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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | The need for a national strategy for chronic pain management in Ireland显示文摘 | Hurley DA Power C | 2006 | Ir J Med Sci2006，175，2： | 1 |
| 3 | Airway inflammatory markers in individuals with cystic fibrosis and non-cystic fibrosis bronchiectasis显示文摘 | Bergin DA Hurley K Mehta A | | 0，，01： | 1 |
| 4 | The survival of skeletal muscle myoblasts invitro is sensitive to a donor of nitric oxide and superoxide, SIN - 1, but not to nitric oxide or superoxide alone 显示文摘 | Lepore DA Stewart AG Tomasi A Anderson RL Hurley JV Morrison WA | 1999 | Nitric Oxide1999，3，： | 1 |
| 5 | Health status of caregiv- ors of children with cerebral palsy显示文摘 | Byrne MB Hurley DA Daly L | 2010 | Child Care Health Dev2010，36，5： | 1 |
| 6 | Public health workforce shortages imperil nation's health 显示文摘 | Draper DA Hurley RE Lauer JR | 2008 | Res Briefs2008，，4： | 1 |
| 7 | Health status of caregivers of children with cerebral palsy显示文摘 | Byrne MB Hurley DA Daly L | 2010 | Child Care Health Dev2010，36，5： | 1 |
| 8 | Health status of care givers of children with cerebral palsy显示文摘 | Byrne MB Hurley DA Daly L | 2010 | Child Care Health Dev2010，36，5： | 1 |
| 9 | Alpha-1 antitryp-sin: a potent anti-inflammatory and potential novel therapeuticagent显示文摘 | Bergin DA Hurley K McElvaney NG | 2012 | Arch Immunol Ther Exp2012，60，2： | 1 |
| 10 | Airway inflammatory markers in individuals with cystic fibrosis and non-cystic fibrosis bronehiectasis显示文摘 | Bergin DA Hurley K Mehta A | 2013 | J Inflamm Res2013，6，1： | 1 |
| 11 | Prior heat stress improves survival of ischemicreperfused skeletal muscle in vivo显示文摘 | Lepore DA Hurley JV Stewart AG | 2000 | Muscle Nerve2000，23，： | 1 |
| 12 | Airway inflammatory markers in individuals with cystic fibrosis and non-cystic fibrosis bronehiectasis 显示文摘 | Bergin DA Hurley K Mehta A | 2013 | J Infiamm Res2013，6，： | 1 |
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