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| 1 | Seasonal water storage change of the Yangtze River basin detected by GRACE显示文摘US-Germany co-sponsered satellite gravimetry mission GRACE (Gravity Recovery And Climate Experiment), launched in March 2002, has been producing monthly time series of Earth gravity models up to degree and order of 120. The GRACE mission consists of two identical satellites flying on an almost polar orbit with an altitude of about 300-500 km and satelite-to-satellite ranging of about 220 km. Thanks to the payloads of space-borne GPS receivers, accelerometers and high-precision K-band satelite-to-satellite ranging mesurements, GRACE gravity models are expected to achieve more than one order of magnitude of improvement over previous models at spatial scales of a few hundred kilometers or larger. Recovery of surface mass re-distribution based on GRACE’s time-varying gravity models is applied to studies in solid Earth geophysics, oceanography, climatology and geodesy. At secular time scales, GRACE is expected to provide valuable information on global ice changes, whose variations have profound influences on global climate, and in particular, on sea level changes. At seasonal time scales, GRACE is expected to reveal surface water changes with an ac- curacy of less than 1 cm, or ocean bottom pressure changes with an accuracy of less than 1 mbar (1 mbar =102 Pa). These surface mass redistribution measurements would impove our understanding of the global and regional mass and energy cycles that are critical to human life. Using 15 GRACE monthly gravity models covering the period from April 2002 to December 2003, this study compares seasonal water storage changes recovered from GRACE data and hydrology models at global and regional scales, with particular focus on the Yangtze River basin of China. Annual amplitude of 3.4 cm of equivalent water height change is found for the Yangtze River basin with maximum in Spring and Autumn, agreeing with two state-of-the-art hydrology models. The differences between GRACE re- sults and model predictions are less than 1-2 cm. We conclude that satellite gravimetry has huge potentials in monitering water storage changes in large river basins such as Yangtze. | HU Xiaogong1, CHEN Jianli1,2, ZHOU Yonghong1, HUANG Cheng1 & LIAO Xinhao1 1. Center for Astro-geodynamics Research, Shanghai Astronomical Observatory, National Astronomical Observatories, Shanghai 200030, China 2. Center for Space Research, University of Texas at Austin, 3925 W. Braker Lane, Suite 200, Austin, TX78750, USA | 2006 | Science China Earth Sciences2006，49，5： | 29 |
| 2 | Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation显示文摘AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or subjected to hypobaric hypoxia(H) to induce PH. Another group was given M and subjected to H to accelerate the disease process(M + H). Right ventricular systolic pressure, right ventricular hypertrophy, lung histology for medial hypertrophy and the presence of neointimal lesions were examined at 2 and 4 wk. The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor(PPAR) γ, caveolin-2, proliferative and antiapoptotic factors(PY-STAT3, p-Erk, Bcl-x L), endothelial nitric oxide synthase(e NOS) and heat shock protein(HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups. Double immunofluorescence technique was used to identify the localization of caveolin-1 in pulmonary arteries in rat lungs and in human PH lung tissue. RESULTS: In the M + H group, PH was more severe compared with M or H group. In the 4 wk M+H group, several arteries with reduced caveolin-1 expression in endothelial layer coupled with an increased expression in smooth muscle cells(SMC), exhibited neointimal lesions. Neointima was present only in the arteries exhibiting enhanced caveolin-1 expression in SMC. Lung tissue obtained from patients with PH also revealed neointimal lesions only in the arteries exhibiting endothelial caveolin-1 loss accompanied by an increased caveolin-1 expression in SMC. Reduction in e NOS and HSP90 expression was present in the M groups(2 and 4 wk), but not in the M + H groups. In both M groups and in the M + H group at 2 wk, endothelial caveolin-1 loss was accompanied by an increase in PPARγ expression. In the M + H group at 4 wk, increase in caveolin-1 expression was accompanied by a reduction in the PPARγ expression. In the H group, there was neither a loss of endothelial caveolin-1, eNOS or HSP 90, nor an increase in SMC caveolin-1 expression; or any alteration in PPARγ expression. Proliferative pathways were activated in all experimental groups. CONCLUSION: Enhanced caveolin-1 expression in SMC follows extensive endothelial caveolin-1 loss with subsequent neointima formation. Increased caveolin-1 expression in SMC, thus, may be a prelude to neointima formation. | Jing Huang John H Wolk Michael H Gewitz James E Loyd James West Eric D Austin Rajamma Mathew | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 3 | Coordination of cooperative advertising in a two-level supply chain when manufacturer offers discount 显示文摘 | Yue J Austin J Wang M Huang Z | 2006 | European Journal of Operational Research2006，168，1： | 1 |
| 4 | Micro- and nanofluidics for DNA analysis显示文摘 | Jonas O. Tegenfeldt Christelle Prinz Han Cao Richard L. Huang Robert H. Austin Stephen Y. Chou Edward C. Cox James C. Sturm | 2004 | Analytical and Bioanalytical Chemistry2004，，7： | 1 |
| 5 | Phase transformations in sputter deposited NiMn thin films显示文摘 | Huang M Ladwig P F Austin Chang Y | 2005 | Thin Solid Films2005，478，12： | 1 |
| 6 | Hepddin hound to α2-maeroglobulin reduces ferroportin-1 expression and en- hances its activity at reducing serum iron levels显示文摘 | Huang ML Austin CJ Sari MA | 2013 | J Biol Chem2013，288，25： | 1 |
| 7 | Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action显示文摘 | Susanne C. Miller Ruili Huang Srilatha Sakamuru Sunita J. Shukla Matias S. Attene-Ramos Paul Shinn Danielle Van Leer William Leister Christopher P. Austin Menghang Xia | 2010 | Biochemical Pharmacology2010，，： | 1 |
| 8 | Object- based land cover classification of shaded areas in high spatial resolution imagery of urban areas: A comparison study 显示文摘 | Zhou Weiqi Huang Ganlin Troy Austin | 2009 | Remote Sensing of Environment2009，113，8： | 1 |
| 9 | Continuous particle separation through deterministic lateral displacement 显示文摘 | Huang L R Cox E C Austin R H | 2004 | Science2004，304，5673： | 1 |
| 10 | Coordination of cooperative advertising in a two-level supply chain when manufacturer offers discount显示文摘 | Jinfeng Yue Jill Austin Min-Chiang Wang Zhimin Huang | 2004 | European Journal of Operational Research2004，，1： | 1 |
| 11 | Continuous particle separation through deterministic lateral displacement显示文摘 | HUANG L R COX E C AUSTIN R H | | 0，，： | 1 |
| 12 | Statins and intracerebral hemorrhage: a retrospective cohort study显示文摘 | Hackam DG Austin PC Huang A | 2012 | Arch Neurol2012，69，1： | 1 |
| 13 | Coordi- nation of cooperative advertising in a two- level supply chain when manufacturer offers discount 显示文摘 | Yue J Austin J Wang M C Huang Zhimin | 2006 | European Journal of Operational Research2006，168，： | 1 |
| 14 | Coordination of cooperative advertising in a two-level supply chain when manufacturer offers discount显示文摘 | Yue J Austin J Wang M C Huang Z | 2006 | European Journal of Operational Research2006，168，： | 1 |
| 15 | Continuous particle separation through deterministic lateral dis- placement 显示文摘 | Huang LR Cox EC Austin RH | 2004 | Science2004，304，5673： | 1 |
| 16 | Pulmonary lymphoma identified as a result of low-dose CT screening for lung cancer显示文摘 | Huang Y Shaham D Austin JH | 2008 | Clin Imaging2008，32，4： | 1 |
| 17 | Coordination of cooperative advertising in a two-level supply chain when manufacturer offers discount显示文摘 | Yue J Austin J Wang M.C Huang Z | | 0，，01： | 1 |
| 18 | Institutional Patient-Specific Intensity Modulated Radiation Therapy Quality Assurance Does Not Predict Unacceptable Plan Delivery as Measured by Imaging and Radiation Oncology Core at Houston’s Head and Neck Phantom显示文摘 | Stephen F. Kry Andrea Molineu James Kerns Austin Faught Jessie Y. Huang Kiley Pulliam Jackie Tonigan Paola Alvarez Francesco Stingo David S. Followill | 2014 | International Journal of Radiation Oncology, Biology, Physics2014，，： | 1 |
| 19 | Pricing and advertisement in a manufacturer–retailer supply chain显示文摘 | Jinfeng Yue Jill Austin Zhimin Huang Bintong Chen | 2013 | European Journal of Operational Research2013，，2： | 1 |
| 20 | Coordination of cooperative advertising in a two-level supply chain when manufacturer offers discount显示文摘 | Yue J Austin J Wang MC Huang Z | 2006 | European Journal of Operational Research2006，168，1： | 1 |
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