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	题名	作者	年代	出处	被引量
1	Recurrence or metastasis of HCC:predictors,early detection and experimental antiangiogenic therapy显示文摘AIM To investigate the predictors forrecurrence or metastasis of HCC,and toevaluate the effect of antiangiogenic therapy onthe growth of transplantable human HCC in nudemice.METHODS RT-PCR was used to measure theexpression of matrix metalloproteinase-9(MMP-9)and vascular endothelial growth factor(VEGF)in 56 pairs of nontumorous liver andtumor samples.Sixty blood samples from humanHCC were examined by nested RT-PCR to find outAFP mRNA.Recombinant human endostatin andpolyclonal antibody against VEGF wereadministered to treat human HCC transplanted innude mice.RESULTS Thirty of 56 HCC samples showedstronger expression of MMP-9 in tumoroustissues than in nontumorous tissues.Fifteen ofthe 26 patients with relative expression level ofMMP-9 more than 0.34 developed tumorrecurrence or metastasis,whereas only 7 of 30patients with relative expression level less than0.34 developed tumor recurrence(P<0.05).There was no significant difference in therelative expression level of VEGF betweenpatients with postoperative recurrence ormetastasis and those without recurrence.AFPmRNA was detectable in 53.3% of patients withHCC.The sensitivity and specificity of AFPmRNA as a marker to detect hematogenousdissemination of HCC cells was 81.8% and84.4%,respectively.Recombinant human endostatin and polyclonal antibody against VEGFinhibited the growth of transplantable HCC innude mice by 52.2% and 45.7%,respectively.CONCLUSION MMP-9 expression in HCCcorrelates with the postoperative recurrence ormetastasis of HCC.Patients with high level ofMMP-9 expression in HCC are susceptible tometastasis.AFP mRNA could serve as anindicator of hematogenous spreading of HCCcells in circulation and a predictor of recurrenceor metastasis of HCC.Antiangiogenesis may bean adjuvant therapy for HCC.	Jiang YF Yang ZH Hu JQ	2000	World Journal of Gastroenterology2000，6，1：	57
2	CYP3A5 * 3 and CYP3A4 * 18 single nucleotide polymorphisms in a Chinese population显示文摘	Hu YF He J Chen GL etal	2005	Clin Chem Acta2005，353，12：	1
3	CYP3A53 and CYP3A418 single nucleotide polymorphisms in a Chinese population显示文摘	Hu YF He J Chen GL	2005	Clin Chim Acta2005，353，12：	1
4	Effect of intravenous immunoglobulin and vitamin C on progression of experimental autoimmune myocarditis in mice显示文摘	Hu YF Gong FQ Chen LQ	2008	Zhejiang Da Xue Xue Bao2008，37，4：	1
5	Genetic polymorphisms of phase II metabolic enzymes and lung cancer susceptibility in a population of Central South China显示文摘	Chen HC Cao YF Hu WX	2006	Dis Markers2006，22，3：	1
6	The gain-of-function 17: a double-edged sword between thrombosis and bleeding in clopidogrel-treated patients 显示文摘	Li Y Tang HL Hu YF variant allele CYP2C19 *	2012	J Thromb Haemost2012，10，2：	1
7	Progression of inflammatory bowel disease in China显示文摘	Wang YF Ouyang Q Hu RW	2010	Dig Dis2010，11，：	1
8	Treatment of vitiligo by transplantation of cultured pure melanocyte suspension:analysis of 120 cases显示文摘	Chen YF Yang PY Hu DN	2004	J Am Acad Dermatol2004，51，1：	1
9	l,aparoscopie Ioal gastrec- tomy for gastric cancer显示文摘	Li GX Wang D Hu YF	2014	Chinese Journal of Operative Procedures of General Surgery (Electronic Version)2014，11，8：	1
10	Quality of life of nasopharyngealcarcinoma survivors in Mainland China显示文摘	Wu Y Hu WH Xia YF ^ al	2007	Qual Life Res2007，16，1：	1
11	Long-term efficacy and safety ofall-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia 显示文摘	HU J LIU YF WU CF	2009	Proc Natl AcadSci USA2009，106，9：	1
12	Biological and molecular basis of human breast cancer显示文摘	Russo J Yang X Hu YF	1998	Front Biosci1998，3，：	1
13	Effects of genetic polymorphisms of CYP3A4, CYP3A5 and MDR1 on cyclosporine pharmacokinetics after renal transplantation显示文摘	Hu YF Qiu W Liu ZQ		Clin Exp Pharmacol Physiol0，33，11：	1
14	CYP3A5 * 3 and CYP3A4 * 18 single nueleotide polymorphisms in a Chinese population 显示文摘	Hu YF He J Chen GL	2005	Clinica Chimiea Acta2005，353，：	1
15	Long-term efficacy and safety of all-trans retinoic acid/Arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia显示文摘	Hu J Liu YF Wu CF		0，，：	1
16	On the physical interpretation of the Mintegral in nonlinear elastic defect mechanics显示文摘	Li Q Hu YF Chen YH		0，，：	1
17	Genetic polymorphisms of phase II metabolic enzymes and lung cancer susceptibility in a population of Central South China显示文摘	Chen HC Cao YF Hu WX	2006	Dis Markers2006，22，3：	1
18	Efficient CT metal curvature diffusion显示文摘	Zhang Y Pu YF Hu JR	2011	Computational and artifact reduction based on fractional-order Mathematical Methods in Medicine2011，2011，2011：	1
19	A new CT metal artifacts reduction algorithm based on fractional-order sinogram inpainting显示文摘	Zhang Y Pu YF Hu JR	2011	Journal of X-ray Science and Technology2011，19，3：	1
20	Pluripotent neural crest stem cells in the adult hair follicle 显示文摘	Sieber-Blum M Grim M Hu YF	2004	Developmental Dynamics2004，231，：	1

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