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| 1 | Class I phosphatidylinositol 3-kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901显示文摘我们试图学习 LY294002 的效果,一级 phosphatidylinositol 3-kinase (PI3K ) 的一个禁止者在增长上,在胃的癌症房间的 apoptosis,和 autophagy 衬里 SGC7901。在这研究,我们证明 LY294002 禁止了胃的癌症 SGC7901 房间的生存能力。我们也证明 LY294002 增加了 1 点亮的联系微导管的蛋白质的表示链 3 (LC3 ) ,并且增加的 monodansylcadaverine (MDC ) 把泡标记。LY294002 由激活 p53 和 caspase-3 激活 autophagy,并且由 up-regulatingp53 和 apoptosis (美洲狮) 的 p53-up-regulated 调节的人导致了 apoptosis。因此, LY294002 可能通过 p53 和下游的点美洲狮的激活在 SGC7901 房间导致 cytotoxicity。这些调查结果建议表明小径的一级 PI3K 的抑制是为管理胃的癌症的潜在的策略。 | Chungen Xing Baosong Zhu Huihui Liu Huihua Yao Lifeng Zhang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，3： | 17 |
| 2 | Functional electrical stimulation-facilitated proliferation and regeneration of neural precursor cells in the brains of rats with cerebral infarction显示文摘Previous studies have shown that proliferation of endogenous neural precursor cells cannot alone compensate for the damage to neurons and axons. From the perspective of neural plasticity, we observed the effects of functional electrical stimulation treatment on endogenous neural precursor cell proliferation and expression of basic fibroblast growth factor and epidermal growth factor in the rat brain on the infarct side. Functional electrical stimulation was performed in rat models of acute middle cerebral artery occlusion. Simultaneously, we set up a placebo stimulation group and a sham-operated group. Immunohistochemical staining showed that, at 7 and 14 days, compared with the placebo group, the numbers of nestin(a neural precursor cell marker)-positive cells in the subgranular zone and subventricular zone were increased in the functional electrical stimulation treatment group. Western blot assays and reverse-transcription PCR showed that total protein levels and gene expression of epidermal growth factor and basic fibroblast growth factor were also upregulated on the infarct side. Prehensile traction test results showed that, at 14 days, prehension function of rats in the functional electrical stimulation group was significantly better than in the placebo group. These results suggest that functional electrical stimulation can promote endogenous neural precursor cell proliferation in the brains of acute cerebral infarction rats, enhance expression of basic fibroblast growth factor and epidermal growth factor, and improve the motor function of rats. | Yun Xiang Huihua Liu Tiebin Yan Zhiqiang Zhuang Dongmei Jin Yuan Peng | 2014 | Neural Regeneration Research2014，9，3： | 13 |
| 3 | ^(40)Ar/^(39)Ar chronology and geochemistry of high-K volcanic rocks in the Mangkang basin, Tibet显示文摘Our two newly obtained high-quality 40Ar/39Ar ages suggest that the high-K volcanic rocks of the Lawuxiang Formation in the Mangkang basin, Tibet were formed at 33.5 ( 0.2 Ma. The tracing of elemental and Pb-Sr-Nd isotopic geochemistry indicates that they were derived from an EM2 enriched mantle in continental subduction caused by transpression. Their evidently negative anomalies in HFSEs such as Nb and Ta make clear that there is an input of continental material into the mantle source. The high-K rocks at 33.5 ( 0.2 Ma in the Mangkang basin may temporally, spatially and compositionally compare with the early one of two-pulse high-K rocks in eastern Tibet distinguished by Wang J. H. Et al., implying that they were formed in the same tectonic setting. | ZHANG Huihua, HE Huaiyu, WANG Jianghai & XIE Guanghong Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China College of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China | 2005 | Science China Earth Sciences2005，48，1： | 13 |
| 4 | Poor performance of the modified early warning score for predicting mortality in critically ill patients presenting to an emergency department显示文摘BACKGROUND:This study was undertaken to validate the use of the modified early warning score(MEWS) as a predictor of patient mortality and intensive care unit(ICU)/ high dependency(HD)admission in an Asian population.METHODS:The MEWS was applied to a retrospective cohort of 1 024 critically ill patients presenting to a large Asian tertiary emergency department(ED) between November 2006 and December2007.Individual MEWS was calculated based on vital signs parameters on arrival at ED.Outcomes of mortality and ICU/HD admission were obtained from hospital records.The ability of the composite MEWS and its individual components to predict mortality within 30 days from ED visit was assessed.Sensitivity,specificity,positive and negative predictive values were derived and compared with values from other cohorts.A MEWS of ≥4 was chosen as the cut-off value for poor prognosis based on previous studies.RESULTS:A total of 311(30.4%) critically ill patients were presented with a MEWS ≥4.Their mean age was 61.4 years(SD 18.1) with a male to female ratio of 1.10.Of the 311 patients,53(17%)died within 30 days,64(20.6%) were admitted to ICU and 86(27.7%) were admitted to HD.The area under the receiver operating characteristic curve was 0.71 with a sensitivity of 53.0%and a specificity of 72.1%in addition to a positive predictive value(PPV) of 17.0%and a negative predictive value(NPV)of 93.4%(MEWS cut-off of ≥4) for predicting mortality.CONCLUSION:The composite MEWS did not perform well in predicting poor patient outcomes for critically ill patients presenting to an ED. | Le Onn Ho Huihua Li Nur Shahidah Zhi Xiong Koh Papia Sultana Marcus Eng Hock Ong | 2013 | World Journal of Emergency Medicine2013，4，4： | 12 |
| 5 | Personalized Privacy-Preserving Trajectory Data Publishing显示文摘Due to the popularity of mobile internet and location-aware devices,there is an explosion of location and tra jectory data of moving objects.A few proposals have been proposed for privacy preserving tra jectory data publishing,and most of them assume the attacks with the same adversarial background knowledge.In practice,different users have different privacy requirements.Such non-personalized privacy assumption does not meet the personalized privacy requirements,meanwhile,it looses the chance to achieve better utility by taking advantage of differences of users' privacy requirements.We study the personalized tra jectory k-anonymity criterion for trajectory data publication.Specifically,we explore and propose an overall framework which provides privacy preserving services based on users' personal privacy requests,including tra jectory clustering,editing and publication.We demonstrate the efficiency and effectiveness of our scheme through experiments on real world dataset. | LU Qiwei WANG Caimei XIONG Yan XIA Huihua HUANG Wenchao GONG Xudong | 2017 | Chinese Journal of Electronics2017，26，2： | 6 |
| 6 | Every Banach space with a w*-separable dual hasa 1+ε-equivalent norm with the ball covering property显示文摘A normed space is said to have ball-covering property if its unit sphere can be contained in the union of countably many open balls off the origin. This paper shows that for every ε>0 every Banach space with a w*-separable dual has a 1+ε-equivalent norm with the ball covering property. | CHENG LiXin, SHI HuiHua & ZHANG Wen School of Mathematical Sciences, Xiamen University, Xiamen 361005, China | 2009 | Science China Mathematics2009，52，9： | 6 |
| 7 | Multiscale nanowire-microfluidic hybrid strain sensors with high sensitivity and stretchability显示文摘Nanomaterials with low-dimensional morphology have been explored for enhancing the performance of strain sensors,but it remains difficult to achieve high stretchability and sensitivity simultaneously.In this work,a composite structure strain sensor based on nanomaterials and conductive liquid is designed,demonstrated,and engineered.The nanowire-microfluidic hybrid(NMH)strain sensor responds to multiscale strains from 4%to over 400%,with a high sensitivity and durability under small strain.Metal nanowires and carbon nanotubes are used to fabricate the NMH strain sensors,which simultaneously exhibit record-high average gauge factors and stretchability,far better than the conventional nanowire devices.Quantitative modeling of the electrical characteristics reveals that the effective conductivity percolation through the hybrid structures is the key to achieving high gauge factors for multiscale sensing.The sensors can operate at low voltages and are capable of responding to various mechanical deformations.When fixed on human skin,the sensors can monitor large-scale deformations(skeleton motion)and small-scale deformations(facial expressions and pulses).The sensors are also employed in multichannel,interactive electronic system for wireless control of robotics.Such demonstrations indicate the potential of the sensors as wearable detectors for human motion or as bionic ligaments in soft robotics. | Songjia Han Chunrui Liu Huihua Xu Dongyuan Yao Kanghong Yan Huanliang Zheng Hui-Jiuan Chen Xuchun Gui Sheng Chu Chuan Liu | 2018 | npj Flexible Electronics2018，2，1： | 6 |
| 8 | Stepping-quenching-partitioning treatment of 20SiMn2MoVA steel and effects of carbon and carbide forming elements显示文摘A novel heat treatment process,stepping quenching and partitioning(S-Q-P),has been developed to manipulate microstructure and mechanical properties of steels.Based on incomplete partitioning of carbon from martensite to austenite,volume fraction and distribution of the retained austenite resulting from the following quenching of the steels could be effectively controlled,and then the synthesized mechanical properties of the steels would be improved.In this paper,20SiMn2MoVA steel was treated with conventional quenching-tempering(Q-T),currently prevailing quenching-partitioning(Q-P) and S-Q-P processes,respectively.The results indicated that the volume fraction of the retained austenite of the steel treated by Q-P and S-Q-P processes increased significantly that resulted in the increase of ductility and decrease of strength.The product of strength and ductility of the steel treated by S-Q-P process reached 23.7GPa%,that was increased by about 13% and 7% compared with that after Q-T and Q-P processes,respectively.Compared with the great improvement of the synthesized mechanical property obtained by S-Q-P process with another steel 35SiMn,there would be some factors that deteriorated the effect of S-Q-P process on 20SiMn2MoVA steel.It was found by microstructural testing that the carbide forming elements V and Mo in the steel led to precipitation of carbides during partitioning period and lack of carbon in austenite.As a result,less austenite would remain after final quenching and mechanical properties of the steel would be influenced.The results would be beneficial for understanding the principle of S-Q-P process and improving the design of the S-Q-P steel compositions. | ZHU YueFeng WANG FengYing ZHOU HuiHua WANG Guan JIANG BoZhi | 2012 | Science China(Technological Sciences)2012，55，7： | 5 |
| 9 | Correlation between echolocation calls and morphological features among three kinds of bats显示文摘The correlation between echolocation sound and morphological features of 18 species of bats, which are subordinated to 3 families including rhinolophidae, hipposideridae and vespertilionidae is studied. Pearson's correlation and regression analysis are adopted to analyze the correlations between noseleaf width (NW) and forearm length (FAL), NW and dominant frequency (DF), FAL and DF. The results show a positive correlation between NW and FAL and a negative correlation between NW and DF in Rhinolophidae. In each family, there is a negative correlation between FAL and DF. Some species have a higher or lower frequency than predicted one according to their body size. There are significant differences of the regression equation of FAL and DF among the three families. For the bats with the same body size, the order in frequency is: hipposiderid bats> rhinolophid bats> vespertilionid bats. The mechanism of interrelationship between FAL and DF of bats, the reason why these deviations occur in correlativity of the three families and the mechanism of the interaction between morphological, physiological and ecological characteristics are discussed. | FENG Jiang , CHEN Min, LI Zhenxin, ZHANG Shuyi, ZHAO Huihua and ZHOU Jiang(1. Environmental Science Department, Northeast Normal University, Changchun 130024, China 2. Institute of Zoology, The Chinese Academy of Sciences, Beijing 100080, China 3. Biology Department, Guizhou Normal University, Guiyang 550000, China) | 2002 | Progress in Natural Science:Materials International2002，12，9： | 4 |
| 10 | VisComposer: A Visual Programmable Composition Environment for Information Visualization显示文摘As the amount of data being collected has increased,the need for tools that can enable the visual exploration of data has also grown.This has led to the development of a variety of widely used programming frameworks for information visualization.Unfortunately,such frameworks demand comprehensive visualization and coding skills and require users to develop visualization from scratch.An alternative is to create interactive visualization design environments that require lttle to no programming.However,these tools only supports a small portion of visual formns.We present a programmable integrated development environment(IDE),VisComposer,that supports the development of expressive visualization using a drag and-drop visual interface.Vis-Composer exposes the programmability by customizing desired components within a modular-ized visualization composition pipeline,effectively balancing the capability gap between expert coders and visualization artists.The implemented system empowers users to compose compre-bensive visualizations with real-time preview and optimization features,and supports prototyp-ing,sharing and reuse of the effects by means of an intuitive visual composer.Visual program-ming and textual programming integrated in our system allow users to compose more complex visual effects while retaining the simplicity of use.We demonstrate the performance of VisCom-poser with a variety of examples and an informal user evaluation. | Honghui Mei Wei Chen Yuxin Ma Huihua Guan Wanqi Hu | 2018 | Visual Informatics2018，2，1： | 4 |
| 11 | Contrast-enhanced ultrasound is helpful in the differentiation of malignant and benign breast lesions显示文摘 | Hongjia Zhao Rong Xu Qiufang Ouyang Lidian Chen Baowei Dong Ye Huihua | 2009 | European Journal of Radiology2009，，2： | 4 |
| 12 | Physiological characteristics and commercial application of edible mushroom dietary fiber显示文摘Edible mushrooms are considered as healthy food because they are low in calories and fat but rich in proteins minerals and dietary fiber(DF). Edible mushrooms are recognized as new potential resource of DF since the components of edible mushroom dietary fiber(EMDF) have shown special physiological and pharmacological effects on human and animals. In this article,the soluble and insoluble fractions of DF in different edible mushroom species have been evaluated. Biological effects of EMDF are related to promoting desired responses,for example,reducing blood cholesterol,protecting cells from free radicals attack by antioxidative effects,attenuating levels and fluctuations of blood glucose and selectively supporting the growth of beneficial gut bacteria. The EMDF plays an important role in reducing risk of cardiovascular diseases,diabetes mellitus and intestinal diseases. The non-starch polysaccharides(NSP),a kind of EMDF,is the best known and most potent mushroom-derived substances with antitumor and immunomodulatory properties. EMDF has also been reported to take part in the control of body weight,lipid homeostasis and insulin sensitivity due to its effect on specific chemical structures and physical properties. Many pharmaceutical substances with potent and unique health- enhancing properties were isolated recently from edible mushrooms and distributed worldwide. Mushroom-based dietary supplements(DSs) with potential therapeutic effects are produced from the mycelia or the fruiting bodies of mushrooms,and are consumed in the forms of capsules,tablets,or extracts. The EMDF, based on its special physiological functions on human health,shows a wide range of potential application prospects. | Zhang Chenju Xu Chunhua Yu Xiaobing Zheng Huihua Chen Hui | 2014 | Engineering Sciences2014，12，1： | 4 |
| 13 | A novel microstructural design and heat treatment technique based on gradient control of carbon partitioning between austenite and martensite for high strength steels显示文摘Based on gradient control of carbon partitioning between martensite and austenite during heat treatment of steels,a stepping-quenching-partitioning(S-Q-P) process is developed for high strength steels.The S-Q-P process involves several quenching processes at progressively lower temperatures between martensite-start(Ms) and martensite-finish(Mf) temperatures,each followed by a partitioning treatment at either the initial quenching temperature or above that temperature.A novel microstructure is designed based on the S-Q-P process.Sizes and distributions of retained austenite and high-carbon martensite surrounded by martensite laths can be manipulated by the partitioning duration and temperature,and quenching temperature of the S-Q-P process.Alloying element Si is employed in the S-Q-P steel to suppress formation of carbides and create suitable amount of retained austenite.A steel of 0.39C-1.22Mn-1.12Si-0.23Cr(wt.%) treated by the S-Q-P process is endowed with some special microstructural characteristics:some strips of retained austenite located at edges of martensite blocks with high density of dislocations and between martensite laths,some small blocks of twinned martensites distributed among bundles of the low-carbon martensite lath.The mechanical properties of the medium carbon steel after the S-Q-P process can reach ultimate tensile strength(Rm) of 1240 MPa,total elongation(EI) of 25%,and product of strength and ductility(PSD) of 31.2 GPa% that are much more improved than those after the conventional quenching-tempering(Q-T) and currently prevailing quenching-partitioning(Q-P) treatments.The PSD of the tested steel after the S-Q-P process increases by 67% and 32% as compared with those after the Q-T and Q-P processes,respectively. | WANG FengYing ZHU YueFeng ZHOU HuiHua JIANG BoZhi WANG Guan | 2013 | Science China(Technological Sciences)2013，56，8： | 4 |
| 14 | A Method for Crude Oil Selection and Blending Optimization Based on Improved Cuckoo Search Algorithm显示文摘Refineries often need to find similar crude oil to replace the scarce crude oil for stabilizing the feedstock property. We introduced the method for calculation of crude blended properties firstly, and then created a crude oil selection and blending optimization model based on the data of crude oil property. The model is a mixed-integer nonlinear programming(MINLP) with constraints, and the target is to maximize the similarity between the blended crude oil and the objective crude oil. Furthermore, the model takes into account the selection of crude oils and their blending ratios simultaneously, and transforms the problem of looking for similar crude oil into the crude oil selection and blending optimization problem. We applied the Improved Cuckoo Search(ICS) algorithm to solving the model. Through the simulations, ICS was compared with the genetic algorithm, the particle swarm optimization algorithm and the CPLEX solver. The results show that ICS has very good optimization efficiency. The blending solution can provide a reference for refineries to find the similar crude oil. And the method proposed can also give some references to selection and blending optimization of other materials. | Yang Huihua Ma Wei Zhang Xiaofeng Li Hu Tian Songbai | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，4： | 4 |
| 15 | Are foreign monks better at chanting? The effect of ‘airborne’ SDICs on anti-corruption显示文摘The independence of supervision agency is of great importance for anti-corruption.After the leadership transition of the provincial Congress of the Chinese Communist Party in 2006,Secretaries of Discipline Inspection Commission(SDICs)were suddenly dispatched from the centre or transferred from another province in China(‘airborne’SDICs)to enhance their independence in inspecting corruption cases.To investigate the effect of this policy reform,we collect data of SDICs and anti-corruption in 31 provinces from 2003 to 2014,and evaluate this policy using the difference-in-differences econometrics method.We find that there is no significant effect of these‘airborne’SDICs whether from the centre or another province on anti-corruption.This result is robust to different measurements of anti-corruption and subsamples.We argue that the dispatch of external SDICs is not enough to ensure the independence of supervision agency,because local discipline inspection commissions(DICs)are still subject to local Chinese Communist Party committees in terms of personnel,funds and property.This paper has important policy implications for the current anti-corruption campaign in China. | Huihua Nie Mengqi Wang | 2016 | Economic and Political Studies2016，4，1： | 4 |
| 16 | Preparation of NiFe binary alloy nanocrystals for nonvolatile memory applications显示文摘In this work,an idea which applies binary alloy nanocrystal floating gate to nonvolatile memory application was introduced.The relationship between binary alloy’s work function and its composition was discussed theoretically.A nanocrystal floating gate structure with NiFe nanocrystals embedded in SiO2 dielectric layers was fabricated by magnetron sputtering.The micro-structure and composition deviation of the prepared NiFe nanocrystals were also investigated by TEM and EDS. | WANG Li,SUN HongFang,ZHOU HuiHua & ZHU Jing Beijing National Center for Electron Microscopy Laboratory,Department of Materials Science and Engineering,Tsinghua University,Beijing 100084,China | 2010 | Science China(Technological Sciences)2010，53，9： | 3 |
| 17 | Cross-correlation function based multipath mitigation technique for cosine-BOC signals显示文摘We propose a new multipath mitigation technique based on cross-correlation function for the new cosine phased binary offset carrier(cosine-BOC) modulated signals, which will most likely be employed in both European Galileo system and Chinese Compass system. This technique is implemented to create an optimum cross-correlation function via designing the modulated symbols of the local signal. And the structure of the code tracking loop for cosine-BOC signals is quite simple including only two real correlators. Results demonstrate that the technique efficiently eliminates the ranging errors in the medium and long multipath regions with respect to the conventional receiver correlation techniques. | Huihua Chen Weimin Jia Minli Yao | 2013 | Journal of Systems Engineering and Electronics2013，24，5： | 3 |
| 18 | STUDY ON THE SYNTHESIS AND PHYSICOCHEMICAL PROPERTIES OF SUCROSE POLYESTER显示文摘 | LIU Zhongdong LIU Huihua LUO Peng LIU Peng Xiao Fugang | 2006 | Chinese Journal of Reactive Polymers2006，15，1： | 3 |
| 19 | DataV:Data Visualization on large high-resolution displays显示文摘In recent years,the technology and applications of visualizations on large high-resolution displays(LHDs)have received widespread attention because of its perceptual benefits and improved productivity.However,existing work on LHD visualization lacks both comprehensive guidance for design requirements and tools developed for its specific usage scenarios.In this paper,we present the scenarios,design,and implementation of DataV,a Software-as-a-Service(SaaS)visual deployment tool that enables rapid construction and cross-platform publishing of interactive visualization on LHDs.Our framework can support rich components for the high-performance rendering of multisource heterogeneous data.DataV provides a full-fledged toolchain to help the user efficiently specify layout and interactions.We present its accessibility and impressive visual effects with examples and comparison with Tableau,Power BI,VisComposer,and iVisDesigner.We also report the performance of using DataV for 3D map rendering by comparing it with deck.gl. | Honghui Mei Huihua Guan Chengye Xin Xiao Wen Wei Chen | 2020 | Visual Informatics2020，4，3： | 3 |
| 20 | Control system for cryogenic permanent magnet undulator(CPMU)of high energy photon source(HEPS)显示文摘Background High energy photon source(HEPS)is the fourth-generation light source,which uses a large number of highperformance insertion devices to generate synchrotron radiation.The control system is an important part of the insertion device(ID).Purpose Cryogenic permanent magnet undulator(CPMU)is one kind of IDs that works in liquid nitrogen temperature and ultra-high vacuum environment,and its control system is more difficult and complex than in-air ID.The design of the control system for CPMU will be introduced in detail.Method The sub-systems include high-precision magnetic gap control,safety protection,measurement and compensation of magnetic gap at cryogenic temperature and cryogenic temperature monitoring.Mature,reliable,stable technical schemes are designed to meet the technical specifications of sub-systems.Results The experiment results show that the magnetic gap motion accuracy can be controlled within 0.2–0.3μm under the step size of 1μm.The safety protection system has been tested in turn,and the predetermined protection can be achieved.The average value of magnetic gap cold contraction is 1.512 mm measured by optical micrometer,and the compensation is realized by software.The average temperature of the main magnet structure measured by the temperature sensors is 81.0 K,and the temperature gradient is 0.7 K/m.The temperature monitoring is reliable and stable.Conclusion The CPMU control system which is based on EPICS has been successfully applied to the CPMU prototype,and the test results have met the design specifications. | Shutao Zhao Jianshe Cao Huihua Lu Xiaoyu Li Shuchen Sun Yajun Sun Xiangzhen Zhang Lei Zhang Yuhui Li Zhiqiang Li Wan Chen Lingling Gong Qing Guo Keyun Gong Yongsheng Huang Yanwei Yang Yufeng Yang | 2021 | Radiation Detection Technology and Methods2021，5，1： | 2 |
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