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| 1 | Inactivation of TFEB and NF-kB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion显示文摘It is critical to regulate the senescence-associated secretory phenotype(SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. In this study, we demonstrated that marchantin M(Mar-M, a naturally occurring bisbibenzyl) suppressed proinflammatory SASP components which were elevated in chemotherapy-resistant cells. Mar-M treatment attenuated the pro-tumorigenic effects of SASP and enhanced survival in drug-resistant mouse models.No toxicity was detected on normal fibroblast cells or in animals following this treatment. Inactivation of transcription factor EB(TFEB) and nuclear factor-k B(NF-k B) by Mar-M significantly accounted for its suppression on the components of SASP. Furthermore, inhibition of SASP by Mar-M contributed to a synergistic effect during co-treatment with doxorubicin to lower toxicity and enhance antitumor efficacy. Thus, chemotherapy-driven pro-inflammatory activity, seen to contribute to drug-resistance, is an important target for Mar-M. By decreasing SASP, Mar-M may be a potential approach to overcome tumor malignancy. | Huanmin Niu Lilin Qian Bin Sun Wenjian Liu Fang Wang Qian Wang Xiaotian Ji Yanhai Luo Effat Un Nesa Hongxiang Lou Huiqing Yuan | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 4 |
| 2 | Materials Experiment on Tiangong-2 Space Laboratory显示文摘During the China's Tiangong-2(TG-2) flight mission, the experiments of 18 kinds of material samples were conducted in space by using a Multiple Materials Processing Furnace(MMPF) mounted in the orbital module of the TG-2 space laboratory. After the experiments of 12 kinds of samples of the first and second batches were completed successfully, astronauts packed and brought them back to the ground by ShenzhouII spacecraft. By studying processing and formation on semiconductor and optoelectronics materials, metal alloys and metastable materials, functional single-crystal, micro-and nano-composite materials encapsulated in sample ampoules both in space and on Earth, we expect to explore some physical and chemical processes and mechanism of the materials formation that are normally obscured and therefore are difficult to study quantitatively on the ground due to the gravity-induced convection, to obtain the processing and synthesis technology for preparing high quality materials, and lead to the improvement and development of materials processing techniques on Earth, and also develop the experiment device and comprehensive ability for materials experiment in microgravity environment. This report briefly introduces the main points of each research work and preliminary comparative analysis results of 12 samples carried out by scientists undertaking research task. | LI Xiangyang LU Ye MENG Xiangjian WANG Jianlu WANG Reng CHEN Lidong HUA Zile LI Xiaoya SHI Jianlin LIU Jinfeng XU Guisheng WEI Bingbo XIE Wenjun YIN Zhigang ZHANG Xingwang JIANG Hongxiang LI Hong LUO Xinghong ZHANG Haifeng ZHAO Jiuzhou WANG Binbin PAN Mingxiang | 2018 | 空间科学学报2018，38，5： | 4 |
| 3 | Laser-generated thermoelastic acoustic sources and acoustic waves in anisotropic plate显示文摘The effect of anisotropy on the ultrasound wave generation and propagation in the unidirectional fi- ber-reinforced composite plate has been investigated. A quantitative numerical model for the la- ser-generated ultrasound in the thermoelastic regime was presented by using a finite element method. All factors, such as spatial and time distributions of the incident laser beam, optical penetration, ther- mal diffusivity, and source-receiver distance can be taken into account. Numerical results show that the effect on ultrasound waveform of the size of the laser volume source produces strong bipolar longitu- dinal waves and improves the amplitude and directivity of the longitudinal waves. A fiber-reinforced composite material exhibits isotropic or homogenous behavior for ultrasonic wave propagation per- pendicular to the fiber direction. For ultrasonic propagation along the fiber direction, ultrasonic dis- persion resulting from the inhomogeneous nature of the material affects the laser ultrasonic waveforms. As the dimensions of the laser pulse are increased in space and time, the displacement waveform be- comes broader and its magnitude decreases. | XU BaiQiang WANG Feng FENG Jun WANG JiJun SUN HongXiang LUO Ying | 2009 | Science China(Technological Sciences)2009，52，3： | 3 |
| 4 | Multi-channel phase regeneration of QPSK signals based on phase sensitive amplification显示文摘In this paper,we propose and demonstrate simultaneous phase regeneration of four different channels of QPSK signal based on phase sensitive amplification.The configuration can be divided into two parts.The first one uses four wave mixing in high nonlinear fiber(HNLF)to generate the corresponding three harmonic conjugates precisely at the frequency of the original signals.The other one uses optical combiner to realize coherent addition which is aimed at completely removing the interaction in phase regeneration stage.The simulation results suggest that this scheme can optimize signal constellation to a large extend especially in high noise environment.Besides,optical signal to noise ratio(OSNR)can improve more than 3 dB while the bit-error-rate(BER)reaches 10 – 3 with a constant white noise and 15° phase noise. | Hongxiang WANG Tiantian LUO Yuefeng JI | 2019 | Frontiers of Optoelectronics2019，12，1： | 3 |
| 5 | Composition and origin of lipid biomarkers in the surface sediments from the southern Challenger Deep, Mariana Trench显示文摘The surface sediments collected from the southern Mariana Trench at water depths between ca.4900 m and 7068 m were studied using lipid biomarker analyses to reveal the origin and distribution of organic matters. For all samples, an unresolved complex mixture(UCM) was present in the hydrocarbon fractions, wherein resistant component tricyclic terpanes were detected but C_(27)-C _(29) regular steranes and hopanes indicative of a higher molecular weight range of petroleum were almost absent.This biomarker distribution patterns suggested that the UCM and tricyclic terpanes may be introduced by contamination of diesel fuels or shipping activities and oil seepage elsewhere. The well-developed faults and strike-slip faults in the Mariana subduction zone may serve as passages for the petroleum hydrocarbons. In addition, the relative high contents of even n-alkanes and low Carbon Preference Indices indicated that the n-alkanes were mainly derived from bacteria or algae. For GDGTs, the predominance of GDGT-0 and crenarchaeol, together with low GDGT-0/Crenarchaeol ratios(ranging from0.86 to 1.64), suggests that the GDGTs in samples from the southern Mariana Trench were mainly derived from planktic Thaumarchaeota. However, the high GDGT-0/crenarchaeol ratio(10.5) in sample BC07 suggests that the GDGTs probably were introduced by methanogens in a more anoxic environment. Furthermore, the n-alkanes C_(19)-C_(22) and the n-fatty acids C_(20:0)-C_(22:0) were depleted in^(13)C by 3‰ compared to n-alkanes C_(16)-C_(18) and the n-fatty acids C_(14:0)-C_(18:0), respectively, which was interpreted to result from the preferential reaction of fatty acid fragments with carbon 'lighter' terminal carboxyl groups during carbon chain elongation from the precursors to products. The abundance of total alkanes, carboxylic acids, alcohols and total lipids were generally increased along the down-going seaward plate, suggesting the lateral organic matter inputs play an important role in organic matter accumulation in hadal trenches. The extremely high contents of biomarkers in sample BC11 were most likely related to trench topography and current dynamics, since the lower steepness caused by graben texture and proximity to the trench axis may result in higher sedimentation rate. This paper, for the first time, showed the biomarker patterns in surface sediments of the Mariana Trench and shed light on biogeochemistry of the hardly reached trench environment. | Hongxiang Guan Linying Chen Min Luo Lihua Liu Shengyi Mao Huangmin Ge Mei Zhang Jiasong Fang Duofu Chen | 2019 | Geoscience Frontiers2019，10，1： | 2 |
| 6 | Glycolysis Recycling of Waste Polyurethane Rigid Foam Using Different Catalysts显示文摘Dramatically increasing waste polyurethane rigid foam(WPRF)draws the attention of the world.A mixture of ethylene glycol(EG)and diethylene glycol(DEG)is used as glycolysis agents.WPRF was subjected to alcoholysis using different catalysts which are titanium ethylene glycol and potassium hydroxide to obtain recycled polyol,respectively.The effect of a different catalyst on the viscosity and hydroxyl value of recycled polyol is discussed.The regenerated polyurethane(RPU)is performed using the recycled polyol.Infrared spectrum,compressive strength,apparent density,water absorption,scanning electron microscope,and thermogravimetric analysis are carried out to investigate the effect of WPRF degradation using different catalysts.The results show that titanium glycol is more efficient than potassium hydroxide in almost all conditions.The viscosity of the recycled polyol is relatively low,and the hydroxyl value meets the requirements of industrial use.When the titanium glycol titanium addition amount is 0.05%,the prepared RPU has a compressive strength of 0.24 MPa,an apparent density of 41.75 kg/m^(3),and a good foam structure.Besides,the water absorption rate of the RPU under the two catalytic systems is not much different,and the thermal stability is good.The recycled polyol can generally partially replace traditional polyols to prepare polyurethane rigid foams with good comprehensive properties. | Xiaohua Gu Hongxiang Luo Shiwei Lv Peng Chen | 2021 | Journal of Renewable Materials2021，9，7： | 2 |
| 7 | Towards efficient deep neural network training by FPGA-based batch-level parallelism显示文摘Training deep neural networks(DNNs)requires a significant amount of time and resources to obtain acceptable results,which severely limits its deployment in resource-limited platforms.This paper proposes DarkFPGA,a novel customizable framework to efficiently accelerate the entire DNN training on a single FPGA platform.First,we explore batch-level parallelism to enable efficient FPGA-based DNN training.Second,we devise a novel hardware architecture optimised by a batch-oriented data pattern and tiling techniques to effectively exploit parallelism.Moreover,an analytical model is developed to determine the optimal design parameters for the DarkFPGA accelerator with respect to a specific network specification and FPGA resource constraints.Our results show that the accelerator is able to perform about 10 times faster than CPU training and about a third of the energy consumption than GPU training using 8-bit integers for training VGG-like networks on the CIFAR dataset for the Maxeler MAX5 platform. | Cheng Luo Man-Kit Sit Hongxiang Fan Shuanglong Liu Wayne Luk Ce Guo | 2020 | Journal of Semiconductors2020，41，2： | 2 |
| 8 | Multifunctional all-polymer photovoltaic blend with simultaneously improved efficiency(18.04%),stability and mechanical durability显示文摘One of the most appealing material systems for solar energy conversion is allpolymer blend.Presently,the three key merits(power conversion efficiency,operation stability and mechanical robustness)exhibited a trade-off in a particular all-polymer blend system,which greatly limit its commercial application.Diverting the classic ternary tactic of organic solar cells based on polymer,nonfullerene small molecule and fullerene,herein we demonstrate that the three merits of a benchmark all-polymer blend PM6:PY-IT can be simultaneously maximized via the introduction of a polymerized fullerene derivative PPCBMB.Importantly,the addition of the guest component promoted the power conversion efficiency of PM6:PY-IT blend from 16.59%to 18.04%.Meanwhile,the device stability and film ductility are also improved due to the addition of this polymerized fullerene material.Morphology and device physics analyses reveal that optimal ternary system contains well-maintained molecular packing and crystallinity,being beneficial to keeping favorable charge transport and the reduced domain size contributed to charge generation and ductility improvement.Furthermore,the ternary photovoltaic blend was successfully used as photocatalysts,and an excellent heavy metal removal from water was demonstrated.This study showcases the multi-functions of all-polymer blends via the use of polymerized fullerenes. | Tao Liu Kangkang Zhou Ruijie Ma Libin Zhang Ciyuan Huang Zhenghui Luo Hongxiang Zhu Shangfei Yao Chuluo Yang Bingsuo Zou Long Ye | 2023 | Aggregate2023，4，3： | 0 |
| 9 | HYDROFORMYLATION OF OLEFINS CATALYZED BY HOMOGENEOUS HETERONUCLEAR METAL CLUSTER [PhCH_2Me_3N][FeCo_3(CO)_(12)]显示文摘Hydroformylation of olefins catalyzed by heteronuclear metal cluster [PhCH2Me3N]-[FeCo3(CO)12] was studied. The effect of temperature, pressure, and solvent ect. on olefin hydroformylation was examined. The results show that for the hydroformylation of various olefins, e.g. 1-hexene, isobutene, 2-octene, cyclohexene, diisobutene, and styrene, the Fe-Co cluster exhibits rather high activity under mild conditions. For example, under the pressure such of 4 MPa, H2/CO ratio of 1: 1, at 120℃, 1-hexene was hydroformylated to heptanal with the conversion of > 80% and the selectivity of > 95% in 1 hr. | Luo Yuzhong, Fu Hongxiang, Zhang Shuwei(Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou, China) Wang Yunpu, Wu Nan, Zhang Aimi(Northwestern Teachers College, Lanzhou, China) | 1990 | 分子催化1990，4，S1： | 0 |
| 10 | Tribo-corrosion mechanisms and electromechanical behaviours for metal implants materials of CoCrMo,Ti6Al4V and Ti15Mo alloys显示文摘Corrosion and wear play significant roles in the aseptic loosening of artificial hip joints for the long-term service.In this present study,tribo-corrosion tests were carried out through a reciprocating ball-on-plate system to evaluate the corrosion and wear prop-erties of CoCrMo,Ti6Al4V and Ti15Mo alloys in a simulated body fluid(SBF)solution.It was found that the tribo-corrosion behaviours of CoCrMo/Al_(2)O_(3)and Ti15Mo/Al_(2)O_(3)systems had significant wear-corrosion synergistic interaction,and wear-induced corro-sion was dominant.For Ti6Al4V/Al_(2)O_(3)systems,their wear mechanism under SBF lubrication was a combination of abrasive,adhesive and fatigue wear.While the wear mechanism of the Ti15Mo/Al_(2)O_(3)system under synergistic interaction was a combination of abrasive and adhesive wear.Finally,it was suggested that the Ti15Mo alloy would be the better alternative for metal implant applications compared with the CoCrMo alloy for the consideration of both wear and potential poisonous ions such as Co(III)and Cr(VI). | Hongxiang Wang Jingjing Zheng Xiaolei Sun Yong Luo | 2022 | Biosurface and Biotribology2022，8，1： | 0 |
| 11 | HYDROFORMYLATION OF ETHYLENE CATALYZED BY HOMOGENEOUS METAL CLUSTERS显示文摘This paper deals with a study of hydroformylation of ethylene catalyzed by homoge-neous metal clusters.〔PhCH2Me3N〕〔FeCo3(CO)12〕and〔PhCH2Me3N〕〔RuCO3(CO)12〕show high catalytic activity for the hydroform ylation of ethylene compared with YCCo3(CO)9,CO4(CO)10(PPh)2,Co2(CO)6(PBu3)2,and Fe2(CO)4(C5H5)2.The reacton rate ofheteronuclear clusters is faster than that with homonuclear clusters.The effect of tempera-ture and pressure on hydroformylation of ethylene with〔PhCH2Me3〕〔FeCo3(CO)12〕ascatalyst was studied.The experimental results.show that the conversion of ethylene exceeds90% with a selectivity up to 95% at temperature 130℃ and pressure 3.9 MPa.When studiedwith high pressure in situ infrared spectroscopic method,PhCCo3(CO)9 was found to havehigher thermostability than 〔PhCH2Me3N〕〔FeCo3(CO)12〕. | Fu Hongxiang, Luo Yuzong , Zhang Shuwei, Ren Xu (Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China) | 1989 | 分子催化1989，3，S1： | 0 |
| 12 | Synthesis of titanium carbide coating on Ti15Mo alloy and its tribological behaviour显示文摘Ti15Mo alloy has been regarded as one of the most potential biomedical materials due to its excellent performance.However,the low hardness and poor wear resistance of titanium alloy limit the further application.Therefore,high temperature solid carburising technology was performed on the surface of Ti15Mo alloys to prepare titanium carbide(TiC)coating with graphene(G)as the carburising agent.The microstructure,mechanical properties,and tribological properties of TiC coating under different lubricants were investigated.Results showed that TiC coating was closely bonded to the titanium substrate.The maximum thickness of TiC coating treated with 1150°C was approximately 184.02μm,and the microhardness of alloys treated with 1100°C can achieve 1221.5 HV.All modified Ti15Mo alloys showed improved tribological performance compared to the original samples.The wear mechanisms of modified Ti15Mo alloys were abrasive wear and adhesive wear under the SBF lubricant,and the TiC coating was slightly peeled off.The overall friction coefficient and wear rate under 25%calf serum lubricant were lower than the SBF lubricant,and surface scratches were almost absent,and slight abrasive wear and adhesive wear occurred on the surface. | Hongxiang Wang Jiajia Shen Weipeng Zhang Zhentao Xu Jingjing Zheng Yong Luo | 2023 | Biosurface and Biotribology2023，9，4： | 0 |
| 13 | Targeting of VPS 18 by the lysosomotropic agent RDN reverses TFE3-mediated drug resistance显示文摘Dear Editor,Multidrug resistance(MDR)is still a major challenge for successful cancer treatments.Numerous mechanisms that confer therapy-induced drug resistance have been extensively investigated to explore how to combat the MDR.In this regard,lysosomal sequestration has demonstrated to be a mechanism contributing to drug resistance via an/,off-target,/effect in which hydrophobic and weakly basic chemotherapeutic agents are trapped in lysosomes,sequestering them from their targets. | Huanmin Niu Lilin Qian Yanhai Luo Fang Wang Hongbo Zheng Yanhui Gao Hanbo Wang Xuelei Hu Huiqing Yuan Hongxiang Lou | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 0 |
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