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| 1 | RANKL deletion in periodontal ligament and bone lining cells blocks orthodontic tooth movement显示文摘The bone remodeling process in response to orthodontic forces requires the activity of osteoclasts to allow teeth to move in the direction of the force applied. Receptor activator of nuclear factor-κB ligand(RANKL) is essential for this process although its cellular source in response to orthodontic forces has not been determined. Orthodontic tooth movement is considered to be an aseptic inflammatory process that is stimulated by leukocytes including T and B lymphocytes which are presumed to stimulate bone resorption. We determined whether periodontal ligament and bone lining cells were an essential source of RANKL by tamoxifen induced deletion of RANKL in which Cre recombinase was driven by a 3.2 kb reporter element of the Col1α1 gene in experimental mice(Col1α1.CreER^(TM+).RANKL^(f/f)) and compared results with littermate controls(Col1α1.CreER^(TM-).RANKL^(f/f)). By examination of Col1α1.CreER^(TM+).ROSA26 reporter mice we showed tissue specificity of tamoxifen induced Cre recombinase predominantly in the periodontal ligament and bone lining cells. Surprisingly we found that most of the orthodontic tooth movement and formation of osteoclasts was blocked in the experimental mice, which also had a reduced periodontal ligament space. Thus, we demonstrate for the first time that RANKL produced by periodontal ligament and bone lining cells provide the major driving force for tooth movement and osteoclastogenesis in response to orthodontic forces. | Chia-Ying Yang Hyeran Helen Jeon Ahmed Alshabab Yu Jin Lee Chun-Hsi Chung Dana T. Graves | 2018 | International Journal of Oral Science2018，10，1： | 10 |
| 2 | Current trends in the development and application of molecular technologies for cancer epigenetics显示文摘Current progress in epigenetic research supports the view that diet and dietary components are important in cancer etiology by enhancing or inhibiting carcinogenesis.Since diet and dietary factors may significantly contribute to the causation and progression of many cancers,it is important to find the molecular mechanisms of action of such dietary factors for cancer prevention and treatment.Recently,the role of epigenetic mechanisms in the cancer development and progression has attracted more attention as additional evidence along with traditional DNA sequence based mechanisms such as mutations and structural re-arrangements.Such an increasing interest in cancer epigenetics has also accelerated the development and application of molecular assays and tools for DNA methylation detection and histone modification enrichment analysis.In this paper,key assays and methods for epigenetic research are reviewed and discussed in terms of their utility and usability.In addition,more advanced methods for genome-wide analysis are introduced as part of upcoming research trends and directions. | Hyeran Jang Hyunjin Shin | 2013 | World Journal of Gastroenterology2013，19，7： | 3 |
| 3 | A simple, flexible and high-throughput cloning system for plant genome editing via CRISPR-Cas system显示文摘CRISPR-Cas9 system is now widely used to edit a target genome in animals and plants. Cas9 protein derived from Streptococcus pyogenes(Sp Cas9) cleaves double-stranded DNA targeted by a chimeric single-guide RNA(sg RNA). For plant genome editing, Agrobacterium-mediated T-DNA transformation has been broadly used to express Cas9 proteins and sg RNAs under the control of Ca MV 35 S and U6/U3 promoter, respectively. We here developed a simple and high-throughput binary vector system to clone a 19 20 bp of sg RNA, which binds to the reverse complement of a target locus, in a large T-DNA binary vector containing an Sp Cas9 expressing cassette. Twostep cloning procedures:(1) annealing two target-specific oligonucleotides with overhangs specific to the Aar I restriction enzyme site of the binary vector; and(2) ligating the annealed oligonucleotides into the two Aar I sites of the vector, facilitate the high-throughput production of the positive clones. In addition, Cas9-coding sequence and U6/U3 promoter can be easily exchanged via the GatewayTMsystem and unique Eco RI/Xho I sites on the vector, respectively. We examined the mutation ratio and patterns when we transformed these constructs into Arabidopsis thaliana and a wild tobacco, Nicotiana attenuata. Our vector system will be useful to generate targeted large-scale knock-out lines of model as well as non-model plant. | Hyeran Kim Sang-Tae Kim Jahee Ryu Min Kyung Choi Jiyeon Kweon Beum-Chang Kang Hyo-Min Ahn Suji Bae Jungeun Kim Jin-Soo Kim Sang-Gyu Kim | 2016 | Journal of Integrative Plant Biology2016，58，8： | 2 |
| 4 | FRIP:A region-based image retrieval tool using automatic image segmentation and stepwise boolean and mtching显示文摘 | Byoung Chul Ko Hyeran Byun | 2005 | IEEE Transactions on Multimedia2005，7，1： | 1 |
| 5 | Surface energy effects on osteoblast spatial growth and mineralization显示文摘 | Jung Yul Lim Michael C. Shaughnessy Zhiyi Zhou Hyeran Noh Erwin A. Vogler Henry J. Donahue | 2008 | Biomaterials2008，，12： | 1 |
| 6 | Incremental face recognition for large-scale social network services显示文摘 | KWONTAEG C KAR-ANN T HYERAN B | 2012 | Pattern Recognition2012，45，8： | 1 |
| 7 | Effect of Weissella Confusa Strain PL9001 on the Adherence and Growth of Helicobacter Pylori显示文摘 | HYERAN N MISUN HA ON BAE | 2002 | Applied and Enviorenmental Microbiology2002，68，9： | 1 |
| 8 | Detection of dominant flow and abnormal events in surveillance video显示文摘 | Sooyeong K Hyeran B | 2011 | Optical Engineering2011，50，27： | 1 |
| 9 | Salient human detection for robot vision显示文摘 | Kwak Sooyeong Ko ByoungChul Byun Hyeran | 2007 | Pattern Analysis & Applications2007，10，4： | 1 |
| 10 | Analysis of vaginal lactic acid producing bacteria in healthy women 显示文摘 | HYERAN N KYUNGHEE W YEONHEE L | 2007 | J Microbiol2007，45，6： | 1 |
| 11 | The barley ERF-type transcription factor HvRAF confers enhanced pathogen resistance and salt tolerance in Arabidopsis显示文摘 | Jinwook Jung So Youn Won Seok Cheol Suh HyeRan Kim Rod Wing Yeonhwa Jeong Ingyu Hwang Minkyun Kim | 2007 | Planta2007，，3： | 1 |
| 12 | Automatic generation of structured hyperdocuments from document images显示文摘 | Jeong-Seon Park Hyeran Byun | 2002 | Pattern Recognition2002，35，： | 1 |
| 13 | Near-Infrared Fluorescent pH-Sensitive Probes via Unexpected Barbituric Acid Mediated Synthesis显示文摘 | Hyeran L Mikhail Y B Kevin G | 2009 | Org Lett2009，11，： | 1 |
| 14 | Analysis of vaginal lactic acid producing bacteria in healthy women 显示文摘 | HYERAN N KYUNGHEEe W YEONHEE L | 2007 | Microbio12007，45，： | 1 |
| 15 | Distalization of the mandibular dentition with mini-implants to correct a Class III malocclusion with a midline deviation显示文摘 | Kyu-Rhim Chung Seong-Hun Kim HyeRan Choo Yoon-Ah Kook Jason B. Cope | 2010 | American Journal of Orthodontics & Dentofacial Orthopedics2010，，1： | 1 |
| 16 | Random sheared fosmid library as a new genomic tool to accelerate complete finishing of rice (Oryza sativa spp. Nipponbare) genome sequence: sequencing of gap-specific fosmid clones uncovers new euchromatic portions of the genome显示文摘 | Jetty S. S. Ammiraju Yeisoo Yu Meizhong Luo Dave Kudrna HyeRan Kim Jose L. Goicoechea Yuichi Katayose Takashi Matsumoto Jianzhong Wu Takuji Sasaki Rod A. Wing | 2005 | Theoretical and Applied Genetics2005，，8： | 1 |
| 17 | FRIP:A regionbased image retrieval tool using automatic image segmentation and stepwise boolean and matching显示文摘 | Byun Hyeran | 2005 | IEEE Transactions on Multimedia2005，7，1： | 1 |
| 18 | The barley ERF-type transcription factor HvRAF confers enhanced pathogen resistance and salt tolerance in Arabidopsis显示文摘 | Jinwook Jung So Youn Won Seok Cheol Suh HyeRan Kim Rod Wing Yeonhwa Jeong Ingyu Hwang Minkyun Kim | 2007 | Planta2007，，3： | 1 |
| 19 | Differential lineage-specific amplification of transposable elements is responsible for genome size variation in Gossypium显示文摘 | Jennifer S H HyeRan K John D N | 2006 | Genome Research2006，16，10： | 1 |
| 20 | FRIP: a region image retrieval tool using automatic image segmentation and stepwise boolean and matching显示文摘 | ByoungChul Ko Hyeran Byun | 2005 | IEEE Trans On Multimedia2005，7，1： | 1 |
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