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	题名	作者	年代	出处	被引量
1	Mycobacterium bovis bacille Calmette-Guérin (BCG) enhances human β-defensin-1 gene transcription in human pulmonary gland epithelial cells显示文摘AIM: To examine the stimulatory effect of bacille Calmette-Guérin (BCG) cell wall components on human [β-defensin-1 (hBD-1)gene expression and analyze the response element in the 5'-flanking region of the gene. METHODS:BCG cell wall proteins were fractionated by Sephadex G-150 chromatography. Using reverse-transcription polymerase chain reaction (RT-PCR) and Northern hybridization analysis, hBD-1 mRNA expression was detected in ahuman pulmonary gland epithelial cell line SPC-A-1 cells. Progressive deletions of 5'-flanking region of hBD-1 genewere produced by PCR and ligated into promoterless chloramphenicol acetyltransferase (CAT) expression plasmidto construct pCAT reporter plasmids. Reporter gene expression was determined by ELISA. RESULTS: Therewas an obvious enhancement of hBD-1 mRNA expression after stimulation with heat-inactivated BCG whole cells(50mg/L), or the cell wall components with a molecular weight of 18-30 kDa (3mg/L) for 8 h. The upstreamsequence between -314 bp and +54 bp had the inducible activity by BCG, which contained CCAAT/enhancerbinding protein-β (C/EBPβ), activator protein-1 (AP-1), and CP2 cis element. CONCLUSION: BCG cell wallcomponents (18-30 kDa) can stimulate hBD-1 mRNA expression in pulmonary gland epithelial cells. The sequence(-314/+54) containing C/EBPβ, AP-1, and CP2 binding sites in the upstream of hBD-1 is involved in this induction.	ZHUBing-Dong FENGYun HUANGNing, WUQi WANGBo-Yao	2003	Acta Pharmacologica Sinica2003，24，9：	4
2	Gastrodia elatapreventrat pheochromocytoma cells from serum-deprived apoptosis:throle of the MAPK family显示文摘	HuangN K LinY L Cheng J J	2004	Life Sci2004，75，13：	1
3	Anewviewof non- linear water waves=The Hilbert spectrum 显示文摘	HuangN E ShenZ LongSR	1999	Annual Review of Fluid Mechanics1999，31，：	1
4	A new view of nonlinear water waves: the Hilbert spectrum显示文摘	HuangN E ShenZ LongSR	1999	Annu Rev Fluid Mech1999，31，：	1
5	TheempiricalmodedecompositionandtheHilbertspectrumfornon-linearandnon-sta-tionarytimeseriesanalysis显示文摘	HuangNE ShenZ LongSR etal	1988	ProceedingsoftheRoyalSocietyofLondonSeriesA1988，454，：	1
6	Synthesis and characr terization of ultra small PbS nanorods in sucrose ester microemulsion显示文摘	Huangn M Radiman S Lim H N	2009	Mater Lett2009，63，34：	1
7	Who is at risk of death in an earthquake? 显示文摘	ChouYJ HuangN LeeCH etal	2004	Am J Epidemiol2004，160，7：	1
8	A B spline approach for empirical mode decompositions显示文摘	Chen Q H Huangn E Riemenschneider S	2006	Advances in Computational Mathematics2006，，24：	1
9	A new view of nonlinear water waves:the Hilbert Spectrum显示文摘	HUANGN E SHEN Z LONGRS		0，，01：	1
10	A confidence limit for the empirical mode decomposition and Hilbert spectral analysis 显示文摘	HUANGN E WU M L LONGS R	2003	Proc R Soc London Ser A2003，459，2037：	1
11	2011, On the time-varying lxend in global-mean surface temperature显示文摘	WuZ HuangNE WallaceJM	2011	Climate Dynam2011，37，：	1
12	The em- pirical mode decomposition and the Hilbert spectrum for nun-linear and non-stationary time series analysis 显示文摘	HUANGN E SHEN Z LONG SR	1998	Proc R Soc Lond A1998，454，：	1
13	A new view of nonlinear waterwaves:the Hilbert spectrum显示文摘	HUANGNE SHENZ LONGSR	1999	Ann Rev Fluid Mech1999，31，：	1
14	A new view of nonlinear water waves:The Hilbert spectrum显示文摘	HuangN E Shen Z Long S R	1999	Annual Review of Fluid Mechanics1999，，31：	1
15	Theempiri cal mode decomposition and the Hilbert spectrum for nonlinear and non--station time series analysis显示文摘	HuangNE ShenZ LongSR etal	1998	Proc R Soc London1998，45，4：	1
16	The Em- pirical Mode Decomposition and the Hilbert Spectrum for Non- linear and Non-stationary Time Series Analysis 显示文摘	HuangNE Shen Z Long S R	1998	Proceedings of the Royal Society1998，454，1971：	1
17	Theempirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘	HUANGNE SHENZ LONGSR	1998	Proceedings of Royal Society of London A1998，454，：	1
18	The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis 显示文摘	HuangN E ShenZ LongSR	1998	Proc R Soc Lond1998，454，：	1
19	Astudyofthecharacteristicsofwhitenoiseusingtheempiricalmodedecompositionmethod显示文摘	WuZ HuangNE		0，，460：	1
20	Synthesis of SiC nanowires by thermal evaporation method without catalyst assistant显示文摘	Chen K Huangn Z H Huang J T	2013	Ceramics International2013，39，：	1

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