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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 3 | Impedance formulas for planar magnetic structures with spiral windings显示文摘 | Hurley W G Duffy M C O'Reilly S | 1999 | IEEE Trans on Indu Electronics1999，46，2： | 1 |
| 4 | Bilateral increased apoptosis and bilateral accumulation of cadmium in infertile men with left varicocele显示文摘 | Millan C Hurley I | 2004 | Hum Reprod2004，19，3： | 1 |
| 5 | Allelic diversity in the TGFβ1 regulatory region: characterization of novel functional single nucleotide polymorphisms 显示文摘 | Shah R Rahaman B Hurley C K | 2006 | Hum Genet2006，119，12： | 1 |
| 6 | Phonon Focusing in Cubic Crystals显示文摘 | Hurley D C Wolfe J P | 1985 | Phys Rev B1985，32，： | 1 |
| 7 | Comprehensive analytic formulae for stellar evolution as a function of mass and metallicity 显示文摘 | Hurley J R Pols O R Tout C A | 2000 | Monthly Notices of the Royal Astronomical Society2000，315，： | 1 |
| 8 | Quantitative elastic-property measurements at the nanoscale with atomic force acoustic microscopy 显示文摘 | HURLEY D C KOPYCINSKA-MULLER M KOS A B | 2005 | Advanced Engineering Materials2005，7，8： | 1 |
| 9 | Mercury methylation in periphyton of the Florida Everglades 显示文摘 | Cleckner L B Gilmour C C Hurley J P | 1999 | Limnology and Oceanography1999，44，7： | 1 |
| 10 | Restricted expression of DMRT3 in chicken and mouse embryos显示文摘 | Hurley T M | 2002 | Mech Dev2002，119，： | 1 |
| 11 | Seminal lead concentrations negativelyaffect outcomes of artificial insemination显示文摘 | HURLEY I R MILLAN C | 2003 | Ferility Sterility2003，80，3： | 1 |
| 12 | Electrophoretic comparisons of laetoferrin from bovine mammary secretions, milk neurophils, and human milk 显示文摘 | Hurley W L Grieve R C J Hegarty H M | 1993 | J Dairy Sci1993，76，： | 1 |
| 13 | Quantitative subsurface contact reso- nance force microscopy of model polymer nanocom- posites 显示文摘 | Killgore J P Kelly J Y Stafford C M Fasolka M J Hurley D C | 2011 | Nanotechnology2011，22，17： | 1 |
| 14 | Mapping substrate/film adhesion with contact resonance-frequency atomic force mi croscopy 显示文摘 | Hurley D C Kopycinska Muller M Langlois E D Kos A B Barbosa N | 2006 | Applied Physics Letters2006，89，02： | 1 |
| 15 | Longitudinal study of grass pollen exposure, symptoms, and exhaled nitric oxide in childhood seasonal allergic asthma显示文摘 | Roberts G Hurley C Bush A | 2004 | Thorax2004，59，： | 1 |
| 16 | Calculation of self and mutual impedances in planar magnetic structure显示文摘 | Duffy M C | 1995 | IEEE Trans Magn1995，31，： | 1 |
| 17 | Effects of quality, quantity,and timing of colostrum feeding and addition of a dried colostrumsupplement on immunoglobulin G1 absorption in Holstein bullcalves显示文摘 | Morin D E Mccoy G C Hurley W L | 1997 | J Dairy Sci1997，80，4： | 1 |
| 18 | Percutaneous Vertebroplasty显示文摘 | Hurley MC Kaakaji R Dabus C | 2009 | Neurosurg Clin N A m2009，20，3： | 1 |
| 19 | Quantitative nanoscale modu- lus measurements and elastic imaging of SnO2 nanobe- lts 显示文摘 | Zheng Y G Geer R E Dovidenko K Kopyeinska- Muller M Hurley D C | 2006 | Journal of Applied Physics2006，100，12： | 1 |
| 20 | Exploratory and confirmatory factor analysis:guidelines,issues,and alternatives显示文摘 | SCANDURA T A SCHRIESHEIM C A | 1997 | Journal of Organizational Behavior (1986-1998)1997，18，6： | 1 |
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