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| 1 | Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors显示文摘The International Committee of Medical Journal Editors (ICMJE) believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk.In a growing consensus,many funders around the world-foundations,government agencies,and industry-now mandate data sharing.Here,we outline ICMJE's proposed requirements to help meet this obligation.We encourage feedback on the proposed requirements.Anyone can provide feedback at www.icmje.org by April 18,2016. | Darren B Taichman Joyce Backus Christopher Baethge Howard Bauchner Peter W de Leeuw Jeffrey M Drazen John Fletcher Frank Frizelle Irish Groves Abraham Haileamlak Astrid James Christine Laine Larry Peiperl Anja Pinborg Peush Sahni Si-Nan Wu | 2016 | Chinese Medical Journal2016，，2： | 20 |
| 2 | Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set显示文摘The apple(Malus×domestica)cultivar Honeycrisp has become important economically and as a breeding parent.An earlier study with SSR markers indicated the original recorded pedigree of‘Honeycrisp’was incorrect and‘Keepsake’was identified as one putative parent,the other being unknown.The objective of this study was to verify‘Keepsake’as a parent and identify and genetically describe the unknown parent and its grandparents.A multi-family based dense and high-quality integrated SNP map was created using the apple 8 K Illumina Infinium SNP array.This map was used alongside a large pedigree-connected data set from the RosBREED project to build extended SNP haplotypes and to identify pedigree relationships.‘Keepsake’was verified as one parent of‘Honeycrisp’and‘Duchess of Oldenburg’and‘Golden Delicious’were identified as grandparents through the unknown parent.Following this finding,siblings of‘Honeycrisp’were identified using the SNP data.Breeding records from several of these siblings suggested that the previously unreported parent is a University of Minnesota selection,MN1627.This selection is no longer available,but now is genetically described through imputed SNP haplotypes.We also present the mosaic grandparental composition of‘Honeycrisp’for each of its 17 chromosome pairs.This new pedigree and genetic information will be useful in future pedigree-based genetic studies to connect‘Honeycrisp’with other cultivars used widely in apple breeding programs.The created SNP linkage map will benefit future research using the data from the Illumina apple 8 and 20 K and Affymetrix 480 K SNP arrays. | Nicholas P Howard Eric van de Weg David S Bedford Cameron P Peace Stijn Vanderzande Matthew D Clark Soon Li Teh Lichun Cai James J Luby | 2017 | Horticulture Research2017，4，1： | 9 |
| 3 | Executive Summary: Heart Disease and Stroke Statistics— 2010 Update: A Report From the American Heart Association显示文摘 | Donald Lloyd-Jones Robert J. Adams Todd M. Brown Mercedes Carnethon Shifan Dai Giovanni De Simone T. Bruce Ferguson Earl Ford Karen Furie Cathleen Gillespie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern P. Michael Ho Virginia Howard Brett Kissela Stev | 2010 | Circulation2010，，7： | 5 |
| 4 | Heart Disease and Stroke Statistics—2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Donald Lloyd-Jones Robert Adams Mercedes Carnethon Giovanni De Simone T Bruce Ferguson Katherine Flegal Earl Ford Karen Furie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern Michael Ho Virginia Howard Brett Kissela Steven Kittner Daniel Lackland Lynda L | 2009 | Circulation2009，，3： | 4 |
| 5 | Coronary artery stents and non-cardiac surgery 显示文摘 | Howard Alpe GM de Bono J Hudsmith L | 2007 | Br J Anaesth2007，98，5： | 1 |
| 6 | Metabolic syndrome and risk of incident cardiovascular events and death: a systematic re- view and meta-analysis of longitudinal studies 显示文摘 | Gami AS Witt B J Howard DE | 2007 | J Am Coil Car- diol2007，49，4： | 1 |
| 7 | Fibroblast Growth Factor 23, Bone Mineral Density, and Risk of Hip Fracture Among Older Adults: The Cardiovascular Health Study显示文摘 | Anna Jovanovich Petra Bù?ková Michel Chonchol John Robbins Howard A. Fink Ian H. de Boer Bryan Kestenbaum Ronit Katz Laura Carbone Jennifer Lee Gail A. Laughlin Kenneth J. Mukamal Linda F. Fried Michael G. Shlipak Joachim H. Ix | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，8： | 1 |
| 8 | Exposure-Response Analysis in Patients With Schizophrenia to Assess the Effect of Asenapine on QTc Prolongation显示文摘 | Sunny Chapel Matt M. Hutmacher George Haig Howard Bockbrader Rik de Greef Sheldon H. Preskorn Richard L. Lalonde | 2009 | Journal of Clinical Pharmacology2009，，： | 1 |
| 9 | Current concepts in imaging of small bowel obstruction 显示文摘 | Maglinte DD Heitkamp DE Howard TJ | 2003 | Radiol Clin North Am2003，41，2： | 1 |
| 10 | Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta- analysis of longitudinal studies显示文摘 | Gami AS Witt BJ Howard DE | 2007 | J Am Coil Cardiol2007，49，4： | 1 |
| 11 | Day - night pattern of sudden death in obstructive sleep apnea 显示文摘 | Gami AS Howard DE Olson EJ | 2005 | N Engl J Med2005，352，12： | 1 |
| 12 | Ecotoxicity and uptake of polymer coated gold nanoparticles显示文摘 | K. Van Hoecke K. A. C. De Schamphelaere Z. Ali F. Zhang A. Elsaesser P. Rivera-Gil W. J. Parak G. Smagghe C. V. Howard C. R. Janssen | 2013 | Nanotoxicology2013，，1： | 1 |
| 13 | Antithrombotic therapy for atrial fibrillation:antithrombotic therapy and prevention of thrombosis, 9th ed: american college of chest physicians evidence-based clinical practice guidelines显示文摘 | You JJ Singer DE Howard PA | 2012 | Chest2012，141，2： | 1 |
| 14 | Antithrombotic therapy and prevention of thrombosis,9th ed:American college of chest physicians evidence-based clinical practice guidelines 显示文摘 | You JJ Singer DE Howard PA | 2012 | Chest2012，141，2： | 1 |
| 15 | Heart Disease and Stroke Statistics— 2010 Update: A Report From the American Heart Association显示文摘 | Donald Lloyd-Jones Robert J. Adams Todd M. Brown Mercedes Carnethon Shifan Dai Giovanni De Simone T. Bruce Ferguson Earl Ford Karen Furie Cathleen Gillespie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern P. Michael Ho Virginia Howard Brett Kissela Stev | 2010 | Circulation2010，，7： | 1 |
| 16 | Antithrombotic therapy for atrial fibrillation:antithrombotic therapy and prevention of thrombosis,9th ed:American College of Chest Physicians evidence-based clinical practice guidelines显示文摘 | You JJ Singer DE Howard PA | | 0，，2： | 1 |
| 17 | Calculation of particle trajectories in solid rocket motors with arbitrary acceleration显示文摘 | Jayant S Sabnis Frederik J de Jong Howard J Gibeling | 1992 | Journal of Propulsion and Power1992，8，5： | 1 |
| 18 | Heart Disease and Stroke Statistics— 2010 Update: A Report From the American Heart Association显示文摘 | Donald Lloyd-Jones Robert J. Adams Todd M. Brown Mercedes Carnethon Shifan Dai Giovanni De Simone T. Bruce Ferguson Earl Ford Karen Furie Cathleen Gillespie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern P. Michael Ho Virginia Howard Brett Kissela Stev | 2010 | Circulation2010，，7： | 1 |
| 19 | Proton-transfer chemical-ionization mass spectrometry allows real-time analysis of volatile organic compounds released from cutting and drying of crops显示文摘 | DE GOUW I A HOWARD C J CUSTER T G | 2000 | Environmental Science & Technology2000，34，12： | 1 |
| 20 | Functional analysis of pRb2/p130 interaction with cyclins 显示文摘 | CLAUDIO P P DE LUCA A HOWARD C M | 1996 | Cancer Res1996，56，9： | 1 |
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