| 2 | β-catenin/LIN28B promotes the proliferation of human choriocarcinoma cells via Let-7a repression显示文摘Choriocarcinoma is a rare and malignant trophoblastic tumor.However,the molecular mechanisms by which choriocarcinoma is regulated remain unknown.In the present study,we first elucidated that LIN28B was highly expressed in human choriocarcinoma tissues and choriocarcinoma cell lines.Our data further demonstrated that knockdown of LIN28B by small interfering RNA caused an increase in Let-7a expression in JAR cells.In addition,silencing of LIN28B inhibited IGF2BP1 expression and suppressed cell proliferation capacity,both of which can be markedly restored by Let-7a inhibitor.In contrast,LIN28B over-expression-improved cell proliferation was inhibited by Let-7a mimic.Knockdown ofβ-catenin resulted in reduced expression of LIN28B and increased expression of Let-7a.Knockdown ofβ-catenin also caused a decrease in cell proliferation,which can be recovered by re-expression of LIN28B or by Let-7a inhibitor.Collectively,our data indicate thatβ-catenin/LIN28B/Let-7a pathway may be crucial for the regulation of cell proliferation in human choriocarcinoma cells. | Jing Wu Xuan Feng Yan Du Baoxin Luan Huandi Yu Yinhua Yu Lanxiang Wu Hongbo Zhao | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 0 |
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