research of active source repeated exploration. The observation data we obtained makes it possible to follow the temporal and spatial variations of the deep structure of the Qilian Mountain areas. | Zhang Yuansheng Guo Xiao Qin Manzhong Liu Xuzhou Wei Congxin Shen Xuzhang Yan Wenhua Zou Rui Yin Liang Wang Yahong Sun Dianfeng Feng Hongwu Zhang Lifeng Guo Yingxia | 2016 | Earthquake Research in China2016，30，3： | 4 |
| 3 | Effect of magnetic field of arc chamber and operating mechanism on current limiting characteristics of low voltage circuit breakers 显示文摘 | CHEN Degui LIU Hongwu SUN Haitao | 2003 | IEICE Transactions on Electronics2003，86，6： | 1 |
| 4 | Photoluminescence of YVO 4 :Tm phosphor prepared by a polymerizable complex method显示文摘 | Hongwu Zhang Xiaoyan Fu Shuyun Niu Gongquan Sun Qin Xin | 2004 | Solid State Communications2004，，8： | 1 |
| 5 | Activating transcription factor 4 mediates a multidrug resistance phenotype of esophageal squamous cell carcinoma cells through transactivation of STAT3 expression显示文摘 | Hongwu Zhu Xiong Chen Bin Chen Bei Chen Jianyong Fan Weibing Song Ziying Xie Dan Jiang Qiuqiong Li Meihua Zhou Dayong Sun Yagang Zhao | 2014 | Cancer Letters2014，，1： | 1 |
| 6 | Photoluminescence of YVO 4 :Tm phosphor prepared by a polymerizable complex method显示文摘 | Hongwu Zhang Xiaoyan Fu Shuyun Niu Gongquan Sun Qin Xin | 2004 | Solid State Communications2004，，8： | 1 |
| 7 | Active control of wall acoustic impedance显示文摘 | ZHAO Hongwu SUN Xiaofeng | 1999 | AIAA Journal1999，37，7： | 1 |
| 8 | Long afterglow yellow luminescence from Pr^(3+) doped SrSc_(2)O_(4)显示文摘A yellow emitting long afterglow luminescence material SrSc_(2)O_(4):Pr^(3+)was successfully prepared by solid state reaction method.SrSc_(2)O_(4):Pr^(3+)phosphor shows a long afterglow luminescence peak at about 495,545,621,630 and 657 nm,respectively,corresponding to the f–f transitions of Pr^(3+).The afterglow chromaticity coordinates of SrSc_(2)O_(4):1 at%Pr^(3+)were calculated to be(0.35,0.41),indicating that the afterglow emission is close to the light of yellow region.And,the afterglow luminescence of the optimal sample doped by 1 at%Pr^(3+)can persist for over 3 h.The thermoluminescence results suggest that there are three types of traps with depth of 0.61,0.69 and 0.78 eV exiting for all the samples,which are produced by the addition of Pr^(3+)ions.The trap density of SrSc_(2)O_(4):1 at%Pr^(3+)is the maximum when the incorporation of Pr^(3+)ions reaches 1 at%,which thus results in the longest afterglow luminescence.All the results indicate that SrSc_(2)O_(4):Pr^(3+)can be a potential candidate of novel long afterglow phosphors. | Xiaoyan Fu Shenghui Zheng Yanfeng Meng Wenzhi Sun Hongwu Zhang | 2022 | Journal of Rare Earths2022，40，4： | 1 |
| 9 | Pressure drop and heat transfer in rotating smooth square U-duct under high rotation numbers显示文摘 | QIU Lu DENG Hongwu SUN Jining | 2013 | International Journal of Heat transfer and Mass Transfer2013，66，6： | 1 |
| 10 | A multi-channel full-duplex 60GHz-band radio-over-fiber system 显示文摘 | Yang Hongwu Sun Junqiang Du Qiujiao | 2010 | Optik2010，121，22： | 1 |
| 11 | Effect of Magnetic Field of Arc Chamber and Operating Mechanism on Current Limiting Characteristics of Low Voltage Circuit Breakers显示文摘 | Chen Degui Liu Hongwu Sun Haitao | 2003 | IEICE Transactions on Electronics2003，86，6： | 1 |
| 12 | Data-Driven Synthetic Cell Factories Development for Industrial Biomanufacturing显示文摘Revolutionary breakthroughs in artificial intelligence (AI) and machine learning (ML) have had a profound impact on a widerange of scientific disciplines, including the development of artificial cell factories for biomanufacturing. In this paper, wereview the latest studies on the application of data-driven methods for the design of new proteins, pathways, and strains. Wefirst briefly introduce the various types of data and databases relevant to industrial biomanufacturing, which are the basis fordata-driven research. Different types of algorithms, including traditional ML and more recent deep learning methods, are alsopresented. We then demonstrate how these data-based approaches can be applied to address various issues in cell factorydevelopment using examples from recent studies, including the prediction of protein function, improvement of metabolicmodels, and estimation of missing kinetic parameters, design of non-natural biosynthesis pathways, and pathway optimization.In the last section, we discuss the current limitations of these data-driven approaches and propose that data-driven methodsshould be integrated with mechanistic models to complement each other and facilitate the development of synthetic strains forindustrial biomanufacturing. | Zhenkun Shi Pi Liu Xiaoping Liao Zhitao Mao Jianqi Zhang Qinhong Wang Jibin Sun Hongwu Ma Yanhe Ma | 2022 | BioDesign Research2022，，1： | 0 |
| 13 | Integrating surface and interface engineering to improve optoelectronic performance and environmental stability of MXenebased heterojunction towards broadband photodetection显示文摘Two-/three-dimensional(2D/3D)heterojunction-based photodetectors have attracted much attention due to their highly efficient photoelectric conversion driven by the built-in electric field for high-speed photoresponse.However,a large dark current induced by unexpected surface states at the interface between 2D materials and 3D bulks is widely observed in such structures,greatly degrading their optoelectronic performance.Herein,a heterojunction of proton acid HCl treated MXene(H-MXene)/TiO_(2)/Si via integrating surface and interface engineering is fabricated,which exhibits decreased dark current and improved environmental stability.A feasible strategy to optimize the interface properties between MXene and Si is proposed by an in-situ oxidation process of MXene into TiO_(2),resulting in a suppressed dark current as well as high specific detectivity.Benefitting from the enhanced light absorption of MXene on the bulk Si substrate,the photoresponse of as-fabricated devices in the near-infrared region is also elevated.Moreover,the treatment of proton acid HCl on the surface of MXene brings better conductivity and environmental stability due to the decreased layer spacing of MXene,which is further confirmed by both experimental and theoretical methods.This work opens a unique way to comprehensively boost the optoelectronic performance of MXene-based photodetectors. | Zhifang Liu Mingjie Li Yilin Sun Huaipeng Wang Hongwu Chen Yulan Tian Han Wang Yingtao Ding Zhiming Chen | 2023 | Nano Research2023，16，7： | 0 |
| 14 | Comparison of two methods for evaluating lower urinary tract symptoms in cervical cancer patients following radical hysterectomy显示文摘Objective:To compare the degree of agreement and consistency of urodynamic studies(UDS)with low urinary tract symptoms(LUTS)questionnaires for evaluating LUTS in cervical cancer patients following radical hysterectomy(RH)and pelvic lymphadenectomy.Methods:From January 2012 to March 2015,204 cervical cancer patients who underwent RH in 13 hospitals were evaluated using the Incontinence Questionnaire-Female Lower Urinary Tract Symptoms(ICIQ-FLUTS)and the Overactive Bladder Symptom Score(OABSS).Urodynamic tests were also performed on these patients during the same period.Results:Study participants’age ranged from 23 to 75 years,with a mean(standard deviation)of 48.0±9.3 years.Using questionnaires,the prevalence of patients with LUTS symptoms,including storage symptoms,voiding symptoms,stress urinary incontinence(SUI)and overactive bladder(OAB)was 86.3%,77.0%,62.7%,52.9%and 14.7%,respectively.For UDS,the corresponding prevalence was 89.7%,70.1%,66.7%,46.6%and 13.2%,respectively.The diagnostic concordance of questionnaires and UDS for storage symptoms,voiding symptoms,SUI and OAB was 79.9%,66.7%,66.7%,57.4%and 79.9%,respectively.For voiding symptoms,the correlation coefficient was 0.272,which was higher than that of storage symptoms,SUI and OAB. | Fang An Sha Wang Zhiqi Wang Lingying Wu Qiubo Lv Aiming Lv Hongwu Wen Jinsong Han Yumei Wu Yunong Gao Qing Liu Sumei Wang Hongxia Li Luwen Wang Yanlong Wang Ruifang Wu Huan Li Xiuli Sun | 2021 | Gynecology and Obstetrics Clinical Medicine2021，1，2： | 0 |
| 15 | The exploration and utilization of functional substances in edible insects: a review显示文摘Edible insects as food have been considered as a core future protein source. Not only are edible insects abundant in nutrient value, but also have numbers of functional substances, which could provide a multiple valuable benefits for humans. This review examines and summarizes the functional substances in edible insects and their special effects for people, as well as the use and prospects for these functional substances. There are many functional substances in edible insects, such as antimicrobial peptides, interferon, sex attractant hormones, cordycepin, active polysaccharides, microelement, chitin/chitosan, steroidal material, vitamin, lecithin, etc., which could provide multiple benefits for human beings. These special functional substances could help people enhance immunity, inhibit tumor, regulate intestinal function, relieve fatigue, anti oxidation, protect against colds, improve sleeping, promote the growth and development, as well as reducing blood sugar and blood pressure, among others. According to these valuable efficacies, the functional substances extracted from edible insects can be exploited mainly in three ways: edible insects are used to discover new medicines or health care products for people;and edible insects are applied in chemical, agricultural, food technology, pollutant treatment and textile sectors;as well as being consumed as animal feedstuff for livestock and other animals, which indirectly meet the different requirements for humans. Currently, edible insects have generated global interest to be developed as different forms of products and has promoted more research and development. However, pupae and larvae are still the main consumption ways in the market, which is unacceptable to most people. It is expected that the edible insect industry would be prosperous and sustainable by integrating the power of beneficial policies and regulations, huge consumer demand and proper strategies of promotion and production. | Lei Qian Pan Deng Fajun Chen Ye Cao Hongwu Sun Huaijian Liao | 2022 | Food Production, Processing and Nutrition2022，4，1： | 0 |
| 16 | Transcriptional landscapes of de novo root regeneration from detached Arabidopsis leaves revealed by time-lapse and single-cell RNA sequencing analyses显示文摘Detached Arabidopsis thaliana leaves can regenerate adventitious roots,providing a platformfor studying de novo root regeneration(DNRR).However,the comprehensive transcriptional framework of DNRR remains elusive.Here,we provide a high-resolution landscape of transcriptome reprogramming from wound response to root organogenesis in DNRR and show key factors involved in DNRR.Time-lapse RNA sequencing(RNA-seq)of the entire leaf within 12 h of leaf detachment revealed rapid activation of jasmonate,ethylene,and reactive oxygen species(ROS)pathways in response towounding.Genetic analyses confirmed that ethylene andROSmay serve as wound signals to promoteDNRR.Next,time-lapse RNA-seq within 5 d of leaf detachment revealed the activation of genes involved in organogenesis,wound-induced regeneration,and resource allocation in the wounded region of detached leaves during adventitious rooting.Genetic studies showed that BLADE-ON-PETIOLE1/2,which control aboveground organs,PLETHORA3/5/7,which control root organogenesis,and ETHYLENE RESPONSE FACTOR115,which controlswound-induced regeneration,are involved in DNRR.Furthermore,single-cell RNA-seq data revealed gene expression patterns in thewounded region of detached leaves during adventitious rooting.Overall,our study not only provides transcriptome tools but also reveals key factors involved in DNRR from detached Arabidopsis leaves. | Wu Liu Yuyun Zhang Xing Fang Sorrel Tran Ning Zhai Zhengfei Yang Fu Guo Lyuqin Chen Jie Yu Madalene SIson Teng Zhang Lijun Sun Hongwu Bian Yijing Zhang Li Yang Lin Xu | 2022 | Plant Communications2022，3，4： | 0 |
| 17 | Edible insects as a food source:a review显示文摘The practice of eating insects has been documented for a long time.With obvious economic and environmental advantages,edible insects are in the spotlight recently due to their enormous potential in multiple industries.A number of research has been conducted to maximize their value,but concerns have been raised for the food security.In this review,we compared the characteristics of edible insects with other traditional protein sources.The progress of modern entomophagy was introduced.The benefits and risks of eating insects were summarized.Additionally,the shortcoming of current production were discussed.Feasible ways and strategies were proposed to promote the consumption of edible insects. | Chufei Tang Ding Yang Huaijian Liao Hongwu Sun Chuanjing Liu Lanjun Wei Fanfan Li | 2019 | Food Production, Processing and Nutrition2019，1，1： | 0 |
| 18 | The design and experimental investigation of control system for acoustic liner with adjustable impedance显示文摘A kind of new acoustic liner with adjustable impedance has been proposed. At the same time, a set of control system has been designed for this kind of liner. Many experimental results have been obtained based on this control system. In fact, the present investigation shows the possibi1ity of active control of sound absorption coefficient or impedance of a liner according to external sound source condition by means of a standing wave tube. The experimental results show that the sound absorption coefficient of the liner can keep optimal under any sound source condition by controlling the cavity depth and the flow rate through the perforated plate of the liner. In addition, hoth the resistance and the reactance of the liner can also be controlled independently corresponding to any given condition. which is necessary to control unsteady How in turbomachinery. | ZHAO Hongwu SUN Xiaofeng(Beijing University of Aeronautics and Astronautics Beijing 100083) | 1999 | Chinese Journal of Acoustics1999，18，1： | 0 |
| 19 | Epicardial adipose tissue around the superior vena cava: A single center study of factors related to atrial fibrillation显示文摘The superior vena cava(SVC)is the main component of non-pulmonary vein(PV)ectopy in patients with atrial fibrillation(AF).Researchers have found that epicardial adipose tissue(EAT)volume is related to the AF substrate,which can be defined by the low voltage area(LVA).This study aimed to investigate the relationship between SVC-EAT and SVC-AF.Twenty-six patients with SVC-AF triggers were identified as the SVC-AF group.Other three groups were defined and included as the LVA-AF group(LVA>5%),non-LVA-AF group(LVA<5%),and physical examination(PE)group.EAT around left atrium(LA-EAT)and SVC-EAT volumes were obtained using a cardiac risk assessment module.According to the SVC/LA-EAT ratio,there are significant differences between the SVC-AF group and the three control groups(the SVC-AF group 0.092±0.041 vs.the LVA-AF group 0.054±0.026,the non-LVA-AF group 0.052±0.022,and the PE group 0.052±0.019,all P<0.001).Receiver operating characteristic curve analysis suggests the optimal cut-off point of SVC/LA-EAT ratio is 6.8%for detecting SVC-AF patients,with 81.1%sensitivity,73.1%specificity,and an area under the curve of 0.83(95%confidence interval,0.75-0.91).Those with SVC-AF have a higher SVC/LA-EAT ratio and empirical SVC isolation could be considered if the SVC/LA-EAT ratio was over 6.8%. | Xingxing Sun Jun Wang Qing Yan Weizhu Ju Fengxiang Zhang Gang Yang Kai Gu Hailei Liu Zidun wang Xiaohong Jiang Mingfang Li Di Xu Yi Xu Hongwu Chen Minglong Chen | 2022 | The Journal of Biomedical Research2022，36，6： | 0 |
| 20 | A nomogram predicting atrial fibrillation in patients with dilated cardiomyopathy显示文摘To the Editor:Dilated cardiomyopathy(DCM)is a type of primary myocardial disease with unknown etiology.[1]It is a disorder of the heart muscle mainly characterized by left ventricular dilation and systolic dysfunction,resulting from the response of the myocardium to genetic and environmental insults.The clinical manifestations arc progressive heart failure,arrhythmia,thromboembolism,and even sudden death. | Yangming Mao Yanmin Liu Jian Zhang Yeqian Zhu Xinguang Chen Ling Sun Yao Lu Hongwu Chen Weizhu Ju Gang Yang Pengcheng Zhao Minglong Chen Fengxiang Zhang | 2022 | Chinese Medical Journal2022，，8： | 0 |
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