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| 1 | Magnitude of modulation of gene expression in aneuploid maize depends on the extent of genomic imbalance显示文摘Aneuploidy has profound effects on an organism,typically more so than polyploidy,and the basis of this contrast is not fully understood.A dosage series of the maize long arm of chromosome 1(1L)was used to compa re relative global gene expression in diffe rent types and degrees of aneuploidy to gain insights into how the magnitude of genomic imbalance as well as hypoploidy affects global gene expression.While previously available methods require a selective examination of specific genes,RNA sequencing provides a whole-genome view of gene expression in aneuploids.Most studies of global aneuploidy effects have concentrated on individual types of aneuploids because multiple dose aneuploidies of the same genomic region are difficult to produce in most model genetic organisms.The genetic toolkit of maize allows the examination of multiple ploidies and 1-4 doses of chromosome arms.Thus,a detailed examination of expression changes both on the varied chromosome arms and elsewhere in the genome is possible,in both hypoploids and hyperploids,compared with euploid controls.Previous studies observed the inverse trans effect,in which genes not varied in DNA dosage were expressed in a negative relationship to the varied chromosomal region.This response was also the major type of changes found globally in this study.Many genes varied in dosage showed proportional expression changes,though some were seen to be partly or fully dosage compensated.It was also found that the effects of aneuploidy were progressive,with more severe aneuploids producing effects of greater magnitude. | Adam F·Johnson Jie Hou Hua Yang Xiaowen Shi Chen Chen Md Soliman Islam Tieming Ji Jianlin Cheng James A·Birchler | 2020 | Journal of Genetics and Genomics2020，47，2： | 3 |
| 2 | Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells intumor-draining lymph nodes显示文摘 | Munn DH Sharma MD Hou D | 2004 | J Clin Invest2004，114，2： | 1 |
| 3 | Expression of indoleamine 2, 3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes 显示文摘 | Munn DH Sharma MD Hou D | 2004 | J Clin Invest2004，114，2： | 1 |
| 4 | Inhibition of IDO in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with anti-tumor responses 显示文摘 | Hou DY Muller A J Sharma MD | 2007 | Cancer Res2007，67，4： | 1 |
| 5 | Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor draining lymph nodes显示文摘 | Munn DH Sharma MD Hou D | 2004 | J Clin Invest2004，114，： | 1 |
| 6 | Expression of indoleamine 2,3- dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes 显示文摘 | Munn DH Sharma MD Hou D | 2004 | J Clin Invest2004，114，2： | 1 |
| 7 | Inhibition of Autophagy by 3-MA Enhances the Effect of 5-FU-Induced Apoptosis in Colon Cancer Cells显示文摘 | Jie Li MD Ni Hou MD PhD Ahmad Faried MD PhD Soichi Tsutsumi MD PhD Toshiyuki Takeuchi MD PhD Hiroyuki Kuwano MD PhD | 2009 | Annals of Surgical Oncology2009，，3： | 1 |
| 8 | Expression of in- doleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes显示文摘 | MUNN DH SHARMA MD HOU D | 2004 | J Clin Invest2004，114，2： | 1 |
| 9 | Inhibition of indoleamine 2, 3-dioxygenase in dendritic cells by stereoisomers of antltumor responses 1-methyl-tryptophan correlates with 显示文摘 | Hou DY Muller A J Sharma MD | 2007 | Cancer Res2007，67，2： | 1 |
| 10 | Reprogrammed foxp3 ( + ) regulatory T ceils provide essential help to support cross-presenta- tion and CD8( + ) T cell priming in naive mice 显示文摘 | Sharma MD Hou DY Baban B | 2010 | Immunity2010，33，6： | 1 |
| 11 | Expression of indoleamine 2,3-dioxygenase by plasmaeytoid dendritic cells in tumor-draining lymph nodes 显示文摘 | Munn DH Sharma MD Hou D | 2004 | J Clin Invest2004，114，2： | 1 |
| 12 | Expression of in doleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor draining lymph nodes显示文摘 | Munn DH Sharma MD Hou D | 2004 | J Clin Invest2004，114，2： | 1 |
| 13 | Expression of indoleamine 2,3-dioxygenase by plasmaeytoid dendritic cells in tumor-draining lymph-nodes显示文摘 | Munn DH Sharma MD Hou D | 2004 | J Clin Invest2004，114，2： | 1 |
| 14 | Indoleamine 2,3-dioxygenase controls conversion of foxp3+ Tregs to ThlT-like ceils in tumor- draining lymph nodes 显示文摘 | Sharma MD Hou DY Liu Y | 2009 | Blood2009，113，24： | 1 |
| 15 | Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes显示文摘 | Munn DH Sharma MD Hou D | 2004 | J Clin Invest2004，114，2： | 1 |
| 16 | Inhibition of indoleamine 2,3 - dioxygenase in dendritic cells by stereoisomers of 1 - methyl - tryptophan correlates with antitumor responses 显示文摘 | Hou DY Muller AJ Sharma MD | 2007 | Cancer Res2007，67，2： | 1 |
| 17 | Inhibition of in- doleamine 2,3-dioxygenase in dendritic ceils by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses 显示文摘 | HOU DY MULLER AJ SHARMA MD | 2007 | Cancer Res2007，67，2： | 1 |
| 18 | Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes显示文摘 | Munn DH Sharma MD Hou D | 2004 | J Clin Invest2004，114，2： | 1 |
| 19 | Indoleamine 2,3-dioxygenase- controls conversion of Foxp3^+ Tregs to Thl7-1ike cells in tumor- draining lymph nodes显示文摘 | Sharma MD Hou DY Liu Y | 2009 | Blood2009，113，24： | 1 |
| 20 | Preparation and characterization of CdS nanotubes and nanowires by electrochemical synthe- sis in ion - track templates 显示文摘 | Mo D Liu J Yao I'Ll Duan JL Hou MD Sun YM Chen YF Xue ZH Zhang L | 2008 | Journal of Crystal Growth2008，310，： | 1 |
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