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| 1 | Plasmacytoid Dendritic Cells Act as the Most Competent Cell Type in Linking Antiviral Innate and Adaptive Immune Responses显示文摘Appropriate in vivo control of plasmacytoid dendritic cell (pDC) recruitment and activation is a fundamental requirement for defense against viral infection. During this process, a pivotal event that influences the outcome of viral infection is the production of high levels of type I interferon by pDCs. In particular, recent research findings showed that pDCs not only shape the nature of innate resistance, but are also responsible for the successful transition from innate to adaptive immunity for viral resistance. In addition, pDCs can differentiate into antigen presenting cells that may regulate tolerance to a given pathogen. Importantly, in a series of recent clinical studies,pDCs appeared to be defective in number and function in conditions of chronic viral diseases such as infected with HIV-1, HBV or HCV. pDC-associated clinical antiviral therapy is also emerging. This review describes research findings exanining the functional and antiviral properties of in vivo pDC plasticity. | Zheng Zhang~1 Fu-Sheng Wang~(1,2) ~1Research Center of Biological Therapy,Beijing 302 Hospital,Beijing 100039,China ~2Research Centre of Biological Therapy,Beijing Institute of Infectious Diseases,Beijing 302 Hospital,100 Xi Si Huan Middle Road,Beijing 100039,China. | 2005 | Cellular & Molecular Immunology2005，2，6： | 16 |
| 2 | Light-controlled synthesis of uniform platinum nano- dendrites with markedly enhanced electrocatalytic activity显示文摘我们报导一在基于锌(II ) 播种途径的 situ 快在白轻照耀下面的卟啉(ZnP ) ,与悦耳的尺寸导致一致的球形的铂 nanodendrites。铂 nanodendrites 展览显著地与商业铂黑色相比向氧减小反应(ORR ) 和甲醇氧化反应(粗腐殖质) 改进了 electrocatalytic 活动。 | Weifeng Si Jia Li Huanqiao Li Shushuang Li Jie Yin Huan Xu Xinwen Guo Tao, Zhang Yujiang Song | 2013 | Nano Research2013，6，10： | 7 |
| 3 | Ypsiyunnosides A-E,Five New Cholestanol Glycosides from Ypsilandra yunnanensis显示文摘Phytochemicalinvestigation onthe whole plants of Ypsilandra yunnanensiswas carried out forthe firsttime andledtothe isolation of five new cholestanol glycosides,ypsiyunnosides A–E(1–5),and one known analogue.Their structures were determined mainly by detailed spectroscopic analysis,including extensive 1D and 2D NMR,MS and UV,as well as chemical methods.Among them,compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon,which was identified as(23R,25R)-3β,16α,26-triol-16,23-cyclocholest-5,17(20)-dien-22-one.Their induced platelet aggregation activities and cytotoxicities were evaluated.Graphical Abstract Five new cholestanol glycosides,ypsiyunnosides A–E(1–5),were isolated from the whole plants of Ypsilandra yunnanensis.Compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon.Their structures were elucidated by a combination of 1D and 2D NMR,MS and chemical analysis. | Yu Chen Yong-Ai Si Wei Ni Huan Yan Xu-Jie Qin Chang-Xiang Chen Hai-Yang Liu | 2016 | Natural Products and Bioprospecting2016，6，3： | 4 |
| 4 | A New Insight into the Influence of Composition of Fault Rocks on Aseismic and Seismic Fault Slip显示文摘Active faults can slip either slowly and continuously by
aseismic creep, or abruptly by a seismic event. Both slip
modes of faults are closely related to the composition of
fault rocks. However, the actual materials resulting in
differences of slip behavior remain uncertain. The
Guanxian-Anxian fault (GAF) characterized by long-term
aseismic creep and the Yingxiu-Beichuan fault (YBF)
slipping by large earthquakes in the Longmen Shan fault
zone (LSFZ) are ideal examples for exploring the above
issues. Here, in the light of observation and component
analyses, we find that the distribution of carbonate
minerals in both faults is distinct. | HE Xiangli LI Haibing WANG Huan SI Jialiang ZHANG Lei XU Zhiqin SUN Zhiming | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 3 |
| 5 | Synchronous multiple primary gastrointestinal cancers with CDH1 mutations:A case report显示文摘BACKGROUND Synchronous multiple primary cancers (SMPC) mean two or more malignant tumors occurring simultaneously and with different origins no matter what types they are or where they are located. The carcinogenesis of SMPC often involves variations of some specific genes. However, the correlation between CDH1 mutations and synchronous multiple primary gastrointestinal cancers is largely unknown. CASE SUMMARY A 62-year-old woman had sustained abdominal pain for one week and visited our hospital. Gastrointestinal endoscopy revealed multiple small polypoid lesions in both the stomach and colorectum. Computed tomography and laboratory results were within normal limits. Pathological evaluation confirmed signet ring cell carcinoma without obvious metastatic evidence. Malignant cells showed negativity for E-cadherin and positivity for β-catenin in the cytoplasm and nucleus. DNA sequencing performed on paraffin-embedded tissue revealed two exactly coincident alterations in CDH1, C.57T>G and C.1418A>T. CONCLUSION This case suggests that the combination of CDH1 mutations and WNT/β-catenin signaling activation contributes to the carcinogenesis of gastrointestinal SMPC. | Mu-Ni Hu Wei Lv Rui-Yue Hu Yi-Fan Si Xiao-Wen Lu Yan-Juan Deng Huan Deng | 2019 | World Journal of Clinical Cases2019，7，13： | 3 |
| 6 | Two New Steroidal Saponins from Ypsilandra thibetica显示文摘Two new monosaccharide steroidal saponins,named ypsilandroside S(1)and ypsilandroside T(2),have been isolated from the whole plants of Ypsilandra thibetica.Their structures were elucidated as heloniogenin 3-O-b-D-apiofuranoside(1)and pregna 5,16-dien-3b,12a-diol-20-one-3-O-b-D-apiofuranoside(2)by spectroscopic techniques(1D and 2D NMR,MS).Compounds 1 and 2 were tested for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. | Yong-Ai Si Huan Yan Wei Ni Zhen-Hua Liu Ting-Xiang Lu Chang-Xiang Cheng Hai-Yang Liu | 2014 | Natural Products and Bioprospecting2014，4，6： | 2 |
| 7 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 8 | The development of HIV vaccines targeting gp41 membrane-proximal external region (MPER): challenges and prospects显示文摘 | Huan Liu Xiaojie Su Lulu Si Lu Lu Shibo Jiang | 2018 | Protein & Cell2018，9，7： | 2 |
| 9 | Co2P: A facile solid state synthesis and its applications in alkalinerechargeable batteries 显示文摘 | PENG W X JIAO L F HUAN Q N LI L YANG J Q ZHAO Q Q WANG Q H DU H M L|U G SI Y C WANG Y J YUAN H T | 2012 | J Alloys Compd2012，511，： | 1 |
| 10 | Preparation of spherical iron nanoclusters in ethanol–water solution for nitrate removal显示文摘 | Wei Wang Zhao-hui Jin Tie-long Li Huan Zhang Si Gao | 2006 | Chemosphere2006，，8： | 1 |
| 11 | 观察恒河猴隐睾(热刺激)模型中睾丸细胞细胞外信号调节激酶1和2(ERK1/2)的激活 | Xue-Sen Zhang~+ Zhi-Hong Zhang~+ Shu-Hua Guo Wei Yang,Zhu-Qiang Zhang Jin-Xiang Yuan Xuan Jin Zhao-Yuan Hu Yi-Xun Liu State Key Laboratory of Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,25 Bei Si Huan Road West,Beijing 100081,China | 2006 | Asian Journal of Andrology2006，8，A03： | 1 |
| 12 | Transcriptome and metabolome analysis reveal that oral secretions from Helicoverpa armigera and Spodoptera litura influence wound-induced host response in cotton显示文摘Cotton(Gossypium hirsutum)is an important fiber crop worldwide.Insect attack causes cotton yield and quality losses.However,little is known about the mechanism of cotton response to insect attack.We simulated insect feeding by applying insect oral secretions(OS)to wounds,and combined transcriptome and metabolome analysis to investigate how OS from two major pest species(Helicoverpa armigera and Spodoptera litura)affect cotton defense responses.We found that respectively 12,668 and 13,379 genes were differentially expressed in comparison with wounding alone.On addition of OS,the jasmonic acid signaling pathway was rapidly and strongly induced,whereas genes involved in salicylic acid biosynthesis were downregulated.On constructing a coexpression gene network,we identified a hub gene encoding a leucine-rich repeat receptor kinase that may play an important role in early signal recognition and transduction.OS from the two insect species altered the abundance of flavonoid-related compounds in different patterns.Gossypol remained in lower concentration after OS application than after wounding alone,suggesting a suppressive effect of OS on cotton defense response.This study illustrated transcriptional and metabolic changes of cotton in responding to OS from two chewing insect species,identified potential key response genes,and revealed evidence for OS inhibition of wounding-induced cotton defense response. | Huan Si Hongling Liu Yiwen Sun Zhongping Xu Sijia Liang Bo Li Xiao Ding Jianying Li Qiongqiong Wang Lin Sun Xianlong Zhang Shuangxia Jin | 2020 | The Crop Journal2020，8，6： | 1 |
| 13 | Piperlongumine Induces Apoptosis and Synergizes with Cisplatin or Paclitaxel in Human Ovarian Cancer Cells显示文摘 | Li-Hua Gong Xiu-Xiu Chen Huan Wang Qi-Wei Jiang Shi-Shi Pan Jian-Ge Qiu Xiao-Long Mei You-Qiu Xue Wu-Ming Qin Fei-Yun Zheng Zhi Shi Xiao-Jian Yan Si Jin | 2014 | Oxidative Medicine and Cellular Longevity2014，，： | 1 |
| 14 | Characteristics of the fault-related rocks, fault zones and the principal slip zone in the Wenchuan Earthquake Fault Scientific Drilling Project Hole-1 (WFSD-1)显示文摘 | Haibing Li Huan Wang Zhiqin Xu Jialiang Si Junling Pei Tianfu Li Yao Huang Sheng-Rong Song Li-Wei Kuo Zhiming Sun Marie-Luce Chevalier Dongliang Liu | 2012 | Tectonophysics2012，，： | 1 |
| 15 | Preparation of spherical iron nanoclusters in ethanol-water solution for nitrate removal显示文摘 | WANG Wei JIN Zhao-hui LI Tie-long ZHANG Huan GAO Si | 2006 | Chemosphere2006，65，8： | 1 |
| 16 | Advances in the treatment of multi-pollutant flue gas in China's building materials industry显示文摘In most of the world’s building material industries,the control of flue gas pollutants mainly focuses on a single pollutant.However,given the large capacity and high contribution of China’s building materials industry to global air pollution,the need to develop multipollutant emission reduction technology is urgent.Recently,China has focused on reducing the emissions of flue gas pollutants in the building materials industry,established many key research and development projects,and gradually implemented more stringent pollutant emission limits.This project focuses on the most recent advances in flue gas emission control technology in China’s building materials industry,including denitration,dust removal,desulfurization,synergistic multi-pollutant emission reduction,and the construction of pilot research and demonstration projects for pollutant removal in several building material industries.On this basis,revised pollutant limits in flue gas emitted in China’s building material industry are proposed. | Shangchao Xiong Jianjun Chen Hao Liu Wenzhe Si Yue Peng Xuecheng Wu Huan Liu Junhua Li | 2023 | Journal of Environmental Sciences2023，，1： | 1 |
| 17 | Link resist- ance function near Chinese curbside stops 显示文摘 | Huan Mei Yang Xiaobao Si Bingfeng | 2011 | Journal of Beijing Institute of Technology2011，20，1： | 1 |
| 18 | Effect of flow field distribution on the synthesis of sub-micron ZSM-5 molecular sieve in a quasi-solid system显示文摘Scale-up synthesis of sub-micron ZSM-5 molecular sieve in a quasi-solid system was investigated. Compared with traditional hydrothermal synthesis, the synthesis in a quasi-solid system has the advantages of high yield, short crystallization time, low energy consumption as well as low emissions. However, the high solid content in the quasi-solid system can cause the mass and heat transfer problems and make scalable production difficult. In order to solve the problem, we have developed a method for the optimization of the mass and heat transfer. By this method one can vary the flow field in the reactor by changing the stirrer speed. Scale-up synthesis of the sub-micron ZSM-5 molecular sieve in a quasi-solid system was carried out in a 5 L reactor with double propeller-type agitators. The process was investigated with product characterization using X-ray diffraction (XRD) and scanning electron microscopy (SEM) and the flow field information was collected using laser Doppler velocimetry (LDV). The results showed that the flow field patterns can be tuned by using different stirrer speeds, the morphology and size of as-synthesized of ZSM-5 can be effectively controlled. | Xia Zhi Hu Si Zhang Huan Li Xiaofeng Gong Yanjun Dou Tao | 2013 | Petroleum Science2013，10，1： | 0 |
| 19 | A review of multilingual information organization and retrieval research abroad in the last ten years显示文摘The multilinguality of online information has become the major obstacle to the sharing of online information resources across nations.To overcome this obstacle,there is an urgent need fordeveloping methods and technologies of multilingual information organization and retrieval.Recent years witnessed significant progress in the research on both cross lingual and multilingual information organization and retrieval,which dates back to the 1960s but remains | Li SI Xiaozhe ZHUANG Huan JIA | 2015 | Journal of Library Science in China2015，，1： | 0 |
| 20 | Natural regulatory T cells and bifunctional regulatory T cells:potential targets of traditional Chinese medicine in treating colitis-associated colon cancer显示文摘Colon cancer(CRC)is one of the most common malignancies globally,ranking third in terms of new cancer cases and second as a cause of cancer deaths[1].In recent 30 years,the incidence and mortality rates of CRC in China have been increasing,gradually exceeding the global levels[2].Due to the fact that most CRC patients are diagnosed at the advanced stage,the treatment of this disease is challenging and often ineffective.Therefore,prevention and early diagnosis of CRC are crucial. | Ning Wang Huan Pei Li-Wei Xing Si Wang Jia-Bao Liao Wei-Bo Wen Yu-Hong Bian Huan-Tian Cui | 2024 | Integrative Medicine Discovery2024，8，6： | 0 |
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