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| 1 | Regulation of drug metabolism and toxicity by multiple factors of genetics,epigenetics,lncRNAs,gut microbiota,and diseases:a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations(MDO)显示文摘Variations in drug metabolism may alter drug efficacy and cause toxicity;better understanding of the mechanisms and risks shall help to practice precision medicine.At the 21 st International Symposium on Microsomes and Drug Oxidations held in Davis,California,USA,in October 2-6,2016,a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind variable drug metabolism and toxicity,and discussed potential implications to personalized medications.A considerably insightful overview was provided on genetic and epigenetic regulation of gene expression involved in drug absorption,distribution,metabolism,and excretion(ADME) and drug response.Altered drug metabolism and disposition as well as molecular mechanisms among diseased and special populations were presented.In addition,the roles of gut microbiota in drug metabolism and toxicology as well as long non-coding RNAs in liver functions and diseases were discussed.These findings may offer new insights into improved understanding of ADME regulatory mechanisms and advance drug metabolism research. | Ai-Ming Yu Magnus Ingelman-Sundberg Nathan J.Cherrington Lauren M.Aleksunes Ulrich M.Zanger Wen Xie Hyunyoung Jeong Edward M.Morgan Peter J.Turnbaugh Curtis D.Klaassen Aadra P.Bhatt Matthew R.Redinbo Pengying Hao David J.Waxman Li Wang Xiao-bo Zhong | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 3 |
| 2 | Predicting the Present with Google Trends显示文摘 | HYUNYOUNG CHOI HAL VARIAN | 2012 | Economic Record2012，，： | 2 |
| 3 | Predicting the Present with Google Trends显示文摘 | HYUNYOUNG CHOI HAL VARIAN | 2012 | Economic Record2012，，： | 2 |
| 4 | 17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α显示文摘UDP-glucuronosyltransferase 1A9(UGT1A9) is a major phase II enzyme responsible for elimination of drugs and endogenous molecules.Clinical data have shown increased elimination of UGT1A9 substrates in pregnant women or oral contraceptive users,but the role of estrogen in the regulation of UGT1A9 expression remains unknown.In this study,we investigated the effect of 17β-estradiol(E2) on UGT1A9 expression and the role of ERα in the transcriptional regulation of UGT1A9.E2 significantly increased UGT1A9 promoter activity in Hep G2 cells in the presence of ERα.UGT1A9 induction by E2 was abrogated by antiestrogen ICI182,780 in Hep G2 cells that constitutively express ERα.Results from transient transfection of ERα mutants into Hep G2 cells demonstrated that mutation at DNA-binding domain of ERα abrogates increased UGT1A9 promoter activity by E2.Deletion and mutation assays of UGT1A9 promoter revealed a putative ERE located within -2262/-1987 region.Examination of healthy human liver tissues revealed significantly higher UGT1A9 expression in women as compared to men.Together,these findings provide a mechanistic basis for the previous clinical reports and may shed a light on identifying sources for inter-individual variability in UGT1A9-mediated drug metabolism. | Sung-joon Cho Miaoran Ning Yanyan Zhang Leah H.Rubin Hyunyoung Jeong | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 2 |
| 5 | Optimal brassiere wirebased on the 3D anthropometric measurements of under breast curve显示文摘 | Lee HyunYoung Hong Kyunghi | | 0，，03： | 1 |
| 6 | Biosorption of nanoparticles to heterotrophic wastewater biomass显示文摘 | Mehlika A. Kiser Hodon Ryu Hyunyoung Jang Kiril Hristovski Paul Westerhoff | 2010 | Water Research2010，，14： | 1 |
| 7 | Graph the- oretic topological analysis of web service networks 显示文摘 | Hyunyoung Kil Seog-Chan O Ergin Elmacioglu | 2009 | World Wide Web2009，21，3： | 1 |
| 8 | Measurement protocol of women's nude breasts using 3D scanning technique 显示文摘 | LEE Hyunyoung KYUNGHI Honga | 2004 | Applied Ergonomics2004，35，： | 1 |
| 9 | Cervical strain determined by ultrasound elastography and its association with spontaneous preterm delivery显示文摘 | Edgar Hernandez-Andrade Roberto Romero Steven J. Korzeniewski Hyunyoung Ahn Alma Aurioles-Garibay Maynor Garcia Alyse G. Schwartz Lami Yeo Tinnakorn Chaiworapongsa Sonia S. Hassan | 2014 | Journal of Perinatal Medicine2014，，2： | 1 |
| 10 | Graph Theoretic Topological Analysis of Web Service Networks显示文摘 | Hyunyoung Kil Seog-Chan Oh Ergin Elmacioglu Wonhong Nam Dongwon Lee | 2009 | World Wide Web2009，，3： | 1 |
| 11 | A Distributed Authentication Scheme for a Wireless Sensing System显示文摘 | Bauer K Lee Hyunyoung | 2008 | ACM Transactions on Infor mation and System Security2008，11，13： | 1 |
| 12 | Multidimensional Hybrid Architecture Encapsulating Cobalt Oxide Nanoparticles into Carbon Nanotube Branched Nitrogen-Doped Reduced Graphene Oxide Networks for Lithium–Sulfur Batteries显示文摘Lithium–sulfur batteries(LSBs)are regarded as promising candidates for the next-generation energy storage devices owing to their high-theoretical capacity(1675 mAh g^(−1))and affordable cost.However,several limitations of LSBs such as the lithium polysulfide shuttle,large volume expansion,and low electrical conductivity of sulfur need to be resolved for practical applications.To address these limitations,herein,a multidimensional architectured hybrid(Co@CNT/nG),where Co_(3)O_(4) nanoparticles are encapsulated into threedimensional(3D)porous N-doped reduced graphene oxide interconnected with carbon nanotube(CNT)branches,is synthesized through a simple pyrolysis method.The synergistic effect achieved through the homogeneously distributed and encapsulated Co_(3)O_(4) nanoparticles,the interconnected CNT branches,and the 3D hierarchical porous structure and N-doping of Co@CNT/nG significantly suppresses the shuttle effect of lithium polysulfides and enhances the conversion redox kinetics for the improved sulfur utilization.We validate this effect through various measurements including symmetric cells,Li_(2)S nucleation,shuttle currents,Tafel slopes,diffusion coefficients,and post-mortem analyses.Importantly,Co@CNT/nG-70S-based LSB cells achieve a high-specific capacity of 1193.1 mAh g^(−1) at 0.1 C and a low capacity decay rate of 0.030%per cycle for 700 cycles at 5 C,delivering a high areal capacity of 5.62 mAh cm^(−2) even with a loading of 6.5 mg cm^(−2). | Jeong Seok Yeon Young Hun Ko Tae Ho Park Hyunyoung Park Jongsoon Kim Ho Seok Park | 2022 | Energy & Environmental Materials2022，5，2： | 1 |
| 13 | Identification of long-range transported haze phenomena and their meteorological features over Northeast Asia显示文摘 | Jo HyunYoung Kim CheolHee | 2013 | J Appl Meteor Climatol2013，52，： | 1 |
| 14 | Measurement protocol of women's nude breasts using 3D scanning technique 显示文摘 | LEE Hyunyoung KYUNGHI Honga | 2004 | Applied Ergonomics2004，35，： | 1 |
| 15 | Biosorption of nanoparticles to heterotrophic wastewater biomass显示文摘 | Mehlika A. Kiser Hodon Ryu Hyunyoung Jang Kiril Hristovski Paul Westerhoff | 2010 | Water Research2010，，14： | 1 |
| 16 | A distributed authentication scheme for a wireless sensing system显示文摘 | Bauer K Lee Hyunyoung | 2008 | ACM Transactions on Information and System Security2008，11，13： | 1 |
| 17 | Unexpected Li displacement and suppressed phase transition enabling highly stabilized oxygen redox in P3-type Na layered oxide cathode显示文摘Oxygen redox is considered a new paradigm for increasing the practical capacity and energy density of the layered oxide cathodes for Na-ion batteries. However, severe local structural changes and phase transitions during anionic redox reactions lead to poor electrochemical performance with sluggish kinetics.Here, we propose a synergy of Li-Cu cations in harnessing the full potential of oxygen redox, through Li displacement and suppressed phase transition in P3-type layered oxide cathode. P3-type Na_(0.7)[Li_(0.1)Cu_(0.2)Mn_(0.7)]O_(2) cathode delivers a large specific capacity of ~212 mA h g^(-1)at 15 mA g^(-1). The discharge capacity is maintained up to ~90% of the initial capacity after 100 cycles, with stable occurrence of the oxygen redox in the high-voltage region. Through advanced experimental analyses and first-principles calculations, it is confirmed that a stepwise redox reaction based on Cu and O ions occurs for the charge-compensation mechanism upon charging. Based on a concrete understanding of the reaction mechanism, the Li displacement by the synergy of Li-Cu cations plays a crucial role in suppressing the structural change of the P3-type layered material under the oxygen redox reaction, and it is expected to be an effective strategy for stabilizing the oxygen redox in the layered oxides of Na-ion batteries. | Myungeun Choi Hobin Ahn Hyunyoung Park Yongseok Lee Jinho Ahn Bonyoung Ku Junseong Kim Wonseok Ko Jungmin Kang Jung-Keun Yoo Duho Kim Jongsoon Kim | 2023 | Journal of Energy Chemistry2023，，10： | 0 |
| 18 | Occurrence of anionic redox with absence of full oxidation to Ru^(5+) in high-energy P2-type layered oxide cathode显示文摘The anionic redox has been widely studied in layered-oxide-cathodes in attempts to achieve highenergy-density for Na-ion batteries(NIBs).It is known that an oxidation state of Mn^(4+) or Ru^(5+) is essential for the anionic reaction of O^(2-)/O~-to occur during Na^(+) de/intercalation.However,here,we report that the anionic redox can occur in Ru-based layered-oxide-cathodes before full oxidation of Ru^(4+)/Ru^(5+).Combining studies using first-principles calculation and experimental techniques reveals that further Na^(+) deintercalation from P2-Na_(0.33)[Mg_(0.33)Ru_(0.67)]O_(2) is based on anionic oxidation after 0.33 mol Na^(+) deintercalation from P2-Na_(0.67)[Mg_(0.33)Ru_(0.67)]O_(2) with cationic oxidation of Ru^(4+)/Ru^(4.5+).Especially,it is revealed that the only oxygen neighboring 2Mg/1 Ru can participate in the anionic redox during Na^(+) de/intercalation,which implies that the Na-O-Mg arrangement in the P2-Na_(0.33)[M9_(0.33)Ru_(0.67)]O_(2) structure can dramatically lower the thermodynamic stability of the anionic redox than that of cationic redox.Through the O anionic and Ru cationic reaction,P2-Na_(0.67)[Mg_(0.33)Ru_(0.67)]O_(2) exhibits not only a large specific capacity of~172 mA h g^(-1) but also excellent power-capability via facile Na^(+) diffusion and reversible structural change during charge/discharge.These findings suggest a novel strategy that can increase the activity of anionic redox by modulating the local environment around oxygen to develop high-energy-density cathode materials for NIBs. | Jinho Ahn Hyunyoung Park Wonseok Ko Yongseok Lee Jungmin Kang Seokjin Lee Sangyeop Lee Eunji Sim Kyuwook Ihm Jihyun Hong Jung-Keun Yoo Kyojin Ku Jongsoon Kim | 2023 | Journal of Energy Chemistry2023，，9： | 0 |
| 19 | Inhomogeneous lithium-storage reaction triggering the inefficiency of all-solid-state batteries显示文摘All-solid-state batteries offer an attractive option for developing safe lithium-ion batteries.Among the various solid-state electrolyte candidates for their applications,sulfide solid electrolytes are the most suitable owing to their high ionic conductivity and facile processability.However,their performance is extensively lower compared with those of conventional liquid electrolyte-based batteries mainly because of interfacial reactions between the solid electrolytes and high capacity cathodes.Moreover,the kinetic evolution reaction in the composite cathode of all-solid-state lithium batteries has not been actively discussed.Here,electrochemical analyses were performed to investigate the differences between the organic liquid electrolyte-based battery and all-solid-state battery systems.Combined with electrochemical analyses and synchrotron-based in situ and ex situ X-ray analyses,it was confirmed that inhomogeneous reactions were due to physical contact.Loosely contacted and/or isolated active material particles account for the inhomogeneously charged regions,which further intensify the inhomogeneous reactions during extended cycles,thereby increasing the polarization of the system.This study highlighted the benefits of electrochemo-mechanical integrity for securing a smooth conduction pathway and the development of a reliable homogeneous reaction system for the success of solid-state batteries. | Jaeyoung Kim Wontae Lee Jangwhan Seok Eunkang Lee Woosung Choi Hyunyoung Park Soyeong Yun Minji Kim Jun Lim Won-Sub Yoon | 2022 | Journal of Energy Chemistry2022，31，3： | 0 |
| 20 | A comprehensive review of pre-lithiation/sodiation additives for Li-ion and Na-ion batteries显示文摘Lithium/Sodium-ion batteries(LIB/SIB)have attracted enormous attention as a promising electrochemical energy storage system due to their high energy density and long cycle life.One of the major hurdles is the initial irreversible capacity loss during the first few cycles owing to forming the solid electrolyte interphase layer(SEI).This process consumes a profusion of lithium/sodium,which reduces the overall energy density and cycle life.Thus,a suitable approach to compensate for the irreversible capacity loss must be developed to improve the energy density and cycle life.Pre-lithiation/sodiation is a widely accepted process to compensate for the irreversible capacity loss during the initial cycles.Various strategies such as physical,chemical,and electrochemical pre-lithiation/sodiation have been explored;however,these approaches add an extra step to the current manufacturing process.Alternative to these strategies,pre-lithiation/sodiation additives have attracted enormous attention due to their easy adaptability and compatibility with the current battery manufacturing process.In this review,we consolidate recent developments and emphasize the importance of using pre-lithiation/sodiation additives(anode and cathode)to overcome the irreversible capacity loss during the initial cycles in lithium/sodium-ion batteries.This review also addresses the technical and scientific challenges of using pre-lithiation/sodiation additives and offers the insights to boost the energy density and cycle life with their possible commercial exploration.The most important prerequisites for designing effective pre-lithiation/sodiation additives have been explored and the future directions have been discussed. | Pranav Kulkarni Hyunyoung Jung Debasis Ghosh Mohammed Jalalah Mabkhoot Alsaiari Farid A.Harraz R.Geetha Balakrishna | 2023 | Journal of Energy Chemistry2023，，1： | 0 |
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