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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | 纬度依赖背景场误差协方差及其对台风同化和预报的影响研究显示文摘合理的背景场误差协方差矩阵是做好变分同化的关键。为进一步认识背景场误差协方差矩阵在中尺度预报中的作用,对背景场误差协方差中平衡关系的纬度依赖特征及其对中尺度同化及预报效果的影响进行了研究。为使得平衡关系既包含纬度依赖特征,又降低纬度依赖带来的非平衡的噪音信息,在背景场误差协方差矩阵构造的平衡变换过程中引入了递归滤波的方法,对平衡变换中的回归系数进行了滤波平滑。同化单点观测的理想试验表明纬度依赖的背景场误差协方差具有更合理的动力关系,且滤波后的背景场误差协方差既保持了纬度依赖特征且明显平滑了噪音信息。台风'莫拉克'同化数值模拟试验表明纬度依赖的背景场误差协方差明显提高了36 h及以上的中心海平面最低气压和路径预报的预报效果。 | 陈耀登 曾腊梅 HUANG Xiang-yu WANG Hong-li 高玉芳 RIZVI S R H | 2014 | 热带气象学报2014，30，4： | 6 |
| 4 | 金刚石中的冰-Ⅶ相包裹体:来自地球深部地幔的含水流体证据显示文摘水在地球内部不同圈层的存在形态、分布、含量以及全球水循环一直以来都是固体地球科学研究的前沿热点问题之一。冰-Ⅶ相作为水的一种高压相,目前已经被国际矿物学会认定为一种新矿物。 | Tschauner O Huang S Greenberg E Prakapenka V B Rossman G R Shen A H Zhang D Newville M Lanzirotti A Tait K 张宝华 | 2018 | 矿物岩石地球化学通报2018，37，6： | 4 |
| 5 | Isozyme inheritance and variation in Actinidia显示文摘 | Huang H W Fenny D Wang Z R Jiang Z W Huang R H Wang S M | 1997 | Heredity1997，78，： | 2 |
| 6 | Bone induction by BMP-2 transduced stem cells derived from human fat显示文摘 | Dragoo J L Choi J Y Lieberman J R Huang J, Zuk P A, Zhang J, Hedrick M H, Benhaim P | | 0，，： | 2 |
| 7 | Remote Sensing of Successional Changes in Wetland Vegetation as Monitored During a Four Year Drawdown of a Former Cooling Lake显示文摘 | Jensen J R Huang X Mackey H E | 1997 | Applied Geographic Studies1997，，1： | 1 |
| 8 | Rational syntheses, characterization, crystal structure, and replacement reactions of coordinated water molecules of ^10- (M =Cd, Co, Cu, Fe, Mn, Ni or Zn) 显示文摘 | Bi L H Huang R D Peng J | 2001 | J Chem Soc Dalton Trans2001，，： | 1 |
| 9 | Developmental expression of key steroidogenie enzymes in the brain of protandrous black porgy fisb, Acanthopagrus sehlegeli 显示文摘 | Tomy S Wu G C Huang H R | 2007 | Neuroendoerinol2007，9，8： | 1 |
| 10 | Topotecan in the treatment of relapsed small cell lung cancer patients with poor performance status显示文摘 | Treat J Huang C H Lane S R | 2004 | Oncologist2004，9，2： | 1 |
| 11 | Tanshinone Ⅱ A protects cardiac myoeytes against oxidative stress-triggered damage and apoptosis显示文摘 | Fu J Huang H Du J Pi R Chen J Liu P | 2007 | Eur J Pharmacol2007，568，13： | 1 |
| 12 | Robust H∞ control for uncertain linear time - invariant descriptor systems 显示文摘 | Huang J C Wang H S Chang F R | 2000 | IEEE Proceedings of Control Theory and Applications2000，147，6： | 1 |
| 13 | Analysis of wax hydrocarbons in petroleum source rocks from the Damintun depression, eastern China,using high temperature gas chromatography 显示文摘 | Huang H P Steve R L Gordon D L | 2003 | Organic Geochemistry2003，34，： | 1 |
| 14 | Visual interpretation of hand gestures for human-computer interaction: a review显示文摘 | Pavlovic V I Sharma R Huang H S | 1997 | IEEE Transactions on Pattern Analysis and Machine Learning1997，19，7： | 1 |
| 15 | Crystallization and preliminary crystallographic studies of a novel antifungal protein with five disulfide bridges from Eucommia ulmoides Oliver显示文摘 | XIANG Y HUANG R H LIU W | 2002 | Acta Crystallogr D Biol Crystallogr2002，58，： | 1 |
| 16 | Experimental Study on the Characterization of Worn Surface Topography with CharacteristicRoughness Parameter显示文摘 | Zhu H Ge S R Huang X L | 2003 | Wear2003，255，16： | 1 |
| 17 | Amine-grafted MCM-48 and silica xerogel as superior sorbents for acidic gas removal from natural gas显示文摘 | Huang H Y Yang R T Chinn D | 2003 | Ind Eng Chem Res2003，42，12： | 1 |
| 18 | Preparation andcharacteristics of quatemized chitosan/ poly(acrylonitrile)composite nanofiltration membrane from epichlorohydrincross-linking 显示文摘 | Huang R H Chen G H Sun M K | 2007 | Carbohydr Polym2007，70，3： | 1 |
| 19 | A parameterization scheme of surface turbulent momentum and sensible heat over the gobi underlying surface 显示文摘 | ZHANG Q HUANG R H TIAN H | 2003 | Advance in Atmospheric Sciences2003，20，1： | 1 |
| 20 | A fuzzy multi-criteria decision making approach for solving a bi-objective personnel assignment problem显示文摘 | Huang D K Chiu H N Yeh R H | 2009 | Computers & Industrial Engineering2009，56，1： | 1 |
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