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| 1 | SPIRIT 2013声明:定义临床研究方案的标准条目显示文摘临床研究方案是临床研究设计、实行、报告和评价的基础。然而,临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》(Standard Protocol Items:Recommendations for Interventional Trials 2013 ),简称SPIRIT2013声明,一个临床研究方案必须报告的条目指引的系统建立和范围。 | An-Wen Chan Jennifer M.Tetzlaff Douglas G.Altman Andreas Laupacis Peter C.GΦtzsche Karmela Krleza-Jeri AsbjΦrn Hróbjartsson Howard Mann Kay Dickersin Jesse A.Berlin Caroline J.Doré Wendy R.Parulekar William S.M.Summerskill Trish Groves Kenneth F.Schulz Harold C.Sox Frank W.Rockhold Drummond Rennie David Moher 钟丽丹 郑颂华 吴泰相 李幼平 商洪才 张伯礼 唐旭东 吕爱平 卞兆祥 | 2013 | 中国循证医学杂志2013，13，12： | 23 |
| 2 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 3 | Diabetes and Cardiovascular Disease: A Statement for Healthcare Professionals From the American Heart Association显示文摘 | Scott M. Grundy Ivor J. Benjamin Gregory L. Burke Alan Chait Robert H. Eckel Barbara V. Howard William Mitch Sidney C. Smith James R. Sowers | 1999 | Circulation1999，，10： | 3 |
| 4 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | The Lancet2014，，9911： | 3 |
| 5 | Executive Summary: Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association显示文摘 | Véronique L. Roger Alan S. Go Donald M. Lloyd-Jones Emelia J. Benjamin Jarett D. Berry William B. Borden Dawn M. Bravata Shifan Dai Earl S. Ford Caroline S. Fox Heather J. Fullerton Cathleen Gillespie Susan M. Hailpern John A. Heit Virginia J. Howard Bret | 2012 | Circulation2012，，1： | 2 |
| 6 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | 2014 (9911)2014，，9911： | 2 |
| 7 | The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease显示文摘 | Guy M. McKhann David S. Knopman Howard Chertkow Bradley T. Hyman Clifford R. Jack Claudia H. Kawas William E. Klunk Walter J. Koroshetz Jennifer J. Manly Richard Mayeux Richard C. Mohs John C. Morris Martin N. Rossor Philip Scheltens Maria C. Carrillo Bil | 2011 | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2011，，3： | 2 |
| 8 | Diabetes and Cardiovascular Disease: A Statement for Healthcare Professionals From the American Heart Association显示文摘 | Scott M. Grundy Ivor J. Benjamin Gregory L. Burke Alan Chait Robert H. Eckel Barbara V. Howard William Mitch Sidney C. Smith James R. Sowers | 1999 | Circulation1999，，10： | 2 |
| 9 | Thermal Expansion Coefficient and Mechanical Properties of Friction Stir Welded Invar (Fe-36%Ni)显示文摘 | Bharat K. Jasthi William J. Arbegast Stanley M. Howard | 2009 | Journal of Materials Engineering and Performance2009，，7： | 2 |
| 10 | Tissue oxygen tension as a predictor of colonic anastomotic healing显示文摘 | William G. Sheridan F.R.C.S.I. F.R.C.S. Richard H. Lowndes C.Biol. M.I.Biol. Mr. Howard L. Young Ch.M. F.R.C.S | 1987 | Diseases of the Colon & Rectum1987，，11： | 2 |
| 11 | The Influence of Total Nodes Examined, Number of Positive Nodes, and Lymph Node Ratio on Survival After Surgical Resection and Adjuvant Chemoradiation for Pancreatic Cancer: A Secondary Analysis of RTOG 9704显示文摘 | Timothy N. Showalter Kathryn A. Winter Adam C. Berger William F. Regine Ross A. Abrams Howard Safran John P. Hoffman Al B. Benson John S. MacDonald Christopher G. Willett | 2011 | International Journal of Radiation Oncology Biology Physics2011，，5： | 2 |
| 12 | Tissue oxygen tension as a predictor of colonic anastomotic healing显示文摘 | William G. Sheridan Richard H. Lowndes Howard L. Young | 1987 | Diseases of the Colon & Rectum1987，，： | 2 |
| 13 | Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer显示文摘 | Catherine S.M. Diefenbach Zharna Shah Alexia Iasonos Richard R. Barakat Douglas A. Levine Carol Aghajanian Paul Sabbatini Martee L. Hensley Jason Konner William Tew David Spriggs Martin Fleisher Howard Thaler Jakob Dupont | 2006 | Gynecologic Oncology2006，，： | 2 |
| 14 | A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance显示文摘 | Christopher B. Newgard Jie An James R. Bain Michael J. Muehlbauer Robert D. Stevens Lillian F. Lien Andrea M. Haqq Svati H. Shah Michelle Arlotto Cris A. Slentz James Rochon Dianne Gallup Olga Ilkayeva Brett R. Wenner William S. Yancy Howard Eisenson Gera | 2009 | Cell Metabolism2009，，4： | 2 |
| 15 | Using a distributed approach to relieve and integrate information from heterogeneous distributed databases显示文摘 | Hazem T EL-Khatib Howard Williams David H Matwick | 2002 | Computer Journal2002，45，4： | 1 |
| 16 | China's Re-tention Challenges 显示文摘 | Howard A Liu L Wellins R and Williams S | 2007 | Go Magazine2007，2，： | 1 |
| 17 | Factors control- ling riffle scale hyporheic exchange flows and their seasonal changes in a gaining stream z a three dimensional groundwater flow rnodel显示文摘 | Storey R G Howard K W F Williams D D | 2003 | Water Resources Research2003，39，2： | 1 |
| 18 | Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association显示文摘 | Michael Miller Neil J. Stone Christie Ballantyne Vera Bittner Michael H. Criqui Henry N. Ginsberg Anne Carol Goldberg William James Howard Marc S. Jacobson Penny M. Kris-Etherton Terry A. Lennie Moshe Levi Theodore Mazzone Subramanian Pennathur | 2011 | Circulation2011，，20： | 1 |
| 19 | Brompheniramine, loratadine, and placebo in allergic rhinitis: a placebo-controlled compatative clinical trial 显示文摘 | Howard M Druce MD William R | 1998 | J Clin Pharmacol1998，38，： | 1 |
| 20 | Incidence and Types of Adverse Events and Negligent Care in Utah and Colorado显示文摘 | Eric J. Thomas David M. Studdert Helen R. Burstin E. John Orav Timothy Zeena Elliott J. Williams K. Mason Howard Paul C. Weiler Troyen A. Brennan | 2000 | Medical Care2000，，3： | 1 |
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