|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Critical size limit of biodegradable nanopartides for enhanced lymph node trafficking and paracortex penetration显示文摘Lymph node (LN) targeti ng through interstitial drain age of nan oparticles (NPs) is an attractive strategy to stimulate a pote nt immune respo nse, as LNs are the primary site for lymphocyte priming by antigen presenting cells (APCs) and triggering of an adaptive immune response. NP size has been shown to influence the efficiency of LN-targeting and retention after subcutaneous injection. For clinical translation, biodegradable NPs are preferred as carrier for vaccine delivery. However, the selective 'size gateM for effective LN-drainage, particularly the kinetics of LN trafficking, is less well defined. This is partly due to the challenge in generating size-controlled NPs from biodegradable polymers in the sub-100-nm range. Here, we report the preparation of three sets of poly(lactic-co-glycolic)-b-poly(ethylene-glycol)(PLGA-b-PEG) NPs with number average diameters of 20-, 40-, and 100-nm and narrow size distributions using flash nanoprecipitation. Using NPs labeled with a near-infrared dye, we showed that 20-nm NPs drain rapidly across proximal and distal LNs following subcutaneous inoculation in mice and are retai ned in LNs more effectively than NPs with a nu mber average diameter of 40-nm. The drain age of 100-nm NPs was n egligible. Furthermore, the 20-nm NPs showed the highest degree of penetration around the paracortex region and had enhanced access to dendritic cells in the LNs. Together, these data confirmed that small, size-controlled PLGA-b-PEG NPs at the lower threshold of about 30-nm are most effective for LN trafficking, retention, and APC uptake after s.c. administration. This report could inform the design of LN-targeted NP carrier for the delivery of therapeutic or prophylactic vaccines. | Gregory P. Howard Garima Verma Xiyu Ke Winter M. Thayer Timothy Hamerly Victoria K. Baxter John E. Lee Rhoel R. Dinglasan Hai-Quan Mao | 2019 | Nano Research2019，12，4： | 3 |
| 2 | Cerebral infarction verified by cranial computed tomography and prognosis for survival following transient iscbemic attack显示文摘 | Evans GW Howard G Murros KE | 1991 | Stroke1991，22，4： | 1 |
| 3 | Cerebral Infarction verified by cranal computer tomography end prognosis for survival following TIA显示文摘 | Evans GW Howard GW Murros KE | 1991 | Stroke1991，29，4： | 1 |
| 4 | Alpha-quartz-induced chemokine expression by rat lung epithelial cells: effects of in vivo and in vitro particle exposure 显示文摘 | Driscoll KE Howard BW Carter JM | 1996 | Am J Pathol1996，149，5： | 1 |
| 5 | Expression by rat lung epithelial cells : effects of in vitro and in vivo mineral dust exposure显示文摘 | DRISCOLL KE HOWARD BW CARTER JM | 1996 | Am J Pathol1996，149，： | 1 |
| 6 | Oral immunization with recombinant listeria monocytogenes controls virus load after vaginal challenge with feline immunodeflciency virus 显示文摘 | Stevens R Howard KE Nordone S et at | 2004 | J Virol2004，78，15： | 1 |
| 7 | Cerebral infarction verified by cranial computed tomography and prognosis for survival following transient ischemic attack显示文摘 | Evans GW Howard G Murros KE | | Stroke0，，： | 1 |
| 8 | Cancer screening and age in the United States and Europe 显示文摘 | Howard D Richardson LC Thorpe KE | 2009 | Health Affairs2009，28，6： | 1 |
| 9 | Economics of mastitis control显示文摘 | Gill R Howard WH Leslie KE | 1990 | J Dairy Sci1990，73，： | 1 |
| 10 | The relationship of cata- ract and cataract extraction to age-related macular degenera- tion:the Beaver Dam Eye Study显示文摘 | Klein BE Howard KP Lee KE | 2012 | Ophthalmology2012，119，8： | 1 |
| 11 | Interleukin-10 regulates guartz-induced pulmonary inflammation in rats显示文摘 | Carter JM Howard BW | 1998 | Am J Physiol1998，275，： | 1 |
| 12 | Ethanol inhibits human bone cell proliferation and function in vitro显示文摘 | Friday KE Howard GA | 1991 | Metabolism1991，40，6： | 1 |
| 13 | Cerebral infarction verified by cranial computed tomography and prognosis for survival following transient ischemic attack显示文摘 | Vans GW Howard G Multos KE | 1991 | Stroke1991，22，： | 1 |
| 14 | The facilitation of picture naming in aphasia显示文摘 | Howard D Patterson KE Franklin S | 1985 | Cognitive Neuropsychology1985，2，： | 1 |
| 15 | Herceptin and Gemcitabine for Metastatic Pancreatic Cancers That Overexpress HER-2/ neu #显示文摘 | Howard Safran David Iannitti Ramesh Ramanathan Jonathan D. Schwartz Margaret Steinhoff Chris Nauman Paul Hesketh Ritesh Rathore Robert Wolff Umadevi Tantravahi Marilyn Hughes Chris Maia Terry Pasquariello Lisa Goldstein Thomas King James Y. Tsai Teresa Ke | 2004 | Cancer Investigation2004，，5： | 1 |
| 16 | The treatment of word retrieval deficits in aphasia:A comparison of two therapy methods显示文摘 | Howard D Patterson KE Franklin S | 1985 | Brain1985，108，： | 1 |
| 17 | Herceptin and Gemcitabine for Metastatic Pancreatic Cancers That Overexpress HER-2/ neu #显示文摘 | Howard Safran David Iannitti Ramesh Ramanathan Jonathan D. Schwartz Margaret Steinhoff Chris Nauman Paul Hesketh Ritesh Rathore Robert Wolff Umadevi Tantravahi Marilyn Hughes Chris Maia Terry Pasquariello Lisa Goldstein Thomas King James Y. Tsai Teresa Ke | 2004 | Cancer Investigation2004，，5： | 1 |
| 18 | Alpha - quartz - induced chemokine expression by rat lung epithelial cells: effects of in vivo and in vitro particle exposure显示文摘 | Driseoll KE Howard BW Carter JM | 1996 | AmJ Pathol1996，149，5： | 1 |
| 19 | Basal expression levels of IFNAR an Jak- STAT components are determinants of cell type specific differences cardiacantiviral responses 显示文摘 | Zurney J Howard KE Sherry B | 2007 | J Virol2007，81，13： | 1 |
| 20 | Visually-induced sickness in normal and bilaterally labyrinthine-defective subjects显示文摘 | Cheung BS Howard IP MoneyONE KE | 1991 | Aviat Space Environ Med1991，62，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员