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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | The Critical Rainfall Characteristics for Torrents and Debris Flows in the Wenchuan Earthquake Stricken Area显示文摘Critical rainfall assessment is a very important tool for hazard management of torrents and debris flows in mountainous areas. The Wenchuan Earthquake 2008 caused huge casualties and property damages in the earthquake-stricken area,which also generated large quantities of loose solid materials and increased occurrence probabilities of debris flows. There is an urgent need to quantify the critical rainfall distribution in the area so that better hazard management could be planned and if real time rainfall forecast is available,torrent and debris flow early-warning could be issued in advance. This study is based on 49-year observations (1954-2003) of up to 678 torrent and debris flow events. Detailed contour maps of 1 hour and 24 hour critical rainfalls have been generated (Due to the data limitation,there was insufficient 10 minute critical rainfall to make its contour map). Generally,the contour maps from 1 hour and 24 hours have similar patterns. Three zones with low,medium and high critical rainfalls have been identified. The characteristics of the critical rainfall zones are linked with the local vegetation cover and land forms. Further studies and observations are needed to validate the finding and improve the contour maps. | CHEN Ningsheng YANG Chenglin ZHOU Wei HU Guisheng LI Huan David Han | 2009 | Journal of Mountain Science2009，6，4： | 35 |
| 3 | Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma显示文摘Sorafenib is the first-line medication for advanced hepatocellular carcinoma(HCC),but it can only extend limited survival.It is imperative to find a combination strategy to increase sorafenib efficacy.Artesunate is such a preferred candidate,because artesunate is clinically well-tolerated and more importantly both drugs can induce ferroptosis through different mechanisms.In this study we investigated the combined effect of sorafenib and artesunate in inducing ferroptosis of HCC and elucidated the involved molecular mechanisms.We showed that artesunate greatly enhanced the anticancer effects of low dose of sorafenib against Huh7,SNU-449,and SNU-182 HCC cell lines in vitro and against Huh7 cell xenograft model in Balb/c nude mice.The combination index method confirmed that the combined effect of sorafenib and artesunate was synergistic.Compared with the treatment with artesunate or sorafenib alone,combined treatment induced significantly exacerbated lipid peroxidation and ferroptosis,which was blocked by N-acetyl cysteine and ferroptosis inhibitors liproxstatin-1 and deferoxamine mesylate,but not by inhibitors of other types of cell death(z-VAD,necrostatin-1 and belnacasan).In Huh7 cells,we demonstrated that the combined treatment induced oxidative stress and lysosome-mediated ferritinophagy,two essential aspects of ferroptosis.Sorafenib at low dose mainly caused oxidative stress through mitochondrial impairments and SLC7A11-invovled glutathione depletion.Artesunate-induced lysosome activation synergized with sorafenib-mediated pro-oxidative effects by promoting sequential reactions including lysosomal cathepsin B/L activation,ferritin degradation,lipid peroxidation,and consequent ferroptosis.Taken together,artesunate could be repurposed to sensitize sorafenib in HCC treatment.The combined treatment can be easily translated into clinical applications. | Zhong-jie Li Hui-qi Dai Xiao-wei Huang Ji Feng Jing-huan Deng Zi-xuan Wang Xiao-mei Yang Yu-jia Liu Yong Wu Pan-hong Chen Huan Shi Ji-gang Wang Jing Zhou Guo-dong Lu | 2021 | Acta Pharmacologica Sinica2021，42，2： | 31 |
| 4 | Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway显示文摘 | Mei-qi ZHANG Yue-liang ZHENG Huan CHEN Jian-feng TU Ye SHEN Jun-ping GUO Xiang-hong YANG Shu-ren YUAN Liang-zhong CHEN Jing-jie CHAI Jian-hong LU Chang-lin ZHAI | 2013 | Acta Pharmacologica Sinica2013，34，11： | 30 |
| 5 | Morphological study on colonic pathology in ulcerative colitis treated by moxibustion显示文摘AIM To observe the therapeutic effect ofmoxibustion on ulcerative colitis and itsinfluence on the colonic mucosal morphology.METHODS Forty-six patients with ulcerativecolitis were randomly divided into themoxibustion with herbal medicine underneathgroup and the western medicine group.Thirtypatients were treated with the abovemoxibustion and 16 patients with Salicylayefapyridine(SASP).The colonic mucosa of 13patients in the moxibustion group was observedby colonoscopy before and after the treatment.Mucin was also analyzed by H.E and AB-PASstaining.RESULTS Seventeen patients were clinicallycured,12 were improved and 1 unchanged in themoxibustion group.In the control group,5patients were clinically cured,7 improved and 4unchanged.Thirteen patients with active UCwere taken as the subjects for histopathologicanalysis in this study.The colonic mucosallesions were remarkably improved and thecharacteristic of the mucin also changed.Inmost sections,the chronic inflammation ofmucosa was geatly ameliorated(P<0.01).Theinflammatory cell infiltratation much decreased and neutrophils,disapeared in most sections(P<0.001).The goblet cells significantlyincreased(P<0.001);crypt paracrypt abscessor mucosal ulceration was seen(P<0.001).CONCLUSION The rate of cure of ulcerative colitis by moxibustion with herbal medicine beneath is superior to that by SASP. This sort of moxibustion can effectively improve the colonic mucosal lesions and restore the proportion of mucoprotein to near normal. | Huan Gan Wu Li Bin Zhou Da Ren Shi Shi Min Liu Hui Rong Liu Bi Meng Zhang Han Ping Chen Lin Shan Zhang | 2000 | World Journal of Gastroenterology2000，6，6： | 28 |
| 6 | Effect of Sancaijiangtang on plasma nitric oxide and endothelin-1 levels in patients with type 2 diabetes mellitus and vascular dementia:a single-blind randomized controlled trial显示文摘OBJECTIVE: To observe the effect of Sancaijiangtang powders on plasma nitric oxide and endothelin-1 levels. We sought to identify the common pathological link and mechanism of action for Traditional Chinese medicine in type 2 diabetes mellitus and vascular dementia,and to explicate the material basis for treating the different diseases with the same method in Traditional Chinese Medicine.METHODS: In total,168 patients with type 2 diabetes mellitus and vascular dementia were enrolled in the study,and randomly divided into two groups by simple randomization. Patients in the treatment group received oral Sancaijiangtang powders with pioglitazone hydrochloride three times daily,while patients in the control group received pioglitazone hydrochloride alone. The treatment course was for12 weeks. Mini-mental state examinations(Chinese version) and Montreal Cognitive Assessments(Beijing version) were performed,and fasting plasma glucose,fasting insulin,hemoglobin A1 c,homeostasis model assessment of insulin resistance,plasma nitric oxide and endothelin-1 levels were measured before and after the treatment.RESULTS: The post-treatment levels for all measurements in both groups were better than pre-treatment levels(P < 0.05). The post-treatment levels for all measurements in the treatment group were better than the levels measured in the control group(P < 0.05).CONCLUSION: Type 2 diabetes mellitus and vascular dementia have common pathological mechanisms for insulin resistance and endothelium dysfunction. Sancaijiangtang powders could improve the release of nitric oxide and inhibit the secretion of endothelin-1. Therefore,the material basis exists for treating the different diseases with the same method in Traditional Chinese Medicine. | Guo Qiang Cao Wenzhai Zhao Huan Zhu Yuxia Yang Dongdong Zhong Sen Chen Qiu | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 24 |
| 7 | Hemorrhagic cystitis following hematopoietic stem cell transplantation:incidence,risk factors and association with CMV reactivation and graft-versus-host disease显示文摘背景在 allogenic 以后的出血性的膀胱炎(HC ) 的明确的致病造血的干细胞移植(allo-HSCT ) 一直不好阐明。在 HC 遗体的发展的复活和 graft-versus-host 疾病(GVHD ) 遮住的 cytomegalovirus (CMV ) 的角色。这研究在 allo-HSCT 以后为 HC 决定了发生和风险因素并且与 CMV 复活和 GVHD 分析了它的协会。我们回顾地在高度学习了 250 个病人的方法为 CMV 冒险疾病都基于 busulfan/cyclophosphamide (BU/CY ) 经历了 allo-HSCT myloablative 政体。发生,病原学,风险因素和 HC 的临床的管理是在 180 天以内开发的 investigated.Results HC 在 72 移植病人与28.8%的全面发生和在有 匹配HLA 的相关施主( MRD )的病人的12.6%的发生,34.38%在那些与 匹配HLA 的无关的施主(泥),49.45%在那些与错配的相关施主( MMRD )。CMV-viremia 显著地增加了以后的发作 HC (LOHC ) 的发生;然而,仅仅, 9 实际上从有 CMV viruria 的 15 个病人开发了 LOHC。多重回归分析识别了等级 - 尖锐 GVHD (RR=2.75;95% CI 1.63-4.66;P0.01 ) 并且从泥或 MMRD 的接枝(RR=2.60;95% CI 1.52-5.20;P0.01 ) 为 HC 的同样独立的风险因素。事件顺序分析显示事件在 GVHD initiation.Conclusions CMV-viremia 附近开始了的 HC 的一个多数是为 LOHC 的一个高风险因素。我们的数据也显示出在尖锐 GVHD 和 HC 之间的关联,它建议 alloimmunity 可以涉及 HC 的致病。 | XU Lan-ping ZHANG Hong-yu HUANG Xiao-jun LIU Kai-yan LIU Dai-hong HAN Wei CHEN Huan CHEN Yu-hong GAO Zhi-yong ZHANG Yao-chen LU Dao-pei | 2007 | Chinese Medical Journal2007，，19： | 22 |
| 8 | Administration of imatinib in the first 90 days after allogeneic hematopoietic cell transplantation in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia显示文摘背景恶化在 allogeneic 以后经常发生在有费城染色体积极的尖锐成淋巴细胞的白血病的病人的造血的房间移植( allo-HCT )(Ph+所有)在 allo-HCT 前后的最小的剩余疾病( MRD )的 .Detection rate.Early 与更高的恶化被联系在 allo-HCT 以后的 imatinib 的管理可以阻止周期性的Ph+ ALL.The 目的这研究是当时,在阻止 hematological 恶化评估 imatinib 的安全和功效 imatinib | CHEN Huan LIU Kai-yan XU Lan-ping LIU Dai-hong CHEN Yu-hong SHI Hong-xia HAN Wei ZHAN Xiao-hui WANG Yu ZHAO Ting HUANG Xiao-jun | 2011 | Chinese Medical Journal2011，，2： | 23 |
| 9 | Early kidney injury during long-term adefovir dipivoxil therapy for chronic hepatitis B显示文摘AIM: To evaluate urine β2-microglobulin(β2-M), retinol-binding protein(RBP) excretion, and renal impairment with adefovir dipivoxil(ADV) for chronic hepatitis B. METHODS: We enrolled 165 patients with chronic hepatitis B infection who were treated with ADV monotherapy(n = 90) or ADV plus lamivudine combination therapy(n = 75). An additional 165 chronic hepatitis B patients treated with entecavir were recruited as controls. We detected serum creatinine, urine β2-M, and RBP levels, and estimated the glomerular filtration rate(e GFR) at the initiation of antiviral therapy and every 6 mo for a period of five years. RESULTS: Urine β2-M abnormalities were observed in patients during the first(n = 3), second(n = 7), third(n = 11), fourth(n = 16), and fifth(n = 21) year of ADV treatment. Urinary RBP abnormalities were observed in patients during the first(n = 2), second(n = 8), third(n = 12), fourth(n = 15), and fifth(n = 22) year of ADV treatment. e GFR decreased 20%-30% from baseline in 20 patients, 30%-50% in 12 patients, and > 50% in 3 patients during the five years of treatment. Further analysis indicated that decreases in e GFR of ≥ 30% relative to the baseline level correlated significantly with urine RBP and β2-M abnormalities. In contrast, both serum creatinine and e GFR remained stable in patients treated with entecavir, and only one of these patients developed a urine β2-M abnormality, and two developed urine RBP abnormalities during the five years of treatment. CONCLUSION: Urine RBP and β2-M are biomarkers of renal injury during long-term ADV treatment for chronic hepatitis B, and indicate when treatment should be switched to entecavir. | Hong-Yu Jia Feng Ding Jian-Yang Chen Jiang-Shan Lian Yi-Min Zhang Lin-Yan Zeng Dai-Rong Xiang Liang Yu Jian-Hua Hu Guo-Dong Yu Huan Cai Ying-Feng Lu Lin Zheng Lan-Juan Li Yi-Da Yang | 2015 | World Journal of Gastroenterology2015，21，12： | 22 |
| 10 | Intestinal Microbial Community Differs between Acute Pancreatitis Patients and Healthy Volunteers显示文摘包括 45 尖锐胰腺炎和 44 个健康志愿者的案例控制研究被执行调查在肠的微生物引起的社区和尖锐胰腺炎之间的协会。定序的高产量的 16S rRNA 基因 amplicon 被用来介绍样品的 microbiological 作文。总共, 27 微生物引起的数被检测,胰腺炎病人的样品包含了更少数。从尖锐胰腺炎病人的样品从健康志愿者比那些包含了更多的 Bacteroidetes 和 Proteobacteria 和更少 Firmicutes 和 Actinobacteria。PCoA 分析健康志愿者把尖锐胰腺炎病人的烘便的微生物引起的社区与那些区分开来。尖锐胰腺炎病人的肠的微生物与健康志愿者的那些不同。肠的 microbiome 的调整可以为对待尖锐胰腺炎用作其他的策略。 | ZHANG Xi Mei ZHANG Zheng Yu ZHANG Chen Huan WU Jing WANG You Xin ZHANG Guo Xin | 2018 | Biomedical and Environmental Sciences2018，31，1： | 20 |
| 11 | A model for discrimination and prediction of mental workload of aircraft cockpit display interface显示文摘With respect to the ergonomic evaluation and optimization in the mental task design of the aircraft cockpit display interface, the experimental measurement and theoretical modeling of mental workload were carried out under flight simulation task conditions using the performance evaluation, subjective evaluation and physiological measurement methods. The experimental results show that with an increased mental workload, the detection accuracy of flight operation significantly reduced and the reaction time was significantly prolonged; the standard deviation of R-R intervals(SDNN) significantly decreased, while the mean heart rate exhibited little change; the score of NASA_TLX scale significantly increased. On this basis, the indexes sensitive to mental workload were screened, and an integrated model for the discrimination and prediction of mental workload of aircraft cockpit display interface was established based on the Bayesian Fisher discrimination and classification method. The original validation and cross-validation methods were employed to test the accuracy of the results of discrimination and prediction of the integrated model, and the average prediction accuracies determined by these two methods are both higher than 85%. Meanwhile, the integrated model shows a higher accuracy in discrimination and prediction of mental workload compared with single indexes. The model proposed in this paper exhibits a satisfactory coincidence with the measured data and could accurately reflect the variation characteristics of the mental workload of aircraft cockpit display interface, thus providing a basis for the ergonomic evaluation and optimization design of the aircraft cockpit display interface in the future. | Wei Zongmin Zhuang Damin Wanyan Xiaoru Liu Chen Zhuang Huan | 2014 | Chinese Journal of Aeronautics2014，27，5： | 17 |
| 12 | Coinfection with influenza A virus enhances SARS-CoV-2 infectivity显示文摘The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health.Through experimental coinfection with influenza A virus(IAV)and either pseudotyped or live SARS-CoV-2 virus,we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types.Remarkably,in vivo,increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV.Moreover,such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses,likely due to a unique feature of IAV to elevate ACE2 expression.This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection,and thus,prevention of IAV infection is of great significance during the COVID-19 pandemic. | Lei Bai Yongliang Zhao Jiazhen Dong Simeng Liang Ming Guo Xinjin Liu Xin Wang Zhixiang Huang Xiaoyi Sun Zhen Zhang Lianghui Dong Qianyun Liu Yucheng Zheng Danping Niu Min Xiang Kun Song Jiajie Ye Wenchao Zheng Zhidong Tang Mingliang Tang Yu Zhou Chao Shen Li Zhou Yu Chen Huan Yan Ke Lan Ke Xu | 2021 | Cell Research2021，31，4： | 16 |
| 13 | Water in the upper mantle and deep crust of eastern China: concentration, distribution and implications显示文摘Understanding the concentration and distribution of water in the Earth's mantle plays a substantial role in studying its chemical, physical and dynamic processes. After a decade of research, a comprehensive dataset of water content in upper-mantle samples has been built for eastern China, which is now the only place with water-content data from such diverse types of natural samples, and provides an integrated picture of the water content and its distribution in the upper mantle at a continental scale. The main findings include the following:(i) the temporal heterogeneity of the water content in the lithospheric mantle from early Cretaceous(~120 Ma) to Cenozoic(<40 Ma) was tightly connected with the stability of the North China Craton(from its destruction to its consolidation);(ii) the heterogeneous water content in the Cenozoic lithospheric mantle beneath different blocks of eastern China was not only inherited from tectonic settings from which they came, but was also affected later by geological processes they experienced;(iii) the distinct water content between the lowermost crust and lithospheric mantle of eastern China and its induced rheological contrast at the base of the crust indicate that the continental crust–mantle boundary could behave either in a coupled or decoupled manner beneath different areas and/or at different stages;(iv) the alkali basalts of eastern China demonstrate a heterogeneous distribution of water content in the mantle;local and regional comparisons of the water content between the lithospheric mantle and basalts' source indicate that the Cenozoic alkali basalts in eastern China were not sourced from the lithospheric mantle.Instead, the inferred high water contents in the mantle sources suggest that the Cenozoic eastern China basalts were likely sourced from the mantle transition zone(MTZ); and(v) both oceanic and continental crusts may carry a certain amount of water back into the deep mantle of eastern China by plate subduction.Such recycled crustal materials have not only created a local water-rich zone, but have also introduced crustal geochemical signatures into the mantle, both accounting for crustal geochemical imprints in the intra-plate magmatic rocks of eastern China. | Qun-Ke Xia Jia Liu István Kovács Yan-Tao Hao Pei Li Xiao-Zhi Yang Huan Chen Ying-Ming Sheng | 2019 | National Science Review2019，6，1： | 16 |
| 14 | Factors Affecting the Performance of Single-Chamber Soil Microbial Fuel Cells for Power Generation显示文摘There is limited information about the factors that affect the power generation of single-chamber microbial fuel cells(MFCs) using soil organic matter as a fuel source. We examined the effect of soil and water depths, and temperature on the performance of soil MFCs with anode being embedded in the flooded soil and cathode in the overlaying water. Results showed that the MFC with 5 cm deep soil and 3 cm overlaying water exhibited the highest open circuit voltage of 562 mV and a power density of 0.72 mW m-2. The ohmic resistance increased with more soil and water. The polarization resistance of cathode increased with more soil while that of anode increased with more water. During the 30 d operation, the cell voltage positively correlated with temperature and reached a maximum of 162 mV with a 500 ? external load. After the operation, the bacterial 16S rRNA gene from the soil and anode was sequenced. The bacteria in the soil were more diverse than those adhere to the anode where the bacteria were mainly affiliated to Escherichia coli and Deltaproteobacteria. In summary, the two bacterial groups may generate electricity and the electrical properties were affected by temperature and the depth of soil and water. | DENG Huan WU Yi-Cheng ZHANG Fan HUANG Zong-Chuan CHEN Zheng XU Hui-Juan ZHAO Feng | 2014 | Pedosphere2014，24，3： | 15 |
| 15 | Human placenta-derived mesenchymal stem cells loaded on linear ordered collagen scaffold improves functional recovery after completely transected spinal cord injury in canine显示文摘Traumatic spinal cord injury(SCI) is a major challenge in the clinic. In this study, we sought to examine the synergistic effects of linear ordered collagen scaffold(LOCS) and human placenta-derived mesenchymal stem cells(hPMSCs) when transplanted into completely transected beagle dogs. After 36 weeks observation, we found that LOCS+hPMSCs implants promoted better hindlimb locomotor recovery than was observed in the non-treatment(control) group and LOCS group. Histological analysis showed that the regenerated tissue after treatment was well integrated with the host tissue, and dramatically reduced the volume of cystic and chondroitin sulfate proteoglycans(CSPGs) expression. Furthermore, the LOCS+hPMSCs group also showed more neuron-specific βIII-tubulin(Tuj-1)-and NeuN-positive neurons in the lesion area, as well as axonal regeneration, remyelination and synapse formation in the lesion site. Additionally, dogs in the LOCS+hPMSCs group experienced enhanced sprouting of both ascending(CGRP-positive) sensory fibers and descending(5-HT-and TH-positive) motor fibers at the lesion area. All these data together suggested that the combined treatment had beneficial effects on neuronal regeneration and functional improvement in a canine complete transection model. Therefore, LOCS+hPMSCs implantation holds a great promise for bridging the nerve defect and may be clinically useful in the near future. | Sufang Han Zhifeng Xiao Xing Li Huan Zhao Bin Wang Zhixue Qiu Zhi Li Xin Mei Bai Xu Caixia Fan Bing Chen Jin Han Yanzheng Gu Huilin Yang Qin Shi Jianwu Dai | 2018 | Science China(Life Sciences)2018，61，1： | 15 |
| 16 | Preliminary study on the production of transgenic mice harboring hepatitis B virus X gene显示文摘INTRODUCTIONDespiteoverwhelmingepidemiologicalevidencelinkingpersistentHepatitisBVirus(HBV)infectionandthedevelopmentofhepato... | ZHU Huan Zhang 1, CHENG Guo Xiang 2, CHEN Jian Qu 2, KUANG Shu Yuan 3, CHENG Yong 2, ZHANG Xin Li 1, Ll Hou Da 2, XU Shao Fu 2, SHI Jing Quan 1, QIAN Geng Sun 3 and GU Jian Ren 3 | 1998 | World Journal of Gastroenterology1998，4，6： | 14 |
| 17 | Lane departure warning systems and lane line detection methods based on image processing and semantic segmentation:A review显示文摘Recently,the development and application of lane line departure warning systems have been in the market.For any of the systems,the key part of lane line tracking,lane line identification,or lane line departure warning is whether it can accurately and quickly detect lane lines.Since 1990 s,they have been studied and implemented for the situations defined by the good viewing conditions and the clear lane markings on road.After then,the accuracy for particular situations,the robustness for a wide range of scenarios,time efficiency and integration into higher-order tasks define visual lane line detection and tracking as a continuing research subject.At present,these kinds of lane marking line detection methods based on machine vision and image processing can be divided into two categories:the traditional image processing and semantic segmentation(includes deep learning)methods.The former mainly involves feature-based and model-based steps,and which can be classified into similarity-and discontinuity-based ones;and the model-based step includes different parametric straight line,curve or pattern models.The semantic segmentation includes different machine learning,neural network and deep learning methods,which is the new trend for the research and application of lane line departure warning systems.This paper describes and analyzes the lane line departure warning systems,image processing algorithms and semantic segmentation methods for lane line detection. | Weiwei Chen Weixing Wang Kevin Wang Zhaoying Li Huan Li Sheng Liu | 2020 | Journal of Traffic and Transportation Engineering(English Edition)2020，7，6： | 14 |
| 18 | Prognostic factors influencing clinical outcomes of glioblastoma multiforme显示文摘背景 Glioblastoma multiforme (GBM ) 是 astrocytic 肿瘤的最恶意的类型并且与差的预后被联系。在这回顾的研究,我们估计了临床,放射学,基因分子并且与 GBM.Methods A 影响病人的临床的结果的治疗因素与 GBM 116 总计病人收到了在 2006 年 1 月和 2007 年 12 月之间的外科和放射的人,在这研究被包括。 Kaplan-Meier 幸存分析和考克斯回归分析被用来独立地发现因素影响病人的前进免费幸存( PFS )时间和全面幸存( OS ) time.Results 年龄,外科手术前的 Kamofsky 表演规模( KPS )分数,在在操作以后的 2 个星期的 KPS 分数变化,神经病学的赤字症状,肿瘤切除术程度,最大的肿瘤直径,雄辩的外皮的参与或深结构,大脑脑叶的参与, Ki-67 表示水平和辅助化疗 w 当模特儿的比例的危险揭示了的考克斯那年龄 50 年,外科手术前的 KPS 分数 80 ,在操作 0 以后的 KPS 分数变化,单个正面的脑叶的参与,非雄辩的区域或深结构参与,低 Ki-67 表示和辅助化疗是独立有利因素( P < 0.05 )为病人在诊断,外科手术前的 KPS 分数,在 2 星期 postoperation 的 KPS 分数变化,大脑脑叶的参与,雄辩的外皮的参与或深结构的临床的 outcomes.Conclusions 年龄,Ki- | LI Shou-wei QIU Xiao-guang CHEN Bao-shi ZHANG Wei REN Huan WANG Zhong-cheng JIANG Tao | 2009 | Chinese Medical Journal2009，，11： | 13 |
| 19 | A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice显示文摘The transient elevation of cytoplasmic calcium is essential for pathogen-associated molecular pattern(PAMP)-triggered immunity(PTI).However,the calcium channels responsible for this process have remained unknown.Here,we show that rice CDSI(CELL DEATH and SUSCEPTIBLE to BLAST 1)encoding OsCNGC9;a cyclic nucleotide-gated channel protein,positively regulates the resistance to rice blast disease.We show that OsCNGC9 mediates PAMP-induced Ca2+influx and that this event is critical for PAMPs-triggered ROS burst and induction of PTI-related defense gene expression.We further show that a PTI related receptor-lih cytoplasmic kinase OsRLCK185 physically interacts with and phosphorylates OsCNGC9 to activate its channel activity.Our results suggest a signaling cascade linking pattern recognition to calcium channel activation,which is required for initiation of PTI and disease resistance in rice. | Jiachang Wang Xi Liu An Zhang Yulong Ren Fuqing Wu Gang Wang Yang Xu Cailin Lei Shanshan Zhu Tian Pan Yongfei Wang Huan Zhang Fan Wang Yan-Qiu Tan Yupeng Wang Xin Jin Sheng Luo Chunlei Zhou Xiao Zhang Jinling Liu Shuai Wang Lingzhi Meng Yihua Wang Xi Chen Qibing Lin Xin Zhang Xiuping Guo Zhijun Cheng Jiulin Wang Yunlu Tian Shijia Liu Ling Jiang Chuanyin Wu Ertao Wang Jian-Min Zhou Yong-Fei Wang Haiyang Wang Jianmin Wan | 2019 | Cell Research2019，29，10： | 13 |
| 20 | LA-ICP-MS Zircon U-Pb Dating of Intermediate-Acidic Intrusive Rocks and Molybdenite Re-Os Dating from the Bangpu Mo (Cu) Deposit, Tibet and its Geological Implication显示文摘The multi-stage intrusions of intermediate-acid magma occur in the Bangpu mining district, the petrogenic ages of which have been identified. The times and sequences of their emplacement have been collated and stipulated in detail in this paper by using the laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) zircon U-Pb dating method. The ages of biotite monzogranite that were formed before mineralization in the southwest of this mining district are 70±1 Ma (mean square of weighted deviates (MSWD) =9.5, n=8) and 60.60±0.31 Ma (MSWD=3.8, n=16), which belong to the late Cretaceous-early Paleocene in age. That means, they are products of an early tectonicmagmatic event of the collision between the Indian and Asian continentals. The ages of ore-bearing monzogranite porphyry and ore-bearing diorite porphyrite are 16.23±0.19 Ma (MSWD=2.0, n=26) and 15.16±0.09 Ma (MSWD=3.9, n=5) separately, which belong to the middle Miocene in age; namely, they are products of the Gangdese post-collision extensional stage when crust-mantle materials melted and mixed as well as magmatic intrusion simultaneously occurred. Some zircons with ages of 203.6±2.2 Ma (MSWD=1.18, n=7) were captured in the ore-bearing diorite porphyrite, which shows that there had been tectono-magmatic events in the late Triassic-early Jurassic. Molybdenum (copper) ore-bodies produced in the monzogranite porphyry and copper (molybdenum) ore-bodies produced in the diorite porphyrite are the main ore types in this ore deposit. The model ages of Re-Os isotopic dating for the 11 molybdenite are 13.97-15.84 Ma, while isochron ages are 14.09±0.49 Ma (MSWD=26). The isochron ages of seven molybdenite from molybdenum (copper) ore with monzogranite porphyry type are 14.11±0.31 Ma (MSWD=5.2). There is great error in the isochron ages of four molybdenite from copper (molybdenum) ore with diorite porphyrite type, and their weighted average model ages of 14.6±1.2 Ma (MSWD=41), which generally represent the mineralization age. The results about the Re-Os isotopic dating of molybdenite in the ore of different types have limited exactly that, the minerlazation age of this ore deposits is about 14.09 Ma, which belongs to the middle Miocene mineralization. The Bangpu deposit has a uniform metallogenic dynamics background with the porphyry type and skarn-type deposits such as Jiama, Qulong and others. | WANG Liqiang CHEN Yuchuan TANG Juxing LU Pengrui LUO Maocheng WANG Huan CHEN Wei LENG Qiufeng | 2012 | Acta Geologica Sinica(English Edition)2012，86，5： | 13 |
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