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| 1 | The role and potential application of extracellular vesicles in liver cancer显示文摘Liver cancer is one of the most common causes of cancer-related death worldwide and mainly includes hepatocellular carcinoma(HCC)and cholangiocarcinoma(CCA).Extracellular vesicles(EVs)are membrane-derived nanometer-sized vesicles that can be released by different cell types under normal and pathological conditions and thus play important roles in the transmission of biological information between cells.Increasing evidence suggests that liver cancer cell-derived EVs may help establish a favorable microenvironment to support the proliferation,invasion and metastasis of cancer cells.In this review,we summarized the role of EVs in the tumor microenvironment(TME)during the development and progression of liver cancer.As messenger carriers,EVs are loaded by various biomolecules,such as proteins,RNA,DNA,lipids and metabolites,making them potential liquid biopsy biomarkers for the diagnosis and prognosis of liver cancer.We also highlighted the progress of EVs as antigen carriers and EV-based therapeutics in preclinical studies of liver cancer. | Xuewei Qi Shuzhen Chen Huisi He Wen Wen Hongyang Wang | 2021 | Science China(Life Sciences)2021，64，8： | 2 |
| 2 | Anti- ultraviolet and physical properties of woolen fabrics cured with citric acid and TiOJchitosan 显示文摘 | HSIEH Sunghuang ZHANG Fangru L1 Huisi | 2006 | Journal of Applied Polymer Science2006，，100： | 1 |
| 3 | Pore Size Controlled Mesoporous Silicate Powder Prepared by Triblock Copolymer Templates显示文摘 | Yamada T Zhou Huisi Asai K | 2002 | Mater Lett2002，56，2： | 1 |
| 4 | Fast and roubst symmetry detection for brain images based on parallel scale-in- variant feature transform matching and voting显示文摘 | Wu Huisi Wang Defeng | 2013 | International Journal of Imaging Systems and Te- chology2013，41，2： | 1 |
| 5 | Aristolochic acids exposure was not the main cause of liver tumorigenesis in adulthood显示文摘Aristolochic acids(AAs) have long been considered as a potent carcinogen due to its nephrotoxicity. Aristolochic acid I(AAI) reacts with DNA to form covalent aristolactam(AL)-DNA adducts,leading to subsequent A to T transversion mutation, commonly referred as AA mutational signature. Previous research inferred that AAs were widely implicated in liver cancer throughout Asia. In this study, we explored whether AAs exposure was the main cause of liver cancer in the context of HBV infection in China's Mainland. Totally 1256 liver cancer samples were randomly retrieved from 3 medical centers and a refined bioanalytical method was used to detect AAI-DNA adducts. 5.10% of these samples could be identified as AAI positive exposure. Whole genome sequencing suggested 8.41% of 107 liver cancer patients exhibited the dominant AA mutational signature, indicating a relatively low overall AAI exposure rate. In animal models, long-term administration of AAI barely increased liver tumorigenesis in adult mice, opposite from its tumor-inducing role when subjected to infant mice. Furthermore, AAI induced dose-dependent accumulation of AA-DNA adduct in target organs in adult mice, with the most detected in kidney instead of liver. Taken together, our data indicate that AA exposure was not the major threat of liver cancer in adulthood. | Shuzhen Chen Yaping Dong Xinming Qi Qiqi Cao Tao Luo Zhaofang Bai Huisi He Zhecai Fan Lingyan Xu Guozhen Xing Chunyu Wang Zhichao Jin Zhixuan Li Lei Chen Yishan Zhong Jiao Wang Jia Ge Xiaohe Xiao Xiuwu Bian Wen Wen Jin Ren Hongyang Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 6 | Re- sizing by symmetry-summarization 显示文摘 | Wu Huisi Wang Yushuen Feng Kunchuan | 2010 | ACM Transac- tion on Graphics2010，29，6： | 1 |
| 7 | Automatic texture exemplar extraction based on global and local textureness measures显示文摘Texture synthesis is widely used for modeling the appearance of virtual objects. However,traditional texture synthesis techniques emphasize creation of optimal target textures, and pay insufficient attention to choice of suitable input texture exemplars.Currently, obtaining texture exemplars from natural images is a labor intensive task for the artists,requiring careful photography and significant postprocessing. In this paper, we present an automatic texture exemplar extraction method based on global and local textureness measures. To improve the efficiency of dominant texture identification, we first perform Poisson disk sampling to randomly and uniformly crop patches from a natural image. For global textureness assessment, we use a GIST descriptor to distinguish textured patches from non-textured patches,in conjunction with SVM prediction. To identify real texture exemplars consisting solely of the dominant texture, we further measure the local textureness of a patch by extracting and matching the local structure(using binary Gabor pattern(BGP)) and dominant color features(using color histograms) between a patch and its sub-regions. Finally, we obtain optimal texture exemplars by scoring and ranking extracted patches using these global and local textureness measures.We evaluate our method on a variety of images with different kinds of textures. A convincing visual comparison with textures manually selected by an artist and a statistical study demonstrate its effectiveness. | Huisi Wu Xiaomeng Lyu Zhenkun Wen | 2018 | Computational Visual Media2018，4，2： | 1 |
| 8 | A Comparative Study on the Effects of Excess Iodine and Herbs with Excess Iodine on Thyroid Oxidative Stress in Iodine-Deficient Rats显示文摘 | Tianshu Gao Rui Shi Tengche Qi Huisi Yin Lan Mei Xiaoqing Han Peng Cui | 2014 | Biological Trace Element Research2014，，： | 1 |
| 9 | Analysis on Employee Motivation Management of Haidilao From the Perspective of Confucianism Wulun显示文摘It is a common belief that specific nations possess specific cultural traits that are resistant to change. The purpose of this paper is to explore the impact of Confucianism on the organizational management in Haidilao International Holding Ltd.(Haidilao), based on the Five Cardinal Human Relationships (Wulun). The paper also further explains the application of Wulun to daily staff management in Haidilao. It is expected to provide some unique philosophical perspectives to forge a richer understanding field of contemporary business management. | Huisi Chen Yuran Zeng | 2018 | Chinese Business Review2018，17，11： | 0 |
| 10 | Reference-guided structure-aware deep sketch colorization for cartoons显示文摘Digital cartoon production requires extensive manual labor to colorize sketches with visually pleasant color composition and color shading.During colorization,the artist usually takes an existing cartoon image as color guidance,particularly when colorizing related characters or an animation sequence.Reference-guided colorization is more intuitive than colorization with other hints,such as color points or scribbles,or text-based hints.Unfortunately,reference-guided colorization is challenging since the style of the colorized image should match the style of the reference image in terms of both global color composition and local color shading.In this paper,we propose a novel learning-based framework which colorizes a sketch based on a color style feature extracted from a reference color image.Our framework contains a color style extractor to extract the color feature from a color image,a colorization network to generate multi-scale output images by combining a sketch and a color feature,and a multi-scale discriminator to improve the reality of the output image.Extensive qualitative and quantitative evaluations show that our method outperforms existing methods,providing both superior visual quality and style reference consistency in the task of reference-based colorization. | Xueting Liu Wenliang Wu Chengze Li Yifan Li Huisi Wu | 2022 | Computational Visual Media2022，8，1： | 0 |
| 11 | Roles of tumor necrosis factor alpha on sperm acrosin activity and acrosome reaction显示文摘Aim: To study the roles of tumor necrosis factor alpha (TNF-a)on the sperm acrosin activity and acrosome reaction. Methods:The sperm acrosin activity was tested by the method of BAEE/ADH Unity and the acrosome reaction by the Triple-stain technique. Results: TNF-a decreased the sperm acrosin activityand acrosome reaction (P<0.01, P<0.01, respectively); | Shu-LingBian Guo-YiLiu Hai-XiaWen Shu-ZhenWang JiangNi WeiZhang HuiSi | 2004 | Asian Journal of Andrology2004，6，4： | 0 |
| 12 | DiagDO: an efficient model based diagnosis approach with multiple observations显示文摘Model-based diagnosis(MBD)with multiple observations shows its significance in identifying fault location.The existing approaches for MBD with multiple observations use observations which is inconsistent with the prediction of the system.In this paper,we proposed a novel diagnosis approach,namely,the Diagnosis with Different Observations(DiagDO),to exploit the diagnosis when given a set of pseudo normal observations and a set of abnormal observations.Three ideas are proposed in this paper.First,for each pseudo normal observation,we propagate the value of system inputs and gain fanin-free edges to shrink the size of possible faulty components.Second,for each abnormal observation,we utilize filtered nodes to seek surely normal components.Finally,we encode all the surely normal components and parts of dominated components into hard clauses and compute diagnosis using the MaxSAT solver and MCS algorithm.Extensive tests on the ISCAS'85 and ITC'99 benchmarks show that our approach performs better than the state-of-the-art algorithms. | Huisi ZHOU Dantong OUYANG Xinliang TIAN Liming ZHANG | 2023 | Frontiers of Computer Science2023，17，6： | 0 |
| 13 | Efficient Static Compaction of Test Patterns Using Partial Maximum Satisfiability显示文摘Static compaction methods aim at finding unnecessary test patterns to reduce the size of the test set as a post-process of test generation.Techniques based on partial maximum satisfiability are often used to track many hard problems in various domains,including artificial intelligence,computational biology,data mining,and machine learning.We observe that part of the test patterns generated by the commercial Automatic Test Pattern Generation(ATPG)tool is redundant,and the relationship between test patterns and faults,as a significant information,can effectively induce the test patterns reduction process.Considering a test pattern can detect one or more faults,we map the problem of static test compaction to a partial maximum satisfiability problem.Experiments on ISCAS89,ISCAS85,and ITC99 benchmarks show that this approach can reduce the initial test set size generated by TetraMAX18 while maintaining fault coverage. | Huisi Zhou Dantong Ouyang Liming Zhang | 2021 | Tsinghua Science and Technology2021，26，1： | 0 |
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