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| 1 | Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes显示文摘 | Qiaozhen Liu Rui Yang Xiuzhen Huang Hui Zhang Lingjuan He Libo Zhang Xueying Tian Yu Nie Shengshou Hu Yan Yan Li Zhang Zengyong Qiao Qing-Dong Wang Kathy O Lui Bin Zhou | 2016 | Cell Research2016，26，1： | 12 |
| 2 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 3 | Accuracy of triage strategies for human papillomavirus DNA-positive women in low-resource settings:A cross-sectional study in China显示文摘Objective: Care HPV is a human papillomavirus(HPV) DNA test for low-resource settings(LRS).This study assesses optimum triage strategies for care HPV-positive women in LRS.Methods: A total of 2,530 Chinese women were concurrently screened for cervical cancer with visual inspection with acetic acid(VIA),liquid-based cytology and HPV testing by physician-and self-collected care HPV,and physician-collected Hybrid Capture 2(HC2).Screen-positive women were referred to colposcopy with biopsy and endocervical curettage as necessary.HPV-positivity was defined as ≥1.0 relative light units/cutoff(RLU/CO) for both care HPV and HC2.Primary physician-HC2,physician-care HPV and self-care HPV and in sequential screening with cytology,VIA,or increased HPV test-positivity performance,stratified by age,were assessed for cervical intraepithelial neoplasia(CIN) grade 2/3 or worse(CIN2/3+) detection.Results: The sensitivities and specificities of primary HPV testing for CIN2+ were: 83.8%,88.1% for physiciancare HPV; 72.1%,88.2% for self-care HPV; and 97.1%,86.0% for HC2.Physician-care HPV test-positive women with VIA triage had a sensitivity of 30.9% for CIN2+ versus 80.9% with cytology triage.Self-care HPV testpositive women with VIA triage was 26.5% versus 66.2% with cytology triage.The sensitivity of HC2 test-positive women with VIA triage was 38.2% versus 92.6% with cytology triage.The sensitivity of physician-care HPV testing for CIN2+ decreased from 83.8% at ≥1.0 RLU/CO to 72.1% at ≥10.00 RLU/CO,while the sensitivity of selfcare HPV testing decreased from 72.1% at ≥1.0 RLU/CO to 32.4% at ≥10.00 RLU/CO; similar trends were seen with age-stratification.Conclusions: VIA and cytology triage improved specificity for CIN2/3 than no triage.Sensitivity with VIA triage was unsuitable for a mass-screening program.VIA provider training might improve this strategy.Cytology triage could be feasible where a high-quality cytology program exists.Triage of HPV test-positive women by increased test positivity cutoff adds another LRS triage option. | Margaret Wang Shangying Hu Shuang Zha o Wenhua Zhang Qinjing Pan Xun Zhang FengChen Jinxiu Han Junfei Ma Jennifer S.Smith Youlin Qiao Caihong Zhou Fanghui Zhao | 2017 | Chinese Journal of Cancer Research2017，29，6： | 6 |
| 4 | Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium显示文摘 | Hui Zhang Xiuzhen Huang Kuo Liu Juan Tang Lingjuan He Wenjuan pu Qiaozhen Liu Yan Li Xueying Tian Yue Wang Libo Zhang Ying Yu Hongyan Wang Ronggui Hu Fengchao Wang Ting Chen Qing-Dong Wang Zengyong Qiao Li Zhang Kathy O Lui Bin Zhou | 2017 | Cell Research2017，27，9： | 6 |
| 5 | Polysaccharide-based nanomedicines for cancer immunotherapy:A review显示文摘Cancer immunotherapy is an effective antitumor approach through activating immune systems to eradicate tumors by immunotherapeutics.However,direct administration of“naked”immunotherapeutic agents(such as nucleic acids,cytokines,adjuvants or antigens without delivery vehicles)often results in:(1)an unsatisfactory efficacy due to suboptimal pharmacokinetics;(2)strong toxic and side effects due to low targeting(or off-target)efficiency.To overcome these shortcomings,a series of polysaccharide-based nanoparticles have been developed to carry immunotherapeutics to enhance antitumor immune responses with reduced toxicity and side effects.Polysaccharides are a family of natural polymers that hold unique physicochemical and biological properties,as they could interact with immune system to stimulate an enhanced immune response.Their structures offer versatility in synthesizing multifunctional nanocomposites,which could be chemically modified to achieve high stability and bioavailability for delivering therapeutics into tumor tissues.This review aims to highlight recent advances in polysaccharide-based nanomedicines for cancer immunotherapy and propose new perspectives on the use of polysaccharide-based immunotherapeutics. | Yujun Zeng Yufan Xiang Ruilong Sheng Helena Tomás João Rodrigues Zhongwei Gu Hu Zhang Qiyong Gong Kui Luo | 2021 | Bioactive Materials2021，6，10： | 3 |
| 6 | Late Paleozoic magmatism in South China:Oceanic subduction or intracontinental orogeny?显示文摘A gneissic granite with an U-Pb age of 313±4 Ma was found in northeastern Fujian Province,South China.It is an S-type granite characterized by high K2O,Al2O3 and low SiO2,Na2O contents with high A/CNK ratio of 1.22 for the whole rock.Zircons with stubby morphology from the gneissic granite yield 206 Pb/238 U ages ranging from 326 to 301 Ma with a weighted average age of 313±4 Ma,and negative εHf(t) values from -8.35 to -1.74 with Hf model ages (TCDM) of 1.43 to 1.84 Ga.This S-type granite probably originated from late Paleoproterozoic crust in intracontinental orogeny.Integrated with previous results on paleogeographic reconstruction of South China,the nature of Paleozoic basins,Early Permian volcanism and U-Pb-Hf isotope of detrital zircons from the late Paleozoic to early Mesozoic sedimentary rocks,we suggest the occurrence of a late Paleozoic orogeny in the eastern Cathaysia Block,South China.This orogenic cycle includes Late Carboniferous (340-310 Ma) orogeny (compression) episode and Early Permian (287-270 Ma) post-orogenic or intraplate extension episode.Therefore,the late Paleozoic magmatism in the southeastern South China probably occurred during the intraplate orogeny rather than the arc-related process. | YU JinHai LIU Qian HU XiuMian WANG Qin O'REILLY Suzanne Y | 2013 | Science China(Technological Sciences)2013，56，3： | 2 |
| 7 | Hepatitis B virus X protein is both a substrate and a potential inhibitor of the proteasome complex 显示文摘 | Hu ZY Zhang ZS Doo E Coux O Goldberg AL Liang TJ | 1999 | J Virol1999，73，9： | 1 |
| 8 | Pulp and perio- dontal healing, root development and root resorption subsequent to transplantation anc显示文摘 | Paulsen HU Andreasen JO Schwartz O | 1995 | Am J Orthod Dentofacial Orthop1995，108，6： | 1 |
| 9 | Separation of muscle membrane from alkali-solubilized fish muscle proteins显示文摘 | Liang Y Hu]tin H O | 2005 | Journal of Agricultural and Food Chemistry2005，53，10： | 1 |
| 10 | Polymorphisms in CYP1B1,GSTM1,GSTT1 and GSTP1,and susceptibility to breast cancer显示文摘 | VAN EMBURGH B O HU J J LEVINE E A | | 0，，05： | 1 |
| 11 | Renal and extrarenal actions of Klotho显示文摘 | Hu MC Kuro- o M Moe OW | 2013 | Semin Nephrol2013，33，2： | 1 |
| 12 | A survey of outcomes and management of patients post fragility fractures in China 显示文摘 | WANG O HU Y GONG S | 2015 | Osteoporos Int2015，26，11： | 1 |
| 13 | Pilot field-scale demonstration of a novel alum sludge-based constructed wetland system fir enhanced wastewater treatment 显示文摘 | Zhao Y Q Babatunde A O Hu Y S | 2011 | Process Biochcm2011，46，1： | 1 |
| 14 | Water entry an- dexit of a horizontal circular cylinder显示文摘 | Zhu X Y Faltinsen O M Hu C H | 2007 | Journal of Offshore Mechanics and Arctic Engineering2007，129，2： | 1 |
| 15 | Thermal history and tectonic subsidence of the Bohai Basin, northern China: a Cenozoic rifted and local pull-apart basin 显示文摘 | Hu Shengbiao O' Sullivan P B Raza A | 2001 | Physics of Earth and Planetary Interiors2001，126，34： | 1 |
| 16 | All natural composite sandwich beams for structural applications显示文摘 | Dweib M A Hu B O'Donnell A | 2004 | Compos Stmct2004，63，： | 1 |
| 17 | Study of formation behavior of TiC in the Fe-Ti-C system during combustion synthesis 显示文摘 | Zhang M X Hu O D Huang B | 2011 | Refractory Material and Hard Materials2011，，29： | 1 |
| 18 | Unique layered double hydroxide morphologies using reverse microemulsion synthesis显示文摘 | HU Gang O' HARE D | 2005 | Journal of American Chemistry Society2005，127，17： | 1 |
| 19 | A current sensor based on the giant magnetoresistance effect: Design and potential smart grid applications显示文摘 | YONG O Y HE J L HU J | 2012 | Sensors2012，12，15： | 1 |
| 20 | Document configuration control processes captured in a worktlow 显示文摘 | Ba E H Hu W C Yo O W S | 2004 | Computers in Industry2004，53，2： | 1 |
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