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| 1 | One hundred and seventy-eight consecutive pancreatoduodenectomies without mortality:role of the multidisciplinary approach显示文摘BACKGROUND:Pancreatoduodenectomy offers the only chance of cure for patients with periampullary cancers.This,however,is a major undertaking in most patients and is associated with a significant morbidity and mortality.A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis,resection rate,mortality and morbidity.We undertook the study to assess the effect of this approach on diagnosis,resection rates and short-term outcomes such as morbidity and mortality.METHODS:A prospective database of patients presenting with periampullary cancers to a single surgeon between April 2004 and April 2010 was reviewed.All cases were discussed at a multidisciplinary meeting comprising surgeons,gastroenterologists,radiologists,oncologists,radiation oncologists,pathologists and nursing staff.A standardized investigation and management algorithm was followed.Complications were graded according to the Clavien-Dindo classification.RESULTS:A total of 295 patients with a periampullary lesion were discussed and 178 underwent pancreatoduodenectomy (resection rate 60%).Sixty-one patients (34%) required either a vascular or an additional organ resection.Eighty-nine patients experienced complications,of which the commonest was blood transfusion (12%).Thirty-four patients (19%) had major complications,i.e.grade 3 or above.There was no in-hospital,30-day or 60-day mortality.CONCLUSIONS:Pancreatoduodenectomy can safely be performed in high-volume centers with very low mortality.The surgeon's role should be careful patient selection,intensive preoperative investigations,use of a team approach,and an unbiased discussion at a multidisciplinary meeting to optimize the outcome in these patients. | Jaswinder S Samra Raul Alvarado Bachmann Julian Choi Anthony Gill Michael Neale Vikram Puttaswamy Cameron Bell Ian Norton Sarah Cho Steven Blome Ritchie Maher Sivakumar Gananadha Thomas J Hugh | 2011 | Hepatobiliary & Pancreatic Diseases International2011,10,4: | 8 |
| 2 | Mutagenic activity of 27 dyes and related chemicals in the Salmonella/microsome and mouse lymphoma TK^+/- assays显示文摘 | Cameron T P Hughes T J Kirby P E | 1987 | Mutat Res1987,,189: | 1 |
| 3 | Rare-earth-element ordering and structural variation in natural rare-earth-bearing apatites显示文摘 | Hughes J M Cameron M and Mariano A N | 1991 | American Mineralogist1991,76,: | 1 |
| 4 | Going to war does not have to hurt:Preliminary findings from the British deployment to I- raq 显示文摘 | Hughes J H Cameron F Eldridge R | 2005 | The British Journal of Psychiatry2005,186,: | 1 |
| 5 | Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry:a worldwide collaborative project显示文摘 | Mc Hugh D M S Cameron C A Abdenur J E | 2011 | Genet Med2011,13,3: | 1 |
| 6 | Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry:a worldwide collaborative project显示文摘 | Mc Hugh D M S Cameron C A Abdenur J E | 2011 | Genet Med2011,13,3: | 1 |
| 7 | Structural variations in natural F,OH,and Cl apatites显示文摘 | Hughes Maryellen Cameron Kevin D Crowley | 1989 | American Minealogist1989,74,: | 1 |
| 8 | Crystal structures of natural ternary apatites:solid solution in the Ca5(PO4)3X(X = F,OH,Cl)system显示文摘 | Maryellen Cameron Kevin D Crowley | 1990 | American Mineralogist1990,75,: | 1 |
| 9 | Structure variations in natural F, OH, and Cl apatites 显示文摘 | Hughes J M Cameron M Crowley K D | 1989 | Amer Min1989,74,: | 1 |
| 10 | Structural variations in natural F,OH,and CI apatites显示文摘 | Maryllen Cameron Kevin D Crowley | 1989 | American Minealogist1989,74,: | 1 |
| 11 | Going to war does not have to hurt: Preliminary findings from the British deployment to Iraq显示文摘 | Hughes JH Cameron F Eldridge R | 2005 | The British Journal of Psychiatry2005,186,: | 1 |
| 12 | Structural variations in natural F, OH, and C1 aptites 显示文摘 | Hughes J M Cameron M Crowley K D | 1989 | Amer Mine1989,74,: | 1 |
| 13 | Genetic resistance to brucellosis in swine显示文摘 | Cameron H S Hughes E H Gregory P W | 1942 | J Anita Sci1942,,1: | 1 |
| 14 | Ordering of Divalent Cations in the Apatite Structure: Crystal Structure Refinement of Natural Mn-and Sr-bearing Apatit显示文摘 | Hughes J M Cameron M Crowley K D | 1990 | J Amer Miner1990,75,: | 1 |
| 15 | Mutagenic activity of 27 dyes and relat- ed chemicals in the Salmonella microsomeand mouse lymphoma TKd-/-- assays显示文摘 | Cameron T P Hughes T J Kirby P E et al | 1987 | Mutation Research1987,189,: | 1 |
| 16 | 二十一世纪的海洋开发利用显示文摘曼彻斯特大学负责工程、科学与技术政策研究计划的三位年轻的研究人员承担了一项长期预测工作。这是“一项吃力不讨好的困难的工作,这项工作容易被证明是错误的,而难以被证明是正确的。”由于海洋是地球上我们最后未开发的领域,具有极大的潜力,这一情况使预测未来海洋技术的工作变得复杂化,据此,我们在这里仅指出一些有较大可能实现的目标。 | Glyn Ford Luke Georghiu Hugh Cameron 郝龙胜 | 1983 | 科学与社会1983,,Z1: | 0 |