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| 1 | Effect of periocular injection of celecoxib and propranolol on ocular level of vascular endothelial growth factor in a diabetic mouse model显示文摘AIM: To investigate the effects of periocular injection of propranolol and celecoxib on ocular levels of vascular endothelial growth factor(VEGF) in a diabetic mouse model.METHODS: Forty 4-6wk BALB-C male mice weighing20-25 g were used. The study groups included: non-diabetic control(group 1), diabetic control(group 2),diabetic propranolol(group 3), and diabetic celecoxib(group 4). After induction of type 1 diabetes by streptozotocin, propranolol(10 μg) and celecoxib(200 μg dissolved in carboxymethylcellulose 0.5%) were injected periocularly. The ocular level of VEGF was measured in all the study groups using enzyme-linked immuno sorbent assay(ELISA) method. RESULTS: Ocular VEGF level was significantly increased(1.25 fold) in the diabetic control group when compared to the non-diabetic group one week after induction with streptozotocin(P =0.002). Both periocular propranolol and celecoxib significantly reduced ocular VEGF levels(P =0.047 and P <0.001, respectively). The effect was more pronounced with celecoxib. CONCLUSION: The periocular administration of propranolol and celecoxib can significantly reduce ocular VEGF levels in a diabetic mouse model. | Samar Nassiri Gholamreza Houshmand Mostafa Feghhi Alireza Kheirollah Mohammad Bahadoram Nariman Nassiri | 2016 | International Journal of Ophthalmology(English edition)2016，9，6： | 3 |
| 2 | Bone marrow microenvironment: The guardian of leukemia stem cells显示文摘Bone marrow microenvironment (BMM) is the main sanctuary of leukemic stem cells (LSCs) and protects these cells against conventional therapies. However, it may open up an opportunity to target LSCs by breaking the close connection between LSCs and the BMM. The elimination of LSCs is of high importance, since they follow cancer stem cell theory as a part of this population. Based on cancer stem cell theory, a cell with stem cell-like features stands at the apex of the hierarchy and produces a heterogeneous population and governs the disease. Secretion of cytokines, chemokines, and extracellular vesicles, whether through autocrine or paracrine mechanisms by activation of downstream signaling pathways in LSCs, favors their persistence and makes the BMM less hospitable for normal stem cells. While all details about the interactions of the BMM and LSCs remain to be elucidated, some clinical trials have been designed to limit these reciprocal interactions to cure leukemia more effectively. In this review, we focus on chronic myeloid leukemia and acute myeloid leukemia LSCs and their milieu in the bone marrow, how to segregate them from the normal compartment, and finally the possible ways to eliminate these cells. | Mohammad Houshmand Teresa Mortera Blanco Paola Circosta Narjes Yazdi Alireza Kazemi Giuseppe Saglio Mahin Nikougoftar Zarif | 2019 | World Journal of Stem Cells2019，11，8： | 2 |
| 3 | Evaluation of seismic reliability of gravity dam-reservoirinhomogeneous foundation coupled system显示文摘The seismic performance of gravity dam-reservoir-foundation coupled system is investigated utilizing probabilistic approach.In this research,the uncertainties associated with modeling parameters are incorporated in nonlinear response history simulations to realistically quantify their effects on the seismic performance of the system.The methodology is applied to Pine Flat gravity dam and the foundation is considered to be inhomogeneous assuming a constant spatial geometry but with various rock material properties.The sources of uncertainty are taken into account in the reliability analysis using Latin Hypercube Sampling procedure.The effects of the deconvolution process,number of samples,and foundation inhomogeneity are investigated. | Hamid Taghavi GANJI Mohammad ALEMBAGHERI Mohammad Houshmand KHANEGHAHI | 2019 | Frontiers of Structural and Civil Engineering2019，13，3： | 2 |
| 4 | Digital surface models and building extraction: A comparison of IFSAR and LIDAR data显示文摘 | Gamba P Houshmand B | 1959 | IEEE Transactions on International Geoscience and Remote Sensing1959，66，7： | 2 |
| 5 | Joint Analysis of SAR,LiDAR and Aerial Imagery for Simultaneous Ex-traction of Land Cover, DTM and 3D Shape ofBuildings 显示文摘 | Gamba P Houshmand B | 2002 | International J ournal of RemoteSensing2002，23，20： | 1 |
| 6 | The role of molecular imag- ing in diagnosis of deep vein thrombosis显示文摘 | Houshmand S Salavati A Hess S | 2014 | Am J Nucl Med Mol Imaging2014，4，5： | 1 |
| 7 | Sodium current and potassium transient outward current genes in Brugada syndrome: screening and bioinformatics显示文摘 | Holst AG Saber S Houshmand M | 2012 | Can J Cardiol2012，28，2： | 1 |
| 8 | Influence of cytotoxic T lymphocyte antigen -- 4 (CTLA -- 4) gene polymor- phisms in periodontitis显示文摘 | Houshmand B Rafiei A Hajilooi M | 2012 | Arch Oral Biol2012，57，9： | 1 |
| 9 | Modeling of Microwave Active Devices Using the Voltage-Source Approach 显示文摘 | Kuo C N Wu R B Houshmand B Itoh T | 1996 | IEEE Microwave Guided Wave Lett1996，6，5： | 1 |
| 10 | All-die- lectric photonic-assisted radio front-end technology 显示文摘 | Hsu R C J Ayazi A Houshmand B | 2007 | NaturePhotonics2007，1，9： | 1 |
| 11 | A collaborative and integrated platform to support distributed manufacturing system using a service-oriented approach based on cloud computing paradigm显示文摘 | Valilai O F Houshmand M | 2013 | Robotics and Computer-Integrated Manufacturing2013，29，1： | 1 |
| 12 | Downregulation of miR-34a in breast tumors is not associated with either p53 mutations or promoter hypermethylation while it correlates with metastasis显示文摘 | Arash Javeri Massoud Ghaffarpour Masoumeh Fakhr Taha Massoud Houshmand | 2013 | Medical Oncology2013，，1： | 1 |
| 13 | Detection and extraction of buildings from interferomet- ric SAR data 显示文摘 | GAMBA P HOUSHMAND B SACCANI M | 2000 | IEEE Transactions on Geoscience and Remote Sensing2000，38，1： | 1 |
| 14 | The effect of He-Ne and Ga-Al-As laser light on the healing of hard palate mucosa of mice显示文摘 | Farahnaz Fahimipour Mina Mahdian Behzad Houshmand Mohammad Asnaashari Alireza Naser Sadrabadi Seid Emadadin Najafi Farashah Seid Mohsen Mousavifard Arash Khojasteh | 2013 | Lasers in Medical Science2013，，1： | 1 |
| 15 | Different pattern ofgene mutations in Iranian patients with severe con- genital neutropenia (including 2 new mutations) 显示文摘 | Alizadeh Z Fazlollahi MR Houshmand M | 2013 | Iran JAllergy Asthma Immunol2013，12，1： | 1 |
| 16 | Interaction of hepatitis C virus NS5A with La protein revealed by T7 phage display显示文摘 | Houshmand H Bergqvist A | 2003 | Biochem Biophys Res Commun2003，309，3： | 1 |
| 17 | Depressive and anxiety symptoms as risk Factors for temporomandibular joint pain:Aprospective cohort study in the general population 显示文摘 | Kindler S Samietz S Houshmand M | 2012 | Pain2012，13，12： | 1 |
| 18 | Superhydrophobic graphene foams显示文摘 | Singh E Chen Z Houshmand F | 2013 | Small2013，9，1： | 1 |
| 19 | Ammonia modification ofactivated carbon to enhance carbon dioxide adsorption : Effect of pre-oxi-dation显示文摘 | MOHAMMAD SALEH SHAFEEYAN WAN MOHD ASHRI WAN DAUD AMIRHOSSEIN HOUSHMAND | 2011 | Applied Surface Science2011，257，： | 1 |
| 20 | Different pattern of gene mutations in Iranian patients with sever congenial neutropenia (including 2 new mutations) 显示文摘 | Alizadeh Z Fazlollahi MR Houshmand M | 2013 | Iran J Allergy Asthma Immunol2013，12，1： | 1 |
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