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| 1 | Chronic intermittent hypoxia-induced deficits in synaptic plasticity and neurocognitive functions: a role for brain-derived neurotrophic factor显示文摘妨碍的睡觉呼吸暂停(OSA ) 是众所周知的为它的象 neurobehavioral 后果一样新陈代谢。长期的断断续续的组织缺氧(IH ) 是 OSA 的一个主要部件。在最近的年里,实质的进展在阐明被成为了在 neurocognitive 功能上位于长期的 IH 的效果下面的细胞、分子的机制,许多哪个在动物模型基于研究。很多个假设被提出了解释长期的导致 IH 的神经病学的机能障碍。在这些之中,氧化应力和 apoptosis 相关的神经损害的角色广泛地被接受。这里,集中于结果源于动物研究,我们在在长期的 IH 期间在长期的 synaptic 粘性和 neurocognitive 功能引起缺陷加亮导出大脑的神经营养的因素(BDNF ) 的减少的表示的一个可能的角色。在这个题目上的 BDNF 和以前的调查结果之间的可能的关系将被阐明。 | HuiXie Wing-hoYung | 2012 | Acta Pharmacologica Sinica2012，33，1： | 17 |
| 2 | COP9 signalosome subunit PfCsnE regulates secondary metabolism and conidial formation in Pestalotiopsis fici显示文摘The COP9 signalosome(CSN) is a highly conserved multiprotein complex in all eukaryotes and involved in regulation of organism development. In filamentous fungi, several lines of evidence indicate that fungal development and secondary metabolism(SM) are mediated by the fifth subunit of CSN, called CsnE. Here we uncover a connection with CsnE and conidial formation as well as SM regulation in the plant endophytic fungus Pestalotiopsis fici. A homology search of the P. fici genome with CsnE, involved in sexual development and SM in Aspergillus nidulans, identified PfCsnE. Deletion of PfcsnE resulted in a mutant that stopped conidial production, but the conidia are recovered in a PfcsnE complemented strain. This indicates that PfCsnE is required for the formation of conidia. Secondary metabolite analysis demonstrated that the ΔPfcsnE strain produced more chloroisosulochrin, less ficiolide A production in comparison to wild type(WT). Transcriptome analysis of WT andΔPfcsnE strains indicated that PfcsnE impacts the expression levels of 8.37% of 14,797 annotated genes. Specifically, nine biosynthetic gene clusters(BGCs) were up-regulated and three BGCs were down-regulated by PfCsnE. Our results suggest that PfCsnE plays major roles in SM regulation and conidial development in P. fici. | Yanjing Zheng Xiuna Wang Xiaoling Zhang Wei Li Gang Liu Shihua Wang Xiufeng Yan Huixi Zou Wen-Bing Yin | 2017 | Science China(Life Sciences)2017，60，6： | 4 |
| 3 | Identification of novel mutations of IRF6 gene in Chinese families with Van der Woude syndrome显示文摘 | Ye Xiaoqian Jin Huixi Shi Lisong | 2005 | Int J Mol Med2005，16，5： | 1 |
| 4 | Ketanserin stabilizes blood pressure in conscious spontaneously hypertensive rats显示文摘 | Chao‐YuMiao He‐HuiXie HuiYu Zheng‐XuChu Ding‐FengSu | 2003 | Clinical and Experimental Pharmacology and Physiology2003，，3： | 1 |
| 5 | Dynamical Monitoring and Evaluation Methods to Urban Heat Island Effects Based on RS&GIS;显示文摘 | Huixi Xu Yunhao Chen Shangming Dan Wenxia Qiu | 2011 | Procedia Environmental Sciences2011，，： | 1 |
| 6 | Synthesis and Application of Zeolite-encapsulated Nickel Schiff-base Complex显示文摘Transition-metal complex-catalyzed oxidation of organic substrates with molecular oxygen is gaining importance as a viable alternative to the environmentally hazardous metal-oxide-based reagents. The complexes have received much attention recently due to the potential application of these complexes as oxidation catalysts for the oxidation of alkene, enolizable, aldehydes and other organic substrates. Recent studies of our group showed that metal complexes catalyzed the oxidation of organic substrates selectively in the presence of molecular oxygen 1,5. Here, it is reported that zeolite-encapsulated Ni (I) Schiff-base complex exhibit a catalytic activity and selectivity for the oxidation of styrene. | FENG HuiXi | 2001 | Chemical Research in Chinese Universities2001，17，z1： | 0 |
| 7 | Form Properties of Moving Targets Bias Smooth Pursuit Target Selection in Monkeys显示文摘During natural viewing,we often recognize multiple objects,detect their motion,and select one object as the target to track.It remains to be determined how such behavior is guided by the integration of visual form and motion perception.To address this,we studied how monkeys made a choice to track moving targets with different forms by smooth pursuit eye movements in a two-target task.We found that pursuit responses were biased toward the motion direction of a target with a hole.By computing the relative weighting,we found that the target with a hole exhibited a larger weight for vector computation.The global hole feature dominated other form properties.This dominance failed to account for changes in pursuit responses to a target with different forms moving singly.These findings suggest that the integration of visual form and motion perception can reshape the competition in sensorimotor networks to guide behavioral selection. | Huixi Dou Huan Wang Sainan Liu Jun Huang Zuxiang Liu Tiangang Zhou Yan Yang | 2023 | Neuroscience Bulletin2023，39，8： | 0 |
| 8 | Study on the Formation of Urea or Salt Induced Vesicles in Built-system Surfactant显示文摘The spontaneous formation of vesicles in the aqueous of cationic surfactant phosphate (PTA) and anionic surfactant sodium dodecyl sulfate (SDS) at certain mixing ratios have obtained1. The addition of urea or NaI will expand the range of spontaneous vesicle formation. The fact is demonstrated by negative-staining transmission electron microscope(TEM) and dynamic light scattering(DLS) methods. The phenomenon especially in the part of urea is reported by us at first. Mechanism of urea/NaI–induced vesicles formation is discussed from the viewpoint of the molecular geometry packing parameter f, conformation and interaction. | ChangGangHU HuiXIE GanZuoL1 YaAN ZhongNiWANG XiaoYiZHANG JingPingTIAN | 2005 | Chinese Chemical Letters2005，16，5： | 0 |
| 9 | Lower synaptic density associated with gaming disorder:an^(18)F-SynVesT-1 PET imaging study显示文摘Background Internet gaming disorder(IGD)is an ideal model to study the mechanisms underlying synaptic deficits in addiction as it eliminates the confounding effects of substance use.Synaptic loss and deficits are hypothesised to underlie the enduring maladaptive behaviours and impaired cognitive function that contribute to IGD.Aims This study aimed to determine whether subjects with IGD have lower synaptic density than control subjects and the relationship between synaptic density and IGD severity.Methods Eighteen unmedicated subjects diagnosed with current IGD according to the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition criteria and 16 demographically matched healthy controls(HCs)participated in the study and underwent 18F-labelled difluoro-analogue of UCB-J(18F-SynVesT-1)positron emission tomography scans to assess the density of synaptic vesicle glycoprotein 2A(SV2A).The Internet Gaming Disorder Scale-Short Form(IGDS9-SF),Hamilton Rating Scale for Depression(HAMD),Hamilton Anxiety Rating Scale(HAMA),Barratt Impulsiveness Scale Version 11(BIS-11),Stroop Colour-Word Test(SCWT),stop-signal paradigms and N-back tasks were administered to all subjects.Results Patients with IGD had significantly higher scores on the IGDS9-SF,HAMD,HAMA and BIS-11 than HCs.HCs performed better on the two-back and SCWT tests as well as in terms of stop-signal reaction times(SSRTs)in the stop-signal paradigms than patients with IGD.Lower uptake was found in the bilateral putamen,right pregenual anterior cingulate cortex and Rolandic operculum of patients with IGD compared with HCs.Furthermore,in the IGD group,IGDS9-SF scores and daily gaming hours were negatively correlated with the standardised uptake value ratios of 18F-SynVesT-1 in the bilateral putamen.Longer SSRTs were significantly associated with lower SV2A density in the right pregenual anterior cingulate cortex and right Rolandic operculum.Conclusions The in vivo results in this study suggest that lower synaptic density contributes to the severity and impairments in inhibitory control of IGD.These findings may provide further incentive to evaluate interventions that restore synaptic transmission and plasticity to treat IGD. | Jiale Hou Qian Xiao Ming Zhou Ling Xiao Ming Yuan Na Zhong Jiang Long Tao Luo Shuo Hu Huixi Dong | 2023 | General Psychiatry2023，36，5： | 0 |
| 10 | Characteristics and geochemical implications of light hydrocarbons from ultra-deep Ordovician oils in the North Shuntuoguole area, Tarim Basin显示文摘The ultra-deep Ordovician reservoirs in North Shuntuoguole Oilfield(or Shunbei Oilfield)of Sinopec have achieved annual production of one million ton,and the oil&gas in different faults show different physical properties and fluid phases.In this study,the 28 oil samples from the ultra-deep Ordovician were analyzed using whole oil chromatography.The heptane and isoheptane values of the oil samples were in the range of 29.79%‒46.86%and 1.01%-3.06%,respectively,indicating the oils are high mature.The maturity that calculated based on light hydrocarbon values was higher than which calculated by using aromatic hydrocarbon parameters,suggesting the light hydrocarbon maturity mostly reflects the maturity of the late charged hydrocarbon.The 2M-/3M-C5 and 2M-/3M-C_(6) ratios varied in the ranges of 1.41‒1.81 and 0.79-1.09,respectively,and the iC_(5)/nC_(5) and 3M-C_(5)/nC_(6) ratios were 0.31‒0.90 and 0.16-0.37,respectively,indicating that ultra-deep Ordovician reservoirs have not experienced biodegradation.The Mango parameter K_(1) of the oil samples ranges 0.96‒1.01 except for the oil from Well SB4,which suggests that most of the reservoirs have not suffered thermochemical sulfur reduction(TSR).Meanwhile,the oils have not experienced evaporative fractionation since the toluene/nC_(7) and nC_(7)/MCC_(6) ratios range from 0.10-0.38 and 1.50‒1.80,respectively.The close correlation between P_(3) and P_(2)+N_(2) and between P_(2) and N_(2)/P_(3) indicates that the oils from different faults have the same origin.According to the characteristics of LHs rich in n-alkane,as well as other biomarkers,such as aryl isoprenoids,and aromatic hydrocarbon parameters,the oil originated from the source rock of Lower Cambrian Yu’ertusi Formation.Meanwhile,the source rocks in different fault zones slightly differed in organic facies. | Li DONG Anlai MA Huixi LIN Lu YUN Weilong PENG Xiuxiang ZHU | 2022 | Frontiers of Earth Science2022，16，3： | 0 |
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