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| 1 | Comprehensive profiling reveals mechanisms of SOX2-mediated cell fate specification in human ESCs and NPCs显示文摘SOX2 是干细胞,特别胚胎的干细胞(转换字符) 和神经祖先房间(NPC ) 的多重类型的一个关键管理者。理解位于 SOX2 的功能下面的机制为认识到转换字符和 NPC 的完整的潜力是很重要的。通过染色体宽的比较研究,这里,我们证明 SOX2 在人的转换字符(hESCs ) 执行它的不同函数,通过房间类型依赖者和阶段依赖者抄写的导出 hESC 的 NPC (hNPCs ) 编程序。重要地, SOX2 在 hESCs 压制非神经的系并且由禁止正规 Wnt 发信号从 hNPCs 调整神经发生。在 hESCs, SOX2 由表明调节的人, WLS 和 SFRP2 的重要 Wnt 的直接 transcriptional 规定完成如此的抑制。而且, SOX2 经由与 histone 变体 H2A.Z 交往并且招募保证 pluripotent epigenetic 风景到体态的 polycomb 抑压者建筑群 2 在 hESCs 的发展基因。一起,我们的结果推进我们由房间,类型特定的抄写因素控制系特定的基因表达式程序并且指定房间命运的机制的理解。 | Chenlin Zhou Xiaoqin Yang Yiyang Sun Hongyao Yu Yong Zhang Ying Jin | 2016 | Cell Research2016，26，2： | 9 |
| 2 | WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells显示文摘POU 抄写因素 OCT4 不仅在维持 pluripotent 和房间而且幕作为通过基因剂量的一个房间命运决定因素完成的胚胎的茎(ES ) 的自我更新的状态起一个必要作用。然而,控制细胞内部的 OCT4 蛋白质水平的分子的机制留下逃犯。这里,我们报导那人的 WWP2, E3 ubiquitin (Ub ) 蛋白质 ligase,通过它的 WW 领域明确地与 OCT4 交往并且在 vitro 并且在 vivo 提高 OCT4 的 Ub 修正。我们首先证明在人的 ES 房间的内长的 OCT4 能被 Ub post-translationally 修改。而且,我们发现 WWP2 以一种剂量依赖者方式,和 WWP2 的活跃地点半胱氨酸残余通过 26S proteasome 支持了 OCT4 的降级在 OCT4 上为它的酶的活动和解朊的效果被要求。显著地,我们当 WWP2 表示是由特定的 RNA 干扰(RNAi ) 的 downregulated 时,内长的 OCT4 蛋白质水平显著地被提高的数据表演,建议那 WWP2 是为在人的 ES 房间维持合适的 OCT4 蛋白质水平的一个重要管理者。而且,北污点分析证明 WWP2 抄本在多样的人的织物 / 器官是广泛地在场的并且高度在无差别的人的 ES 房间表示了。然而,它的表示水平快速在区分的人的 ES 房间以后被减少,显示 WWP2 表示力量发展地被调整。我们的调查结果证明 WWP2 是在人的 ES 房间的 OCT4 蛋白质水平的一个重要管理者。 | Huiming Xu Weicheng Wang Chunliang Li Hongyao Yu Acong Yang Beibei Wang Ying Jin | 2009 | Cell Research2009，19，5： | 8 |
| 3 | Strengthening effect of Cu-rich phase precipitation in 18Cr9Ni3CuNbN austenitic heat-resisting steel显示文摘The Cu-containing austenitic heat-resistant steel 18Cr9Ni3CuNbN, which is being used as superheater and reheater tube material for modern ultra-super-critical (USC) power plants all over the world, has been investigated at 650 ℃ long time aging till 10 000 h. SEM, TEM and 3DAP (three dimensional atom probe) have been used to follow microstructural changes with mechanical property variations. Experimental results show that Cu-rich phase and MX precipitate in the grains as well as M 23 C 6 precipitates at grain boundaries are the main precipitation strengthening phases in this steel. Among them Cu-rich phase is the most important strengthening phase. Homogeneous distribution of very fine nano-size Cu-rich phase has been formed at very early stage of 650 ℃ aging (less than 1 h). Cu atoms gradually concentrate to Cu-rich particles and the other elements (such as Fe, Cr, Ni etc) diffuse away from Curich particles to γ-matrix with the increasing of aging time at 650 ? C. The growth rate of Cu-rich phase at 650 ℃ long time aging is very slow and the average diameters of Cu-rich phase have been determined by TEM method. Cu-rich phase keeps in about 30 nm till 650 ℃ aging for 10 000 h. It shows that nano-size Cu-rich phase precipitation strengthening can be kept for long time aging at 650 ℃ because of its excellent stability at high temperatures. According to structure stability study and mechanical properties determination results the Cu-rich phase precipitation sequence and its strengthening mechanism model have been suggested and discussed. | Chengyu CHI Hongyao YU Jianxin DONG Xishan XIE Zhengqiang CUI Xiaofang CHEN Fusheng LIN | 2011 | Acta Metallurgica Sinica(English Letters)2011，24，2： | 6 |
| 4 | Correlation Between Phase Stability and Tensile Properties of the Ni-Based Superalloy MAR-M247显示文摘Phase stability and its effect on tensile properties of MAR-M247 alloy have been investigated during thermal exposure at 800–900°C for up to 10,000 h.Detailed investigations reveal that the larger secondaryγ′phase has no obvious growth,but the smaller tertiaryγ′phase obviously coarsens and the coalescence occurs during thermal exposure at 850°C and below.γ′coarsening behavior is consistent with the description of Ostwald ripening theory beforeγ′coalescence.Hf-rich blocky MC carbide shows excellent thermal stability,but Ta-rich script-type MC carbide gradually degenerates via reaction,MC+γ→M_(23)C_(6)+γ′and finally formsγ film around MC and M_(23)C_(6) carbides.With increasing thermal exposure time,the tensile strength decreases.The ductility first increases and then decreases during exposure at 800°C,but it decreases continuously at 900°C.In addition,the ductility keeps almost constant when the exposure time is longer than 5000 h. | Linxu Li Xiufang Gong Changshuai Wang Yunsheng Wu Hongyao Yu Haijun Su Lanzhang Zhou | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，6： | 2 |
| 5 | WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells显示文摘 | Huiming Xu Weicheng Wang Chunliang Li Hongyao Yu Acong Yang Beibei Wang Ying Jin | 2009 | Cell Research2009，19，6： | 1 |
| 6 | 显示文摘 | Xu Hongyao Guang Shanyi Yu Congxuan | 1998 | J Functional Mater1998，27，1： | 1 |
| 7 | A nonenzymatic electrochemical sensor for the detection of hydrogen peroxide in vitro and in vivo fibrosis models显示文摘Fibrosis occurs due to the excessive deposition of extracellular matrix caused by cell injury.After various types of tissue injury,the dysregulation of the internal response can eventually lead to the destruction of organ structure and dysfunction.There is increasing evidence that oxidative stress,which is characterized by excessive production of hydrogen peroxide(H_(2)O_(2)),is an important cause of fibrosis.Therefore,we synthesized a biosensitive and efficient electrochemical H_(2)O_(2)sensor based on PtNi nanoparticle-doped N-reduced graphene oxide(PtNi-N-rGO)to detect H_(2)O_(2)released from transforming growth factorβ1(TGFβ1)-induced myofibroblast.In addition,the sensor could easily detect changes in H_(2)O_(2)in the lung and bronchoalveolar lavage fluid(BALF)of mice with pulmonary fibrosis.Furthermore,the sensor could also detect H_(2)O_(2)in activated hepatic stellate cells and the liver of carbon tetrachloride(CCl_(4))-induced liver fibrosis.Moreover,the alterations in H_(2)O_(2)detected by the sensor were consistent with nicotinamide adenine dinucleotide phosphate oxidase 4(NOX4)protein expression and the staining results of pathological sections.Taken together,these results highlight the use of H_(2)O_(2)sensors for the rapid detection of fibrosis and facilitate the rapid evaluation of antifibrotic drug candidates. | Hongyao Liu Yan Yu Taixiong Xue Cailing Gan Yuting Xie Doudou Wang Peilin Li Zhiyong Qian Tinghong Ye | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
| 8 | Microstructures and Mechanical Properties of the TiC/CM247LC Nickel-Based Composite Fabricated by Selective Laser Melting:Effect of Heat Treatment显示文摘In this study,TiC/CM247LC nickel-based composite was successfully prepared by selective laser melting,then was heat treated at a solid solution temperature of 1260℃and different aging temperature of 840℃,870℃,900℃and 930℃respectively.Effects of aging temperatures on the microstructures and mechanical properties were systematically studied.The results show that the microstructures of all the heat treated samples are composed ofγmatrix,carbides andγ′phase.Theγgrains remain a columnar shape after treatments,but the size ofγ′phase grows up gradually with the increasing aging temperature.The composite treated at an aging temperature of 870℃exhibits the best mechanical properties with the tensile strength of 1073 MPa,yield strength of 1004 MPa and elongation of 7.57%.The plastic deformation and strengthening mechanisms of heat treated composite were systematically investigated. | Yuting Lv Yaojie Liu Zhe Zhang Qiang Zhang Hongyao Yu Rui Wang Guangbao Sun Guijiang Wei | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，12： | 0 |
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