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| 1 | Host Interferon-Stimulated Gene 20 Inhibits Pseudorabies Virus Proliferation显示文摘Host interferon-stimulated gene 20(ISG20)exerts antiviral effects on viruses by degrading viral RNA or by enhancing IFN signaling.Here,we examined the role of ISG20 during pseudorabies virus(PRV)proliferation.We found that ISG20 modulates PRV replication by enhancing IFN signaling.Further,ISG20 expression was upregulated following PRV infection and poly(I:C)treatment.Ectopic expression of ISG20 inhibited PRV proliferation in PK15 cells,whereas knockdown of ISG20 promoted PRV proliferation.In addition,ISG20 expression upregulated IFN-βexpression and enhanced IFN downstream signaling during PRV infection.Notably,PRV UL24 suppressed the transcription of ISG20,thus antagonizing its antiviral effect.Further domain mapping analysis showed that the N terminus(amino acids 1-90)of UL24 was responsible for the inhibition of ISG20 transcription.Collectively,these findings characterize the role of ISG20 in suppressing PRV replication and increase the understanding of host-PRV interplay. | Xiaoyong Chen Dage Sun Sujie Dong Huanjie Zhai Ning Kong Hao Zheng Wu Tong Guoxin Li Tongling Shan Guangzhi Tong | 2021 | Virologica Sinica2021，36，5： | 4 |
| 2 | Influences of alternate partial root-zone irrigation and urea rate on water-and nitrogen-use efficiencies in tomato显示文摘Traditional water and fertilizer inputs are often much higher than the actual demands of tomato,which causes a reduction in water-and fertilizer-use efficiencies.To investigate the advantage of alternate partial root-zone irrigation(AI)on water-and nitrogen(N)-use efficiencies of tomato modified by water and N management,taking conventional irrigation(CI)as the control,the effects of AI on root morphology and activity,fruit yield and water and N use efficiency were studied using pot experiments.There were four combinations of irrigation levels and growing stages of tomato for AI,i.e.AI_(1)(high water(W_(H))from blooming to harvest stage(BHS)),AI_(2)(W_(H)from blooming to fruit setting stage(BFS)and low water(W_(L))at the harvest stage(HS)),AI_(3)(W_(L)at BFS and W_(H)at HS)and AI_(4)(W_(L)at BHS)at three urea rates,i.e.low urea rate(NL),middle urea rate(N_(M))and high urea rate(N_(H))in the form of urea.Irrigation quotas for W_(H)and W_(L)in AI at BFS or HS were 80%and 60%of that in CI,respectively.Compared to CI,AI decreased water consumption by 16.0%-33.1%and increased water use efficiency of yield(WUE_(y))and dry mass(WUE_(d))by 6.7%-11.9%and 10.2%-15.9%,respectively.AI_(1)did not decline yield,total N uptake(TNU)and N use efficiency(NUE)significantly.Compared to NL,N_(M)enhanced tomato yield,TNU,WUE_(y)and WUE_(d)by 28.5%,35.3%,22.6%and 16.3%,respectively.Compared to CINL,AI_(1)N_(M)reduced water consumption by 12.5%,but increased tomato yield,TNU,WUE_(y)and WUE_(d)by 35.5%,58.4%,54.4%and 53.7%,respectively.Therefore,AI_(1)can improve water use efficiency and total N uptake of tomato simultaneously at medium urea rate. | Liu Xiaogang Li Fusheng Zhang Fucang Cai Huanjie Yang Qiliang | 2017 | International Journal of Agricultural and Biological Engineering2017，10，6： | 4 |
| 3 | On-chip chalcogenide microresonators with low-threshold parametric oscillation显示文摘Chalcogenide glass (ChG) is an attractive material for highly efficient nonlinear photonics,which can cover an ultrabroadband wavelength window from the near-visible to the footprint infrared region. However,it remains a challenge to implement highly-efficient and low-threshold optical parametric processes in chip-scale ChG devices due to thermal and light-induced instabilities as well as a high-loss factor in ChG films. Here,we develop a systematic fabrication process for high-performance photonic-chip-integrated ChG devices,by which planarintegrated ChG microresonators with an intrinsic quality (Q) factor above 1 million are demonstrated. In particular,an in situ light-induced annealing method is introduced to overcome the longstanding instability underlying ChG film. In high-Q ChG microresonators,optical parametric oscillations with threshold power as low as 5.4 mW are demonstrated for the first time,to our best knowledge. Our results would contribute to efforts of making efficient and low-threshold optical microcombs not only in the near-infrared as presented but more promisingly in the midinfrared range. | BIN ZHANG PINGYANG ZENG ZELIN YANG DI XIA JIAXIN ZHAO YAODONG SUN YUFEI HUANG JINGCUI SONG JINGSHUN PAN HUANJIE CHENG DUKYONG CHOI ZHAOHUI LI | 2021 | Photonics Research2021，9，7： | 4 |
| 4 | Reciprocal activation ofα5-nAChR and STAT3 in nicotine-induced human lung cancer cell proliferation显示文摘Cigarette smoking is the top environmental risk factor for lung cancer.Nicotine,the addictive component of cigarettes,induces lung cancer cell proliferation,invasion and migration via the activation of nicotinic acetylcholine receptors(nAChRs).Genome-wide association studies(GWAS)show that CHRNA5 gene encoding a5-nAChR is especially relevant to lung cancer.However,the mechanism of this subunit in lung cancer is not clear.In the present study,we demonstrate that the expression of a5-nAChR is correlated with phosphorylated STAT3(pSTAT3)expression,smoking history and lower survival of non-small cell lung cancer(NSCLC)samples.Nicotine increased the levels of a5-nAChR mRNA and protein in NSCLC celllinesandactivatedtheJAK2/STAT3 signaling cascade.Nicotine-induced activation of JAK2/STAT3signaling was inhibited by the silencing of a5-nAChR.Characterization of the CHRNA5 promoter revealed four STAT3-response elements.ChIP assays confirmed that the CHRNA5 promoter contains STAT3 binding sites.BysilencingSTAT3 expression,nicotine-induced upregulation of a5-nAChR was suppressed.Downregulation of a5-nAChR and/or STAT3 expression inhibited nicotine-induced lung cancer cell proliferation.These results suggest that there is a feedback loop between a5-nAChR and STAT3 that contributestothenicotine-inducedtumor cell proliferation,which indicates that a5-nAChR is an important therapeutic target involved in tobacco-associated lung carcinogenesis. | Yao Zhang Yanfei Jia Ping Li Huanjie li Dongjie Xiao YunshanWang Xiaoli Ma | 2017 | Journal of Genetics and Genomics2017，44，7： | 3 |
| 5 | Dual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivo显示文摘 | Huanjie Shao Chun Gao Haikuo Tang Hao Zhang Lewis R. Roberts Bonnie L. Hylander Elizabeth A. Repasky Wen W. Ma Jingxin Qiu Alex A. Adjei Grace K. Dy Chunrong Yu | 2011 | Journal of Hepatology2011，，1： | 2 |
| 6 | Epigenetic regulation in cardiovascular disease:mechanisms and advances in clinical trials显示文摘Epigenetics is closely related to cardiovascular diseases.Genome-wide linkage and association analyses and candidate gene approaches illustrate the multigenic complexity of cardiovascular disease.Several epigenetic mechanisms,such as DNA methylation,histone modification,and noncoding RNA,which are of importance for cardiovascular disease development and regression.Targeting epigenetic key enzymes,especially the DNA methyltransferases,histone methyltransferases,histone acetylases,histone deacetylases and their regulated target genes,could represent an attractive new route for the diagnosis and treatment of cardiovascular diseases.Herein,we summarize the knowledge on epigenetic history and essential regulatory mechanisms in cardiovascular diseases.Furthermore,we discuss the preclinical studies and drugs that are targeted these epigenetic key enzymes for cardiovascular diseases therapy.Finally,we conclude the clinical trials that are going to target some of these processes. | Yuncong Shi Huanji Zhang Suli Huang Li Yin Feng Wang Pei Luo Hui Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 2 |
| 7 | A Dynamic Model for Simulating Atmospheric, Surface and Soil Water interactions in Hillslope of Loess Area Under Natural Conditions and Its Application显示文摘The mechanism of atmospheric, surface and soil water interactions (water transformation) in hillslope under natural conditions was analyzed, and a dynamic model was developed to simulate infiltration, overland flow and soil water movement during natural rainfall in hillslope, by bringing forward concepts such. as rainfall intensity on slope and a correction coefficient of saturated soil water content for soil surface seal. Some factors, including slope angle, slope orientation and raindrop inclination, which affect the rainfall amount on slope, were taken into account while developing the dynamic model. The effect of surface seal on infiltration and water balance under a boundary condition of the second kind was also considered. Application of the model in a field experiment showed that the model simulated precisely the infiltration, overland flow and soil water movement in hillslope under natural rainfall conditions. | ZHANG SHUHAN KANG SHAOZHONG CAI HUANJIE and NIE GUANGYONG Institute of Agricultural Soil-Water Engineering, Northwestern Agricultural University, Yangling 712100 (China) Inner Mongolia institute of Water Conservancy, Huhhot 010020 (China) | 2001 | Pedosphere2001，11，3： | 2 |
| 8 | Experimental study of colonic anastomosis with a degradable stent in a porcine model显示文摘 | YiFan Wang XiuJun Cai HuanJie Cai YueLong Liang DiYu Huang Xiao Liang | 2010 | The American Journal of Surgery2010，，6： | 1 |
| 9 | Protective effect of allicin against acrylamide-induced hepatocyte damage in vitro and in vivo显示文摘 | ZHANG Lulu ZHANG Huanjie MIAO Yutian | 2012 | Food and Chemical Toxicology2012，50，： | 1 |
| 10 | Cclastrol, a Triterpene Extracted from the Chinese 'thunder of god vine, ' Is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice 显示文摘 | Yang Huanjie Chen Di | 2006 | Cancer Research2006，66，9： | 1 |
| 11 | Celastrol,a triterpene extracted from the Chinese “thunder of god vine,,,is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude-mice显示文摘 | Yang Huanjie Chen Di Cui Cindy | 2006 | Cancer Research2006，66，9： | 1 |
| 12 | Regulated deficit irrigation and its several problems in practical use显示文摘 | Cai Huanjie Kang Shaozhong | 1999 | Proceedings of Annual Con ference of Korean Society of Agricultural Engineers1999，10，： | 1 |
| 13 | Construction of the Disciplinary,Academic,and Discourse Systems in the Contemporary Chinese Philosophy of Science and Technology:Retrospect and Prospect显示文摘A review of the decades of research shows that Chinese philosophy of science and technology,on the strength of carrying forward traditions and blazing new trails,has made progress in the construction of discipline system and development of institutions,teaching materials and periodicals,with deepening the discussion on discipline orientation.In academic system construction,driven by efforts to update the academic framework and deepen research on the philosophy of nature,philosophy of science,philosophy of technology,science,technology and society,as well as other traditional fields,achievements have been made in ethical reflections on high technology,engineering ethics,big data and artificial intelligence philosophy,responsible innovation and other emerging,frontier and crosscutting fields.In the construction of discourse system,work has been done to make China’s voice heard on the international stage,excavate and elucidate the excellent traditional Chinese culture,and build disciplines with Chinese characteristics.In short,the achievements of the Chinese philosophy of science and technology have not come easily.Though a diverse and dynamic academic pattern has been formed,and wonderful and unique Chinese discourse has been created,we still face some problems.To accelerate the construction of“Three Systems”of the philosophy of science and technology with Chinese characteristics by building on existing achievements,we should carry forward the tradition of dialectics of nature and strengthen the guidance of Marxism,consolidate the foundation of philosophy and support interdisciplinary interaction and cooperation,track the frontiers of science and technology,and pay attention to the social operation of science and technology. | LEI Huanjie | 2022 | Frontiers of Philosophy in China-Selected Publications from Chinese Universities2022，17，1： | 1 |
| 14 | Celastol, a triterpene extracted from the chinese thunder of god vine is a proteasome inhibitor and suppresses human prostate cancer growth in nude mice 显示文摘 | Yang Huanjie Chen Di Cui Qiuzhi | 2006 | Cancer Res2006，66，9： | 1 |
| 15 | Celastrol, a triterpene extracted from the Chinese 'Thunder of God Vine', is a potent protea-some inhibitor and suppresses human prostate cancer owth in nude mice 显示文摘 | Yang Huanjie Chen Di | 2006 | Cancer Res2006，66，9： | 1 |
| 16 | Estimation of maize evapotranspiration under water deficits in semiarid region显示文摘 | Cai Huanjie Zhang Jianhua | 2000 | Agricultural Water Management2000，，43： | 1 |
| 17 | Application of the steady-state principle of constant-head well permeameter to indirect subsurface drip irrigation显示文摘 | Zhao Weixia Cai Huanjie Zhang Zhenhua | 2009 | Canadian Journal of Soil Science2009，89，5： | 1 |
| 18 | Celastrol, a triterpene extracted from the Chinese thunder of god vine is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice 显示文摘 | YANG Huanjie CHEN Di CUI Qiuzhi et ol | 2006 | Cancer Res2006，66，9： | 1 |
| 19 | Estimation of maize evapotranspiration under water deficits in a semiarid region 显示文摘 | Kang Shaozhong Cai Huanjie Zhang Jianhua | 2000 | Agricultural Water Management2000，，43： | 1 |
| 20 | Exome sequencing identifies rare mutations of LDLR and QTRT1 conferring risk for early-onset coronary artery disease in Chinese显示文摘Despite the advances made over the past decades,the known loci for coronary artery disease(CAD)still only explain<20%of the genetic variation in risk[1,2].The known loci with the strongest effects usually confer a 20%-37%increased CAD risk and the most loci modulate risk by≤10%[1].While most of the current data are from European populations,the use of trans-ethnic analyses could be helpful to identify additional loci.Genetic inheritance may impose a high burden on early-onset coronary artery disease(EOCAD). | Kang Yao Yuxiang Dai Juan Shen Yi Wang Huanjie Yang Runda Wu Qijun Liao Hongyi Wu Xiaodong Fang Shalaimaiti Shali Lili Xu Meng Hao Chenhao Lin Zhonghan Sun Yilian Liu Mengxin Li Zhen Wang Qiang Gao Shuning Zhang Chenguang Li Wei Gao Lei Ge Yunzeng Zou Aijun Sun Juying Qian Li Jin Shangyu Hong Yan Zheng Junbo Ge | 2022 | National Science Review2022，9，8： | 1 |
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