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| 1 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 2 | Evaluation of three tracers for labeling distal cerebrospinal fluidcontacting neurons显示文摘It has been reported that distal cerebrospinal fluidcontacting neurons(dCSF-CNs)can be detected by immunohistochemical assay using cholera toxin subunit B-conjugated horseradish peroxidase(CBHRP).In the present study,another two methods with CB alone or CB-conjugated FITC(CB-FITC)were used,and the results from the three methods were compared.Adult Sprague-Dawley rats were randomly divided into three groups with CB-HRP,CB or CB-FITC.Tracers were diluted to 30%in artificial cerebrospinal fluid and injected separately(in a volume of 3μL)into the lateral ventricle.Animals from the CB-HRP and CB groups were perfused 48 h after surgery while animals from the CB-FITC group were perfused 1,3,6,12,24 or 48 h after surgery.The brain was sectioned(40μm)for immunofluorescence and five sections with positive neurons were selected from each rat for neuron counting.Three clusters of positive neurons in a'Y-like'distribution were detected ventral to the cerebral aqueduct of rats from the three groups.No significant difference was observed among the quantitative data.In the CB-FITC group,stable staining was detected even at 6 h after injection.Taken together,lateral ventricle injection of CB/CB-FITC is a useful method for labeling dCSFCNs in rats.The CB-FITC method makes dCSF-CNs labeling much simpler and more convenient. | Fang Zhou Jiayou Wang Hongxing Zhang He Liu Guangping Zhao Cuihua Zu Xiaoxing Lu Licai Zhang | 2013 | Neuroscience Bulletin2013，29，5： | 7 |
| 3 | Fabrication and characterization of Ce_(0.7)Zr_( 0.3)O_2 nanorods having high specific surface area and large oxygen storage capacity显示文摘Nanorod-like Ce 0.7 Zr 0.3 O 2 solid solutions were synthesized by a sodium dodecyl sulfate-assisted precipi- tation method. The samples were characterized by means of scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and specific surface area measurement. Typical Ce 0.7 Zr 0.3 O 2 nanorods were 40 nm in average diameter and 450 nm in length, with specific surface area and oxygen storage capacity of 194 m 2 /g and 374 mol/g, respectively. | Yucheng Du Shuli Shi Hong He Hongxing Dai | 2011 | Particuology2011，9，1： | 5 |
| 4 | Synthesis and characterization of wormhole-like mesoporous Ce_(0.6)Zr_(0.35)Y_(0.05)O_2 solid solutions显示文摘Nanoparticles of Ce0.6Zr0.35Y0.05O2 (CZY) solid solution have been prepared by the CTAB (hexadecyl-trimethyl ammonium bromide), CTAB-EG (ethylene glycol) templating, and CTAB-EG-NaCl (in which the pores of the precursor synthesized by the CTAB-EG method is filled by a certain amount of NaCl) method, respectively. The physical properties of these materials were characterized by means of tech-niques such as X-ray diffraction (XRD), high resolution scanning electron microscopy (HRSEM), transmission electron microscopy (TEM), selected area electron diffraction (SAED), and N2 adsorp-tion-desorption measurements. The CZY samples synthesized by the above three methods display wormhole-like mesoporous morphology and cubic crystal structures. The materials are narrow in pore size distribution (averaged pore diameter = 5.3―7.1 nm), high in surface areas (95―119 m2/g), and large in pore volumes (0.16―0.18 cm3/g). It has been demonstrated that the introduction of NaCl is capable of retaining the pore structures of solid nanomaterials at high-temperature calcination. | WANG GuoZhi ZHANG Lei DENG JiGuang DAI HongXing HE Hong ZI XueHong | 2007 | Chinese Science Bulletin2007，52，2： | 4 |
| 5 | Preparation of ceria-zirconia solid solution with enhanced oxygen storage capacity and redox performance显示文摘A new method called ultrasonic-assisted membrane reaction(UAMR)was reported for the fabrication of ceria-zirconia solid solution.A series of ceria-zirconia solid solutions with different Ce/Zr molar ratios were prepared by the UAMR method and characterized by Xray diffraction(XRD),N2 adsorption,hydrogen temperature-programmed reduction(H2-TPR),scanning electron microscope(SEM),and transmission electron microscopy(TEM)techniques.The UAMR method proved to be superior,especially when the Ce/Zr molar ratio was lower than 1,in fabricating ceria-zirconia solid solutions with large BET surface area,high oxygen storage capacity(OSC),and low reduction temperature. | Lijing MENG Licheng LIU Xuehong ZI Hongxing DAI Zhen ZHAO Xinping WANG Hong HE | 2010 | Frontiers of Environmental Science & Engineering2010，4，2： | 3 |
| 6 | Analysis on Features of Temperature and Salinity in the Northern Taiwan Straits During February-March, 1998显示文摘The distributional features of temperature and salinity in the northern Taiwan Straits have been analyzed based on the CTD data during February-March, 1998. The characteristics of temperature and salinity are summarized as follows: (1) there exists a coastal water along the western coast of the Taiwan Straits, with low temperature and low salinity at the upper layer; (2) a high temperature and high salinity water tongue extends northeastward along the eastern coast of the Taiwan Strait. | Hu Jianyu , Hong Huasheng, Chen Zhaozhang, He Zhigang, Hong Jiansheng and Liang Hongxing(Institute of Subtropical Oceanography, Xiamen University, Xiamen 361005, China)(College of Oceanography and Environmental Sciences, Xiamen University)(Fujian Institute of Oceanology, Xiamen 361012, China) | 1999 | Marine Science Bulletin1999，1，2： | 3 |
| 7 | Self‐suspended rare‐earth doped up‐conversion luminescent waveguide:propagating and directional radiation显示文摘Near-infrared excited rare-earth(RE)-doped up-conversion(UC)-luminescent materials have attracted enormous attention because of their unique emission properties,such as narrow emission bands,long luminescence lifetimes,and multiple colors.However,current development of RE-doped luminescent material is hindered by weak and narrowband absorption problems and low photon-conversion quantum efficiencies.In addition to conventional approaches to enhance fluorescence intensity,controlling emission directivity to improve detection efficiency has become a promising approach to obtain higher luminescence brightnesses.In this paper,a self-suspended RE-doped UC luminescent waveguide is designed to realize directional emissions.Benefitting from the special morphology of the crown-like NaYF4:Yb3+/Er3+microparticle,the points contact between the waveguide and substrate can be obtained to decrease energy loss.An attractive UC luminescent pattern accompanied by powerful and controllable directional emissions is observed,and the spatial emission angle and intensity distribution are explored and analyzed in detail by introducing Fourier imaging detection and simulation.This work provides a new method for achieving controllable directional fluorescence emissions and obtaining improved detection efficiency by narrowing emission directivity,which has potential applications in 3-dimensional displays and micro-optoelectronic devices,especially when fabricating self-fluorescence micron lasers. | Changjian Zhang Chengyun Zhang Zhenglong Zhang Tao He Xiaohu Mi Ting Kong Zhengkun Fu Hairong Zheng Hongxing Xu | 2020 | Opto-Electronic Advances2020，3，6： | 3 |
| 8 | Preparation and characterization of highly active nanosized strontium-doped lanthanum cobaltate catalysts with high surface areas显示文摘La1?xSrxCoO3?δ (x=0, 0.4) nanoparticles have been prepared using the citric acid complex-ing-hydrothermal synthesis coupled method and citric acid complexing method. The physico-chemical properties of these materials were characterized by means of X-ray diffraction (XRD), high resolution scanning electron microscopy (HRSEM), element analysis (EDX), X-ray photoelectron spectroscopic (XPS), oxygen temperature-programmed desorption (O2-TPD), hydrogen temperature-programmed re-duction (H2-TPR) as well as surface area measure-ments and oxidation state titration. Their catalytic performance was examined for the total oxidation of ethylacetate (EA). It is found that the La1?xSrxCoO3?δ (x=0, 0.4) catalysts were single-phase and rhombo-hedrally-structured perovskites and their surface ar-eas ranged from 16 to 26 m2/g. The Sr-doped sample derived from the coupled procedure was uniformly distributed nanoparticles with a short rod-shaped morphology. The doping of Sr (i) enhanced the con-centrations of Co3+ and oxygen vacancies, (ii) in-creased the amount of oxygen adsorbed on the sur-face at low temperatures, (iii) promoted the mobility of lattice oxygen, and (iv) improved the properties of redox. The La0.6Sr0.4CoO2.78 catalyst prepared by the citric acid complexing-hydrothermal synthesis cou-pled strategy performed the best in the oxidation of EA, furthermore no partially oxidized products were formed. Based on the above results, we conclude that in addition to the surface area, the catalytic ac-tivity of the perovskite-type oxide nanoparticles was associated with the structural defect (oxygen vacancy) concentration and redox ability. | NIU Jianrong LIU Wei DAI Hongxing HE Hong Zl Xuehong LI Peiheng | 2006 | Chinese Science Bulletin2006，51，14： | 2 |
| 9 | Monitoring p21 mRNA expression in living cell based on molecular beacon fluorescence increasing rate显示文摘Studying the expression level of mRNA in living cells will offer tremendous opportunities for ad-vancement in cell biology research,disease diagnostics,and drug discovery.In this paper,a molecular beacon(MB)specific for the important tumor suppressor gene p21 has been designed and synthesized.The fluorescence signal was detected in real-time after the MB entered the cytoplasm of nasopharyn-geal carcinoma cells.After injecting the p21MB into nasopharyngeal carcinoma cell and p33-trans-fected nasopharyngeal carcinoma cell,the consistent increase of fluorescent signal intensity was de-tected in both cell lines,and maximum fluorescence intensity achieved in about 15 min.In about 4 min following microinjection,the fluorescence increasing rate was significantly different between these two cell lines,which indicate the different p21 mRNA expression levels.The results obtained in the real-time detection were also validated by RT-PCR.Analysis of the initial fluorescence increasing rate can effi-ciently reduce the side effect of enzyme and improve the accuracy in living cell mRNA detection. | TANG HongXing YANG XiaoHai WANG KeMin TAN WeiHong LIU Bin HE LiFang WANG Wei | 2008 | Chinese Science Bulletin2008，53，3： | 2 |
| 10 | A comparative investigation of NdSrCu_(1-x) Co_x O_(4-δ) and Sm_(1.8) Ce_(0.2) Cu_(1-x) Co_x O_(4-δ) (x:0–0.4) for NO decomposition显示文摘A series of single-phase T-structured NdSrCu 1-x Co x O 4-δ with oxygen vacancies and T -structured Sm 1.8 Ce 0.2 Cu 1-x Co x O 4-δ (x: 0–0.4) with oxygen excess were prepared using ultrasound-assisted citric acid complexing method, and characterized by means of techniques such as thermogravimetric analysis and NO temperature-programmed desorption (NO-TPD). The catalytic activities of these materials were evaluated for the decomposition of NO. It was found that the NdSrCu 1-x Co x O 4-δ catalysts were of oxygen vacancies whereas the Sm 1.8 Ce 0.2 Cu 1-x Co x O 4-δ ones possessed excessive oxygen (i.e., over-stoichiometric oxygen); with a rise in Co doping level, the oxygen vacancy density of NdSrCu 1-x Co x O 4-δ decreased while the over-stoichiometric oxygen amount of Sm 1.8 Ce 0.2 Cu 1-x Co x O 4-δ increased. The NO-TPD results revealed that NO could be activated much easier over the oxygen-deficient perovskite-like oxides than over the oxygen-excessive perovskite-like oxides, with the NdSrCuO 3.702 catalyst showing the best efficiency in activating NO molecules. Under the conditions of 1.0% NO/helium, 2800 hr -1 , and 600–900°C, the catalytic activity of NO decomposition followed the order of NdSrCuO 3.702 > NdSrCu 0.8 Co 0.2 O 3.736 > NdSrCu 0.6 Co 0.4 O 3.789 > Sm 1.8 Ce 0.2 Cu 0.6 Co 0.4 O 4.187 > Sm 1.8 Ce 0.2 Cu 0.8 Co 0.2 O 4.104 > Sm 1.8 Ce 0.2 CuO 4.045 , in concord with the sequence of decreasing oxygen vacancy or oxygen excess density. Based on the results, we concluded that the higher oxygen vacancy density and the stronger Cu 3+ /Cu 2+ redox ability of NdSrCu 1-x Co x O 4-δ account for the easier activation of NO and consequently improve the catalytic activity of NO decomposition over the catalysts. | Jiguang Deng Lei Zhang Yunsheng Xia Hongxing Dai Hong He | 2010 | Journal of Environmental Sciences2010，22，3： | 2 |
| 11 | Fuzzy clustering method based on perturbation显示文摘 | He Qing Li Hongxing Shi Zhongzhi | 2003 | Computers and Mathematics with Applications2003，46，： | 1 |
| 12 | Single-Crystalline La0.6Sr0.4CoO3-δ Nanowires/Nanorods Derived Hydrothermally Without the Use of a Template: Catalysts Highly Active for Toluene Complete Oxidation显示文摘 | Jiguang Deng Lei Zhang Hongxing Dai Hong He Chak Tong Au | 2008 | Catalysis Letters (-)2008，，3： | 1 |
| 13 | Experimental Study on Two-Stage Catalytic Hydroprocessing of Middle-Temperature Coal Tar to Clean Liquid Fuels显示文摘 | Kan Tao Wang Hongyan He Hongxing | 2011 | Fuel2011，90，： | 1 |
| 14 | Effect of AETiO 3 (AE=Mg, Ca, Sr) doping on dielectric and varistor characteristics of CaCu 3 Ti 4 O 12 ceramic prepared by the sol–gel process显示文摘 | Dong Xu Kai He Renhong Yu Lei Jiao Hongming Yuan Xiujuan Sun Guoping Zhao Hongxing Xu Xiaonong Cheng | 2014 | Journal of Alloys and Compounds2014，，： | 1 |
| 15 | Electrochemical performance of porous Ni 3 Al electrodes for hydrogen evolution reaction显示文摘 | Hongxing Dong Ting Lei Yuehui He Nanping Xu Baiyun Huang C.T. Liu | 2011 | International Journal of Hydrogen Energy2011，，19： | 1 |
| 16 | The corrosion behavior of porous Ni 3 Al intermetallic materials in strong alkali solution显示文摘 | Wu Liang Yao Jiang Dong hongxing Yuehui He Nanping Xu Jin Zou Baiyun Huang C.T. Liu | 2011 | Intermetallics2011，，11： | 1 |
| 17 | Efficient discovery of risk patterns in medical data显示文摘 | Li Jiuyong Fu Ada Wai-chee He Hongxing | 2009 | Artificial Intelligence in Medicine2009，45，： | 1 |
| 18 | Experimental study on two-stage catalytic hydroprocessing of middle-temperature coal tar to clean liquid fuels显示文摘 | Kan Tao Wang Hongyan He Hongxing | 2011 | Fuel2011，90，11： | 1 |
| 19 | Prevenrion and treat-ment of rupture and infection in expanded flaps during auricular re-construction显示文摘 | Jinguang Zhang Leren He Hongxing Zhuang | | 0，，05： | 1 |
| 20 | Electrochemical performance of porous Ni3AI electrodes for hydrogen evolution reaction显示文摘 | Hongxing Dong Ting Lei Yuehui He | 2011 | International Journal of Hydrogen Energy2011，36，12： | 1 |
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