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| 1 | FLEXIBLE MAGNETIC WHEEL TYPE INTELLIGENT WELDING ROBOT FOR SPHERICAL TANK显示文摘An intelligent welding robot for spherical tank's all-position multi-layer welds is developed. Based on the dynamics analyzing and simulation testing, a flexible magnetic wheel mechanism is created as the robot's walking carriage. It makes the robot directly attracted to the surface of the spherical tank so as to realize the all-position walking and welding without rail. At the same time, a CCD real-time tracing system is developed for the robot to repeatedly trace the all-position and multi-layer seams. The welding tests show that the welding robot can make the all-position and multi-layer welds with high tracing accuracy, excellent quality and reliable behavior, and it can be applied for practical production. | Jiang Lipei Jiao Xiangdong Xue Long Ma Hongze Li Mingli Yang Zhaochun Department of Mechanical Engineering, Institute of Petro-chemical Technology,Beijing 102600, China | 2002 | Chinese Journal of Mechanical Engineering2002，15，2： | 9 |
| 2 | Parameter inversion and location determination of evolutionary weak layer for open-pit mine slope显示文摘In light of the complex and dynamic mechanical properties of evolving weak strata in open-pit mines,and the consequent difficulty of determining their mechanical parameters,this study uses the ultimate balance theory,along with the back analysis method combined with monitoring data on field displacement,to carry out parameter inversion using the FLAC3D numerical simulation software.The edge slope of a working pit of the Weijiamao open-pit mine was used as research object to this end.As the results obtained by the constitutive model were consistent with the field monitoring data,the evolving weak strata in the slope and the position of the landslide in the mine could be obtained.The landslide was directed northeast.The mechanism of the edge slope of the working pit was identified as unloading shear failure,and the feasibility of the method of parameter inversion was verified.The internal friction angle φand cohesion C of evolving weak strata in the slope of the open-pit mine were also obtained,where this compensated for the deficiency of laboratory tests and enabled the transformation from qualitative to quantitative analysis.This can provide a reliable basis for the safe operation of open-pit mines. | Zhao Hongze Wang Dongyu Ma Ming Zheng Kaihui | 2020 | International Journal of Coal Science & Technology2020，7，4： | 2 |
| 3 | Homeobox B8 Targets Sterile Alpha Motif Domain-Containing Protein 9 and Drives Glioma Progression显示文摘Gliomas are the most commonly occurring tumors of the central nervous system. Glioblastoma multiforme (GBM) is the most malignant and aggressive brain cancer in adults. Further understanding of the mechanisms underlying the aggressive nature of GBM is urgently needed. Here we identified homeobox B8(HOXB8), a member of the homeobox family, as a crucial contributor to the aggressiveness of GBM. Data mining of publicly accessible RNA sequence datasets and our patient cohorts confirmed a higher expression of HOXB8 in the tumor tissue of GBM patients, and a strong positive correlation between the expression level and pathological grading of tumors and a negative correlation between the expression level and the overall survival rate. We next showed that HOXB8 promotes the proliferation and migration of glioblastoma cells and is crucial for the activation of the PI3K/AKT pathway and expression of epithelial–mesenchymal transition-related genes, possibly through direct binding to the promoter of SAMD9 (Sterile Alpha Motif Domain-Containing Protein 9) and activating its transcription. Collectively, we identified HOXB8 as a critical contributor to the aggressiveness of GBM, which provides insights into a potential therapeutic target for GBM and opens new avenues for improving its treatment outcome. | Wenping Ma Hongze Jin Wenjie Liu Xiaojuan Li Xingang Zhou Xinwu Guo Runfa Tian Qi Cui Junjie Luo Yueying Jiao Youtao Yu Haifeng Yang Hongshan Zhao | 2020 | Neuroscience Bulletin2020，36，4： | 2 |
| 4 | Sinomenine derivatives with embedment of nitrogen-containing heterocycles exhibiting potent TNF-inhibitory activity显示文摘Inhibitory effect on tumor necrosis factor-(TNF-) production by sinomenine derivatives with embedment of small drug-like nitrogen hetereocyclic moieties has been studied in this work.Several new sinomenine derivatives having chlorophenyl substituent have been found to exhibit much more potent TNF-α inhibitory activity than natural sinomenine and other derivatives. | WANG Meng MA LiYan LOU YangTong BIAN Chao ZHOU TingTing ZHOU HaiBin LIAO HongZe MA Zhao YIN DongSheng CHEN AiZhong WANG ShaoZhong YANG ZhenYu SUN Bing YAO ZhuJun | 2012 | Science China Chemistry2012，55，12： | 1 |
| 5 | An online approach for distributor benchmarking 显示文摘 | Hongze Ma Ziqiong Deng Wei Deng Solvang | 2004 | Benchmarking2004，11，： | 1 |
| 6 | An Iterative Approach for Distribution Chain Design in Agile Virtual Environment 显示文摘 | Hongze Ma Reggie Davidrajuh | 2005 | Industrial Management & Data Systems2005，105，6： | 1 |
| 7 | Indirubin-30 -monoxime-loaded PLGA-PEG nanoparticles for potential Alzheimer's disease treatment显示文摘Alzheimer's disease(AD)is an irreversible neurodegenerative disorder,which is pathologically characterized by the deposits of β-amyloid(Aβ),and plays an important role in neuronal death.Indirubin-30-monoxime(I3M)showed neuroprotective effects against Aβ-induced neuronal apoptosis.However,the use of I3M in AD treatment is limited due to its low bioavailability.Herein,PLGA-PEG nanoparticles were synthesized for I3M loading.I3M could release sustainedly sustain release from the I3M-loaded PLGA-PEG nanoparticles(PLGA-PEG-I3M NPs)without obvious burst release.What's more,the PLGA-PEG-I3M NPs could significantly promote the uptake of I3M by PC12 cells through nanoparticle-mediated transport,and improve the efficacy of I3M on the inhibition of Aβfibrillization and oligomerization as well as the neuroprotective activity of I3M on Aβoligomers-induced neuronal death.Thus,the PLGA-PEG-I3M NPs may be a promising platform for AD therapy. | Lingli Jin Qiyao Wang Mengxiang Yang Jiaying Zhang Hongze Liang Hui Tan Zhenjiang Liang Xiaopeng Ma Junying Liu Haiyan Li Xiaodong Cai Wei Cui Lingling Zhao | 2022 | Medicine in Novel Technology and Devices2022，，3： | 0 |
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