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| 1 | Over-expression of WOX1 Leads to Defects in Meristem Development and Polyamine Homeostasis in Arabidopsis显示文摘In plants,the meristem has to maintain a separate population of pluripotent cells that serve two main tasks,i.e.,self-maintenance and organ initiation,which are separated spatially in meristem.Prior to our study,WUS and WUS-like WOX genes had been reported as essential for the development of the SAM.In this study,the consequences of gain of WOX1 function are described.Here we report the identification of an Arabidopsis gain-of-function mutant wox1-D,in which the expression level of the WOX1(WUSCHEL HOMEOBOX 1) was elevated and subtle defects in meristem development were observed.The wox1-D mutant phenotype is dwarfed and slightly bushy,with a smaller shoot apex.The wox1-D mutant also produced small and dark green leaves,and exhibited a failure in anther dehiscence and male sterility.Molecular evidences showed that the transcription of the stem cell marker gene CLV3 was down-regulated in the meristem of wox1-D but accumulated in the other regions,i.e.,in the root-hypocotyl junction and at the sites for lateral root initiation.The fact that the organ size and cell size in leaves of wox1-D are smaller than those in wild type suggests that cell expansion is possibly affected in order to have partially retarded the development of lateral organs,possibly through alteration of CLV3 expression pattern in the meristem.An S-adenosylmethionine decarboxylase(SAMDC) protein,SAMDC1,was found able to interact with WOX1 by yeast two-hybrid and pull-down assays in vitro.HPLC analysis revealed a significant reduction of polyamine content in wox1-D.Our results suggest that WOX1 plays an important role in meristem development in Arabidopsis,possibly via regulation of SAMDC activity and polyamine homeostasis,and/or by regulating CLV3 expression. | Yanxia Zhang Renhong Wu Genji Qin Zhangliang Chen Hongya Gu Li-Jia Qu | 2011 | Journal of Integrative Plant Biology2011，53，6： | 23 |
| 2 | Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein显示文摘Background:Abnormal aggregation of brainα-synuclein is a central step in the pathogenesis of Parkinson’s disease(PD),thus,it is reliable to promote the clearance ofα-synuclein to prevent and treat PD.Recent studies have revealed an essential role of glymphatic system and meningeal lymphatic vessels in the clearance of brain macromolecules,however,their pathophysiological aspects remain elusive.Method:Meningeal lymphatic drainage of 18-week-old A53T mice was blocked via ligating the deep cervical lymph nodes.Six weeks later,glymphatic functions and PD-like phenotypes were systemically analyzed.Results:Glymphatic influx of cerebrospinal fluid tracer was reduced in A53T mice,accompanied with perivascular aggregation ofα-synuclein and impaired polarization of aquaporin 4 expression in substantia nigra.Cervical lymphatic ligation aggravated glymphatic dysfunction of A53T mice,causing more severe accumulation ofα-synuclein,glial activation,inflammation,dopaminergic neuronal loss and motor deficits.Conclusion:The results suggest that brain lymphatic clearance dysfunction may be an aggravating factor in PD pathology. | Wenyan Zou Tinglin Pu Weixi Feng Ming Lu Ying Zheng Renhong Du Ming Xiao Gang Hu | 2019 | Translational Neurodegeneration2019，8，1： | 17 |
| 3 | Robustness of orthogonal matching pursuit under restricted isometry property显示文摘Orthogonal matching pursuit(OMP)algorithm is an efcient method for the recovery of a sparse signal in compressed sensing,due to its ease implementation and low complexity.In this paper,the robustness of the OMP algorithm under the restricted isometry property(RIP) is presented.It is shown that δK+√KθK,1<1is sufcient for the OMP algorithm to recover exactly the support of arbitrary K-sparse signal if its nonzero components are large enough for both l2bounded and l∞bounded noises. | DAN Wei WANG RenHong | 2014 | Science China Mathematics2014，57，3： | 6 |
| 4 | THE INSTABILITY DEGREE IN THE DIEMNSION OF SPACES OF BIVARIATE SPLINE显示文摘In this paper, the dimension of the spaces of bivariate spline with degree less that 2r and smoothness order r on the Morgan-Scott triangulation is considered. The concept of the instability degree in the dimension of spaces of bivariate spline is presented. The results in the paper make us conjecture the instability degree in the dimension of spaces of bivariate spline is infinity. | Zhiqiang Xu and Renhong Wang (Dalian University of Technology, China) | 2002 | Approximation Theory and Its Applications2002，18，1： | 6 |
| 5 | Engineered trimeric ACE2 binds viral spike protein and locks it in'Thfee-up'conformation to potently inhibit SARS-CoV-2 infection显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in a severe global pandemic Following SARS-CoV,SARS-CoV-2 is yet another emerge nt beta-coronavirus threate ning human health.1 However,seventeen years after the SARS pandemic,no targeted vaccines or therapeutics have been approved for SARS,while some of them might have held promise for treating COVID-19.Many neutralizing antibodies against SARS-CoV-2 are currently being developed.However,RNA viruses are known to have high mutation rates. | Liang Guo Wenwen Bi Xinling Wang Wei Xu Renhong Yan Yuanyuan Zhang Kai Zhao Yaning Li Mingfeng Zhang Xia Cai Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Bobo Dang | 2021 | Cell Research2021，31，1： | 5 |
| 6 | The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis显示文摘Dear Editor,Ferroptosis is an iron-dependent,non-apoptotic form of regulated cell death characterized by an accumulation of lipid.derived reactive oxygen species(ROS).The small-molecule compo und erastin in duces ferroptosis via in hibiti ng the cystineglutamate antiporter system x_(c).which consists of two subunits,namely the light chain xCT and the heavy chain 4F2hc(encoded by the SLC7A11 and SLC3A2 genes,respectively).^(1-4) | Renhong Yan Enjun Xie Yaning Li Jin Li Yuanyuan Zhang Ximin Chi Xueping Hu Lei xu Tingjun Hou Brent R.Stockwell Junxia Min Qiang Zhou Fudi Wang | 2022 | Cell Research2022，32，7： | 4 |
| 7 | Flexoelectric materials and their related applications: A focused review显示文摘Flexoelectricity refers to the mechanical-electro coupling between strain gradient and electric polarization, and conversely, the electro-mechanical coupling between electric field gradient and mechanical stress. This unique effect shows a promising size effect which is usually large as the material dimension is shrunk down. Moreover, it could break the limitation of centrosymmetry, and has been found in numerous kinds of materials which cover insulators, liquid crystals, biological materials, and semiconductors. In this review, we will give a brief report about the recent discoveries in flexoelectricity, focusing on the flexoelectric materials and their applications. The theoretical developments in this field are also addressed. In the end, the perspective of flexoelectricity and some open questions which still remain unsolved are commented upon. | Longlong SHU Renhong LIANG Zhenggang RAO Linfeng FEI Shanming KE Yu WANG | 2019 | Journal of Advanced Ceramics2019，8，2： | 4 |
| 8 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies显示文摘Neutralizing monoclonal antibodies(nAbs)to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)represent promising candidates for clinical intervention against coronavirus disease 2019(COVID-19).We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain(RBD)of the viral spike(S)protein and the receptor angiotensin converting enzyme 2(ACE2).However,the structural basis for their potent neutralizing activity remains unclear.Here,we report cryo-EM structures of the ten most potent nAbs in their native full-length IgG-form or in both IgG-form and Fab-form bound to the trimeric S protein of SARS-CoV-2.The bivalent binding of the full-length IgG is found to associate with more RBDs in the“up”conformation than the monovalent binding of Fab,perhaps contributing to the enhanced neutralizing activity of IgG and triggering more shedding of the S1 subunit from the S protein.Comparison of a large number of nAbs identified common and unique structural features associated with their potent neutralizing activities.This work provides a structural basis for further understanding the mechanism of nAbs,especially through revealing the bivalent binding and its correlation with more potent neutralization and the shedding of S1 subunit. | Renhong Yan Ruoke Wang Bin Ju Jinfang Yu Yuanyuan Zhang Nan Liu Jia Wang Qi Zhang Peng Chen Bing Zhou Yaning Li Yaping Shen Shuyuan Zhang Long Tian Yingying Guo Lu Xia Xinyue Zhong Lin Cheng Xiangyang Ge Juanjuan Zhao Hong-Wei Wang Xinquan Wang Zheng Zhang Linqi Zhang Qiang Zhou | 2021 | Cell Research2021，31，5： | 4 |
| 9 | Electro-optic tuning of a single-frequencyultranarrow linewidth microdisk laser显示文摘Single-frequency ultranarrow linewidth on-chip microlasers with a fast wavelength tunability play a game-changing role in a broad spectrum of applications ranging from coherent communication,light detection and ranging,to metrology and sensing.Design and fabrication of such light sources remain a challenge due to the difficulties in making a laser cavity that has an ultrahigh optical quality(Q)factor and supports only a single lasing frequency simultaneously.Here,we demonstrate a unique single-frequency ultranarrow linewidth lasing mechanism on an erbium ion-doped lithium niobate(LN)microdisk through simultaneous excitation of high-Q polygon modes at both pump and laser wavelengths.As the polygon modes are sparse within the optical gain bandwidth compared with the whispering gallery mode counterpart,while their Q factors(above 10 million)are even higher due to the significantly reduced scattering on their propagation paths,single-frequency lasing with a linewidth as narrow as 322 Hz is observed.The measured linewidth is three orders of magnitude narrower than the previous record in on-chip LN microlasers.Finally,enabled by the strong linear electro-optic effect of LN,real-time electro-optical tuning of the microlaser with a high tuning efficiency of∼50 pm∕100 V is demonstrated. | Jintian Lin Saeed Farajollahi Zhiwei Fang Ni Yao Renhong Gao Jianglin Guan Li Deng Tao Lu Min Wang Haisu Zhang Wei Fang Lingling Qiao Ya Cheng | 2022 | Advanced Photonics2022，4，3： | 4 |
| 10 | Effects of Technological Parameters on Carbothermal Reduction and Nitridation of Zircon显示文摘Carbothermal reduction and nitridation(CRN)of zircon(ZrSiO4)permits obtaining different composites of oxides and nitrides such as ZrO2-Si2N2O and ZrN-Si3N4.The effects of technological parameters(carbon source,reaction temperature,and carbon content)on the reaction rate and product phase composition of CRN of zircon were investigated by TGA and XRD.The results show that:(1)carbon source is an important factor for a rapid reaction,and activated carbon is chosen as the carbon source considering the expect products and reaction rate;(2)reaction temperature has vital effect on reaction rate and product.In case of carbon content above 20%,the zircon phase and m-ZrO2 phase decrease with increasing temperature,while the Zr7N8O4 phase increases firstly and then decreases,and the ZrN phase increases continually;(3)different carbon contents result in different reaction products.The higher the carbon content,the lower the starting temperature for the CRN of zircon. | YU Renhong FU Yadong ZHANG Mengmeng WANG Lizhi HONG Quanquan ZHANG Ruohua | 2011 | China's Refractories2011，20，1： | 3 |
| 11 | Nther-type theorem of piecewise algebraic curves on quasi-cross-cut partition显示文摘Nther's theorem of algebraic curves plays an important role in classical algebraic geometry. As the zero set of a bivariate spline, the piecewise algebraic curve is a generalization of the classical algebraic curve. Nther-type theorem of piecewise algebraic curves is very important to construct the Lagrange interpolation sets for bivariate spline spaces. In this paper, using the characteristics of quasi-cross-cut partition, properties of bivariate splines and results in algebraic geometry, the Nther-type theorem of piecewise algebraic curves on the quasi-cross-cut is presented. | ZHU ChunGang & WANG RenHong School of Mathematical Sciences, Dalian University of Technology, Dalian 116024, China | 2009 | Science China Mathematics2009，52，4： | 3 |
| 12 | Viability of primary cultured retinal neurons in a hyperglycemic condition显示文摘The retina of Wistar rats within 1-3 days of birth were dissociated into a retinal cell suspension using 0.05% trypsin digestion. The cell suspension was incubated in Dulbecco's modified Eagle's medium for 24 hours, followed by neurobasal medium for 5-7 days. Nissl staining showed that 79.86% of primary cultured retinal cells were positive and immunocytochemical staining showed that the purity of anti-neurofilament heavy chain antibody-positive cells was 71.53%, indicating that the primary culture system of rat retinal neurons was a reliable and stable cell system with neurons as the predominant cell type. The primary cultured retinal neurons were further treated with 0, 5.5, 15, 25, and 35 mM glucose for 24, 48, and 72 hours. The thiazolyl blue tetrazolium bromide test and flow cytometry showed that with increasing glucose concentration and treatment duration, the viability of retinal neurons was reduced, and apoptosis increased. In particular, 35 mM glucose exhibited the most significant effect at 72 hours. Thus, rat retinal neurons treated with 35 mM glucose for 72 hours can be used to simulate a neuronal model of diabetic retinopathy. | Yu Liu Xueliang Xu Renhong Tang Guoping Chen Xiang Lei Limo Gao Wenjie Li Yu Chen | 2013 | Neural Regeneration Research2013，8，5： | 3 |
| 13 | Real zeros of the zero-dimensional parametric piecewise algebraic variety显示文摘The piecewise algebraic variety is the set of all common zeros of multivariate splines. We show that solving a parametric piecewise algebraic variety amounts to solve a finite number of parametric polynomial systems containing strict inequalities. With the regular decomposition of semi- algebraic systems and the partial cylindrical algebraic decomposition method, we give a method to compute the supremum of the number of torsion-free real zeros of a given zero-dimensional parametric piecewise algebraic variety, and to get distributions of the number of real zeros in every n-dimensional cell when the number reaches the supremum. This method also produces corresponding necessary and suffcient conditions for reaching the supremum and its distributions. We also present an algorithm to produce a necessary and suffcient condition for a given zero-dimensional parametric piecewise algebraic variety to have a given number of distinct torsion-free real zeros in every n-cell in the n-complex. | LAI YiSheng WANG RenHong WU JinMing | 2009 | Science China Mathematics2009，52，4： | 3 |
| 14 | The Viro method for construction of Bernstein-Bézier algebraic hypersurface piece显示文摘This paper proposes a new method for the construction of Bernstein-Bézier algebraic hypersurface on a simplex with prescribed topology.The method is based on the combinatorial patchworking of Viro method.The topology of the Viro Bernstein-Bézier algebraic hypersurface piece is also described. | LAI YiSheng DU WeiPing WANG RenHong | 2012 | Science China Mathematics2012，55，6： | 3 |
| 15 | I warn you because I like you: Voice behavior, employee identifications, and transformational leadership显示文摘 | Wu Liu Renhong Zhu Yongkang Yang | 2009 | The Leadership Quarterly2009，，1： | 2 |
| 16 | Sparse approximate solution of fitting surface to scattered points by MLASSO model显示文摘The goal of this paper is to achieve a computational model and corresponding efficient algorithm for obtaining a sparse representation of the fitting surface to the given scattered data. The basic idea of the model is to utilize the principal shift invariant(PSI) space and the l_1 norm minimization. In order to obtain different sparsity of the approximation solution, the problem is represented as a multilevel LASSO(MLASSO)model with different regularization parameters. The MLASSO model can be solved efficiently by the alternating direction method of multipliers. Numerical experiments indicate that compared to the AGLASSO model and the basic MBA algorithm, the MLASSO model can provide an acceptable compromise between the minimization of the data mismatch term and the sparsity of the solution. Moreover, the solution by the MLASSO model can reflect the regions of the underlying surface where high gradients occur. | Yongxia Hao Chongjun Li Renhong Wang | 2018 | Science China Mathematics2018，61，7： | 2 |
| 17 | Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has become a severe threat to global health.1 The spike(S)protein on the surface of SARS-CoV-2 exploits angiotensin-converting enzyme 2(ACE2)as cellular receptor and mediates the fusion of the viral and the host cell membrane during infection.1,2 The activation of the S protein requires the receptor-binding domain(RBD)binding to the peptidase domain(PD)of ACE2 and the cleavage by host proteases into the N-terminal S1 subunit and the C-terminal S2 subunit.2,3,4 An additional furin cleavage site“RRAR”present in the S1/S2 cleavage region of SARS-CoV-2,which is absent in SARS-CoV that shares about 80%sequence identity with SARS-CoV-2 and caused an epidemic in 2002–2003,might help accelerate the activation of the S protein.S1 consists of the N-terminal domain(NTD),the RBD,subdomain 1 and 2(SD1 and SD2).The RBD adopts two distinct conformations:“up”and“down”.Only the“up”RBD exposes the receptor-binding site.S2,containing the hydrophobic fusion peptide,is responsible for the viral and cell membrane fusion.The molecular mechanism underlying the activation of the S protein of SARS-CoV-2 represents a critical clue for therapeutic development.Here we report the cryo-electron microscopy(cryo-EM)structures of trimeric extracellular domain of the S protein(hereinafter referred to as S)at multiple states and conformations,including the all RBD-locked,activated,S1/S2 trypsin-cleaved,PD of ACE2-bound,and the full-length ACE2-bound states.PD binds to the trimeric S protein with consistent interface,inducing conformational change at adjacent region.The trypsin-digested S protein tends to accommodate more PD molecules.Furthermore,the structure of the S–ACE2–B0AT1 ternary complex indicates that one ACE2 dimer binds two trimeric S proteins simultaneously.These results provide clues for the mechanism of the activation of the S protein of SARS-CoV-2. | Renhong Yan Yuanyuan Zhang Yaning Li Fangfei Ye Yingying Guo Lu Xia Xinyue Zhong Ximin Chi Qiang Zhou | 2021 | Cell Research2021，31，6： | 2 |
| 18 | Effects of Spherical Aggregates Addition on Properties of Al2O3-SiO2 System Castables显示文摘Compared with traditional aggregates,spherical aggregates with high flowability,easy control of particle size distribution and favor of dense packing and so on,are expected to replace traditional aggregates as important raw materials for future high performance refractories. Therefore,investigation of effects of spherical aggregates addition on properties of refractories becomes very meaningful. Using A70 mullite traditional aggregates and A70 mullite spherical aggregates, bauxite homogenization powder,microsilica,and calcium aluminate cement as raw materials,different Al_2O_3-SiO_2system low cement castables were prepared by replacing conventional aggregates with spherical aggregates. The effect of spherical aggregates addition on workability and mechanical properties of castables after heated at different temperatures was researched,and microstructure of the specimen was analyzed by SEM. Compared with traditional irregularly shaped aggregates,spherical aggregates endow castables with better flowability and easy pump ability. By introduction of spherical aggregates into the castables,flowability and pumpability are significantly improved,and water addition and ball completely sunk time are reduced. The introduction of spherical aggregates is favorable to density and cold crushing strength of castables,but unfavorable to CMOR. The effect of spherical aggregates addition on HMOR at1 400 ℃ can be negligible. Microstructure analysis showsthat the boundary bonding between spherical aggregates and matrix is strong,similar to the traditional aggregates. | YU Renhong LIU Pengcheng ZHOU Xiwen ZHOU Ningsheng YANG Dahui DONG Gaofeng | 2017 | China's Refractories2017，26，1： | 2 |
| 19 | Effect of ZrO_2-nitrides Composite Powder Addition on Oxidation Resistance of Al_2O_3-C Refractories显示文摘Oxidation of carbon is the main problem of Al2O3-C refractories.ZrO2-nitrides composite powder was synthesized through carbothermal reduction and nitridation (CRN) of zircon.The effect of ZrO2-nitrides composite powder addition on oxidation resistance of the Al2O3-C refractories was investigated by measuring the thickness of oxidation layer.Phase compositions of the Al2O3-C refractories before and after oxidation were investigated by X-ray diffraction (XRD).Results show that the oxidation resistance of the Al2O3-C refractories can be obviously improved by adding the synthesized ZrO2-nitrides composite powder.The formation of mullite and zircon in the oxidation layer results in the densification of oxidation layer,which prevents oxygen diffusion and improves the oxidation resistance of the Al2O3-C refractories. | ZHANG Mengmeng YU Renhong ZHOU Ningsheng | 2011 | China's Refractories2011，20，3： | 2 |
| 20 | Design and G1 connection of developable surfaces through Bézier geodesics显示文摘 | Li Caiyun Wang Renhong Zhu Chungang | 2011 | Applied Mathematics and Computation2011，218，7： | 1 |
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