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| 1 | Regulation of Toll-like receptor signaling in innate immunity显示文摘Toll-like receptors sense invading pathogens by recognizing a wide variety of conserved pathogen-associated molecular patterns(PAMPs).The members of the TLR family selectively utilize adaptor proteins MyD88,TRIF,TIRAP and TRAM to activate overlapping but distinct signal transduction pathways which trigger production of different panels of mediators such as proinflammatory cytokines and type I interferon.These mediators not only control innate immunity but also direct subsequently developed adaptive immunity.TLR activation is strictly and finely regulated at multiple levels of the signal transduction pathways. | AN HuaZhang,QIAN Cheng & CAO XueTao National Key Laboratory of Medical Immunology & Institute of Immunology,Second Military Medical University,Shanghai 200433,China | 2010 | Science China(Life Sciences)2010，53，1： | 29 |
| 2 | APOLIPOPROTEIN E GENE POLYMORPHISMS AND RISK FOR CORONARY ARTERY DISEASE IN CHINESE XINJIANGUYGUR AND HAN POPULATION显示文摘Objective To examine the relationship between apolipoprotein E (Apo E) gene polymorphism and risk of coronary artery disease (CAD), analyzing association of polymorphism with classical risk factors. Methods A total of 124 patients (including 84 Han population and 40 Uygur population) with angiographically verified CAD or myocardial infarction were prospectively evaluated. Data referring to hypertension, diabetes, and tobacco consump-tion were recorded. The levels of total cholesterol (TC), high density lipoprotein (HDL) cholesterol, Apo A1 and B, and triglycerides (TG) were determined. DNA was obtained from 124 patients and 70 controls. In order to determine Apo E genotypes, DNA was PCR amplified and digested with HhaI. The genetic polymorphism of Apo E is due to three common alleles, epsilon(ε) 2, ε3, ε4, at a single autosomal gene locus. These alleles determine the six phenotypes E2/2, E3/3, E4/4, E4/2, E4/3, and E3/2. Results In Uygur population, the frequency of the ε2, ε3, and ε4 was 0.155, 0.648, and 0.197 respectively. In Han po-pulation, the frequency of the ε2, ε3, and ε4 was 0.081, 0.772, and 0.146 respectively. In the patient group, the frequency of the ε2, ε3, and ε4was 0.060, 0.758, and 0.182 respectively. In the control group, the frequency of the ε2, ε3, and ε4 was 0.193, 0.671, and 0.136 respectively. ε2 frequency of Uygur’ patients and controls was 0.050 and 0.290 respectively. Serum low density lipoprotein (LDL) cholesterol, TC, and TG values tended to decrease from the Apo E-4 phenotypes to Apo E-2 phenotypes. When deletion polymorphism of ε2 was compared with the common risk factors for CAD, its risk ratio (RR) is 4.38. Conclusions These studies confirm and find that Apo E phenotype distribution in Uygur population differs significantly from that in Han population in Xinjiang. CAD patients have significantly lower ε2 allele and slightly higher ε3 or ε4 allele frequency than controls, especially in Uygur population. It shows protective effects of ε2 on CAD. | Sheng-liYang Bing-xianHe Hui-liangLiu Zuo-yunHe HuaZhang Jian-pingLuo Xiu-fangHong Yang-chunZou | 2004 | Chinese Medical Sciences Journal2004，19，2： | 17 |
| 3 | TAOK1 negatively regulates IL-17-mediated signaling and inflammation显示文摘Interleukin 17(IL-17)is an important cytokine that can induce tissue inflammation and is involved in the pathogenesis of numerous autoimmune diseases.However,the regulation of its signaling transduction has not been well described.In this study,we report that thousand and one kinase 1(TAOK1)functions as a negative regulator of IL-17-mediated signal transduction and inflammation.TAOK1 knockdown promotes IL-17-induced cytokine and chemokine expression and the activation of mitogen-activated protein kinases and nuclear factor-κB.We further demonstrate that TAOK1 interacts with IL-17 receptor A(IL-17RA)independent of its kinase activity,and TAOK1 dose-dependently prevents the formation of the IL-17R-Act1(nuclear factor activator 1,also known as tumor necrosis factor receptor-associated factor 3 interacting protein 2)complex.Consistent with this,TAOK1 deficiency exacerbates colitis in the 2,4,6-trinitrobenzenesulfonic acid-induced experimental model of inflammatory bowel disease,likely by its promotion of the IL-17-mediated signaling pathway.TAOK1 expression is decreased in the colons of ulcerative colitis patients.In conclusion,these findings suggest that TAOK1 is involved in the development of IL-17-related autoimmune disorders. | Zhaoru Zhang Zhen Tang Xianwei Ma Kai Sun Liping Fan Jie Fang Jianping Pan Xiaojian Wang Huazhang An Jun Zhou | 2018 | Cellular & Molecular Immunology2018，15，8： | 10 |
| 4 | Effect of the graphitic degree of carbon supports on the catalytic performance of ammonia synthesis over Ba-Ru-K/HSGC catalyst显示文摘A series of high surface area graphitic carbon materials(HSGCs) were prepared by ball-milling method. Effect of the graphitic degree of HSGCs on the catalytic performance of Ba-Ru-K/HSGC-x(x is the ball-milling time in hour) catalysts was studied using ammonia synthesis as a probe reaction. The graphitic degree and pore structure of HSGC-x supports could be successfully tuned via the variation of ball-milling time. Ru nanoparticles of different Ba-Ru-K/HSGC-x catalysts are homogeneously distributed on the supports with the particle sizes ranging from 1.6 to 2.0 nm. The graphitic degree of the support is closely related to its facile electron transfer capability and so plays an important role in improving the intrinsic catalytic performance of Ba-Ru-K/HSGC-x catalyst. | Wei Jiang Ying Li Wenfeng Han Yaping Zhou Haodong Tang Huazhang Liu | 2014 | Journal of Energy Chemistry2014，23，4： | 8 |
| 5 | PROGRESS IN STUDIES OF ELECTROCATALYSTS AND DOPED CARBON ANODES IN ALUMINIUM ELECTROLYSIS CELLS显示文摘PROGRESSINSTUDIESOFELECTROCATALYSTSANDDOPEDCARBONANODESINALUMINIUMELECTROLYSISCELLSPROGRESSINSTUDIESOFELECTROCATALYSTSANDDOPE... | Liu,Yexiang Wang,Xiangmin Huang,YongzhongWang,Huazhang Yang,Jianhong(Department of Nonferrous Metallurgy, Central South University of Technology,Changsha 410083) | 1994 | 中国有色金属学会会刊:英文版1994，4，2： | 4 |
| 6 | Effects of(Mg_(1/3)Sb_(2/3))^(4+)substitution on the structure and microwave dielectric properties of Ce_(2)Zr_(3)(MoO_(4))_(9) ceramics显示文摘Ce2[Zr_(1-x)(Mg_(1/3)Sb_(2/3))_(x)]_(3)(MoO_(4))_(9)(0.02≤x≤0.10)ceramics were prepared by the traditional solid-state method.A single phase,belonging to the space group of R3c,was detected by using X-ray diffraction at the sintering temperatures ranging from 700 to 850℃.The microstructures of samples were examined by applying scanning electron microscopy(SEM).The crystal structure refinement of these samples was investigated in detail by performing the Rietveld refinement method.The intrinsic properties were calculated and explored via far-infrared reflectivity spectroscopy.The correlations between the chemical bond parameters and microwave dielectric properties were calculated and analyzed by Phillips-van Vechten-Levine(P-V-L)theory.Ce_(2)[Zr_(0.94)(Mg_(1/3)Sb_(2/3))_(0.06)]_(3)(Mo0_(4))_(9)ceramics with excellent dielectric properties were sintered at 725℃for 6 h(εr=10.37,Q×f=71,748 GHz,andτf=-13.6 ppm/℃,εr is the dielectric constant,τf is the quality factor,and rf is the temperature coefficient of resonant frequency). | Xu ZHOU Lintao LIU Jiajia SUN Ningkang ZHANG Huazhang SUN Haitao WU Wenhong TAO | 2021 | Journal of Advanced Ceramics2021，10，4： | 4 |
| 7 | MEF2C promotes M1 macrophage polarization and Th1 responses显示文摘The polarization of macrophages to the M1 or M2 phenotype has a pivotal role in inflammation and host defense;however,the underlying molecular mechanism remains unclear.Here,we show that myocyte enhancer factor 2 C(MEF2C)is essential for regulating M1 macrophage polarization in response to infection and inflammation.Global gene expression analysis demonstrated that MEF2C deficiency in macrophages downregulated the expression of M1 phenotypic markers and upregulated the expression of M2 phenotypic markers.MEF2C significantly promoted the expression of interleukin-12 p35 subunit(Il12a)and interleukin-12 p40 subunit(Il12b).Myeloid-specific Mef2c-knockout mice showed reduced IL-12 production and impaired Th1 responses,which led to susceptibility to Listeria monocytogenes infection and protected against DSS-induced IBD in vivo.Mechanistically,we showed that MEF2C directly activated the transcription of Il12a and Il12b.These findings reveal a new function of MEF2C in macrophage polarization and Th1 responses and identify MEF2C as a potential target for therapeutic intervention in inflammatory and autoimmune diseases. | Xibao Zhao Qianqian Di Han Liu Jiazheng Quan Jing Ling Zizhao Zhao Yue Xiao Han Wu Zherui Wu Wengang Song Huazhang An Weilin Chen | 2022 | Cellular & Molecular Immunology2022，19，4： | 4 |
| 8 | Porous ternary complex metal oxide nanoparticles converted from core/shell nanoparticles显示文摘我们表明一个容易、可伸缩的低温度的过程由热退火从综合答案的核心 / 壳金属氧化物 nanoparticles 变换多孔的第三的复杂金属氧化物 nanoparticles。最后的产品在快为预付锂离子电池(解放) 电极材料的潜在的应用控告 / 解除周期期间与一个大能力和高稳定性表明优异电气化学的性质。另外,新故障机制在这些新奇电极材料上被观察。 | Jaewon Lee Huazhang Zhu Gautam Ganapati Yadav James Caruthers Yue Wu | 2016 | Nano Research2016，9，4： | 3 |
| 9 | La_2Ce_2O_7 supported ruthenium as a robust catalyst for ammonia synthesis显示文摘La_2Ce_2O_7 nanoparticles were prepared by citric acid complexation method followed by calcination at varied temperatures. Then, supported with 4 wt% Ru, they were evaluated as the catalysts for ammonia synthesis under conditions similar with industry. With La_2Ce_2O_7 being calcinated at 700 or 800℃, the experimental results indicate that the Ru/La_2Ce_2O_7 catalyst exhibits much higher ammonia concentration or ammonia synthesis rate than that of Ru/CeO_2 and Ru/La_2O_3. In addition, Ru/La_2Ce_2O_7 possesses high stability under over-heating test. In the absence of any promotor, ammonia concentration of Ru/La_2Ce_2O_7 catalyst approaches 14% at 450℃, GHSV of 10000 h^(-1) and pressure of 10 MPa. The rate-determining step of ammonia synthesis, dissociation of N_2 is significantly facilitated by the strong metalesupport interaction(SMSI) between Ru and La_2Ce_2O_7. Due to the interaction, La_2Ce_2O_7 tends to donate electrons to Ru,resulting in the high electron density over the surface of Ru active sites which is favorable for the dissociation of N_2. Consequently, high activity is achieved. | Wenfeng Han Zhi Li Huazhang Liu | 2019 | Journal of Rare Earths2019，37，5： | 3 |
| 10 | A Generalized Acceleration and Deceleration Approach for Continuous Small Line Blocks with Look-ahead显示文摘Generally complex 3D contours are divided into a lot of continuous small line blocks by CAD/CAM software. When these small line blocks are used in conventional way,machine tool has to stop at the end of one move before continuing on to the next to meet accuracy requirement,which results in inefficiency.Look-ahead is an intelligent function that aims at adjusting the feed rate automatically to achieve maximum productivity while maintaining accuracy.By now most researchers just utilize the simplest linear acceleration(ACC)and deceleration(DEC)to deal with look-ahead intelligence.A generalized ACC/DEC ap- proach and corresponding optimal look-ahead algorithm based on dynamic back tracking along a doubly linked list are proposed.An improved rounding strategy for reducing interpolation errors is also presented.By using the proposed techniques,arbitrary velocity profiles that offer look-ahead feature and have the desired ACC/DEC characteristics for movement of a lot of continuous line blocks can be generated efficiently.Both simulations and experiments showed the productivity was dramatically increased without sacri- fice of accuracy. | LUO Fuyuan~1 ZHOU Yunfei~1 YIN Juan~2 (1.National Technical Research Center-Numerical Control System,School of Mechanical Science and Engineering,Huazhang University of Science and Technology,Wuhan 430074,China, 2.School of Machinery and Automobile Engineering,Hefei University of Technology,Hefei 234009,China) | 2006 | 武汉理工大学学报2006，28，S3： | 3 |
| 11 | Role of surface defects of carbon nanotubes on catalytic performance of barium promoted ruthenium catalyst for ammonia synthesis显示文摘Carbon nanotubes(CNTs) with abundant surface defects are prepared by a liquid oxidation and thermal annealing method. The defective CNTs-D supported Ba–Ru/CNTs-D catalysts exhibit superior catalytic performance in ammonia synthesis with a TOF be increased up to 0.30 s-1, which is 2.5 times of oxidized CNTs-O supported Ba–Ru/CNTs-O catalysts and 5 times of the Ba–Ru/CNTs. The characterizations by CO chemisorption, transmission electron microscope, Raman, and X-ray photoelectron spectroscopy revealed that the uniformly well dispersed Ru NPs can be stabilized on the defective sites of CNTs-D. The great improvement of the catalytic performance and stability of the Ba–Ru/CNTs-D is contributed to the strong interaction between Ru NPs and surface defect of the CNTs. | Yongcheng Ma Guojun Lan Wenzhao Fu Ying Lai Wenfeng Han Haodong Tang Huazhang Liu Ying Li | 2020 | Journal of Energy Chemistry2020，29，2： | 2 |
| 12 | EFFECT OF OXIDIZED-LDL ON NF-κB NUCLEAR TRANSLOCATION IN AORTIC SMOOTH MUSCLE CELLS ORIGINATED FROM RATS OF DIFFERENT AGES显示文摘Objective To investigate the molecular mechanism of atherosclerosis that related to age. Methods Immunohistochemistry staining and Western blot were adopted to determine the nuclear translocation of nuclear factor-kappa B (NF-κB) and expression of platelet-derived growth factor B (PDGF-B) in smooth muscle cells (SMCs) co-cultured with low density lipoprotein (LDL), oxidized LDL (ox-LDL), and ox-LDL+high density lipoprotein (HDL) originated from rats of 2 and 10 months old respectively. Fat stain was used to identify the lipid intake in SMCs. Results The optimal stimulation time of ox-LDL to SMCs was 12 hours. NF-κB intensity increased in most nuclei of SMCs that originated from rats of either 2 or 10 months old co-cultured with ox-LDL. The intensity of NF-κB and the amount of intracellular lipid taken in SMCs were more obvious in cells from 10-month-old rats than from the younger ones. Change of PDGF-B expression in SMCs was not remarkable in each group of rats. Conclusions The 10-month-old rats are more susceptive to ox-LDL than 2-month-old rats in activating nuclear transloca- tion of NF-κB. Maybe this is one of the important reasons contributing to the difference between the older and younger rats on the initiation and development of atherosclerosis lesion. Expression of PDGF-B is not associated with the activity of nuclear translocation of NF-κB. | Jun-huaZhang LiZhou Hong-chaoYin Pei-maoLiu HuaZhang Ming-pengShe | 2005 | Chinese Medical Sciences Journal2005，20，2： | 2 |
| 13 | Origin of inhomogeneity in spark plasma sintered bismuth antimony telluride thermoelectric nanocomposites显示文摘Anisotropy and inhomogeneity are ubiquitous in spark plasma sintered thermoelectric devices.However,the origin of inhomogeneity in thermoelectric nanocomposites has rarely been investigated so far.Herein,we systematically study the impact of inhomogeneity in spark plasma sintered bismuth antimony telluride(BiSbTe)thermoelectric nanocomposites fabricated from solution-synthesized nanoplates.The figure of merit can reach 1.18,which,however,can be overestimated to 1.88 without considering the inhomogeneity.Our study reveals that the inhomogeneity in thermoelectric properties is attributed to the non-uniformity of porosity,textures and elemental distribution from electron backscatter diffraction and energy-dispersive spectroscopy characterizations.This finding suggests that the optimization of bulk material homogeneity should also be actively pursued in any future thermoelectric material research. | Enzheng Shi Shuang Cui Nicholas Kempf Qingfeng Xing Thomas Chasapis Huazhang Zhu Zhe Li Je-Hyeong Bahk G.Jeffrey Snyder Yanliang Zhang Renkun Chen Yue Wu | 2020 | Nano Research2020，13，5： | 2 |
| 14 | Synthesis and characterization of semiconductor zinc sulfide nanotubes by soft-template method显示文摘ZnS nanotubes have been successfully synthe-sized from solutions containing a surfactant, Triton X-100(t-octyl-(OCH2CH2)χOH, χ=9, 10). X-ray diffraction (XRD),transmission electron microscope (TEM) and selected areaelectron diffraction (SAED) are employed to characterize thestructure and morphology of as-synthesized product. XRDand SAED pattern indicate that as-obtained products consist of pure polycrystalline cubic-phase ZnS structures. TEM images reveal that most of the products are tubular struc-tures, with diameters ranging between 37--52 nm andlengths up to 3 μm. The wall thickness of as-obtained ZnSnanotube is around 9 nm. The growth mechanism of ZnSnanotubes has also be proposed. | LU Ruitao CAO Chuanbao ZHAI Huazhang ZHU Hesun Research Center of Material Science, Beijing Institute of Technology, Beijing 100081, China Correspondence should be addressed to Cao Chuanbao (e-mail: cbcao@bit.edu.cn) | 2004 | Chinese Science Bulletin2004，49，10： | 2 |
| 15 | Capillary Electrophoretic Immunoassay with Laser-induced Fluorescence Detection for Interferon-gamma显示文摘Capillary electrophoretic immunoassay with laser-induced fluorescence detection for recombinant human interferon-gamma (IFN-g) was established. The limits of detection for three forms of IFN-g are 6.9 ng/L, 5.7 ng/L and 5.0 ng/L, respectively. | HuaZHANG HaiMingWEI WenRuiJIN | 2004 | Chinese Chemical Letters2004，15，1： | 2 |
| 16 | Advanced treatment of coking wastewater by coagulation and zero-va- lent iron processes显示文摘 | Lai Peng Zhao Huazhang Wang Chao | 2007 | Journal of Hazardous Materials2007，147，： | 1 |
| 17 | Shareholding structure and corporate performance of partially privatized firms: Evidence from listed Chinese companies显示文摘 | DaqingQi WoodyWu HuaZhang | | Paeific Basin Finance Journal0，20，8： | 1 |
| 18 | Advanced Treatment of Coking Wastewater by Coagulation and Zero-Valent Iron Processes显示文摘 | Lai Peng Zhao Huazhang Wang Chao | 2007 | J Hazard Mater2007，147，1： | 1 |
| 19 | Defluoridation of drinking water by combined electrocoagulation: effects of the molar ratio of alkalinity and fluoride to A1 (III) 显示文摘 | Zhao Huazhang Yang Wei Zhu Jun | 2009 | Chemosphere2009，74，： | 1 |
| 20 | Advanced treatment of coking wastewater by coagulation and zero-valent iron processes 显示文摘 | Lai Peng Zhao Huazhang Wang Chao | 2007 | Journal of Hazardous Materials2007，147，12： | 1 |
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