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| 1 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 2 | 普萘洛尔治疗婴幼儿血管瘤:对血浆血管内皮细胞生长因子的作用显示文摘普萘洛尔治疗婴幼儿血管瘤(IH)效果显著,但其发病机制及其对血管内皮细胞生长因子(VEGF)的作用尚不清楚。该文旨在明确普萘洛尔的疗效和评估IH患者治疗后血浆VEGF的变化。35例IH患儿被纳入研究。口服普萘洛尔2.0 mg/kg·d,3次/d。以病变大小和颜色的视觉模拟量表(VAS)变化评估疗效。血浆VEGF浓度采用酶联免疫吸附试验测定,各组间进行比较。 | Ozeki M Nozawa A Hori T | 2017 | 中国口腔颌面外科杂志2017，15，1： | 3 |
| 3 | SUMO - 1 conjugation to intact DNA topoisomerase Ⅰ amplifies cleavable complex formation induced by camptothecin 显示文摘 | HORIE K TOMIDA A SUGIMOTO Y | 2002 | Oncogene2002，21，： | 1 |
| 4 | Prevention of limb ampution in patients with limbs ulcers by autologous pe-ripheral blood mononu-clear cell implantation显示文摘 | Horie T Tsuda l | 2005 | Ther Apher Dial2005，9，1： | 1 |
| 5 | Design of an electrohydraulic positioning system using a novel model reference control scheme显示文摘 | Hori N Pannata A S Ukrainetz P R | 1989 | J of Dynamic Systems Measurement & Control1989，111，： | 1 |
| 6 | Pallidal lesions in patients with liver cirrhosis:clinical and MRI evaluation显示文摘 | Weissenborn K Ehrenheim C Hori A | | 0，，03： | 1 |
| 7 | HRS/EHRA/ APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013显示文摘 | PRIORI S G WILDE A A HORIE M | 2013 | Heart Rhythm2013，10，12： | 1 |
| 8 | A numerical study of structural damage detection using changes in the rotation of mode shapes 显示文摘 | Abdo M A B Hori M | 2002 | Journal of Sound and Vibration2002，251，2： | 1 |
| 9 | 显示文摘 | Kimura S Horie A Hiki Y | 2003 | Blood2003，101，10： | 1 |
| 10 | Optimal aeroassisted or bital interception 显示文摘 | Horie K B Conway A | 1999 | Journal of Guidance Control and Dynamics1999，22，5： | 1 |
| 11 | Variability in toxicity of the dinoflagellate Alexandrium tamarense isolated from Hiroshima Bay,western Japan,as a reflection of changing environmental conditions显示文摘 | Hamasaki K Horie M Tokimitsu A | 2001 | J Plank Res2001，23，： | 1 |
| 12 | Effects of ( + )-8′,8′,8′- trifluoroabscisic acid on α-amylase expression and sugar accumulation in rice ceils 显示文摘 | Kashem M A Hori H Itoh K | 1998 | Planta1998，205，： | 1 |
| 13 | Selection of food sources by Ru-ditapes philippinarum and Mactra veneriformis (Bivalva : Mol-lusca) determined from stable isotope analysis 显示文摘 | Kasai A Horie H Sakamoto W | 2004 | Fisheries Sci2004，70，： | 1 |
| 14 | Phase equilibrium measurements and crystallographic analyses on structure-H type gas hydrate formed from the CH4-CO2-neohexane-water system显示文摘 | Uchida T Ohmura R Ikeda I Y Nagao J Takeya S Hori A | 2006 | The Journal of Physical Chemistry B2006，110，10： | 1 |
| 15 | Living-donor liver transplantation for progressive familial intrahepatic cholestasis显示文摘 | Hori T Egawa H Miyagawa-Hayashino A | 2011 | World J Surg2011，35，2： | 1 |
| 16 | Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor显示文摘 | Muto A Hori M Sasaki Y | 2007 | Mol Caneer Ther2007，6，3： | 1 |
| 17 | The Dipeptidyl Peptidase-4 Inhibitor Vildagliptin has the Capacity to Repair/3- Cell Dysfunction and Insulin Resistance显示文摘 | Horie A Tokuyama Y Ishizuka T | 2014 | Hormone and metabolic research : Hormon-und Stoffwechselforschung : Hormones et metabolisme2014，46，11： | 1 |
| 18 | lgAl molecules produced by tonsillar lymphocytes are under-O-glycosylated in IgA nephropathy 显示文摘 | Horie A Hiki Y Odani H | 2003 | Am J Kidney Dis2003，42，3： | 1 |
| 19 | Blood levels ofbrain--derived neurotrophic factor (BDNF)in major depressive dis order 显示文摘 | Yoshimura R Ikenouchi Sugita A Hori H | 2010 | Seishin Shinkeigaku Zasshi2010，112，98： | 1 |
| 20 | Theophylline inhibit sNF alphainduced CD4 expressionon human eosinophils and CD4 eosinphil migration J显示文摘 | Tsukadaira A Okubo Y Horie S | | Int Arch Allergy Immonol0，，： | 1 |
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