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| 1 | Mechanisms and anatomical risk factors of pneumothorax after Bevacizumab use:A case report显示文摘BACKGROUND Bevacizumab is an antiangiogenic agent,and that synergizes with chemotherapeutic drugs.When used in combination therapies,Bevacizumab is associated with adverse events such as hemorrhage,gastrointestinal perforation,delayed wound healing,and pneumothorax.However,the molecular mechanisms underlying these adverse events are not fully understood.CASE SUMMARY A 45-year-old female with multiple lung metastases that were derived from primary breast cancer,was placed on Bevacizumab+paclitaxel therapy,since this combination has a potent antitumor effect.She reported dyspnea before cycle 3,day 1 and we therefore ran a chest X-ray,which detected a right pneumothorax.The coronal plane computed tomography revealed that one solid mass rapidly necrosed and was replaced by a cavity that passed through the bronchus in the right lower lobe.The cavity eventually ruptured the pleura and made the bronchopleural fistula that led to this pneumothorax.Thoracic cavity drainage using an intercostal catheter was performed.On the 7th day of drainage,the patient was discharged from our hospital on recovery.Recurrence of pneumothorax was not reported,and continuation of chemotherapy was made possible by changing the regimen.CONCLUSION Patients with lung metastases surrounding the bronchi and on the pleura should be monitored for pneumothorax by Bevacizumab-containing chemotherapies. | Yuri Ozaki Akiyo Yoshimura Masataka Sawaki Masaya Hattori Naomi Gondo Haruru Kotani Yayoi Adachi Ayumi Kataoka Kayoko Sugino Nanae Horisawa Yuka Endo Kazuki Nozawa Shoko Sakamoto Hiroji Iwata | 2020 | World Journal of Clinical Oncology2020，11，7： | 2 |
| 2 | Prolonged anti-infl ammatory action of D, L-lactide/glycolide copolymer nanosph eres containing betamethasone sodium phosphate for an intra articular delivery system in antigen-induced arthritic rabbit显示文摘 | Horisawa E Hirota T Kawazoe S | 2002 | Pharm Res2002，19，： | 1 |
| 3 | Prolonged anti- infl ammatory action of D, L-lactide/glycolide copolymer nanosph- eres containing betamethasone sodium phosphate for an intra- articular delivery system in antigen-induced arthritic rabbit显示文摘 | Horisawa E Hirota T Kawazoe S | 2002 | Pharm Res2002，19，： | 1 |
| 4 | Size dependency of D, L lactide/glycolide copolymer particulates for intrmarticular de- livery system on phagocytosis in rat synovium显示文摘 | Horisawa E Kubota K Tuboi I | 2002 | Pharm Res2002，19，： | 1 |
| 5 | Frantz's tumor(solid and cystic tumor of the pancreas)with liver metastasis;Successful treatment and long- term follow up显示文摘 | Horisawa M Niinomi N Sato T | 1995 | J pediatr Surg1995，30，： | 1 |
| 6 | Frantz's tumor ( Solid and cystic tumor of the pancreas) with liver metastasis : successful treat- ment and long-term follow-up 显示文摘 | Horisawa M Niinomi N Sato T | 1995 | J Pediatr Surg1995，30，5： | 1 |
| 7 | Biodegradafion of non- lignocellulosic substances ll: physical and chemical properties of sawdust before and after use as artificial soil显示文摘 | HORISAWA S SUNAGAWA M TAMAI Y | 1999 | The Japan Wood Research Society1999，45，： | 1 |
| 8 | c-kit immunoreactive interstitial ceils in the human gastrointestinal tract 显示文摘 | Torihashi S Horisawa M Watanabe Y | 1999 | J Auton Nerv Syst1999，75，1： | 1 |
| 9 | Binding of Iur- asidone,a novel antipsychotic,to rat 5-HT7 receptor; analysis bySB-269970 autoradiography显示文摘 | Horisawa T Ishiyama T Ono M | 2013 | Prog Neuropsychopharmacol Biol Psychiatry2013，40，： | 1 |
| 10 | The effects of selective antagonists of serotonin 5-HTv and 5-HT1A receptors on MK-801-induced impairment of learning and memory in the passive avoidance and morris water maze tests in rats: mechanistic implications for the beneficial effects of the novel atypical antipsychotic lurasidone 显示文摘 | Horisawa T Ishibashi T Nishikawa H | 2011 | Behav Brain Res2011，220，1： | 1 |
| 11 | Distribution of ckit immunopositive cells in normal human colon and in Hirschsprung ' s disease显示文摘 | Horisawa M watanabe Y Torihashi S | | 0，，： | 1 |
| 12 | Anatomical reconstruction of the thyroglossal duct显示文摘 | Horisawa M Ninom N Ito T | 1991 | Pediatr Surg1991，26，7： | 1 |
| 13 | Anatomical reconstruction of the thyroglossal duct显示文摘 | Horisawa M Ninom N Ito T | 1991 | Pediatr Surg1991，26，7： | 1 |
| 14 | Surface machining characteristics of sapphire with fifth harmonic YAG laser pulses显示文摘 | H Horisawa E Hajime | 2004 | Vacuum2004，73，34： | 1 |
| 15 | Neuropsychology:pharmacological profile of lurasidone,a novel antipsychotic agent with potent 5-hydroxytryptamine 7(5-HT7)and 5-HT1Areceptor activity显示文摘 | Ishibashi T Horisawa T Tokuda K | 2010 | Pharmacology2010，334，1： | 1 |
| 16 | Pharmacological profile of lurasidone,a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity显示文摘 | Ishibashi T Horisawa T Tokuda K | | 0，，： | 1 |
| 17 | The relationships of gender,cigarette smoking,and hypertension with the risk of aneurysmal subarachnoid hemorrhage:A case control study in nagoya,Japan显示文摘 | Okamoto K Horisawa R Ohno Y | 2005 | Ann Epidemiol2005，15，10： | 1 |
| 18 | Frantz's tumor (solid and cystic tumor of the pancreas) with liver metastasis:successful treatment and long term follow up显示文摘 | HORISAWA M NIINOMI N SATO T | 1995 | J Ped Surg1995，30，： | 1 |
| 19 | Intrahepatic bile ducts in biliary atresia- a possible factor determining the prognosis 显示文摘 | Ito T Horisawa M Ando H | 1983 | J Pediatr Surg1983，18，2： | 1 |
| 20 | Binding of lurasidone, a novel antipsychotic, to rat 5-HT 7 receptor: Analysis by [ 3 H]SB-269970 autoradiography显示文摘 | Tomoko Horisawa Takeo Ishiyama Michiko Ono Tadashi Ishibashi Mutsuo Taiji | 2013 | Progress in Neuropsychopharmacology & Biological Psychiatry2013，，： | 1 |
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