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| 1 | Higher vitamin D serum concentration increases health related quality of life in patients with inflammatory bowel diseases显示文摘AIM: To investigate the effect of vitamin D(VD) concentrations and VD supplementation on health related quality of life in inflammatory bowel disease(IBD) patients. METHODS: A cohort of 220 IBD patients including 141 Crohn's disease(CD) and 79 ulcerative colitis(UC) patients was followed-up at a tertiary IBD center. A subgroup of the cohort(n = 26) took VD supplements for > 3 mo. Health related quality of life was assessed using the short IBD questionnaire(s IBDQ). VD serum concentration and s IBDQ score were assessed between August and October 2012(summer/autumn period) and between February and April 2013(winter/spring period). The mean VD serum concentration and its correlation with disease activity of CD were determined for each season separately. In a subgroup of patients, the effects of VD supplementation on winter VD serum concentration, change in VD serum concentration from summer to winter, and winter s IBDQ score were analyzed.RESULTS: During the summer/autumn and the winter/spring period, 28% and 42% of IBD patients were VD-deficient(< 20 ng/m L), respectively. In the winter/spring period, there was a significant correlation between s IBDQ score and VD serum concentration in UC patients(r = 0.35, P = 0.02), with a trend towards significance in CD patients(r = 0.17, P = 0.06). In the winter/spring period, VD-insufficient patients(< 30 ng/m L) had a significantly lower mean s IBDQ score than VD-sufficient patients; this was true of both UC(48.3 ± 2.3 vs 56.7 ± 3.4, P = 0.04) and CD(55.7 ± 1.25 vs 60.8 ± 2.14, P = 0.04) patients. In all analyzed scenarios(UC/CD, the summer/autumn period and the winter/spring period), health related quality of life was the highest in patients with VD serum concentrations of 50-59 ng/m L. Supplementation with a median of 800 IU/d VD day did not influence VD serum concentration or the s IBDQ score.CONCLUSION: VD serum concentration correlated with health related quality of life in UC and CD patients during the winter/spring period. | Tibor Hlavaty Anna Krajcovicova Tomas Koller Jozef Toth Monika Nevidanska Martin Huorka Juraj Payer | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Etiology and pathogenesis of acute pancreatitis显示文摘 | Eryanis Payer J Huorka M | 1998 | Bratisl lek listy1998，99，6： | 1 |
| 3 | Etiology and Pathogenesis of Acute Pancreatitis显示文摘 | Ervani S Paver J Huorka M | 2001 | Bratisl LeK Listy2001，8，4： | 1 |
| 4 | Etiology and pathogenesis of acute pancreatitis显示文摘 | Eryani S Payer J Huorka M | 1998 | Bratisl Lek Listy1998，99，： | 1 |
| 5 | Endogenous levels of somatostatin ,C-peptide and insulin in acute pancreatitis显示文摘 | Aleryanis Huorka M Payer J | 1997 | Vnitr Lek1997，43，11： | 1 |
| 6 | Noninvasive scoring algo- rithm to identify significant liver fibrosis among treatment-naive chronic hepatitis C patients 显示文摘 | Koller T Kollerova J Huorka M | 2014 | Eur J Gastroenterol Hepatol2014，26，10： | 1 |
| 7 | Etiology and pathogenesis of acute pancreatitis显示文摘 | Eryani S Payer J Huorka M | 1998 | Bratisl Lek Listy1998，99，6： | 1 |
| 8 | Noninvasive scoring algo- rithm to identify significant liver fibrosis among treatment-naive chronic hepatitis C patients 显示文摘 | Koller T Kollerova J Huorka M | 2014 | Eur J Gastroenterol Hepatol2014，26，10： | 1 |
| 9 | Etiology and patbogenesis of acute pancreatitis 显示文摘 | Eryanjs Payer J Huorka M | 1998 | bratisl Lek listy1998，99，6： | 1 |
| 10 | Colorectal cancer screening in patients with ulcerative and crohn?s colitis with use of colonoscopy, chromoendoscopy and confocal endomicroscopy显示文摘 | Tibor Hlavaty Martin Huorka Tomas Koller Peter Zita Ema Kresanova Boris Rychly Jozef Toth | 2011 | European Journal of Gastroenterology & Hepatology2011，，8： | 1 |
| 11 | Noninvasive scoring algorithm to identify significant liver fibrosis among treatment-naive chronic hepatitis C patients 显示文摘 | Koller T KoUerova J Huorka M | 2014 | Eur J Gastroenterol Hepatol2014，26，10： | 1 |
| 12 | Cholelithiasis and markers of nonalcoholic fatty liver disease in patients with metabolic risk factors显示文摘 | Tomas Koller Jana Kollerova Tibor Hlavaty Martin Huorka Juraj Payer | 2012 | Scandinavian Journal of Gastroenterology2012，，2： | 1 |
| 13 | Endogenous levels of somatostatin, C-peptide and insulin in acute pancreatitis显示文摘 | Aleryani S Huorka M Payer Jr J | 1997 | Vnitr Lek1997，43，11： | 1 |
| 14 | Etiology and pathogensis of acute pancreatitis显示文摘 | ERYANIS A L PAYER J HUORKA M | 1998 | Bratisl Lek List1998，99，： | 1 |
| 15 | Etiology and pathogenesis of acute pancreatitis 显示文摘 | Eryani S Payer J Huorka M | 1998 | Bratisl LekListy1998，99，6： | 1 |
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