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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Analysis of perfluorooctanoate (PFOA) and other perfluorinated compounds (PFCs) in the River Po watershed in N-Italy显示文摘 | Robert Loos Giovanni Locoro Tania Huber Jan Wollgast Eugen H. Christoph Alfred de Jager Bernd Manfred Gawlik Georg Hanke Gunther Umlauf José-Manuel Zaldívar | 2007 | Chemosphere2007，，2： | 2 |
| 3 | Effect of the insulin sensitizer pioglitazone on insulin resistance,hyperandrogenism,and ovulatory dysfunction in women with polycystic ovary syndrome显示文摘 | Brettenthaler N De Geyter C Huber PR | 2004 | J Clin Endocrinol Metab2004，89，8： | 1 |
| 4 | Effect of the insulin sensitizer pioglitazone in insulin resistance, hyperandrogenism,and ovulatory dysfunction in women with polycystic ovary syndrome 显示文摘 | Brettenthaler N De Geyter C Huber PR | 2004 | J Clin Endoerinol Metab2004，89，8： | 1 |
| 5 | Heart rate response of the human fetus to induced maternal hypoxia显示文摘 | Copher DE Huber CP | 1967 | Am J Obstet Gynecol1967，98，3： | 1 |
| 6 | Progesterone serum levels during the follicular phase of the menstrual cycle originate from the crosstalk between the ovaries and the adrenal cortex 显示文摘 | De Geyter C De Geyter M Huber PR | 2002 | Hum Reprod2002，17，4： | 1 |
| 7 | PARP-1, PARP-2 and ATM in the DNA damage response: Functional synergy in mouse development显示文摘 | HUBER A BAI P de MURCIA J M etal | 2004 | DNA Repair(Amst)2004，3，89： | 1 |
| 8 | A modular concept of phenotypic plasticity in plants显示文摘 | de Kroon H Huber H Stuefer JF van Groenendael JM | | 0，，1： | 1 |
| 9 | A modular concept of plant foraging behaviour:the interplay between local responses and systemic control显示文摘 | de Kroon H Visser EJW Huber H Mommer L Hutchings MJ | | 0，，6： | 1 |
| 10 | Early glycoprotein Ⅱb-Ⅲa inhibitors in primary angioplasty-abciximab long-term results (EGYPTALT) cooperation:individual patient's data meta-analysis显示文摘 | De Luca G Bellandi F Huber K | | 0，，12： | 1 |
| 11 | Isolating highly enriched populations of circulating epithelial cells and other rare ceils from blood using a magnetic sweeper device显示文摘 | TALASAZ AH POWELL AA HUBER DE | 2009 | Proc Natl Acad Sci U S A2009，106，10： | 1 |
| 12 | Pre-hospital reperfusion therapy:A strategy to improve therapeutic outcome in patients with ST-elevation myocardial infarction显示文摘 | Huber K de Caterina R Kristensen S D | 2005 | Eur Heart J2005，26，19： | 1 |
| 13 | A modular concept of plant foraging behaviour: the interplay between local responses and systemic control 显示文摘 | De Kroon H Visser EJW Huber H Hutchings MJ | 2009 | Plant Cell Environ2009，32，： | 1 |
| 14 | Proton dynamics in cancer显示文摘 | Huber V De Milito A Harguindey S | 2010 | 1 Trans Med2010，8，10： | 1 |
| 15 | PARP-1,PARP-2 and ATM in the DNA damage response:functional synergy in mouse devel-opment显示文摘 | HUBER A BAI P DE MURCIA J M | 2004 | DNA Repair(Amst)2004，3，89： | 1 |
| 16 | Early glyeoprotein I1 b -III a inhibitors in primary angioplasty- abciximab long-term results (EGYPT-ALT) cooperation:individual patient's data meta-analysis 显示文摘 | DE Luca G Bellandi F Huber K | 2011 | J Thromb Haemost2011，9，12： | 1 |
| 17 | Degradation and solubilication of pectin by β-galactosidases prurified from arocado mesocarp显示文摘 | De Veaal E J I Grous K C Huber D J | 1993 | Physiol Plant1993，87，： | 1 |
| 18 | Effect of dietary protein and energy levels on rumen fermentation in holstein steers显示文摘 | de Faria V P Huber J T | 1984 | Journal of Animal Science1984，58，： | 1 |
| 19 | Detecting faces in pure noise images:a functional MRI study on top-down perception显示文摘 | Zhang H Liu J Huber DE | 2008 | NeuroReport2008，19，： | 1 |
| 20 | Effect of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism,and ovulatory dysfunction in women with polycystic ovary syndrome显示文摘 | Brettenthaler N De Geyter C Huber PR | 2004 | J Clin Endocrinol Metab2004，89，8： | 1 |
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