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| 1 | Synthesis of biodegradable waterborne phosphatidylcholine polyurethanes for soft tissue engineering applications显示文摘To further improve the biocompatibility of polyurethanes,a new lysine 2-(2-aminoethoxy)ethanol phosphatidylcholine(LAPC)is synthesized to use as chain extender for preparing a series of phosphatidylcholine polyurethanes(PCPUs).Poly(e-caprolactone)(PCL)and poly(ethylene glycol)(PEG)are used as soft segments,and L-lysine ethyl ester diisocyanate(LDI),LAPC and L-lysine are used as hard segments.The obtained PCPUs exhibit appropriate mechanical properties with break elongation of 1000–1700%,tensile strength of 7–22 MPa,and relatively high elastic modulus of 11–18 MPa,which could admirably satisfy the requirement for soft tissue engineering scaffolds.The phosphatidylcholine structures can increase the hydrophilicity of PCPU surfaces,which effectively reduce protein adsorption and platelet adhesion while promoting the cell proliferation.In addition,the LAPC chain extender,PCPU films and ultimate degradation products of PCPUs are proved to be nontoxic in cytotoxicity test.More interestingly,the cytokine release test of macrophages manifests that both LAPC and PCPU degradation products could effectively improve the proliferation of macrophages and induce them into a wound-healing phenotype.Thus,the obtained PCPUs have greatly potential applications of soft tissue engineering scaffolds for tissue repair and wound healing. | Hongye Hao Ya Deng Yingke Wu Siyuan Liu Weiwei Lin Jiehua Li Feng Luo | 2017 | Regenerative Biomaterials2017，4，2： | 3 |
| 2 | Crystalline-amorphous interfaces of NiO-CrO_(x)electrocatalysts for boosting the urea oxidation reaction显示文摘The overall energy efficiency of electrochemical systems is severely hindered by the traditional anodic oxygen evolution reaction(OER).Utilizing urea oxidation reaction(UOR)with lower thermodynamic potential to replace OER provides a promising strategy to enhance the energy efficiency.Amorphous and heterojunctions electrocatalysts have been aroused extensive studies owing to their unique physicochemical properties and outperformed activity.Herein,we report a simple method to construct a novel crystalline-amorphous NiO-CrO_(x)heterojunction grown on Ni foam for UOR electrocatalyst.The NiO-CrO_(x)electrocatalyst displays excellent UOR performance with an ultralow working potential of 1.32 V at 10 mA·cm^(−2)and ultra-long stability about 5 days even at 100 mA·cm^(−2).In-situ Raman analysis and temperature-programmed desorption(TPD)measurement verify that the presence of the amorphous CrO_(x)phase can boost the reconstruction from NiO to active NiOOH species and enhance adsorption ability of urea molecule.Besides,the unique crystalline-amorphous interfaces are also benefit to improving the UOR performance. | Xuejie Cao Tongzhou Wang Hongye Qin Guangliang Lin Lihua Zhao Lifang Jiao | 2023 | Nano Research2023，16，3： | 1 |
| 3 | Kinetics studies for the synthesis of dimethyl carbonate from urea and methanol 显示文摘 | Hongye Lin Bolun Yang Jianjun Sun | 2004 | Chemical Engineering Journal2004，104，： | 1 |
| 4 | Generalized convexity based inexact projection method for multiple kernel learning 显示文摘 | LIN L HONGYE S BAOFEN Z | 2014 | Journal of Intelligent and Fuzzy Systems2014，27，4： | 1 |
| 5 | Kinetics studies for the synthesis of dimethyl carbonate from urea and methanol显示文摘 | Hongye Lin Bolun Yang Jianjun Sun | 2004 | Chemical Engineering Journal2004，104，： | 1 |
| 6 | A mitochondria-targeting lipid——small molecule hybrid nanoparticle for imaging and therapy in an orthotopic glioma model显示文摘Hybrid lipid-nanoparticle complexes have shown attractive characteristics as drug carriers due to their integrated advantages from liposomes and nanoparticles.Here we developed a kind of lipid-small molecule hybrid nanoparticles(LPHNPs) for imaging and treatment in an ortho topic glioma model.LPHNPs were prepared by engineering the co-assembly of lipids and an amphiphilic pheophorbide a-quinolinium conjugate(PQC),a mitochondria-targeting small molecule.Compared with the pure nanofiber self-assembled by PQC,LPHNPs not only preserve the comparable antiproliferative potency,but also possess a spherical nanostructure that allows the PQC molecules to be administrated through intravenous injection.Also,this co-assembly remarkably improved the drug-loading capacity and formulation stability against the physical encapsulation using conventional liposomes.By integrating the advantages from liposome and PQC molecule,LPHNPs have minimal system toxicity,enhanced potency of photodynamic therapy(PDT) and visualization capacities of drug biodistribution and tumor imaging.The hybrid nanoparticle demonstrates excellent curative effects to significantly prolong the survival of mice with the orthotopic glioma.The unique co-assembly of lipid and small molecule provides new potential for constructing new liposome-derived nanoformulations and improving cancer treatment. | Menghuan Tang Kai Lin Mythili Ramachandran Longmeng Li Hongye Zou Huzhi Zheng Zhao Ma Yuanpei Li | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 1 |
| 7 | Application of an amphipathic molecule at the NiO_(x)/perovskite interface for improving the efficiency and long-term stability of the inverted perovskite solar cells显示文摘The presence of defects and detrimental reactions at NiO_(x)/perovskite interface extremely limit the efficiency performance and long-term stability of the perovskite solar cells(PSCs) based on NiO_(x).Herein,an amphipathic molecule Triton X100(Triton) is modified on the NiO_(x)surface.The hydrophilic chain of Triton as a Lewis base additive can coordinate with the Ni3+on the NiO_(x)surface which can passivate the interfacial defects and hinder the detrimental reactions at the NiO_(x)/perovskite interface.Additionally,the hydrophobic chain of Triton protrudes from the NiO_(x)surface to prevent moisture from penetrating into the NiO_(x)/perovskite interface.Consequently,the NiO_(x)/Triton-based devices(MAPbI3as absorbing layer) show superior moisture and thermal stability,retaining 88.4% and 64.3% of the initial power conversion efficiency after storage in air(40%-50% relative humidity(RH)) at 25 ℃ for 1070 h and in N2at 85℃ for 800 h,respectively.Moreover,the efficiency increases from 17.59% to 19.89% because of the passivation defect and enhanced hole-extraction capability.Besides,the NiO_(x)/Triton-based PSCs with Cs_(0.05)(MA_(0.15)FA_(0.85))_(0.95)Pb(I_(0.85)Br_(0.15))3perovskite as the light-absorbing layer also exhibits better moisture and thermal stability compared to the control devices,indicating the viability of our strategies.Of particular note,a champion PCE of 22.35% and 20.46% was achieved for small-area(0.1 cm^(2)) and large-area(1.2 cm^(2)) NiO_(x)/Triton-based devices,respectively. | Guibin Shen Hongye Dong Fan Yang Xin Ren Ng Xin Li Fen Lin Cheng Mu | 2023 | Journal of Energy Chemistry2023，，3： | 0 |
| 8 | A constitutive model for cyclic densification of coarse-grained soil filler for the high-speed railway subgrade considering particle breakage显示文摘Purpose–This study aims to propose a semiempirical and semitheoretical cyclic compaction constitutive model of coarse-grained soil filler for the high-speed railway(HSR)subgrade under cyclic load.Design/methodology/approach–According to the basic framework of critical state soil mechanics and in view of the characteristics of the coarse-grained soil filler for the HSR subgrade to bear the train vibration load repeatedly for a long time,the hyperbolic empirical relationship between particle breakage and plastic work was derived.Considering the influence of cyclic vibration time and stress ratio,the particle breakage correction function of coarse-grained soil filler for the HSR subgrade under cyclic load was proposed.According to the classical theory of plastic mechanics,the shearing dilatation equation of the coarse-grained soil filler for the HSR subgrade considering particle breakage was modified and obtained.A semiempirical and semitheoretical cyclic compaction constitutive model of coarse-grained soil filler for the HSR subgrade under cyclic load was further established.The backward Euler method was used to discretize the constitutive equation,build a numerical algorithm of“elastic prediction and plastic modification”and make a secondary development of the program to solve the cyclic compaction model.Findings–Through the comparison with the result of laboratory triaxial test under the cyclic loading of coarse-grained soil filler for the HSR subgrade,the accuracy and applicability of the cyclic compaction model were verified.Results show that the model can accurately predict the cumulative deformation characteristics of coarse-grained soil filler for the HSR subgrade under the train vibration loading repeatedly for a long time.It considers the effects of particle breakage and stress ratio,which can be used to calculate and analyze the stress and deformation evolution law of the subgrade structure for HSR. | Yangsheng Ye Degou Cai Lin Geng Hongye Yan Junkai Yao Feng Chen | 2022 | Railway Sciences2022，1，1： | 0 |
| 9 | New Nuclide Protactinium-239显示文摘New Nuclide Protactinium-239NewNuclideProtactinium-239￥YuanShuanggui;YangWeifan;MuWantong;ZhangXueqian;LiZongwei;YuXian;GuJin... | Yuan Shuanggui Yang Weifan Mu Wantong Zhang Xueqian Li Zongwei Yu Xian Gu Jinnan Guo Yingxiang Gan Zaiguo Liu Hongye Zhao Jinhua Let Xiangguo Guo Junsheng Du Yifei Guo Tianrui Zhao Lin and Zhang Xiang | 1995 | IMP & HIRFL Annual Report1995，，0： | 0 |
| 10 | Tomato SlRUP is a negative regulator of UV-B photomorphogenesis显示文摘Introduction Sunlight is an environmental factor regulating plant growth and development.Plants have evolved a battery of photoreceptors to sense and respond to different wavelengths of light(Jenkins,2017;Liu et al.,2020a).UV-B(280–315 nm)comprises the shortest wavelength of sunlight on the earth surface.In general,low fluence rate UV-B does not generate damage effects on plants,rather it induces plant photomorphogenic responses(Yin and Ulm,2017).High fluence rate UV-B may damage macromolecules,including nucleic acids,protein and membranes(Hideg et al.,2013).The UV-B photoreceptor UVR8 protein((UV RESISTANCE LOCUS 8)perceives the low dose UV-B and triggers UV-B specific signal transduction. | Chunli Zhang Qianwen Zhang Hongye Guo Xiaohui Yu Wenjing Liang Yinhua Chen Ruohe Yin Li Lin | 2021 | Molecular Horticulture2021，1，1： | 0 |
| 11 | Current situation and development trend of design methods for subgrade structure of high speed railways显示文摘Purpose–This method will become a new development trend in subgrade structure design for high speed railways.Design/methodology/approach–This paper summarizes the structural types and design methods of subgrade bed for high speed railways in China,Japan,France,Germany,the United States and other countries based on the study and analysis of existing literature and combined with the research results and practices of high speed railway subgrade engineering at home and abroad.Findings–It is found that in foreign countries,the layered reinforced structure is generally adopted for the subgrade bed of high speed railways,and the unified double-layer or multi-layer structure is adopted for the surface layer of subgrade bed,while the simple structure is adopted in China;in foreign countries,different inspection parameters are adopted to evaluate the compaction state of fillers according to their respective understanding and practice,while in China,compaction coefficient,subsoil coefficient and dynamic deformation modulus are adopted for such evaluation;in foreign countries,the subgrade top deformation control method,the subgrade bottom deformation control method,the subsurface fill strength control method are mainly adopted in subgrade bed structure design of high speed railways,while in China,dynamic deformation control of subgrade surface and dynamic strain control of subgrade bed bottom layer is adopted in the design.However,the cumulative deformation of subgrade caused by train cyclic vibration load is not considered in the existing design methods.Originality/value–This paper introduces a new subgrade structure design method based on whole-process dynamics analysis that meets subgrade functional requirements and is established on the basis of the existing research at home and abroad on prediction methods for cumulative deformation of subgrade soil. | Yangsheng Ye Degou Cai Qianli Zhang Shaowei Wei Hongye Yan Lin Geng | 2023 | Railway Sciences2023，2，3： | 0 |
| 12 | Chinese Tuina remodels the synaptic structure in neuropathic pain rats by downregulating the expression of N-methyl D-aspartate receptor subtype 2B and postsynaptic density protein-95 in the spinal cord dorsal horn显示文摘OBJECTIVE:To investigate whether the Chinese massage system,Tuina,exerts analgesic effects in a rat model of chronic constriction injury(CCI)by remodeling the synaptic structure in the spinal cord dorsal horn(SCDH).METHODS:Sixty-nine male Sprague–Dawley rats were randomly and evenly divided into the normal group,sham group,CCI group,CCI+Tuina group,CCI+MK-801[an N-methyl D-aspartate receptor subtype 2B(NR2B)antagonist]group,and CCI+MK-801+Tuina group.The neuropathic pain model was established using CCI with right sciatic nerve ligation.Tuina was administered 4 d after CCI surgery,using pressing manipulation for 10 min,once daily.Motor function was observed with the inclined plate test,and pain behaviors were observed by the Von Frey test and acetone spray test.At 19 d after surgery,the L3-L5 spinal cord segments were removed.Glutamate,interleukin 1β(IL-1β),and tumor necrosis factor-α(TNF-α)levels were detected by enzyme-linked immunosorbent assay.The protein expression levels of NR2B and postsynaptic density protein-95(PSD-95)were detected by Western blot,and the synaptic structure was observed by transmission electron microscopy(TEM).RESULTS:CCI reduced motor function and caused mechanical and cold allodynia in rats,increased glutamate concentration and TNF-αand IL-1βlevels,and increased expression of synapse-related proteins NR2B and PSD-95 in the SCDH.TEM revealed that the synaptic structure of SCDH neurons was altered.Most of these disease-induced changes were reversed by Tuina and intrathecal injection of MK-801(P<0.05 or<0.01).For the majority of experiments,no significant differences were found between the CCI+MK-801 and CCI+MK-801+Tuina groups.CONCLUSIONS:Chinese Tuina can alleviate pain by remodeling the synaptic structure,and NR2B and PSD-95 receptors in the SCDH may be among its targets. | HUANG Hongye WANG Bingqian CHEN Shuijin FANG Jiayu WANG Xiaohua CHEN Lechun JIANG Yu ZHANG Huanzhen CHEN Jincheng LIN Zhigang | 2023 | Journal of Traditional Chinese Medicine2023，43，4： | 0 |
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