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| 1 | Recurrence or metastasis of HCC:predictors,early detection and experimental antiangiogenic therapy显示文摘AIM To investigate the predictors forrecurrence or metastasis of HCC,and toevaluate the effect of antiangiogenic therapy onthe growth of transplantable human HCC in nudemice.METHODS RT-PCR was used to measure theexpression of matrix metalloproteinase-9(MMP-9)and vascular endothelial growth factor(VEGF)in 56 pairs of nontumorous liver andtumor samples.Sixty blood samples from humanHCC were examined by nested RT-PCR to find outAFP mRNA.Recombinant human endostatin andpolyclonal antibody against VEGF wereadministered to treat human HCC transplanted innude mice.RESULTS Thirty of 56 HCC samples showedstronger expression of MMP-9 in tumoroustissues than in nontumorous tissues.Fifteen ofthe 26 patients with relative expression level ofMMP-9 more than 0.34 developed tumorrecurrence or metastasis,whereas only 7 of 30patients with relative expression level less than0.34 developed tumor recurrence(P<0.05).There was no significant difference in therelative expression level of VEGF betweenpatients with postoperative recurrence ormetastasis and those without recurrence.AFPmRNA was detectable in 53.3% of patients withHCC.The sensitivity and specificity of AFPmRNA as a marker to detect hematogenousdissemination of HCC cells was 81.8% and84.4%,respectively.Recombinant human endostatin and polyclonal antibody against VEGFinhibited the growth of transplantable HCC innude mice by 52.2% and 45.7%,respectively.CONCLUSION MMP-9 expression in HCCcorrelates with the postoperative recurrence ormetastasis of HCC.Patients with high level ofMMP-9 expression in HCC are susceptible tometastasis.AFP mRNA could serve as anindicator of hematogenous spreading of HCCcells in circulation and a predictor of recurrenceor metastasis of HCC.Antiangiogenesis may bean adjuvant therapy for HCC. | Jiang YF Yang ZH Hu JQ | 2000 | World Journal of Gastroenterology2000，6，1： | 57 |
| 2 | Powder Microstructure and Overlay Coating Property ofNiCrAlY Alloy显示文摘这被显示出更好(20-30 亩 m ) 粉末粒子经历快速的复辉和热抽取到导致微细胞的结构的环境,而更粗糙(40-50 亩 m ) 因为慢冷却跟随的复辉,粉末粒子展出粗糙的细胞、树枝状的混合结构。另外,这也被显示越好粉末粒子尺寸,越 higher 机械性质并且冶金热稳定性过分,涂层由把同样分裂成原子的粉末扔了,它大概为粉末的好尺寸部分被归因于稠密的好谷物结构和氧化物层的形成。(编辑作者摘要) 9 个裁判员。 | Chang, XC Wang, JQ Hao, YY Hou, WL Hu, ZQ | 1998 | Journal of Materials Science & Technology1998，14，4： | 3 |
| 3 | Image fragile watermarking based on fusion of multi-resolution tamper detection显示文摘 | HU JQ HUANG JW HUANG DR | 2002 | Electronics Letters2002，38，24： | 1 |
| 4 | Gossypol inhibits phospho rylation of Bcl-2 in human leukemia HL-60 cells显示文摘 | Huang LH Hu JQ Tao WQ | 2010 | Eur J Phar- macol2010，645，13： | 1 |
| 5 | A summary index of infant and child feeding Wactices is associated with child growth in urban Shanghai显示文摘 | Ma JQ Zhou LL Hu YQ | 2012 | BMC Public Health2012，12，： | 1 |
| 6 | Hydrogen sulfide inhibits MPP +- induced apoptosis in PC12 cells显示文摘 | Yin WL He JQ Hu B | 2009 | Life Sci2009，85，： | 1 |
| 7 | Compression Testing of a SiCw/A1 Composite at Temperatures Close to and Above the Solidus of the Matrix Alloy显示文摘 | Geng L Ochiai S Hu JQ | 1998 | Materials Science and Engineering A1998，246，： | 1 |
| 8 | Targeted overexpression of vav3 oncogene in prostatic epithelium induces nonbacterial prostatitis and prostate eancer显示文摘 | Liu Y Mo JQ Hu Q | 2008 | Cancer Res2008，68，15： | 1 |
| 9 | Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis显示文摘 | Liu X Hu H Yin JQ | 2006 | Liver Int2006，26，3： | 1 |
| 10 | The characteristics of verapamil-sensitive idiopathic left ventricular taehycardia combined with a left accessory pathway and the effect of radiofrequency catheter ablation 显示文摘 | Hu JQ Ma J Yang Q | 2011 | Europace2011，10，： | 1 |
| 11 | Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis 显示文摘 | Liu X Hu H Yin JQ | 2006 | Liver Int2006，26，： | 1 |
| 12 | CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1显示文摘 | Ling JQ Li T Hu JF | 2006 | Science2006，312，5771： | 1 |
| 13 | Value of whole body diffusion weighted imaging in diagnostic and therapeutic evaluation cff malig- nant lymphoma显示文摘 | Hu XR Ran R Zhang JQ | 2011 | Chin G J Clin Oncol2011，10，2： | 1 |
| 14 | Study on microstructure of UV - curable polyurethane acrylate films 显示文摘 | Wang F Hu JQ Tu WP | 2008 | Prog Organ Coat2008，62，3： | 1 |
| 15 | Hydrogen sulfide inhibits MPP+-induced apoptosis in PC12 cells显示文摘 | Yin WL He JQ Hu B | | 0，，7： | 1 |
| 16 | A new pan-nitinol occluder for transcatheter closure of ventricular septal defects in a canine model显示文摘 | Ding ZR Qin YW Hu JQ | 2009 | J Interv Cardiol2009，22，： | 1 |
| 17 | Potential neurotoxicity of nanoparticles 显示文摘 | Hu YL Gao JQ | 2010 | Int JPharm2010，394，12： | 1 |
| 18 | Potential neurotoxicity of nanoparticles 显示文摘 | Hu YL Gao JQ | 2010 | Int J Pharmaeeuti2010，394，： | 1 |
| 19 | Therapeutic strategies against TGF - beta signa- ling pathway in hepatic fibrosis显示文摘 | Liu X Hu I-I Yin JQ | 2006 | Liver Int2006，26，1： | 1 |
| 20 | DDPH inhibited L-calcium current and sodium current in a single ventricular myocytes of guinea pig 显示文摘 | Qian JQ | 2001 | Acta Pharmacol Sin2001，22，5： | 1 |
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