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| 1 | Dynamic immune profiling identifies the stronger graft-versus-leukemia (GVL) effects with haploidentical allografts compared to HLA-matched stem cell transplantation显示文摘Haploidentical stem cell transplantation(haplo-SCT)achieves superior or at least comparable clinical outcomes to HLA-matched sibling donor transplantation(MSDT)in treating hematological malignancies.To define the underlying regulatory dynamics,we analyzed time courses of leukemia burden and immune abundance of haplo-SCT or MSDT from multiple dimension.First,we employed two nonirradiated leukemia mouse models which carried human AML-ETO or MLL-AF9 fusion gene to establish haplo-identical and major histocompatibility(MHC)-matched transplantation models and investigated the immune cell dynamic response during leukemia development in vivo.We found that haplo-matching the MHCs of leukemia cells with recipient mouse T cells prolonged leukemic mice survival and reduced leukemia burden.The stronger graft-versus-leukemia activity in haplo-SCT group mainly induced by decreased apoptosis and increased cytotoxic cytokine secretion including tumor necrosis factor–α,interferon-γ,pore-forming proteins and CD107a secreted by T cells or natural killer cells.Furthermore,we conducted a prospective clinical trial which enrolled 135 patients with t(8;21)acute myeloid leukemia that displayed minimal residual disease before transplantation and underwent either haplo-SCT or MSDT.The results showed that the haplo-SCT slowed the kinetics of the leukemia burden in vivo and reduced the cumulative incidence of relapse compared with MSDT.Ex vivo experiments showed that,1 year after transplantation,cytotoxic T lymphocytes from the haplo-SCT group had higher cytotoxicity than those from the MSDT group during the same period.Our results unraveled the role of immune cells in superior antileukemia effects of haplo-SCT compared with MSDT. | Huidong Guo Ying-Jun Chang Yan Hong Lan-Ping Xu Yu Wang Xiao-Hui Zhang Ming Wang Huan Chen Yu-Hong Chen Feng-Rong Wang Wei-Han Yu-Qian Sun Chen-Hua Yan Fei-Fei Tang Xiao-Dong Mo Kai-Yan Liu Xiao-Jun Huang | 2021 | Cellular & Molecular Immunology2021，18，5： | 11 |
| 2 | Relationship between increase rate of human plague in China and global climate index as revealed by cross-spectral and cross-wavelet analyses显示文摘Plague has caused the death of hundreds of millions of people throughout the human history.Today this disease is again re-emerging and hence is again becoming an increasing threat to human health in several parts of the world.However,impacts of global climate variation(e.g.El Nino and Southern Oscillation[ENSO])and global warming on plagues are largely unknown.Using cross-spectral analysis and cross-wavelet analysis,we have analyzed the relationship between increase rate of human plague in China during 1871–2003 and the following climate factors(as measured by the Southern Oscillation Index[SOI],Sea Surface Temperature of east Pacific equator[SST]and air Temperature of the Northern Hemisphere[NHT]).We found in the frequency domain that increase rate of human plague was closely associated with SOI and SST.Cross-spectral analysis reveals that significant coherencies between increase rate of human plague and ENSO were found over short periods(2–3 years),medium periods(6–7 years)and long periods(11–12 years,30–40 years).Cross-wavelet analysis reveals that increase rate of human plague oscillates in phase with SOI,but in anti-phase with SST over periods of 2–4 years and approximately 8 years(6–10 years).These results indicate that ENSO-driven climate variation may be important for occurrences of human plague in China.However,there is a need for a further analysis of the underlying mechanism between human plague in China and ENSO. | Zhibin ZHANG Zhenqing LI Yi TAO Min CHEN Xinyu WEN Lei XU Huidong TIAN Nils Chr.STENSETH | 2007 | Integrative Zoology2007，2，3： | 3 |
| 3 | Carbon-based bifunctional electrocatalysts for oxygen reduction and oxygen evolution reactions:Optimization strategies and mechanistic analysis显示文摘Electrocatalysts are one of the essential components for the devices of high-efficiency green energy storage and conversion,such as metal-air cells,fuel cells,and water electrolysis systems.While catalysts made from noble metals possess high catalytic performance in both oxygen reduction reaction(ORR)and oxygen evolution reaction(OER),their scarcity and expensiveness significantly limit large-scale applications.In this regard,metal-free/non-noble metal carbon-based catalysts have become competitive alternatives to replace catalysts made of noble metals.Nevertheless,low catalytic ORR/OER performance is the challenge of carbon-based catalysts for the commercial applications of metal-air batteries.To solve the problem of poor catalytic performance,two strategies have been proposed:(1)controlling the microstructure of the catalysts to expose more active sites as the channels of rapid mass and electron transfer;and(2)reducing the reaction energy barrier by optimizing the electronic structures of the catalysts via surface engineering.Here,we review different types of bifunctional ORR/OER electrocatalysts with the activated surface sites.We focus on how the challenge can be overcome with different methods of material synthesis,structural and surface characterization,performance validation/optimization,to outline the principles of surface modifications behind catalyst designs.In particular,we provide critical analysis in the challenges that we are facing in structural design and surface engineering of bifunctional ORR/OER catalysts and indicate the possible solution for these problems,providing the society with clearer ideas on the practical prospects of noble-metal-free electrocatalysts for their future applications. | Huidong Xu Jack Yang Riyue Ge Jiujun Zhang Ying Li Mingyuan Zhu Liming Dai Sean Li Wenxian Li | 2022 | Journal of Energy Chemistry2022，31，8： | 2 |
| 4 | Enhanced protonconductivity of sulfonated poly(p-phenylene-co-aryl ether ketone) proton exchange membranes with controlled microblockstructure显示文摘 | He Qingyi Xu Tong Qian Huidong | 2015 | Journal of Power Sources2015，278，： | 1 |
| 5 | Liquid chromatography and tandem mass spectrometry method for the quantitative determination of saxagliptin and its major pharmacologically active 5-monohydroxy metabolite in human plasma: Method validation and overcoming specific and non-specific binding显示文摘 | Xiaohui (Sophia) Xu Roger Demers Huidong Gu Lisa J. Christopher Hong Su Laura Cojocaru David W. Boulton Mark Kirby Bruce Stouffer William G. Humphreys Mark E. Arnold | 2012 | Journal of Chromatography B2012，，： | 1 |
| 6 | Characteristic analysis of rotor dynamics and experiments of active magnetic bearing for HTR - 10GT显示文摘 | Yang Guojun Xu Yang Shi Zhengang Gu Huidong | 2007 | Nuclear Engineering and Design2007，，： | 1 |
| 7 | Experimental investigation of a two-degree-of-freedom vibro-impact system显示文摘 | Wen Guilin Xu Huidong Xiao Lu | 2012 | International Journal of Bifurcation and Chaos2012，22，12： | 1 |
| 8 | High-entropy rare-earth diborodicarbide:A novel class of high-entropy(Y_(0.25)Yb_(0.25)Dy_(0.25)Er_(0.25))B_(2)C_(2)ceramics显示文摘A novel class of high-entropy rare-earth metal diborodicarbide(Y_(0.2)5 Yb_(0.25)Dy_(0.25)Er_(0.25))B_(2)C_(2)(HE-REB_(2)C_(2))ceramics was successfully fabricated using the in-situ reactive spark plasma sintering(SPS)technology for the first time.Single solid solution with a typical tetragonal structure was formed,having a homogeneous distribution of four rare-earth elements,such as Y,Yb,Dy,and Er.Coefficients of thermal expansion(CTEs)along the a and c directions(aa and ac)were determined to be 4.18 and 16.06μK^(-1),respectively.Thermal expansion anisotropy of the as-obtained HE-REB_(2)C_(2)was attributed to anisotropy of the crystal structure of HE-REB_(2)C_(2).The thermal conductivity(k)of HE-REB_(2)C_(2)was 9.2±0.09 W·m^(-1)·K^(-1),which was lower than that of YB_(2)C_(2)(19.2±0.07 W·m^(-1)·K^(-1)),DyB_(2)C_(2)(11.90.06 W·m^(-1)·K^(-1)),and ErB_(2)C_(2)(12.10.03 W·m^(-1)·K^(-1)),due to high-entropy effect and sluggish diffusion effect of high-entropy ceramics(HECs).Furthermore,Vickers hardness of HE-REB_(2)C_(2)was slightly higher than that of REB_(2)C_(2)owing to the solid solution hardening mechanism of HECs.Typical nano-laminated fracture morphologies,such as kink boundaries,delamination,and slipping were observed at the tip of Vickers indents,suggesting ductile behavior of HE-REB_(2)C_(2).This newly investigated class of ductile HE-REB_(2)C_(2)ceramics expanded the family of HECs to diboridcarbide compounds,which can lead to more research works on high-entropy rare-earth diboridcarbides in the near future. | Huidong Xu Longfei Jiang Ke Chen Qing Huang Xiaobing Zhou | 2023 | Journal of Advanced Ceramics2023，12，7： | 0 |
| 9 | 中国科学院大连化学物理研究所的历史及中日催化界友谊回顾(英文)显示文摘This article presents a history of the origins of the Dalian Institute of Chemical Physics, Chinese Academy of Sciences (Abbreviated as DICP) and relates the recent friendship between China and Japan in the field of catalysis. Although the official beginning of DICP is in 1949 with the birth of the People's Republic of China, there are earlier roots that went back to the defeat of Russia by Imperial Japan in 1905. This began a period of occupation and exploitation of Northest Asia by Japan which did not end until its defeat by Allied forces in 1945. During the period of occupation, a laboratory was created called the Central Research Laboratory of the South Manchurian Railroad Company, which was staffed by the best and brightest researchers from Japan, and was able to develop new processes in chemicals and synthetic fuels that fed the Japanese Imperial forces. Between 1945 and 1949, Dalian was administered by the Soviet Union, and the removable equipment from the Laboratory was taken. In this period one individual stood out, the Laboratory Director Marusawa Tsuneya, who risked his life to preserve the scientific records and staff of the institute, and then stayed in Dalian for ten years after the Second World War to help China rebuild its capabilities. The Central Research Laboratory is still preserved as the Old Campus of DICP. The origin of the friendship between China and Japan in catalysis can be traced to Professor Morikawa Kiyoshi, who worked in the Central Research Laboratory and helped commercialize a shale coal liquefaction process. Upon his return to Japan he became Professor at the Tokyo Institute of Technology and in 1975 organized the first visit by Japanese academics to China. This was reciprocated in visits to Japan in 1977 and 1980 by top researchers such as Zhang Dayu, Min Enze, Tsai Khirui, Lu Jiaxi, and Lin Liwu. This resulted in numerous contacts between individuals, which multiplied geometrically. Notably among these were the personal interactions between Guo Xiexian, the Vice-Director of DICP and Tamaru Kenzi, a Professor at the University of Tokyo, which led to a friendship lasting decades and encompassing generations. In 1981, Guo Xiexian organized the first China-Japan-USA Symposium in Dalian, assisted by Tamaru Kenzi, which was attended by over 90 scientists. This meeting was a big success, and was to lead to the organization of many other multi-country conferences, further promoting exchanges. It culminated with the hosting of China of the 16th International Congress on Catalysis in 2016 in Beijing, with Li Can as President. Today DICP is a sprawling organization with over 1300 permanent staff, and is one of the powerhouses of catalysis in the world. From 2000, it has been led by Directors Bao Xinhe, Zhang Tao, and Liu Zhongmin. The Institute is making enormous contributions to research and producing cutting-edge technology, and its future is bright. | S. Ted Oyama Qin Xin Guoxing Xiong Wenjie Shen Jie Xu Hongmei Yin Youzhu Yuan Haichao Liu Huidong Zheng | 2019 | Chinese Journal of Catalysis2019，40，11： | 0 |
| 10 | Screening of autoantibodies as biomarkers in the serum of renal cancer patients based on human proteome microarray显示文摘The autoantibody in patients’serum can act as a biomarker for diagnosing cancer,and the differences in autoantibodies are significantly correlated with the changes in their target proteins.In this study,16 renal cancer(RC)patients were assigned to the disease group,and 16 healthy people were assigned to the healthy control(HC)group.The human proteome microarray consisting of>19,500 proteins was used to examine the differences in IgG and IgM autoantibodies in sera between RC and HC.The comparative analysis of the microarray results shows that 101 types of IgG and 25 types of IgM autoantibodies are significantly higher in RC than in HC.Highly responsive autoantibodies can be candidate biomarkers(e.g.,anti-KCNAB2 IgG and anti-RCN1 IgM).Extensive enzyme-linked immunosorbent assay(ELISA)was performed to screen sera in 72 RC patients and 66 healthy volunteers to verify the effectiveness of the new autoantibodies.The AUCs of anti-KCNAB2 IgG and anti-GAPDH IgG were 0.833 and 0.753,respectively.KCNAB2 achieves high protein expression,and its high mRNA level is confirmed to be an unfavorable prognostic marker in clear cell renal cell carcinoma(ccRCC)tissues.This study suggests that the highthroughput human proteome microarray can effectively screen autoantibodies in serum as candidate biomarkers,and their corresponding target proteins can lay a basis for the in-depth investigation into renal cancer. | Yangyang Sun Chengxi Liu Huidong Zhong Chenguang Wang Haibo Xu Wei Chen | 2022 | Acta Biochimica et Biophysica Sinica2022，54，12： | 0 |
| 11 | Improving the WRF/urban modeling system in China by developing a national urban dataset显示文摘Accurate modeling of urban climate is essential to predict potential environmental risks in cities.Urban datasets,such as urban land use and urban canopy parameters(UCPs),are key input data for urban climate models and largely affect their performance.However,access to reliable urban datasets is a challenge,especially in fast urbanizing countries.In this study,we developed a high-resolution national urban dataset in China(NUDC)for the WRF/urban modeling system and evaluated its effect on urban climate modeling.Specifically,an optimization method based on building morphology was proposed to classify urban land use types.The key UCPs,including building height and width,street width,surface imperviousness,and anthropogenic heat flux,were calculated for both single-layer Urban Canopy Model(UCM)and multiple-layer Building Energy Parameterization(BEP).The results show that the derived morphological-based urban land use classification could better reflect the urban characteristics,compared to the socioeconomic-function-based classification.The UCPs varied largely in spatial within and across the cities.The integration of the developed urban land use and UCPs datasets significantly improved the representation of urban canopy characteristics,contributing to a more accurate modeling of near-surface air temperature,humidity,and wind in urban areas.The UCM performed better in the modeling of air temperature and humidity,while the BEP performed better in the modeling of wind speed.The newly developed NUDC can advance the study of urban climate and improve the prediction of potential urban environmental risks in China. | Huidong Li Fenghui Yuan Lidu Shen Yage Liu Zhonghua Zheng Xu Zhou | 2022 | Geoscience Frontiers2022，13，4： | 0 |
| 12 | 中压全调节大功率电源系统在北斗三号卫星上的应用显示文摘China’s BeiDou Navigation Satellite System(BDS)construction has been completed and the system has been formally commissioned.Most of the Electric Power Systems(EPSs)for MEO satellites were developed by the Shanghai Institute of Space Power-sources.The 42 V medium-voltage fully-regulated high-power EPS has been adopted for the first time in medium Earth orbit,with an output power reaching about 3 kW.Compared with the 42 V medium-voltage semi-regulated bus power system used in the Regional Navigation BDS-2 satellite,the EPS of the BDS-3 MEO satellites has increased power by about 80%,adopting many newly developed products such as high-efficient triple junction GaAs solar cells,high-energy-density lithium ion batteries and a high-efficient autonomous power control unit(PCU).Based on the studies on the medium-voltage fully-regulated and high-power EPS technical principles,and the adaptability and reliability of various working modes,the test verifications for the EPS were conducted both on the ground and in orbit.Compared with other global navigation satellite systems such as GPS,Galileo and GLONASS,the EPS of the BDS-3 MEO satellite has a long design life time which is equivalent to that of the GPS and Galileo,but with a larger power supply capability and power ratio,distinguishing its advancement in the field of satellite power technology. | LI Xuping LEI Hu XU Huidong LUO Guo | 2020 | Aerospace China2020，21，4： | 0 |
| 13 | Ultrafine MoO_(x)clusters anchored on g-C_(3)N_(4)with nitrogen/oxygen dual defects for synergistic efficient O_(2)activation and tetracycline photodegradation显示文摘Photocatalytic O_(2)activation to generate reactive oxygen species is crucially important for purifying organic pollutants,yet remains a challenge due to poor adsorption of O_(2)and low efficiency of electron transfer.Herein,we demonstrate that ultrafine MoO_(x)clusters anchored on graphitic carbon nitride(g-C_(3)N_(4))with dual nitrogen/oxygen defects promote the photocatalytic activation of O_(2)to generate·O_(2)−for the degradation of tetracycline hydrochloride(TCH).A range of characterization techniques and density functional theory(DFT)calculations reveal that the introduction of the nitrogen/oxygen dual defects and MoO_(x)clusters enhances the O_(2)adsorption energy from−2.77 to−2.94 eV.We find that MoO_(x)clusters with oxygen vacancies(Ov)and surface Ov-mediated Moδ+(3≥δ≥2)possess unpaired localized electrons,which act as electron capture centers to transfer electrons to the MoO_(x)clusters.These electrons can then transfer to the surface adsorbed O_(2),thus promoting the photocatalytic conversion of O_(2)to·O_(2)−and,simultaneously,realizing the efficient separation of photogenerated electron–hole pairs.Our fully-optimized MoO_(x)/g-C_(3)N_(4)catalyst with dual nitrogen/oxygen defects manifests outstanding photoactivities,achieving 79%degradation efficiency toward TCH within 120 min under visible light irradiation,representing nearly 7 times higher activity than pristine g-C_(3)N_(4).Finally,based on the results of liquid chromatograph mass spectrometry and DFT calculations,the possible photocatalytic degradation pathways of TCH were proposed. | Huidong Shen Xinyu Zhan Song Hong Liang Xu Chunming Yang Alex W.Robertson Leiduan Hao Feng Fu Zhenyu Sun | 2023 | Nano Research2023，16，8： | 0 |
| 14 | Facile construction of aggregation-induced emission molecular liquids via Piers-Rubinsztajn reaction for green fluorescent ink显示文摘Solvent-free luminescent molecular liquids(LMLs), which exhibit nonvolatile fluidic nature and active optoelectronic properties, were widely used. For further development, we introduced siloxane units into AIE molecules, designed and synthesized TPE derivatives with siloxane side chains via facile Piers-Rubinsztajn reaction. The obtained AIE molecular liquids exhibit unique photophysical properties. Compared with the obtained alkyl TPE-solids, siloxane TPE show liquid state, which proves that the siloxane units have stronger liquefaction effect than alkyl. Viscosity test shows that siloxane TPE-liquids has far more lower viscosity and better fluidity than the long-chain alkyl molecular liquids in previous research. All those properties are attributed to the weak interaction between flexible molecular chains of siloxane. Besides,fluorescence test shows temperature responsiveness of siloxane TPE-liquids. We developed this lowviscosity nonvolatile AIE molecular liquid as green fluorescent ink. | Rong Fu Longyue Yu Junying Zhang Huidong Yu Shengyu Feng Xing-Dong Xu | 2022 | Chinese Chemical Letters2022，33，4： | 0 |
| 15 | Development and test in grid of 630 kVA three-phase high temperature superconducting transformer显示文摘A 630-kVA 10.5 kV/0.4 kV three-phase high temperature superconducting(HTS)power transformer was successfully developed and tested in a live grid.The windings were wound by hermetic stainless steelreinforced multi-filamentary Bi2223/Ag tapes.The structures of primary windings are solenoid with insulation and cooling path among layers,and those of secondary windings consist of double-pancakes connected in parallel.Toroidal cryostat is made from electrical insulating glass fiber reinforced plastics(GFRP)materials with room temperature bore for commercial amorphous alloy core with five limbs.Windings are laid in the toroidal cryostat so that the amorphous core operates at room temperature.An insulation technology of double-half wrapping up the Bi2223/Ag tape with Kapton film is used by a winding machine developed by the authors.Fundamental characteristics of the transformer are obtained by standard short-circuit and no-load tests,and it is shown that the transformer meets operating requirements in a live grid. | Yinshun WANG Xiang ZHAO Junjie HAN Huidong LI Yin GUAN Qing BAO Xi XU Shaotao DAI Naihao SONG Fengyuan ZHANG Liangzhen LIN Liye XIAO | 2009 | Frontiers of Electrical and Electronic Engineering in China2009，4，1： | 0 |
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