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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | 显示文摘 | Saiz E Hwang C W Suganuma K | 2003 | Acta Materialia2003，51，： | 2 |
| 3 | Partial interferon - gam- mareceptor deficiency and non - tuberculous mycobacterial |ungdis- ease 显示文摘 | HWANG J H KOH W J KIM E J | 2006 | Tuberculosis ( Edinb)2006，86，5： | 1 |
| 4 | C-terminal deletion mutant of pokeweed antiviral protein inhibits viral infection but does not depurinate host ribosomes 显示文摘 | Tumer N E Hwang D J | 1997 | Proc Natl Acad Sci USA1997，94，8： | 1 |
| 5 | A secure nonrepudiable threshold proxy signature scheme with known signers显示文摘 | Hwang M S Lin I C Lu E J L | 2000 | International Journal of Informatica2000，11，2： | 1 |
| 6 | Laparoscopic management of extra-adrenal pheochromocytoma显示文摘 | Hwang J Shoaf G Uchio E M | 2004 | J Urol2004，171，： | 1 |
| 7 | Characterization of sodium hyaluronate blends using frit inlet asymmetrical flow field-flow frac- tionation and multiangle light scattering显示文摘 | Ali M Hwang E Cho IH | 2012 | Analytical and bioanalyti- cal chemistry2012，402，3： | 1 |
| 8 | Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH-diaphorase显示文摘 | Bredit D S Glatt C E Hwang P M | 1991 | Neruon1991，7，： | 1 |
| 9 | In situ quartz crystal microbalance studies of nickel hydrous oxide films in alkaline electrolytes显示文摘 | Mo Y Hwang E Scherson D | 1996 | J Electrochem Soc1996，143，1： | 1 |
| 10 | Innervation of the lower eyelid in relation to blepharoplasty and midface lift:clinical observation and cadaveric study显示文摘 | LEE D K LEE E J | 2001 | Ann Plast Surg2001，47，1： | 1 |
| 11 | An LTV model and customer segmentation based on customer value:a case study on the wireless telecommunication industry显示文摘 | Jung T Suh E | 2004 | Expert Systems with Applications2004，26，： | 1 |
| 12 | Ten-yeas survival of patieants whit locally advanced stage Ⅰb- Ⅱb cervical cancer after neoadjuvant chemotherapy and radical hysterectomy显示文摘 | HWANG Y Y MOON H CHO SH E | 2001 | Gynecol Oncol2001，82，： | 1 |
| 13 | A new evolutionary particle filter for the prevention of sample impoverishment 显示文摘 | PARK S HWANG J P KIM E | 2009 | IEEE Transactions on Evolutionary Computation2009，13，4： | 1 |
| 14 | Fuzzy model based adaptive synchronization of uncertain chaotic systems: Robust tracking control approach显示文摘 | Hwang E J Hyun C H Kim E | 2009 | Physics Letters A2009，373，： | 1 |
| 15 | The biochemical andphysical effects of Effect of electrical stimulation on beef andsheep meat tendemess显示文摘 | Hwang I H Devine C E Hopkins D L | 2003 | Meat Science2003，65，： | 1 |
| 16 | 查看详情显示文摘 | Priyadarshi A Kim E. E Hwang K. Y | | 0，，： | 1 |
| 17 | Antiallodynic Effects of Electroacupuncture Combined with MK-801 Treatment through the Regulation of p35/p25 in Experimental Diabetic Neuropathy显示文摘 | Hwang HS Yang E J Lee SM | | 0，，03： | 1 |
| 18 | Security enhancement on a new authentication scheme with anonymity for wireless environments显示文摘 | Lee C C Hwang M S Liao I E | 2006 | IEEE Trans on Industrial Electronics2006，53，5： | 1 |
| 19 | Paraquaintoxication in Korea 显示文摘 | Hwang K Y Lee E Y Hong S Y | 2002 | Arch Environ Health2002，57，2： | 1 |
| 20 | Overexpression of ATP sulfurylase in Indian mustard leads to increased selenate uptake,reduction,and tolerance显示文摘 | PILON-MITS E A H HWANG S LYTLE C M | 1999 | Plant Physiol1999，119，10： | 1 |
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