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| 1 | Time range of Mesozoic tectonic regime inversion in eastern North China Block显示文摘An important tectonic inversion took place in eastern North China Block(NCB) during Mesozoic, which caused a great lithosphere thinning, reconstruction of basin-range series, powerful interaction between mantle and crust, a vast granitic intrusion and volcanism, and large-scale metallogenic explosion. The time range of the Mesozoic tectonic regime inversion in the eastern North China Block is one of the key issues to understand mechanism of tectonic regime inversion. Our updated results for recognizing the time range are mainly obtained from the following aspects: structural analyses along northern and southern margins of the NCB and within the NCB for revealing tectonic inversion from compression to extension and structural striking from ~EW to NNE; geothermic analyses of the eastern sedimental basins for a great change of thermal history and regime; basin analysis for basin inversion from compression to extension and basin migration from ~EW to NNE; petrological and geochemical studies of volcanic rocks and lowermost crust xenoliths for recognizing peak period of mantle upwelling and intense interaction between mantle and crust, and main metallogenic epoch. All the studies of the above give the same time range from~150-140 Ma to ~110-100Ma, peaking at ~120 Ma. | ZHAI Mingguo ZHU Rixiang LIU Jianming MENG Qingren HOU Quanlin HU Shengbiao LIU Wei LI Zhong ZHANG Hongfu ZHANG Huafeng | 2004 | Science China Earth Sciences2004，47，2： | 89 |
| 2 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions显示文摘癌症房间被知道经历新陈代谢的 reprogramming 然而,支撑幸存和快速的增长 oncogenic 损害怎么在各种各样的强调条件下面协调新陈代谢的开关,尚待充分被阐明。这里,我们显示出葡萄糖或夫酸安的那剥夺,为癌症房间的二主要营养来源,被伴随由的戏剧性地激活的丝氨酸生合成小径(SSP ) 提高了 cMyc 表示。我们进一步鉴别那 cMyc 刺激了 SSP 激活由 transcriptionally 多重 SSP 酶的 upregulating 表示。而且,我们证明 cMyc 便于的 SSP 激活导致了提高的谷胱甘肽(GSH ) 生产,房间周期前进和 nucleic 酸合成,它在剥夺营养素的条件下面特别为房间幸存和增长是必要的。我们进一步揭开了那 phosphoserine 磷酸酶( PSPH ), SSP 小径的最后的限制率的酶,在 vitro 并且在 vivo 为 驾驶cMyc 的癌症前进是批评的,并且重要地, PSPH 的异常表示高度在 hepatocellular 与死亡被相关癌( HCC )病人,一般来说建议在这 调整cMyc 的酶,或 SSP 激活之间的一种潜在的原因的关系,并且癌症开发。一起拿,我们的结果表明 cMyc 的那异常表情导致提高的 SSP 激活,新陈代谢的开关的必要部分,在剥夺营养素的条件下面便于癌症前进。 | Linchong Sun Libing Song Qianfen Wan Gongwei Wu Xinghua Li Yinghui Wang Jin Wang Zhaoji Liu Xiuying Zhong Xiaoping He Shengqi Shen Xin Pan Ailing Li Yulan Wang Ping Gao Huiru Tang Huafeng Zhang | 2015 | Cell Research2015，25，4： | 33 |
| 3 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 4 | Hypoxia and cancer cell metabolism显示文摘过去的十年见证证据证明那 hypoxic 微型环境,是典型 duringcancer 开发,在调整癌症房间新陈代谢起关键作用的快速的累积。在这评论,特别地,我们将集中于 hypoxicresponse 的角色它的主人管理者组织缺氧可诱导的 factor-1 在调整葡萄糖,在癌症房间的类脂化合物,以及氨基的 acidmetabolism。我们将也由指向特定的小径讨论治疗学的机会在癌症房间的那 facilitatemetabolic reprogramming。 | De Huang Chenchen Li Huafeng Zhang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，3： | 20 |
| 5 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 6 | OsGRF4 controls grain shape, panicle length and seed shattering in rice显示文摘Traits such as grain shape, panicle length and seed shattering, play important roles in grain yield and harvest. In this study, the cloning and functional analysis of PANICLE TRAITS 2(PT2), a novel gene from the Indica rice Chuandali(CDL), is reported. PT2 is synonymous with Growth-Regulating Factor 4(OsGRF4), which encodes a growth-regulating factor that positively regulates grain shape and panicle length and negatively regulates seed shattering. Higher expression of OsGRF4 is correlated with larger grain, longer panicle and lower seed shattering. A unique OsGRF4 mutation, which occurs at the Osmi RNA396 target site of OsGRF4, seems to be associated with high levels of OsGRF4 expression, and results in phenotypic difference. Further research showed that OsGRF4 regulated two cytokinin dehydrogenase precursor genes(CKX5 and CKX1) resulting in increased cytokinin levels,which might affect the panicle traits. High storage capacity and moderate seed shattering of OsGRF4 may be useful in high-yield breeding and mechanized harvesting of rice. Our Resefindings provide additional insight into the molecular basis of panicle growth. | Pingyong Sun Wuhan Zhang Yihua Wang Qiang He Fu Shu Hai Liu Jie Wang Jianmin Wang Longping Yuan Huafeng Deng | 2016 | Journal of Integrative Plant Biology2016，58，10： | 16 |
| 7 | Paleoproterozoic Potassic Granitoids in the Sushui Complex from the Zhongtiao Mountains,Northern China:Geochronology,Geochemistry and Petrogenesis显示文摘Paleoproterozoic potassic granitoids in the southern Sushui Complex from the Zhongtiao Mountains yielded SHRIMP zircon U-Pb ages of 1968–1944 Ma. Lithologically, the potassic granitoid series consists chiefly of monzodiorite, quartz monzonite and syenogranite. Their trace elements and Sm-Nd isotope characteristics indicate that they were derived from partial melting of Archean TTG rocks in an overthickened continental crust. Petrogenesis of this potassic granitoid series implies a collisional environment within the Trans-North China Orogen in the Paleoproterozoic, which supports a tectonic model of Eastern and Western Continental Blocks being amalgamated in the Paleoproterozoic. | TIAN Wei LIU Shuwen ZHANG Huafeng | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 14 |
| 8 | Metabolic reprogramming and epigenetic modifications on the path to cancer显示文摘Metabolic rewiring and epigenetic remodeling,which are closely linked and reciprocally regulate each other,are among the well-known cancer hallmarks.Recent evi-dence suggests that many metabolites serve as sub-strates or cofactors of chromatin-modifying enzymes as a consequence of the translocation or spatial regional-ization of enzymes or metabolites.Various metabolic alterations and epigenetic modifications also reportedly drive immune escape or impede immunosurveillance within certain contexts,playing important roles in tumor progression.In this review,we focus on how metabolic reprogramming of tumor cells and immune cells reshapes epigenetic alterations,in particular the acety-lation and methylation of histone proteins and DNA.We also discuss other eminent metabolic modifications such as,succinylation,hydroxybutyrylation,and lacty-lation,and update the current advances in metabolism-and epigenetic modification-based therapeutic pro-spects in cancer. | Linchong Sun Huafeng Zhang Ping Gao | 2022 | Protein & Cell2022，13，12： | 10 |
| 9 | Application of wavelet transform in feature extraction and pattern recognition of wideband echoes显示文摘A novel approach to extract edge features from wideband echo is proposed. The set of extracted features not only represents the echo waveform in a concise way, but also is sufficient and well suited for classification of non-stationary echo data from objects with different property.The feature extraction is derived from the Discrete Dyadic Wavlet Transform (DDWT) of the echo through the undecimated algorithm. The motivation we use the DDWT is that it is time-shift-invariant which is beneficial for localization of edge, and the wavelet coefficients at larger scale represent the main shape feature of echo, i.e. edge, and the noise and modulated high-frequency components are reduced with scale increased. Some experimental results using real data which contain 144 samples from 4 classes of lake bottoms with different sediments are provided. The results show that our approach is a prospective way to represent wideband echo for reliable recognition of nonstationary echo with great variability. | ZHAO Jianping HUANG Jianguo ZHANG Huafeng(College of Marine Engineering, Northwestern Polytechnical University Xi’an 710072) | 1998 | Chinese Journal of Acoustics1998，17，3： | 8 |
| 10 | Laser Ablation ICP-MS U-Pb Zircon Geochronology of Granitoids and Quartz Veins in the Shihu Gold Mine, Taihang Orogen, North China: Timing of Gold-mineralization and Tectonic Implications显示文摘The Shihu gold deposit, situated in the Taihang Mesozoic orogen of the North China Craton (NCC), is hosted by ductile-brittle faults within Archean metamorphic core complex. The deposit is characterized by gold-bearing quartz-polymetallic sulfides veins. The Mapeng granitoids stock and intermediate-basic dikes intruded the metamorphic basement rocks, and are spatially related to gold mineralization. Detailed laser ablation inductively coupled plasma mass spectrometry (LA ICP-MS) U- Pb zircon ages of the granitic rocks, dykes and mineralized quartz veins in the studied area reveal its magmatic and mineralized history. The mineralized quartz veins contain inherited zircons with ages of about 2.55 Ga and 1.84 Ga, probably coming from the basement. These two Precambrian events are coeval with those in other parts of the NCC. The Mapeng granitoid stock, the largest intrusion in the area, was emplaced at ca. 130 Ma, and is coeval with magmatic zircon populations from diorites and quartz diorite pophyrites in the same region. The ca. 130 Ma magmatism and gold mineralization were most likely related to an underplating event that took place in the Taihang orogen at Late Mesozoic. The timing of gold mineralization with respect to felsic magmatism in the area is similar to those observed in other major gold-producing provinces in the NCC. This episode is simultaneous with those in the eastern margin of NCC, indicative of a widespread late Yanshanian metallogenic event that was a response to the Early Cretaceous lithosphere in the eastern NCC, in which the mesothermal gold deposits were formed from similar tectono-magmatic environments. | CAO Ye LI Shengrong XIONG Xianxiao LI Zhenzhen LIU Xiaobin YAO Meijuan ZHANG Huafeng | 2012 | Acta Geologica Sinica(English Edition)2012，86，5： | 8 |
| 11 | Fine mapping of GS2, a dominant gene for big grain rice显示文摘Grain shape as a major determinant of rice yield and quality is widely believed to be controlled by quantitative trait loci(QTL). We have identified a novel gene 'GS2' to largely regulate grain length and width in rice. The GS2 allele in the big-grain rice line ‘CDL’functioned in a dominant manner. In the present study, we employed a chromosome walking strategy in the residual heterozygous lines from recombinant inbred population between cultivar 'R1126' and CDL, and located the GS2 gene in an interval of ~33.2 kb flanked by marker GL2-35-1 and GL2-12 in the long arm of rice chromosome 2. According to genome annotations, three putative gene loci, LOC_Os02g47280, LOC_Os02g47290 and LOC_Os02g47300, exist in this candidate region. In addition, allelic analysis with previously reported genes demonstrated that GS2 was novel for regulating rice grain shape. These results will help promote the cloning and functional characterization of the GS2 gene and further develop linked markers to be used in marker-assisted breeding. | Wuhan Zhang Pingyong Sun Qiang He Fu Shu Jie Wang Huafeng Deng | 2013 | The Crop Journal2013，1，2： | 7 |
| 12 | Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer显示文摘Metformin is currently a strong candidate anti-tumor agent in multiple cancers.However,its anti-tumor effectiveness varies among different cancers or sub-populations,potentially due to tumor heterogeneity.It thus remains unclear which hepatocellular carcinoma(HCC)patient subpopulation(s)can benefit from met-formin treatment.Here,through a genome-wide CRISPR-Cas9-based knockout screen,we find that DOCK1 levels determine the anti-tumor effects of met-formin and that DOCK1 is a synthetic lethal target of metformin in HCC.Mechanistically,metformin promotes DOCK1 phosphorylation,which activates RAC1 to facilitate cell survival,leading to metformin resistance.The DOCK1-selective inhibitor,TBOPP,potentiates anti-tumor activity by metformin in vitro in liver cancer cell lines and patient-derived HCC organoids,and in vivo in xenografted liver cancer cells and immunocompetent mouse liver cancer models.Notably,metformin improves overall survival of HCC patients with low DOCK1 levels but not among patients with high DOCK1 expression.This study shows that metformin effective-ness depends on DOCK1 levels and that combining metformin with DOCK1 inhibition may provide a promising personalized therapeutic strategy for met-formin-resistant HCC patients. | Junru Feng Hui Lu Wenhao Ma Wenjing Tian Zhuan Lu Hongying Yang Yongping Cai Pengfei Cai Yuchen Sun Zilong Zhou Jiaqian Feng Jiazhong Deng Ying Shu Kun Qu Weidong Jia Ping Gao Huafeng Zhang | 2022 | Protein & Cell2022，13，11： | 5 |
| 13 | Laser probe ^(40)Ar/^(39)Ar dating for quartz from auriferous quartz veins in the Shihu gold deposit,western Hebei Province,North China显示文摘The Shihu gold deposit is situated in the central shear zone of the Meso-Cenozoic Fuping metamorphic core complex in the middle-northern part of the Taihang Mountains.This kind of gold deposits named after 'Shihu type' widely occurs in this region.Gold-bearing quartz veins are their most important industrial orebodies.Detailed laser 40Ar/39Ar geochronology of the mineralized quartz veins in the study area reveals details of its tectono-magmatic history.The 40Ar/39Ar ages for the quartz are between 134.4 Ma and 155.9 Ma with a mean age of 141±4 Ma on the isochron line and 139±7 Ma on the inverse isochron line,respectively,which is interpreted to be the best estimate of the crystalline age of the quartz veins.The gold mineralization was most likely related to an underplating event that took place in the northern part of the Taihang Mountain at ca.140 Ma.The timing of gold mineralization in the area is similar to those observed in other major gold-producing provinces in the NCC.This episode is simultaneous with those in the eastern NCC,indicative of a widespread late Yanshanian metallogenic event that was a response either to the subduction of the Izanagi-Pacific plate beneath eastern China or to the removal of the Early Cretaceous lithosphere in the eastern NCC.The ore-forming material sources may be the Early Precambrian metamorphic basement,instead of intermediate-acid rock bodies and dykes. | CAO Ye LI Shengrong ZHANG Huafeng AO Chong LI Zhenzhen LIU Xiaobin | 2010 | Chinese Journal Of Geochemistry2010，29，4： | 5 |
| 14 | 北斗导航系统卫星激光测距综述显示文摘Satellite laser ranging(SLR)is an unambiguous measurement technique and generates high accuracy satellite orbit data.All satellites in the BeiDou navigation satellite system(BDS)carried laser retro-reflector arrays(LRAs),so they can be tracked by ground SLR stations in order to provide the accurate observation data.The Shanghai astronomical observatory(SHAO)designed the LRAs,and also developed the dedicated SLR systems using a 1 m-aperture telescope and a transportable cabin-based SLR system with a telescopes of 60 cm aperture.These enable BDS satellite ranging during daytime and nighttime with centimeter-level precision,allowing highly accurate estimations of satellite orbits.Moreover,some of the BDS satellites are also equipped with laser time transfer(LTT)payloads,which were developed by the SHAO and China Academy of Space Technology(CAST),providing a highly accurate time comparison between the satellites and ground clocks.This paper describes the dedicated SLR system and the design of the LRAs for BDS satellites,as well as global SLR measurements.The SLR tracking data is used for evaluating the orbit accuracy of BDS satellites and broadcast ephemeris,with an accuracy of less than 1 m.The LTT measurements to BDS satellites for a single shot have a precision of approximately 300 picoseconds,with a time stability of 20 picoseconds in 500 s. | ZHANG Haifeng LONG Mingliang YANG Huafeng MENG Wendong CHENG Zhi’en DENG Huarong ZHANG Zhongping ZHANG A’li | 2020 | Aerospace China2020，21，4： | 4 |
| 15 | An efficient energy aware virtual network migration based on genetic algorithm显示文摘1 Introduction The network virtualization has attached lots of attention from researchers. Most of the prior studies aim at designing embedding solutions for the VN requests to maximize the revenue for infrastructure providers (InPs) while rarely focusing on the energy costs, which is a vital component. Several proposed energy saving methods focus on the energy optimization when the VN requests arrive. However, since the VN requests arrive and depart dynamically and therefore the resource of physical network changes, this optimization needs to be re-optimized. Figure 1 illustrates this context. | Peng XU Xu LIU Huafeng CAO Zhongbao ZHANG | 2019 | Frontiers of Computer Science2019，13，2： | 3 |
| 16 | Moving Average Model with an Alternative GARCH-Type Error显示文摘Motivated by the double autoregressive model with order p(DAR(p) model), in this paper,we study the moving average model with an alternative GARCH error. The model is an extension from DAR(p) model by letting the order p goes to infinity. The quasi maximum likelihood estimator of the parameters in the model is shown to be asymptotically normal, without any strong moment conditions.Simulation results confirm that our estimators perform well. We also apply our model to study a real data set and it has better fitting performance compared to DAR model for the considered data. | Huafeng ZHU Xingfa ZHANG Xin LIANG Yuan LI | 2018 | Journal of Systems Science and Information2018，9，2： | 2 |
| 17 | Petrologic indicators of prograde metamorphism in Paleoproterozoic garnet mafic granulites from the Huai'an complex, North China Craton显示文摘Reconstruction of pressure-temperature-time(P-T-t)paths and thermal regimes are essential for inferring tectono-metamorphic processes involved in the formation of metamorphic terranes.However,the P-T information,especially the prograde evolution is generally preserved incompletely due to the fast intra-or inter-grains diffusion under high-temperatures.It may result | Jialin Wu Mingguo Zhai Huafeng Zhang Jinghui Guo Haozheng Wang Wenqiang Yang Hong Zhang Bo Hu | 2018 | Science Bulletin2018，63，2： | 2 |
| 18 | Are Acila divaricata and Acila mirabilis One Species or Two Distinct Species? Evidence from COI Mitochondrial DNA显示文摘Acila divaricata(Hinds, 1843) and A. mirabilis(Adams and Reeve, 1850) are common benthic bivalves in China. A number of researchers have proposed that the latter species is a junior synonym of the former species. Because of morphological similarities, it is difficult to distinguish these two species based on visual examination only. For better understanding of their taxonomy, the mitochondrial COI gene fragments of five individuals of A. divaricata from the East China Sea and six individuals of A. mirabilis from the Yellow Sea were sequenced in this study. The phylogenetic relationships of the obtained COI sequences, together with nineteen sequences of three species of the genus Nucula, were analyzed. The pairwise intra- and inter-specific distances for the COI sequences ranged from 0.002 to 0.017 and from 0.128 to 0.134, respectively, and no overlap was found. Phylogenetically, A. divaricata and A. mirabilis form distinct clades and cluster into a sister to all other Nucula species. The results indicated that A. divaricata and A. mirabilis are two distinct species. The differences in the morphology and distribution between the two species were briefly discussed. | ZHANG Junlong SHI Huafeng XU Fengshan SHA Zhongli | 2014 | Journal of Ocean University of China2014，13，2： | 2 |
| 19 | Progress of Optical Fiber Sensors and Its Application in Harsh Environment显示文摘Fiber sensors have been developed for industry application with significant advantages.In this paper,Fiber sensors for oil field service and harsh environment monitoring which have been investigated in Tsinghua University are demonstrated.By discussing the requirements of practical applications,the key technologies of long-period fiber grating(LPFG)based fiber sensor,optical spectrum analyzer for oil detection,laser induced breakdown spectroscopy(LIBS)system for soil contamination monitoring,and seismic sensor arrays are described. | Min ZHANG Xiaohong MA Liwei WANG Shurong LAI Hongpu ZHOU Huafeng ZHAO Yanbiao LIAO | 2011 | Photonic Sensors2011，1，1： | 2 |
| 20 | Design of a large-range rotary microgripper with freeform geometries using a genetic algorithm显示文摘This paper describes a novel electrostatically actuated microgripper with freeform geometries designed by a genetic algorithm.This new semiautomated design methodology is capable of designing near-optimal MEMS devices that are robust to fabrication tolerances.The use of freeform geometries designed by a genetic algorithm significantly improves the performance of the microgripper.An experiment shows that the designed microgripper has a large displacement(91.5μm)with a low actuation voltage(47.5 V),which agrees well with the theory.The microgripper has a large actuation displacement and can handle micro-objects with a size from 10 to 100μm.A grasping experiment on human hair with a diameter of 77μm was performed to prove the functionality of the gripper.The result confirmed the superior performance of the new design methodology enabling freeform geometries.This design method can also be extended to the design of many other MEMS devices. | Chen Wang Yuan Wang Weidong Fang Xiaoxiao Song Aojie Quan Michiel Gidts Hemin Zhang Huafeng Liu Jian Bai Sina Sadeghpour Michael Kraft | 2022 | Microsystems & Nanoengineering2022，8，1： | 2 |
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