|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is the ongoing global pandemic that poses substantial challenges to public health worldwide.A subset of COVID-19 patients experience systemic inflammatory response,known as cytokine storm,which may lead to death.Receptor-interacting serine/threonine-protein kinase 1(RIPK1)is an important mediator of inflammation and cell death.Here,we examined the interaction of RIPK1-mediated innate immunity with SARS-CoV-2 infection.We found evidence of RIPK1 activation in human COVID-19 lung pathological samples,and cultured human lung organoids and ACE2 transgenic mice infected by SARS-CoV-2.Inhibition of RIPK1 using multiple smallmolecule inhibitors reduced the viral load of SARS-CoV-2 in human lung organoids.Furthermore,therapeutic dosing of the RIPK1 inhibitor Nec-1s reduced mortality and lung viral load,and blocked the CNS manifestation of SARS-CoV-2 in ACE2 transgenic mice.Mechanistically,we found that the RNA-dependent RNA polymerase of SARS-CoV-2,NSP12,a highly conserved central component of coronaviral replication and transcription machinery,promoted the activation of RIPK1.Furthermore,NSP12323L variant,encoded by the SARS-CoV-2 C14408T variant first detected in Lombardy,Italy,that carries a Pro323Leu amino acid substitution in NSP12,showed increased ability to activate RIPK1.Inhibition of RIPK1 downregulated the transcriptional induction of proinflammatory cytokines and host factors including ACE2 and EGFR that promote viral entry into cells.Our results suggest that SARS-CoV-2 may have an unexpected and unusual ability to hijack the RIPK1-mediated host defense response to promote its own propagation and that inhibition of RIPK1 may provide a therapeutic option for the treatment of COVID-19. | Gang Xu Ying Li Shengyuan Zhang Haoran Peng Yunyun Wang Dekang Li Taijie Jin Zhuohao He Yilun Tong Chunting Qi Guowei Wu Kangyun Dong Jizhou Gou Yang Liu Tongyang Xiao Jing Qu Liang Li Liang Liu Ping Zhao Zheng Zhang Junying Yuan | 2021 | Cell Research2021，31，12： | 6 |
| 2 | Helicobacter heilmannii sensu stricto-related gastric ulcers:A case report显示文摘A spiral bacterium(SH9),morphologically different from Helicobacter pylori(H.pylori),was found in a 62-yearold woman’s gastric mucosa.Gastroscopic examination revealed multiple gastric ulcers near the pyloric ring;mapping gastric biopsy showed mild mononuclear infiltration with large lymphoid follicles in the antrum,without corpus atrophy.Urea breath test and H.pylori culture were negative,but Giemsa staining of biopsies revealed tightly coiled bacteria that immunostained with anti-H.pylori antibody.Sequencing of SH9 16S rRNA and the partial urease A and B subunit genes showed that the former sequence had highest similarity(99%;1302/1315 bp)to Helicobacter heilmannii(H.heilmannii)sensu stricto(H.heilmannii s.s.)BC1 obtained from a bobcat,while the latter sequence confirmed highest similarity(98.3%;1467/1493 bp)to H.heilmannii s.s.HU2 obtained from a human.The patient was diagnosed with multiple gastric ulcers associated with H.heilmannii s.s.infection.After triple therapy(amoxicillin,clarithromycin,and lansoprazole)with regimen for eradicating H.pylori,gastroscopy showed ulcer improvement and no H.heilmannii s.s.upon biopsy. | Takehisa Matsumoto Masatomo Kawakubo Taiji Akamatsu Naohiko Koide Naoko Ogiwara Seiko Kubota Mitsutoshi Sugano Yoshiyuki Kawakami Tsutomu Katsuyama Hiroyoshi Ota | 2014 | World Journal of Gastroenterology2014，20，12： | 4 |
| 3 | 血管紧张素Ⅱ1_A型受体基因对糖尿病嵌合体小鼠肾脏细胞外基质重塑的影响显示文摘目的探讨血管紧张素Ⅱ(AngⅡ)1A型(AT1A)受体基因对糖尿病嵌合体 (chimeric)小鼠肾脏细胞外基质的影响。方法嵌合体小鼠全身组织包括肾脏由AngⅡ1A型受体(AT1A)野生型细胞(AT1A+/+)和AngⅡ受体AT1A基因敲除细胞(AT1A-/-)两组不同克隆来源的细胞组成。在AT1A嵌合体小鼠腹腔内注射链尿佐菌素(STZ,300 mg/kg),诱导糖尿病模型 12周后,取肾脏组织作连续冰冻切片。β半乳糖苷酶(LacZ)染色区分不同基因型的肾小球。 PAS染色检测其细胞外基质的表达。免疫组化方法检测转化生长因子(TGF)β1、纤溶酶原激活物抑制物(PAI)1、终末糖基化产物(AGE)、硝基酪氨酸(nitrotyrosine)的表达。比较两种基因型肾小球细胞外基质和各细胞因子的表达变化。结果在糖尿病状态下,AT1A+/+和AT1A-/-小鼠肾小球细胞外基质均较对照组明显增多(P<0.05)。两种基因型相比,AT1A-/-基因型肾小球的表达绝对值显著高于AT1A+/+基因型肾小球(P<0.05)。但从正常状态到糖尿病形成过程中, 其升高幅度却显著低于AT1A+/+基因型肾小球(P<0.01)。各种细胞因子在糖尿病状态下的表达均显著增加(P<0.05),AT1A-/-基因型肾小球的绝对数值显著高于AT1A+/+基因型肾小球 (P<0.05),但AT1A-/-基因型肾小球细胞因子表达的变化幅度低于AT1A+/+基因型肾小球 (P<0.01)。结论 AT1A基因缺失使得部分肾小球代偿性上调TGF-β1、PAI-1、AGE和nitrotyrosine 的表达。AT1A受体在一定程度上影响了TGF-β1、PAI-1、AGE和nitrotyrosine的表达而参与了糖尿病小鼠肾脏细胞外基质的重塑,但并非独立决定因素。 | 刘英莉 忻菁 顾勇 马骥 Taiji Matsusaka Iekuni Ichikawa 林善锬 | 2006 | 中华肾脏病杂志2006，22，3： | 4 |
| 4 | Evolution and protein interactions of AP2 proteins in Brassicaceae: Evidence linking development and environmental responses显示文摘Plants have evolved a large number of transcription factors(TF), which are enriched among duplicate genes,highlighting their roles in complex regulatory networks. The APETALA2/EREBP-like genes constitute a large plant TF family and participate in development and stress responses. To probe the conservation and divergence of AP2/EREBP genes,we analyzed the duplication patterns of this family in Brassicaceae and identified interacting proteins of representative Arabidopsis AP2/EREBP proteins. We found that many AP2/EREBP duplicates generated early in Brassicaceae history were quickly lost, but many others were retained in all tested Brassicaceae species, suggesting early functional divergence followed by persistent conservation. In addition,the sequences of the AP2 domain and exon numbers were highly conserved in rosids. Furthermore, we used 16 A.thaliana AP2/EREBP proteins as baits in yeast screens and identified 1,970 potential AP2/EREBP-interacting proteins,with a small subset of interactions verified in planta. Many AP2 genes also exhibit reduced expression in an antherdefective mutant, providing a possible link to developmental regulation. The putative AP2-interacting proteins participate in many functions in development and stress responses,including photomorphogenesis, flower development, pathogenesis, drought and cold responses, abscisic acid and auxin signaling. Our results present the AP2/EREBP evolution patterns in Brassicaceae, and support a proposed interaction network of AP2/EREBP proteins and their putative interacting proteins for further study. | Liping Zeng Yue Yin Chenjiang You Qianli Pan Duo Xu Taijie Jin Bailong Zhang Hong Ma | 2016 | Journal of Integrative Plant Biology2016，58，6： | 3 |
| 5 | Study on Improvement of Seismic Performance of Transmission Tower Using Viscous Damper显示文摘 | Masayuki Matsumoto Akira Kasai Taiji Mazda Nobuyuki Ishida Yuki Ito | 2017 | Journal of Civil Engineering and Architecture2017，11，5： | 3 |
| 6 | Characteristics of Metachronous Gastric Tumors after Endoscopic Submucosal Dissection for Gastric Intraepithelial Neoplasms显示文摘 | Tomoyuki Boda Masanori Ito Shiro Oka Yoko Kitamura Norifumi Numata Yoji Sanomura Taiji Matsuo Shinji Tanaka Masaharu Yoshihara Koji Arihiro Kazuaki Chayama Sergio Morini | 2014 | Gastroenterology Research and Practice2014，，： | 2 |
| 7 | 三菱重工地面燃气轮机热障涂层研究进展显示文摘燃气轮机联合循环热效率的提高,要求涡轮进口温度不断增加。目前,三菱重工(MHI)已经积极参与日本国家项目,通过发展1700℃级燃气轮机,以使联合循环热效率实现达到62%指标。在此国家项目中开发的部分组件技术适用于1600℃级燃气轮机M501J,它具有世界上最高的涡轮进口温度。而热障涂层(TBC)是实现此目标的最关键技术之一。在发展先进的热障涂层中,在MHI工厂中建立名为T点的试验电厂是有必要的。在真实热部件中制备的先进TBC可以在工厂中进行验证,并且运行后的效果可以得到反馈。本文讨论了TBC的开发以及在三菱重工实际电厂中的验证。 | Yoshifumi Okajima Daisuke Kudo Naotoshi Okaya Taiji Torigoe Hideaki Kaneko Masahiko Mega Eisaku Ito Junichiro Masada Keizo Tsukagoshi 吴琼 | 2014 | 热喷涂技术2014，，3： | 2 |
| 8 | A Putative Chloroplast-Localized Ca2+/H+ Antiporter CCHA1 Is Involved in Calcium and pH Homeostasis and Required for PSII Function in Arabidopsis显示文摘钙为叶绿体,不是在仅仅是重要的它的光合而且 nonphotosynthetic 功能。多重 Ca 2+/H+ transporters 和隧道在血浆膜和植物房间的细胞器膜被描述了并且学习;然而,分子的身份和叶绿体 Ca 2+/H+ antiporters 的生理的角色仍然保持未知。这里,我们报导 UPF0016 家庭,的一个成员的鉴定和描述 CCHA1 (叶绿体局部性的潜在的 Ca 2+/H+ antiporter ) ,在 Arabidopsis thaliana。我们观察到 ccha1 异种植物开发了苍白的绿叶子并且与损害 photosystem II (PSII ) 功能一起显示出严重地阻碍的生长。CCHA1 本地化到 PSII 核心子单元和演变氧的建筑群的叶绿体,和层次显著地与野类型相比在 ccha1 异种被减少。在高 Ca 2+ 集中, Arabidopsis CCHA1 部分救了酵母 gdt1 0 异种的生长缺点,它在 Ca 2+/H+ antiporter 是有缺点的。ccha1 异种植物也在 pH 显示出重要敏感到 CaCl 2 和 MnCl 2, 以及变化的高集中。一起拿这些结果,我们建议 CCHA1 可能在 Arabidopsis 与批评功能把通常认为的叶绿体局部性的 Ca 2+/H+ antiporter 编码为 PSII 的规定并且在叶绿体 Ca 2+ 和 pH 动态平衡。 | Chao Wang Weitao Xu Honglei Jin Taijie Zhang Jianbin Lai Xuan Zhou Shengchun Zhang Shengjie Liu Xuewu Duan Hongbin Wang Changlian Peng Chengwei Yang | 2016 | Molecular Plant2016，9，8： | 2 |
| 9 | Mallory-Weiss tear during gastric endoscopic submucosal dissection显示文摘A 78-year-old woman was referred to our department for treatment of an early gastric cancer. Esophagogastroduodenoscopy (EGD) demonstrated a flat elevated lesion and a polypoid lesion on the greater curvature of the antrum. Histological analysis of, endoscopic biopsy samples taken from these lesions revealed an adenocarcinoma and a hyperplastic polyp, respectively. ESD was conducted for removal of the lesions. Carbon dioxide (CO2) in- stead of room air was used for insufflation, and the patient was adequately sedated without struggling or vomiting during the treatment. No significant bleeding from the lesion was observed during ESD, but fresh blood was identified endoscopically. Surprisingly, a Mallory- Weiss tear with active bleeding was detected on the lesser curvature of the gastric corpus. A total of eight hemoclips were applied for hemostasis. Both lesions were completely removed en bloc, and no bleeding or perforation developed after ESD. Histologically, the first lesion was apapillary carcinoma limited to the mucosal layer and without lymphovascular invasion or involvement of the surgical margins, while the second lesion was a benign hyperplastic polyp. | Hiroki Hongou Kuangi Fu Hiroya Ueyama Taiji Takahashi Tsutomu Takeda Akihisa Miyazaki Sumio Watanabe | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，7： | 2 |
| 10 | Overexpression of a 60-kDa heat shock protein enhances cytoprotective function of small intestinal epithelial cells显示文摘 | Makiko Takada Michiro Otaka Taiji Takahashi Yuko Izumi Kumiko Tamaki Tomoyoshi Shibuya Naoto Sakamoto Taro Osada Sou Yamamoto Ryuichi Ishida Masaru Odashima Hideaki Itoh Sumio Watanabe | 2010 | Life Sciences2010，，13： | 2 |
| 11 | Local extension of pancreatic carcinoma: assessment with thin-section helical CT versus with breath-hold fast MR imaging ROC analysis显示文摘 | Taiji N Yamashita Y Yasuko A | 1999 | Radiology1999，212，2： | 1 |
| 12 | Green’s relations and regularity for semigroups of transformations that preserve reverse direction equivalence显示文摘 | DENG Lunzhi ZENG Jiwen YOU Taijie | 2011 | Semigroup Forum2011，83，3： | 1 |
| 13 | Crack detection and sizing technique by ultrasonic and electromagnetic methods显示文摘 | Ichiro Komura Taiji Hirasawa Satoshi Nagai Jun-ichi Takabayashi Katsuhiko Naruse | 2001 | Nuclear Engineering and Design2001，，2： | 1 |
| 14 | Use of 8n ultrahigh-laser scanner forconstructing three-dimensional shapes of dentition and occlusion显示文摘 | Taiji Sohmura Tetsuya Kojima Kazumichi Wakabayashi | 2000 | J Prothct Dent2000，84，3： | 1 |
| 15 | Depolymerization of poly(butylene terephthalate) using high-temperature and high-pressure methanol 显示文摘 | Mitsuhiro Shibata Taiji Masuda Ryutoku Yosomiya | 2000 | Journal of Applied Polymer Science2000，，77： | 1 |
| 16 | Colorimetric assay for lysozyme using Micrococcus luteus labeled with a blue dye,Remazol brilliant blue R as a substrate chem显示文摘 | Yuji I Hidenori Y Taiji I | 1992 | Pharm Bull1992，40，6： | 1 |
| 17 | Hearing loss in Turner syndrome显示文摘 | Morimoto N Tanaka T Taiji H | 2006 | J Pediatr2006，149，5： | 1 |
| 18 | Financial Development and Income Inequality显示文摘 | Hiroshi Daisaka Taiji Furusawa Globalization Noriyu- ki Yanggawa | 2014 | Pacific Economic Review2014，19，5： | 1 |
| 19 | Evaluation of hearing recovery and efficacy of steroid treatment in sudden deafness显示文摘 | Kanzaki J Taiji H Ogawa K | 1988 | Atca Otolaryngol Suppl1988，456，： | 1 |
| 20 | Mutation screening of BMP4, BMP7, HOXA4 and HOXB6 genes in Chinese patients with hypospadias 显示文摘 | Taiji Chen Qiang Li Yan Shen | 2007 | European Journal of Human Genetics2007，，15： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员