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| 1 | Challenges and strategies in high-accuracy manufacturing of the world’s largest SiC aspheric mirror显示文摘In the process of manufacturing the world’s largest silicon carbide(SiC)aspheric mirror,the primary difficulties are mirror blank preparation,asphere fabrication,and testing,as well as cladding and coating.Specifically,the challenges include the homogeneity of the complicated structure casting,accuracy and efficiency of the fabrication process,print-through effect,fidelity and precision of test procedure,stress and denseness of cladding process,the dynamic range of interferometric measurement,and air turbulence error due to the long optical path.To break through such a barrier of difficulties,we proposed the water-soluble room temperature vanishing mold and gel casting technology,homogeneous microstructure reaction-formed joint technology,nano-accuracy efficient compound fabrication,gravity unloading technology,high-denseness low-defect physical vapor deposition(PVD)Si-cladding technology,test data fusion method,and time-domain averaging method,etc.Based on the proposed technologies and methods,we have accomplished the world’s largest SiC aspheric mirror with a size of φ4.03 m.The impressive performance of the SiC aspheric mirror is validated by the characteristics of the fabricated SiC aspheric mirror.The aerial density of the SiC blank is less than 120 kg/m^(2),surface shape test accuracy is better than 6 nm RMS,thickness inhomogeneity of the cladding layer is less than 5%,and the final surface figure error and roughness are 15.2 nm RMS and 0.8 nm RMS,respectively. | Xuejun Zhang Haixiang Hu Xiaokun Wang Xiao Luo Ge Zhang Wenxing Zhao Xiaoyi Wang Zhenyu Liu Ling Xiong Erhui Qi Congcong Cui Yanchao Wang Yingjie Li Xu Wang Longxiang Li Yang Bai Qiang Cheng Zhiyu Zhang Ruigang Li Wa Tang Xuefeng Zeng Weijie Deng Feng Zhang | 2022 | Light(Science & Applications)2022，11，12： | 3 |
| 2 | CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development显示文摘尽管 HCO 3− 被知道为早胚胎开发被要求,它的准确角色留下逃犯。这里,我们报导 HCO 3− 在在 preimplantation 胚胎开发期间通过调停 CFTR 的流入调整 miR-125b 表示充当环境暗示。结果证明在 preimplantation 胚胎开发的 HCO 3− 的效果能被介入压制一条 HCO 3−-conducting 隧道的函数, CFTR,由一个特定的禁止者或基因大美人。细胞外的 HCO 3− 的移动或 CFTR 的抑制在 2 个房间阶段老鼠胚胎减少 miR-125b 表示。miR-125b 击倒模仿 HCO 3− 移动和 CFTR 抑制的效果,当 miR-125b 先锋的注射颠倒它时。在人和老鼠胚胎的 miR-125b upregulates p53 串联的 Downregulation。miR-125b 的激活被显示被 sAC/PKA-dependent 调停 NF-κ 的原子 shuttling; B。这些结果在在 preimplantation 胚胎开发期间连接环境 HCO 3− 到 miR-125b 的激活的信号 transduction 揭示了 CFTR 的一个关键角色并且在 miRNAs 的规定显示了离子隧道的重要性。 | Yong Chao Lu Hui Chen Kin Lam Fok Lai Ling Tsang Mei Kuen Yu Xiao Hu Zhang Jing Chen Xiaohua Jiang Yiu Wa Chung Alvin Chun Hang Ma Anskar Yu Hung Leung He Feng Huang Hsiao Chang Chan | 2012 | Cell Research2012，22，10： | 2 |
| 3 | Dual role for nitric oxide in dynorphin spinal neurotoxicity显示文摘 | Hu WH Li F Qiang WA | 1999 | J Neurotrauma1999，16，1： | 1 |
| 4 | Sonochemical and microwave-assisted synthesis of linked single-crystalline ZnO rods显示文摘 | Hu X L Zhu Y J Wa S W | 2004 | Mater Chem Phys2004，88，： | 1 |
| 5 | Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype显示文摘 | Kan L Hu M Gomes WA | 2004 | Am T Pathol2004，165，4： | 1 |
| 6 | Regional differences in distribution and functional expression of smal-conductance Ca2+-activated K+channels in rat brain显示文摘 | Sailer CA Hu H Kaufmann WA Trieb M Schwarzer C Storm JF | 2002 | J Neurosci2002，22，22： | 1 |
| 7 | Aptamer in Bioanalytical Applications显示文摘 | Iliuk AB Hu L Tao WA | | 0，，12： | 1 |
| 8 | Prevalence of gsp oncogenes in Chinese acromegalic patients 显示文摘 | Lei T Bai XJ Hu WA | 1998 | Zentralbl Neurochir1998，，： | 1 |
| 9 | Effect of Khat on apoptosis and related gene Smac/DIABLO expression in the cerebral cortex of rats following transient focal ischemia显示文摘 | Alsharafi WA Bi F Hu Y | 2015 | Environ- mental Toxicology and Pharmacology2015，39，1： | 1 |
| 10 | Impact of psychoparameters on quality of life in patients with irritable bowel syndrome 显示文摘 | Wang WA He JQ Hu PJ | 2004 | Word Chin J Digestol2004，12，7： | 1 |
| 11 | A New Tracking System for Three Magnetic Objectives 显示文摘 | Yang WA Hu C Li M | 2010 | IEEE Transactions on Magnetics2010，46，12： | 1 |
| 12 | Dural role for nitric oxide in dynorphin s pinal neurotoxicity显示文摘 | Li F Qiang WA | 1999 | J Neurotrauma1999，16，1： | 1 |
| 13 | Aptamer in bioanalytical applications显示文摘 | Iliuk AB Hu L Tao WA | | 0，，12： | 1 |
| 14 | Expression, secretion and functional characterization of three laccases in E. coli显示文摘Endocrine Disrupting Chemicals(EDCs)are a group of molecules that can influence hormonal balance,causing disturbance of the reproductive system and other health problems.Despite the efforts to eliminate EDC in the environment,all current approaches are inefficient and expensive.In previous research,studies revealed that laccase-producing microorganisms may be a potential candidate for EDC degradation,as laccases have been found to be able to degrade many kinds of EDCs effectively and steadily.Here,we created two recombinant laccases,each fused with secretion peptide,Novel Signal Peptide 4(NSP4),and expressed them in Escherichia coli(E.coli,BL21),together with one laccase without secretion peptide.We first optimized the culture condition of expressing these laccases.Then,we test the activity of the recombinant laccases of decolorizing of a synthetic dye,indigo carmine.Finally,we confirmed the secreted can degrade one of the EDCs,β-estradiol,showing the potential of using the laccase secretion system to degrade toxic compounds. | Yating Mo Hou Ip Lao Sau Wa Au Ieng Chon Li Jeremy Hu Hoi Man Yuen Wai Man Cheong Owen Lok In Lo Leo Chi U.Seak | 2022 | Synthetic and Systems Biotechnology2022，7，1： | 1 |
| 15 | Dual role for nitric oxide in dynorphm spinal neurotoxicity 显示文摘 | Hu WH Li F Qiang WA | 1999 | Jourual of Neuro- trauma1999，16，1： | 1 |
| 16 | Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype 显示文摘 | Kan L Hu M Gomes WA | 2004 | Am J Pathol2004，165，： | 1 |
| 17 | Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phonotype显示文摘 | Kan L Hu M Comes WA | 2004 | Am J Patbo12004，165，4： | 1 |
| 18 | Pooled analysis of the performance of liquid‐based cytology in population‐based cervical cancer screening studies in China显示文摘 | Qin‐Jing Pan Shang‐ying Hu Xun Zhang Pu‐wa Ci Wen‐hua Zhang Hui‐qin Guo Jian Cao Fang‐hui Zhao Alice Lytwyn You‐lin Qiao | 2013 | Cancer Cytopathology2013，，9： | 1 |
| 19 | Functional magnetic resonance imaging as a management tool for cerebral AVM 显示文摘 | Latchaw RE Hu X Hall WA | 1995 | J Neurosurgery1995，37，4： | 1 |
| 20 | Transgenic mice overex-pressing BMP4 develop a fibrodysplasia ossificans progressiva(FOP)-like phenotype显示文摘 | Kan L Hu M Gomes WA | 2004 | Am J Pathol2004，165，4： | 1 |
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