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| 1 | Preliminary research on Megalake Jilantai-Hetao in the arid areas of China during the Late Quaternary显示文摘我们识别了 geomorphological,在通过地调查并且通过地区性的遥感的分析的当前的 Jilantai 盐湖附近的高湖层次的沉积、生物的证据想象。在约 1060, 1050, 1044 和 1035 m a.s.l 的举起有四组海岸线,是在当前的盐湖上面的 37, 27, 21 和 12 m 分别地出现。沙和石子的沿岸的存款在在 1070 和 1080 m a.s.l 之间的举起被发现,比水流高的 47 ~ 57 m 腌湖表面,尽管 palaeoshoreline 地形仅仅在几个地点被保存。在 Herimuxini,在 Ulan Buh 荒芜的、典型湖的沉积和沙石子的北边缘上,沿岸的存款也发生在 1080 m a.s.l 并且在下面的举起。典型吐痰扩大的 A 11-km-long 从逐渐地在它的大拐弯上沿着黄河的南部的银行在一些沙石子石场从 1050 ~ 1035 m a.s.l 在举起减少的这条海岸线东方海岸线特征例如在水文学计量器车站和 Shilazhao 镇附近定位的那些,被识别。沿岸的存款 overlying 冲积的洪水的层在 Hangjin 在 Balagong 附近发生在沙石场县。也有沙滩岩石和沿岸的存款,沿着 Langshan-Yinshan 山的南部的山麓在几个地点在 cut-and-built 平台上保存。另外,揭示水下的三角洲沉积的侧面在 Wuhai 附近被识别,在黄河进入盆的地方。典型的湖沉积也在 Hetao 平原的东方结束在 Togtoh 站台存在。水的软体动物壳在沿岸的存款是普通的,包括 Corbicula 的几种,根值 lagotis, R。xauricularia 和 Gyraulus convexiusculus。Ostracode 壳能也在更好的沉积被识别。典型垂直 prograding 序列在湖的沉积很好被保存的露头是明显的。滚动波浪的卵石和沙滩岩石很通常在更高的举起在堤在侧面的顶上被保存。所有这些证据建议曾经有一个巨大的palaeo湖,用到达我们指的 ∼1080 m a.s.l 的最高的湖水平盖住 Jilantai 区域和 Hetao 平原的大多数部分巨大的 paleolake ,比现代的湖贝加尔湖大,作为“ Megalake Jilantai-Hetao ”. OSL 标明日期结果显示大湖以前形成了 ∼60 —50 ka,和在在 1060 和 1035 m a.s.l 之间的举起的四条海岸线多半从 ∼60 ∼50 ka 代表湖水平变化到早 Holocene。Megalake Jilantai-Hetao 的发现将多半影响黄河的发展的理解在期间晚第四级, Ulan Buh 和 Kubq 的进化抛弃,在这个区域的 neotectonism,并且可能地区性的气候的变化。 | CHEN FaHu FAN YuXin CHUN Xi D.B. MADSEN C.G. OVIATT ZHAO Hui YANG LiPing SUN Yang | 2008 | Chinese Science Bulletin2008，53，11： | 23 |
| 2 | Clinical diagnostic performance of the simultaneous amplification and testing methods for detection of the Mycobacterium tuberculosis complex for smear-negative or sputum-scarce pulmonary tuberculosis in China显示文摘 | Fan Lin Zhang Qing Cheng Liping Liu Zhibing Ji Xiaobing Cui Zhenling Ju Jingliang Xiao Heping | 2014 | Chinese Medical Journal2014，，10： | 19 |
| 3 | Sedimentary documents and Optically Stimulated Luminescence (OSL) dating for formation of the present landform of the northern Ulan Buh Desert,northern China显示文摘GPR reflecting sections and core profiles revealed that sand dunes of the northern Ulan Buh Desert are overlying shallow lacustrine or palustrine sediments. Optical dating results of sediments from three core profiles indicate that the area of the northern Ulan Buh Desert was still covered by the shallow lake or marsh during 8.4-6.4 ka, and eolian sand started to accumulate since around 2 ka. Such a result supports the idea that the present desert landform of the northern Ulan Buh Desert started to form since 2 ka, which was likely a response to the desertification caused by ruin of the Han Dynasty and the large-scale abandonment of farming of the Han nationality. Our research results are consistent with the previous archaeological studies, and support the idea that the Ulan Buh Desert is composed of two parts with different histories, i.e., the old southern Ulan Buh Desert and the young northern Ulan Buh Desert. | Fan YuXin Chen FaHu Fan TianLai Zhao Hui Yang LiPing | 2010 | Science China Earth Sciences2010，53，11： | 15 |
| 4 | High-precision relocation of the aftershock sequence of the January 8,2022,M_(S)6.9 Menyuan earthquake显示文摘The 2022 Menyuan M_(S)6.9 earthquake,which occurred on January 8,is the most destructive earthquake to occur near the Lenglongling(LLL)fault since the 2016 Menyuan M_(S)6.4 earthquake.We relocated the mainshock and aftershocks with phase arrival time observations for three days after the mainshock from the Qinghai Seismic Network using the double-difference method.The total length and width of the aftershock sequence are approximately 32 km and 5 km,respectively,and the aftershocks are mainly concentrated at a depth of 7-12 km.The relocated sequence can be divided into 18 km west and 13 km east segments with a boundary approximately 5 km east of the mainshock,where aftershocks are sparse.The east and west fault structures revealed by aftershock locations differ significantly.The west fault strikes EW and inclines to the south at a 71°-90°angle,whereas the east fault strikes 133°and has a smaller dip angle.Elastic strain accumulates at conjunctions of faults with different slip rates where it is prone to large earthquakes.Based on surface traces of faults,the distribution of relocated earthquake sequence and surface ruptures,the mainshock was determined to have occurred at the conjunction of the Tuolaishan(TLS)fault and LLL fault,and the west and east segments of the aftershock sequence were on the TLS fault and LLL fault,respectively.Aftershocks migrate in the early and late stages of the earthquake sequence.In the first 1.5 h after the mainshock,aftershocks expand westward from the mainshock.In the late stage,seismicity on the northeast side of the east fault is higher than that in other regions.The migration rate of the west segment of the aftershock sequence is approximately 4.5 km/decade and the afterslip may exist in the source region. | Liping Fan Boren Li Shirong Liao Ce Jiang Lihua Fang | 2022 | Earthquake Science2022，35，2： | 14 |
| 5 | Carbon-based solid-liquid lubricating coatings for space applications-A review显示文摘Despite continuous improvements in machine elements over the past few decades,lubrication issues have impeded human exploration of the universe because single solid or liquid lubrication systems have been unable to satisfy the ever-increasing performance requirements of space tribology.In this study,we present an overview of the development of carbon-based films as protective coatings,with reference to their high hardness,low friction,and chemical inertness,and with a particular focus on diamond-like carbon(DLC)films.We also discuss the design of carbon-based solid-liquid synergy lubricating coatings with regards to their physicochemical properties and tribological performance.Solid-liquid composite coatings are fabricated via spinning liquid lubricants on solid lubricating films.Such duplex lubricating coatings are considered the most ideal lubrication choice for moving mechanical systems in space as they can overcome the drawback of adhesion and cold-welding associated with solid films under harsh space conditions and can minimize the crosslinking or chain scission of liquid lubricants under space irradiation.State of the art carbon-based solid-liquid synergy lubricating systems therefore holds great promise for space applications due to solid/liquid synergies resulting in superior qualities including excellent friction reduction and anti-wear properties as well as strong anti-irradiation capacities,thereby meeting the requirements of high reliability,high precision,high efficiency,and long lifetime for space drive mechanisms. | Xiaoqiang FAN QunJi XUE Liping WANG | 2015 | Friction2015，3，3： | 13 |
| 6 | A Two-step Estimation Method of Troposphere Delay with Consideration of Mapping Function Errors显示文摘Mapping function errors are usually not taken into consideration, when space geodetic data observed by VLBI, GNSS and some other techniques are utilized to estimate troposphere delay, which could, however, probably bring non-ignorable errors to solutions. After analyzing the variation of mapping function errors with elevation angles based on several-year meteorological data, this paper constructed a model of this error and then proposed a two-step estimation method of troposphere delay with consideration of mapping function errors. The experimental results indicate that the method put forward by this paper could reduce the slant path delay residuals efficiently and improve the estimation accuracy of wet tropospheric delay to some extent. | Haopeng FAN Zhongmiao SUN Liping ZHANG Xiaogang LIU | 2020 | Journal of Geodesy and Geoinformation Science2020，3，1： | 11 |
| 7 | TAOK1 negatively regulates IL-17-mediated signaling and inflammation显示文摘Interleukin 17(IL-17)is an important cytokine that can induce tissue inflammation and is involved in the pathogenesis of numerous autoimmune diseases.However,the regulation of its signaling transduction has not been well described.In this study,we report that thousand and one kinase 1(TAOK1)functions as a negative regulator of IL-17-mediated signal transduction and inflammation.TAOK1 knockdown promotes IL-17-induced cytokine and chemokine expression and the activation of mitogen-activated protein kinases and nuclear factor-κB.We further demonstrate that TAOK1 interacts with IL-17 receptor A(IL-17RA)independent of its kinase activity,and TAOK1 dose-dependently prevents the formation of the IL-17R-Act1(nuclear factor activator 1,also known as tumor necrosis factor receptor-associated factor 3 interacting protein 2)complex.Consistent with this,TAOK1 deficiency exacerbates colitis in the 2,4,6-trinitrobenzenesulfonic acid-induced experimental model of inflammatory bowel disease,likely by its promotion of the IL-17-mediated signaling pathway.TAOK1 expression is decreased in the colons of ulcerative colitis patients.In conclusion,these findings suggest that TAOK1 is involved in the development of IL-17-related autoimmune disorders. | Zhaoru Zhang Zhen Tang Xianwei Ma Kai Sun Liping Fan Jie Fang Jianping Pan Xiaojian Wang Huazhang An Jun Zhou | 2018 | Cellular & Molecular Immunology2018，15，8： | 10 |
| 8 | Tribological properties of conductive lubricating greases显示文摘Three kinds of new conductive lubricating greases were prepared using lithium ionic liquids as the base oil and the polytetrafluoroethylene(PTFE)as the thickener.These lithium ionic liquids([Li(PEG)X])were obtained by blending lithium salts(LiBF4,LiPF6 and LiNTf2)with poly(ethylene glycol)(PEG)because lithium salts have an extremely high solubility in PEG.The conductivities and contact resistances of the prepared lubricating greases were investigated using the DDSJ‐308A conductivity meter and the reciprocating ball‐on‐disk UMT‐2MT sliding tester.In addition,their tribological properties were investigated in detail.Scanning electron microscopy and X‐ray photoelectron spectroscopy were employed to explore the friction mechanisms.The results suggest that the prepared lubricating greases have high conductivities and excellent tribological properties.The high conductivities are attributed to ion diffusion or migration of the lithium ionic liquids with an external electric field,and the excellent tribological properties depend on the formation of boundary protective films. | Xiaoqiang FAN Yanqiu XIA Liping WANG | 2014 | Friction2014，2，4： | 10 |
| 9 | Land-surface processes and summer-cloud-precipitation characteristics in the Tibetan Plateau and their effects on downstream weather:a review and perspective显示文摘Correct understanding of the land-surface processes and cloud-precipitation processes in the Tibetan Plateau(TP)is an important prerequisite for the study and forecast of the downstream activities of weather systems and one of the key points for understanding the global atmospheric movement.In order to show the achievements that have been made,this paper reviews the progress on the observations for the atmospheric boundary layer,land-surface heat fluxes,cloud-precipitation distributions and vertical structures by using ground-and space-based multiplatform,multisensor instruments and the effect of the cloud system in the TP on the downstream weather.The results show that the form drag related to the topography,land-atmosphere momentum and scalar fluxes is an important part of the parameterization process.The sensible heat flux decreased especially in the central and northern TP caused by the decrease in wind speeds and the differences in the ground-air temperatures.Observations show that the cloud and precipitation over the TP have a strong diurnal variation.Studies also show the compressed-air column in the troposphere by the higher-altitude terrain of the TP makes particles inside clouds vary at a shorter distance in the vertical direction than those in the non-plateau area so that precipitation intensity over the TP is usually small with short duration,and the vertical structure of the convective precipitation over the TP is obviously different from that in other regions.In addition,the influence of the TP on severe weather downstream is preliminarily understood from the mechanism.It is necessary to use model simulations and observation techniques to reveal the difference between cloud precipitation in the TP and non-plateau areas in order to understand the cloud microphysical parameters over the TP and the processes of the land boundary layer affecting cloud,precipitation and weather in the downstream regions. | Yunfei Fu Yaoming Ma Lei Zhong Yuanjian Yang Xueliang Guo Chenghai Wang Xiaofeng Xu Kun Yang Xiangde Xu Liping Liu Guangzhou Fan Yueqing Li Donghai Wang | 2020 | National Science Review2020，7，3： | 10 |
| 10 | Paleoenvironmental implications of high-density records in Co-rich seamount crusts from the Pacific Ocean显示文摘Co-rich seamount crusts have been shown to possess great potential for providing information on paleoceanographic and paleoclimatic changes. High resolution data are essential to decipher and correctly understand such high-density records. With the development of modern microprobe techniques, detailed sampling of crusts can be performed and it is possible to retrieve detailed information about envi- ronmental changes recorded in the seamount crusts. We report here geochemical results of more than 40 elements (including all rare earth elements) of four Co-rich seamount crust samples, which were collected from seamounts in the central and western Pacific Ocean. These data were obtained with two micro-probe techniques: Electron Probe Micro Analyzer and Laser Ablation Inductively Coupled Plasma Mass Spectrometry. The chronological framework of the seamount crust samples was determined using the cos- mogenic 10Be and the Co-chronometer. Records of elemental composition, P, and Al/(Fe + Mn) and Y/Ho ratios across the sections of the four samples are used to identify paleoceanographic and paleoclimatic events over the past ~30 Ma. These data show that: (1) Al/(Fe + Mn) in the western Pacific seamount crust is a useful proxy for the assessment of changes of source materials related to the variability of the Asian monsoon; (2) P and Y/Ho can be used as proxies to infer biogenic episodes. Finally we discuss the methodology related to dating and micro-probe analysis used in crust study. | WANG XiaoHong ZHOU LiPing WANG YiMin ZHANG XueHua LIU XiaoMing FAN XingTao LIU KeXin ZHOU JianXiong | 2008 | Science China Earth Sciences2008，51，10： | 5 |
| 11 | C0818,a novel curcumin derivative,interacts with Hsp90 and inhibits Hsp90 ATPase activity显示文摘The aims of the present study were to estimate the affinity between 3,5-(E)-bis(3-methoxy-4-hydroxybenzal)-4-piperidinone hydrochloride(C0818) and heat shock protein 90 (Hsp90) and to investigate the inhibitory effects of this compound on Hsp90 ATPase activity. Fluorescence spectroscopy was used to examine the affinity between varying concentrations of C0818 and Hsp90, N-Hsp90, MHsp90 and C-Hsp90. Fluorescence intensities were recorded in the range of 290–510 nm at 293, 303 and 310 K, respectively. A colorimetric assay for inorganic phosphate(based on the formation of a phosphomolybdate complex and the subsequent reaction with malachite green) were used to examine the inhibitory effects of C0818 on Hsp90 ATPase activity. The equilibrium dissociation constant K_D value of C0818 was found to be 23.41270.943 μmol/L. The interaction between C0818 and Hsp90 was driven mainly by electrostatic interactions. C0818 showed the strongest affinity with C-Hsp90. These results conclusively demonstrate the inhibitory activity of C0818 on the activity of Hsp90 ATPase. | Yingjuan Fan Yang Liu Lianru Zhang Fang Cai Liping Zhu Jianhua Xu | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 5 |
| 12 | In situ generated thrombin in the protein corona of zeolites: Relevance of the functional proteins to its biological impact显示文摘到 nanomaterial 表面的血浆蛋白质的吸附在他们的简历功能上有大影响。然而,有在在蛋白质日冕和材料的生物身份的功能的蛋白质之间的关系的有限理解。这里,我们证明在里面 situ 在 Ca 沸石表面的蛋白质日冕产生了凝血酵素显示一个钙依赖者,不平常地高(3,000 NIH U/mg ) procoagulant 活动,它对 antithrombin 释放是甚至稳定的。移开包含的 Ca < 啜 class= “ a-plus-plus ” > 在沸石的 2+ 由 antithrombin 导致释放。我们的观察建议凝血酵素活动能被无机的表面和阳离子调整。最重要地,我们的发现在蛋白质日冕和材料的 procoagulant 活动显示在 biomolecules 之间的连接,提供为沸石 hemostatics 的 procoagulant 机制的一个新分子的基础。 | Yunlong Li Xiaofeng Liao Xiaoxi Zhang Guicen Ma Shuai Zuo Liping Xiao Galen D. Stucky Zhugang Wang Xian Chen Xiaoqiang Shang Jie Fan | 2014 | Nano Research2014，7，10： | 5 |
| 13 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 14 | Cloning, Characterization, and Expression Patterns of Three Sarco/Endoplasmic Reticulum Ca^2+-ATPase Isoforms from Pearl Oyster (Pinctada fucata)显示文摘大量钙被要求因为 molluskbiomineralization.Sarco/endoplasmic 蜂窝胃 Ca^(2+)-ATPase (SERCA ) 是有支撑钙动态平衡的功能的著名蛋白质。怎么它可能在珍珠牡蛎简历矿化作用的过程工作?三 SERCA isoforms ,也就是, PSERA , PSERB ,和 PSERC 从珍珠牡蛎被克隆,三 isoforms 的 Pinctada fucata.The cDNAs 被reversetranscription聚合酶链反应( RT-PCR )和编码 1007 氨基酸的 3568 bp 的 cDNA ends.PSERAconsisted 的快速的扩大孤立, PSERB 包括了编码 1024 氨基酸的 3953 bp ,由编码 1000 氨基酸的 3450 bp 组成的 andPSERC 。三 isoforms 从另外的种类与 SERCA 显示出高相同(65%-87%) 。与从另外的无脊椎动物的结果一致, DNA 印迹分析表明三 isoforms 从麝猫帽子也与脊椎动物的 SERCA1, SERCA2,和 SERCA3 有关的一个单身者发源。 threeisoforms 的拼接的机制类似于脊椎动物 SERCA3.Semiquantitative RT-PCR 的 isoforms 的被执行学习结果显示出的三 isoforms.The 的表示模式那 PSERB 无所不在地在所有测试纸巾被表示并且是潜在的“家务” SERCA isoform ;在内转肌肌肉表示的 PSERAwas 并且脚并且是可能的是肌肉特定的 isoform ,除了内转肌肌肉或脚, andPSERC 在鳃和披风与最高的表示层次在另外的纸巾被表示,显示它是 non-muscle-specific isoform 和力量在珍珠牡蛎简历矿化作用期间涉及钙动态平衡。 | Weimin FAN Changzhong LI Shuo LI Qiaoli FENG Liping XIE Rongqing ZHANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，9： | 4 |
| 15 | Polyelectrolytes/α-Fe_(2)O_(3) modification of carbon cloth anode for dealing with food wastewater in microbial fuel cell显示文摘In this paper,the layer-by-layer assembled polydimethyl diallyl ammonium chloride(PDADMAC),poly sodium-p-styrene sulfonate(PSS)and α-Fe_(2)O_(3) modified carbon cloth(CC),nitric acid activated CC,blank CC were used as anodes in two-chamber microbial fuel cell(MFC)for dealing with food wastewater.The electricity production of microbial fuel cell increased dramatically after modification of the anode.When four double layers of PDADMAC and PSS and one layer α-Fe_(2)O_(3) was assembled on CC(CC/(PDADMAC/PSS)4/α-Fe_(2)O_(3)),the highest current 0.48 mA and the highest power density 0.285 W/m2 were obtained.The electrode process of CC/(PDADMAC/PSS)4/α-Fe_(2)O_(3) anode in MFC was controlled by the electron production step,while the blank CC anode was an electron diversion-controlled process.The high electricity production of nitric acid treated CC anode in MFC was due to the amino group after activation,which made microbes easy to anchor on the anode surface.The effect of polyelectrolytes and α-Fe_(2)O_(3) on the performance improvement of MFC was due to both physical and chemical properties of the anode surface. | Meicong Wang Zinuo Wang Fei Hu Liping Fan Xuejun Zhang | 2020 | Carbon Resources Conversion2020，3，1： | 4 |
| 16 | Visualization of aging-associated chromatin alterations with an engineered TALE system显示文摘在实时房间的特定的 genomic loci 的可视化在多样的生物过程期间是为在染色质建筑学的动态变化的调查的一个前提,例如细胞的老化。然而,当前的精确 genomic 成像方法被缺乏妨碍荧光灯有高特性和 signal-to-noise 的探针形成对照。我们发现那常规抄写像使活跃之物的受动器(故事) 趋于形成蛋白质总数,从而在成像应用程序损害他们的性能。通过屏蔽,我们发现有故事的那熔化 thioredoxin 阻止了总数形成,开基于故事的 genomic 成像的完整的力量。用熔化 thioredoxin 的故事(TTALE ) ,我们在各种各样的 genomic loci 完成了高质量的成像并且观察联系老化(epi ) 在在人和老鼠早衰模型的 telomeres 和着丝点的 genomic 改变。重要地,我们鉴别 ribosomal DNA 的摩擦为人的老化作为一个分子的标记重复。我们的学习为精确在 vitro 并且在 vivo 监视染色质动力学建立一个简单、柔韧的成像方法。 | Ruotong Ren Liping Deng Yanhong Xue Keiichiro Suzuki Weiqi Zhang Yang Yu Jun Wu Liang Sun Xiaojun Gong Huiqin Luan Fan Yang Zhenyu Ju Xiaoqing Ren Si Wang Hong Tang Lingling Geng Weizhou Zhang Jian Li Jie Qiao Tao Xu Jing Qu Guang-Hui Liu | 2017 | Cell Research2017，27，4： | 4 |
| 17 | Comparison of the earthquake detection abilities of PhaseNet and EQTransformer with the Yangbi and Maduo earthquakes显示文摘PhaseNet and EQTransformer are two state-of-the-art earthquake detection methods that have been increasingly applied worldwide.To evaluate the generaliz-ation ability of the two models and provide insights for the development of new models,this study took the sequences of the Yunnan Yangbi M6.4 earthquake and Qinghai Maduo M7.4 earthquake as examples to compare the earthquake detection effects of the two abovementioned models as well as their abilities to process dense seismic sequences.It has been demonstrated from the corresponding research that due to the differences in seismic waveforms found in different geographical regions,the picking performance is reduced when the two models are applied directly to the detection of the Yangbi and Maduo earthquakes.PhaseNet has a higher recall than EQTransformer,but the recall of both models is reduced by 13%-56%when compared with the results rep-orted in the original papers.The analysis results indicate that neural networks with deeper layers and complex structures may not necessarily enhance earthquake detection perfor-mance.In designing earthquake detection models,attention should be paid to not only the balance of depth,width,and architecture but also to the quality and quantity of the training datasets.In addition,noise datasets should be incorporated during training.According to the continuous waveforms detected 21 days before the Yangbi and Maduo earthquakes,the Yangbi earthquake exhibited foreshock,while the Maduo earthquake showed no foreshock activity,indicating that the two earthquakes’nucleation processes were different. | Ce Jiang Lihua Fang Liping Fan Boren Li | 2021 | Earthquake Science2021，34，5： | 4 |
| 18 | Loss of Wip1 aggravates brain injury after ischaemia/reperfusion by overactivating microglia显示文摘Background and purpose The inflammatory response mediated by microglia/macrophages is closely related to cerebral ischaemia/reperfusion injury.Wild-type p53-induced protein phosphatase 1(Wip1),a serine/threonine phosphatase,is expressed in various tissues.A growing number of reports have suggested that Wip1 is a negative regulator of inflammation in peripheral tissue;however,its role in the central nervous system(CNS)remains unclear.This study aimed to clarify whether Wip1 can inhibit CNS inflammation by regulating microglia/macrophage functions after ischaemic injury.Methods A model of middle cerebral artery occlusion and reperfusion was established in mice.CNS inflammation was simulated by lipopolysaccharide treatment of primary microglia.Laser speckle imaging was used to monitor regional cerebral blood flow.Behavioural outcomes were assessed with a TreadScan gait analysis system.TTC staining was used to evaluate the infarct volume,and western blotting and immunofluorescence staining were applied to detect the phenotypical transformation of microglia.ELISA was performed to detect the levels of inflammatory factors.Results Wip1 expression was increased after ischaemia/reperfusion.Wip1-knockout(KO)mice displayed more severe brain injury than wild-type mice,as indicated by aggravated motor dysfunction,greater brain infarct volumes and higher expression of inflammatory cytokines(interleukin-6 and tumour necrosis factor alpha)in the brain.We also found that Wip1 depletion increased microglial/macrophage activation in both in vitro and in vivo models,which all showed activation of microglia/macrophages.Lentivirus-Ppm1d reversed the injury induced by Wip1-KO.Conclusions Our results suggest that Wip1 may inhibit neuroinflammation by inhibiting microglial/macrophage activation after brain ischaemia/reperfusion injury. | Feng Yan Xiang Cheng Ming Zhao Shenghui Gong Ying Han Liping Ding Di Wu Yumin Luo Wei Zuo Lingling Zhu Ming Fan Xunming Ji | 2021 | Stroke & Vascular Neurology2021，6，3： | 4 |
| 19 | Downregulation of KCTD12 contributes to melanoma stemness by modulating CD271显示文摘Objective: Cancer metastasis remains the primary cause of cancer-related death worldwide.In a previous study, we found that levels of BTB/POZ domain-containing protein KCTD12 are lower in metastatic melanoma cells than in parental melanoma cells.The purpose of this study was to identify the roles of KCTD12 in cancer metastasis.Methods: The Cancer Genome Atlas(TCGA) datasets were used to evaluate the relationship between KCTD12 and skin cutaneous melanoma(SKCM) prognosis.The effects of endogenous KCTD12 on biological behaviors were examined using the MTT assay.The impacts of KCTD12 on melanoma stemness were explored using spheroid formation assay.KCTD12 knockout A375 cells were generated to confirm the inhibitory effect of KCTD12 on CD271, and a mouse metastatic model was used to determine the impact of KCTD12 on melanoma metastasis in vivo.Results: KCTD12 levels were lower in lung metastatic cells than in paired parental melanoma cells, and low KCTD12 expression indicated a poor prognosis in SKCM.Cancer metastasis-related capacities were higher in lung metastatic cells than in parental melanoma cells.Moreover, KCTD12 knockdown enhanced tumor growth and metastasis both in vitro and in vivo.Mechanistically, the interaction between KCTD12 and CD271 might be responsible for the stemness transformation after KCTD12 knockdown.Conclusions: This study identifies for the first time the role of the interaction between KCTD12 and CD271 in inducing melanoma cell stemness transformation.Moreover, KCTD12 repression enhances melanoma cell growth, adhesion, migration and invasion. | Weiyu Shen Yumei Li Bifei Li Liping Zheng Xiaodong Xie Jingqing Le Yusheng Lu Tao Li Fan Chen Lee Jia | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 20 | The carbon isotopic compositions of Non-methane Hydrocarbons in atmosphere显示文摘Carbon isotopic compositions of atmospheric Non-methane Hydrocarbons(NMHCs) in the urban areas of Taiyuan and Lanzhou in summer were reported and the sources of NMHCs are discussed.Carbon isotopic ratios(δ 13C) of vehicle exhaust,coal-combustion exhaust,fuel volatiles and cooking exhaust were also measured with thermal desorption-gas chromatography-isotope ratio-mass spectrometry(TD-GC-IR-MS).δ 13C values of NMHCs in the urban areas of Lanzhou and Taiyuan range from-32.3‰ to-22.3‰ and from-32.8‰ to-18.1‰.δ 13C values of vehicle exhaust,coal-combustion exhaust,fuel volatiles and cooking exhaust are-32.6‰―-21.7‰,-24.5‰―-22.3‰,-32.5‰―-27.4‰ and-31.6‰―-24.5‰,respectively.The data indicate that vehicle exhaust and cooking exhaust make a significant contribution to the atmospheric NMHCs.Therefore,to reduce emissions of vehicle exhaust and cook-ing exhaust is critical for controlling atmospheric NMHCs pollution in summer. | PENG Lin ZHANG HuiMin REN ZhaoFang MU Ling SHI RuiLiang CHANG LiPing LI Fan | 2009 | Chinese Science Bulletin2009，54，8： | 3 |
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