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| 1 | Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes显示文摘 | Qiaozhen Liu Rui Yang Xiuzhen Huang Hui Zhang Lingjuan He Libo Zhang Xueying Tian Yu Nie Shengshou Hu Yan Yan Li Zhang Zengyong Qiao Qing-Dong Wang Kathy O Lui Bin Zhou | 2016 | Cell Research2016，26，1： | 12 |
| 2 | The Discovery of Natural Native Uranium and Its Significance显示文摘This study analyzed the composition and uranium valence of pitchblendes sampled from the hydrothermal Guidong and Zhuguang uranium deposits of the middle Nanling metallogenic belt, Southern China using X-ray photoelectron spectroscopy(XPS).A revolutionary discovery is that the uranium not only exists in the forms of tetravalent and hexavalent uranium oxides, but also occurs in the form of native uranium.This is the first discovery of the existence of native uranium in nature.It greatly helps to reveal the origin of hydrothermal mineralization of uranium, and also has great significance for studying the thermal energy, formation and evolution of the earth. | LI Ziying HUANG Zhizhang LI Xiuzhen GUO Jian FAN Chou | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 8 |
| 3 | Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium显示文摘 | Hui Zhang Xiuzhen Huang Kuo Liu Juan Tang Lingjuan He Wenjuan pu Qiaozhen Liu Yan Li Xueying Tian Yue Wang Libo Zhang Ying Yu Hongyan Wang Ronggui Hu Fengchao Wang Ting Chen Qing-Dong Wang Zengyong Qiao Li Zhang Kathy O Lui Bin Zhou | 2017 | Cell Research2017，27，9： | 6 |
| 4 | TRIM14 promotes endothelial activation via activating NF-κB signaling pathway显示文摘Endothelial activation by proinflammatory cytokines is closely associated to the pathogenesis of atherosclerosis and other vascular diseases;however, the molecular mechanisms controlling endothelial activation are not fully understood. Here we identify TRIM14 as a new positive regulator of endothelial activation via activating NF-κB signal pathway. TRIM14 is highly expressed in human vascular endothelial cells (ECs) and markedly induced by inflammatory stimuli such as TNF-α, IL-1β, and LPS. Overexpression of TRIM14 significantly increased the expression of adhesion molecules such as VCAM-1, ICAM-1, E-selectin, and cytokines such as CCL2, IL-8, CXCL-1, and TNF-α in activated ECs and by which it facilitated monocyte adhesion to ECs. Conversely, knockdown of TRIM14 has opposite effect on endothelial activation. Upon TNF-α stimulation, TRIM14 is recruited to IKK complex via directly binding to NEMO and promotes the phosphorylation of IκBα and p65, which is dependent on its K63-linked ubiquitination. Meanwhile, p65 can directly bind to the promoter regions of human TRIM14 gene and control its mRNA transcription. Finally, TRIM14 protein level is significantly upregulated in mouse and human atheroma compared to normal arteries. Taken together, these results indicate that TRIM14-NF-κB forms a positive feedback loop to enhance EC activation and TRIM14 may be a potential therapeutic target for vascular inflammatory diseases such as atherosclerosis. | Xuan Huang Yong Li Xiuzhen Li Daping Fan Hong-Bo Xin Mingui Fu | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 5 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013，23，9： | 3 |
| 6 | Occurrence and transfer of heavy metals in sediments and plants of Aegiceras corniculatum community in the Qinzhou Bay,southwestern China显示文摘Mangrove wetlands can reduce heavy metal pollution by trapping heavy metals.In this study,the concentration,transport and bioaccumulation of Cr,Cd,Cu,Zn and Pb in the sediments and different parts of Aegiceras corniculatum at four different sites in the Qinzhou Bay in southwestern China were investigated.The results showed that although the potential ecological risk of all five heavy metals was slight,the concentration of Cr was at a moderate pollution level due to the emissions of industries and aquaculture waste water.Core sediment records indicated that the concentrations of heavy metals at the depth of 0–20 cm were relatively high,showing an increasing trend of heavy metals over the past 20–30 years.Cr,Cu,Pb and Cd accumulated mainly in the roots of A.corniculatum,while Zn accumulated mainly in the stems.Aegiceras corniculatum showed the strongest transport capacity for Zn and Cu and the strongest bioaccumulation ability for Cd.Compared with other mangrove communities,A.corniculatum can be chosen as a restoration species in tropical and subtropical coastal zones polluted by Zn,Cu and Cd. | Xing Huang Xueping Wang Xiuzhen Li Zhongzheng Yan Yongguang Sun | 2020 | Acta Oceanologica Sinica2020，39，2： | 2 |
| 7 | Epicardium-to-fat transition in injured heart显示文摘 | Qiaozhen Liu Xiuzhen Huang Jin-Hee Oh Ruei-Zeng Lin Shengzhong Duan Ying Yu Rui Yang Ju Qiu Juan M Melero-Martin William T Pu Bin Zhou | 2014 | Cell Research2014，24，11： | 2 |
| 8 | Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth显示文摘 | Yi Li Huan Zhao Xiuzhen Huang Juan Tang Shaohua Zhang Yan Li Xiuxiu Liu Lingjuan He Zhengyu Ju Kathy O. Lui Bin-Zhou | 2018 | Cell Research2018，28，7： | 2 |
| 9 | Multifunctional Reduced Graphene Oxide Hydrogel as Drug Carrier for Localized and Synergic Photothermal/Photodynamics/Chemo Therapy显示文摘To combine localized drug release with multimodal therapy for malignant tumor, a composite hydrogel as an integrative drug delivery system was facilely prepared. The system contains spinach extract(SE),reduced graphene oxide(r GO) and gold nanocages(Au NCs). SE conduces to the formation of hydrogel,and also serves as a green material for improving the biocompatibility of hydrogel, and a natural photosensitizer for killing tumor cells under laser radiation(660 nm). Au NCs show obvious photothermy and can enhance the generation of cytotoxic singlet oxygen(1O2). The composite hydrogel shell on tumor cells exhibits several competitive advantages including enhanced antitumor effect by retaining the high concentration of drugs around cancer cell, excellent PDT/PTT compatibility as well as high loading and controllable release of fluorouracil(5-FU) for synergetic multimodal treatment. The survival rate of He La cells incubated with 5-FU loaded hydrogel under NIR radiation for 10 min sharply decreases to 1.2%, indicating remarkably improved antitumor effects. These results demonstrate that the hydrogel is an excellent delivery carrier for localizable, NIR-responsive and combined PTT/PDT/Chemo synergetic antitumor. | Guanru Chang Shikuo Li Fangzhi Huang Xiuzhen Zhang Yuhua Shen Anjian Xie | 2016 | Journal of Materials Science & Technology2016，32，8： | 1 |
| 10 | Optimization of Ultrasonic Extraction Process of Oenanthe benghalensis Polysaccharide by Orthogonal Test显示文摘[Objectives] The research aimed to explore extraction method of Oenanthe benghalensis polysaccharide,and determine the optimal process of its ultrasonic extraction by orthogonal test. [Methods] Phenol-sulfuric acid method was used to determine polysaccharide's content. Based on single-factor experiment and orthogonal test,the influences of solid-liquid ratio( A),ultrasonic extraction temperature( B),ultrasonic power( C) and ultrasonic time( D) on extraction rate of O. benghalensis polysaccharide were studied,and the optimal process of ultrasonic extraction was selected. [Results] The influence order of solid-liquid ratio( A),ultrasonic extraction temperature( B),ultrasonic power( C) and ultrasonic time( D) on extraction rate of O. benghalensis polysaccharide was A > D > B > C. Via the orthogonal test,it was determined that the optimal extraction condition of O. benghalensis polysaccharide was as below: solid-liquid ratio 1∶ 25( g/mL),extraction temperature 60℃,extraction power 80 W,extraction time 40 min. Under the condition,extraction rate of O. benghalensis polysaccharide was9. 80%. [Conclusions] The process could provide the reference basis for extracting and producing O. benghalensis polysaccharides. | Liufu LU Aiyue LUO Bingyang LIN Zhenlian XIE Guangyu GAN Xiuzhen HUANG Zhidong LEI Shimei CHEN Suoyi HUANG | 2018 | Medicinal Plant2018，9，5： | 1 |
| 11 | The growth and Cu and Zn uptake of pakchois (Brassica chinesis L.) in an acidic soil as affected by chicken or pig manure显示文摘 | Xiuzhen Hao Dongmei Zhou Deqian Huang Hailin Zhang Yujun Wang | 2007 | Journal of Environmental Science and Health Part B2007，，8： | 1 |
| 12 | Apolynomial-time approximation scheme for the minimum-connected dominating set in ad hoc wireless networks 显示文摘 | Cheng Xiuzhen Huang Xiso Li Deying | 2003 | Networks2003，42，2： | 1 |
| 13 | Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death显示文摘 | Long Chen Baoshan Xu Lei Liu Yan Luo Hongyu Zhou Wenxing Chen Tao Shen Xiuzhen Han Christopher D. Kontos Shile Huang | 2010 | Free Radical Biology and Medicine2010，，5： | 1 |
| 14 | A Polynomial-time Approximation Scheme for the Minimum-connected Dominating Set in Ad hoc Wireless Networks显示文摘 | Cheng Xiuzhen Huang Xiao Li Deying | 2003 | Networks2003，42，4： | 1 |
| 15 | Waterlogging risk assessment for winter wheat using multi-source data in the middle and lower reaches of Yangtze River显示文摘Waterlogging is a serious agro-meteorological disaster caused by excessive soil water,which usually causes tremendous crop yield losses.The region of middle and lower reaches of Yangtze River in China is an important production base of winter wheat,and is an area prone to waterlogging.The risk assessment of winter wheat waterlogging can provide more thorough understanding about the risk-prone environment related with food safety in this region.This study combined a variety of environmental and agricultural factors and assessed the waterlogging risk of winter wheat from the aspects of sensitivity of hazard formative environments,hazard risk,and vulnerability of hazard-affected body using multi-source data.Furthermore,it constructed a compound waterlogging risk assessment model to classify the study area into high,relatively high,moderate,and low risky areas,respectively.The results showed that the proposed model could more comprehensively reflect the occurrence mechanism of winter wheat waterlogging by synchronizing geographical,agricultural,and meteorological factors.The waterlogging regionalization based on the model could reasonably represent the spatial distribution and differentiate regional characteristics of winter wheat waterlogging in the study area. | Yuanyuan Chen Jingfeng Huang Xiaodong Song Hongyan Wu Shaoxue Sheng Zhixiong Liu Xiuzhen Wang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，5： | 0 |
| 16 | Effect of inguinal hernia on the thickness and blood flow of spermatic cord in boys显示文摘Objective To evaluate the effect of inguinal hernia(IH)on the spermatic cord using spermatic cord ultrasonography(SCU).Methods From January 2016 to January 2017,boys with IH who received SCU at the start of open herniorrhaphy(OH)were enrolled in this study.The age and weight at SCU,width of the spermatic cord(SC-W),peak systolic velocity(PSV)in the spermatic artery(SA-PSV)and velocity in the pampiniform plexus(PP-V),and the interval between the initial and the second OH in boys with metachronous inguinal hernia(MIH)were recorded,and the relationship among them was studied.Boys with unilateral IH comprised the IH group,and boys with MIH comprised the MIH group.Boys with polydactylism served as the control.One-way analysis of variance tested the differences among groups.Spearman’s r tested the relationship between SC-W in the MIH group and the interval.results A total of 80 boys were enrolled in this study(IH group 29,MIH group 26,and control group 25).SA-PSV and PP-V in the hernia side were faster and slower than the control,respectively.There was no significant difference in PP-V and SA-PSV of the treated side in the MIH group and in the control group.After herniorrhaphy,SC-W was tapered down to normal size.SC-W,SA-PSV,and PP-V in the treated side were all highly correlated to the interval in a curvilinear manner.Conclusion PSV was positively correlated with SC-W in boys with IH,and PP-V was negatively correlated;herniorrhaphy could reverse the impairment. | Shoujiang Huang Canping Li Xiuzhen Yang Jianfeng Liang Dongpi Wang | 2019 | World Journal of Pediatric Surgery2019，2，2： | 0 |
| 17 | Studies on high-yielding cultivation of rice in Guangdong by diagnosis and control of chlorophyll content and LAI显示文摘During the 1970's and 1980's studies on the rela-tion between LAI and yield had been carried out inGAAS.The main results were as follows:(1)Usingthe accumulated LAI value at three stages,i.e.panicle initiation(PI),heading(H)and 20 d afterheading(H_(20)),to analyze the relation between LAIand yield was more accurrate than only using theLAI value at H stage(see table);(2)Reaching cer- | LIN Xiuzhen HUANG Qiumei TU Zengping Rice Research Institute,Guangdong Academy of Agricultural Sciences(GAAS),Guangzhou 510640,China | 1991 | Chinese Rice Research Newsletter1991，，2： | 0 |
| 18 | A Genetic-Algorithm-Based Information Evolution Model for Social Networks显示文摘the existing information diffusion models focus on analyzing the spatial distribution of certain pieces of messages in social networks. However, these conventional models ignored another important characteristic of diffusion: gradually changing of message contents due to the ‘new' and ‘comment' mechanisms. A novel genetic-algorithm-based information evolution model is proposed to reproduce both the diffusion and development process of information in social networks. This model firstly proposes a five-tuple to represent three types of topics: independent, competitive and mutually exclusive. Furthermore, it adopts mutation operator and forms new crossover and mutation rules to simulate four typical interactions between individuals, which bring the advantage of reproducing the information evolution process in both popularity and content.A series of experiments tested on public datasets demonstrate that: 1) independent and competitive topics of information rarely affect each other while mutually exclusive topics significantly suppress the diffusion processes of each other; 2) lower mutation probability leads to decreasing of final information amount. The experimental results show that our evolution model is more reasonable and feasible in demonstrating the evolution of information in social networks. | Yanan Wang Xiuzhen Chen Jianhua Li Wanyu Huang | 2016 | China Communications2016，13，12： | 0 |
| 19 | Transcriptome profile analysis of the accompanying migratory parasitic wasp Aenasius bambawalei(=Aenasius arizonensis girault)(Hymenoptera:Encyrtidae):Genes related to fertilization involved at different stage of ovary development显示文摘Age-related declines in fertilization success have been reported for a wide range of species.The fertilization of parasitic wasps is closely related to egg production and sperm storage.Aenasius bambawalei(Hymenoptera:Encyridae)is a key parasitic wasp of the important invasive mealybug Phenacoccus solenopsis(Hemiptera:Pseudococcidae).The female offspring ratio of this parasitic wasp was declined with parental age in mass rearing under laboratory conditions.To investigate the molecular mechanisms involved in the reproduction of A.bambawalei,an extensive analysis of the impact of age on transcriptome profile of mated ovaries of this wasp was performed by comparing the gene expression profiles of various maternal ages:the early stage(ES),the intermediate stage(IS),and the advanced stage(AS).In total,358 differentially expressed genes were identified,with 17.60%(63 genes)of the changes associated with greater expression in fertilization.Moreover,the expression of serine protease 47 precursor,serine protease inhibitor 3/4,glucose dehydrogenase,fatty acyl-CoA reductase 1-like,major royal jelly,and acyl-CoA delta(11)desaturase-like was detected by real-time fluorescence quantitative(RT-qPCR).The results showed that fertilization related genes exhibited a stage-specific pattern.Egg production and sperm storage genes in A.bambawalei were significantly modified in the transcriptome,providing a starting point for the genetic dissection of fertilization. | JUAN ZHANG JUN HUANG YAYUAN TANG XIUZHEN LONG | 2022 | BIOCELL2022，46，1： | 0 |
| 20 | Real- and momentum-indirect neutral and charged excitons in a multi-valley semiconductor显示文摘Excitons dominate the photonic and optoelectronic properties of a material.Although significant advancements exist in understanding various types of excitons,progress on excitons that are indirect in both real-and momentum-spaces is still limited.Here,we demonstrate the real-and momentum-indirect neutral and charged excitons(including their phonon replicas)in a multi-valley semiconductor of bilayer MoS_(2),by performing electric-field/doping-density dependent photoluminescence.Together with first-principles calculations,we uncover that the observed real-and momentum-indirect exciton involves electron/hole from K/Γvalley,solving the longstanding controversy of its momentum origin.Remarkably,the binding energy of real-and momentum-indirect charged exciton is extremely large(i.e.,~59 meV),more than twice that of real-and momentum-direct charged exciton(i.e.,~24 meV).The giant binding energy,along with the electrical tunability and long lifetime,endows real-and momentum-indirect excitons an emerging platform to study many-body physics and to illuminate developments in photonics and optoelectronics. | Zhiheng Huang Yuhui Li Tao Bo Yanchong Zhao Fanfan Wu Lu Li Yalong Yuan Yiru Ji Le Liu Jinpeng Tian Yanbang Chu Xiaozhou Zan Yalin Peng Xiuzhen Li Yangkun Zhang Kenji Watanabe Takashi Taniguchi Zhipei Sun Wei Yang Dongxia Shi Shixuan Du Luojun Du Guangyu Zhang | 2023 | National Science Open2023，2，4： | 0 |
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